Bibliothek

Tropenmedizinische Spezialbibliothek
Tropenmedizinische Spezialbibliothek

Die Bibliothek besteht seit der Gründung des Instituts im Jahre 1900 und ist als älteste und größte tropenmedizinische Spezialbibliothek in Deutschland die nationale Referenzbibliothek für Tropenmedizin; sie nimmt am bundesweiten Leihverkehr für medizinische Fachliteratur teil.

Sie führt die Bestände an Monographien und Zeitschriften aus den Sammelgebieten Tropenmedizin, Parasitologie, Immunologie, Virologie, Molekularbiologie (ca. 46.000 Bände, 48.000 Sonderdrucke und 96 laufend gehaltene Zeitschriften, davon 56 elektronisch) und macht sie den Mitarbeitern zugänglich. Sie beschafft nicht vorgehaltene Literatur und erschließt den Archivbestand zur Geschichte des Instituts.

Die Bibliothek ist öffentlich zugänglich, und ihre Nutzung ist auch für auswärtige Nutzer kostenfrei. Sie ist eine Präsenzbibliothek; Entleihungen sind nur innerhalb des Instituts möglich.Die Bestände sind über den Gemeinsamen Bibliotheksverbund erfasst: www.gbv.de

Bei Fragen wenden Sie sich bitte an die Bibliothekarin.

Linkliste

Zeitschriften

Publikationen aus dem Institut

Jahresberichte geben Auskunft über Forschungsprojekte, Veranstaltungen, sowie Publikationen und Aktivitäten der Mitarbeiter und sind vorwiegend in englischer Sprache abgefasst. Bericht des Direktors und der Sektionssprecher auch auf Deutsch.

Jahresbericht 2014/2015 (deutsch) (PDF-Version, 5,7 MB)
ISSN 2193-0899
Jahresbericht 2014/2015 (englisch) (PDF-Version, 5,4 MB)
ISSN 1616-4504

Jahresbericht 2012/2013 (deutsch) (PDF-Version, 5,4 MB)
ISSN 2193-0899
Jahresbericht 2012/2013 (englisch) (PDF-Version, 5,7 MB)
ISSN 1616-4504

Jahresbericht 2010/2011 (deutsch) (PDF-Version, 5,7 MB)
ISSN 2193-0899
Jahresbericht 2010/2011 (englisch) (PDF-Version, 5,7 MB)
ISSN 2193-0899

Jahresbericht 2008/2009 (deutsch)(PDF-Version, 4,3 MB)
Jahresbericht 2008/2009 (englisch) (PDF-Version, 4,3 MB)
ISSN 1616-4504

Tätigkeitsbericht 2006/2007 (PDF-Version, 5,4 MB)
ISSN 1616-4504

Tätigkeitsbericht 2004/2005 (PDF-Version, 5,8 MB)
ISSN 1616-4504

Tätigkeitsbericht 2002/2003 (PDF-Version, 3,0 MB)
ISSN 1616-4504

Publikationen über das Institut

Forschen - Heilen - Lehren: 100 Jahre Hamburger Tropeninstitut
von Sven Tode unter Mitarbeit von Kathrin Kompisch (22 Seiten)
Vorschau (als PDF-Version)

Wissenschaftliche Arbeiten aus 100 Jahren Hamburger Tropenmedizin
von Erich Mannweiler (28 Seiten)
Vorschau (als PDF-Version)

Die beiden Aufsätze sind in einem Sonderband zum Jahresbericht 1999/2000 erschienen. Leider ist es jedoch vergriffen.

Bernhard-Nocht-Institut Hamburg 1900-2000
Katalog zur Ausstellung
52 Seiten
ISBN 3-921762-01-4

Geschichte des Instituts für Schiffs- und Tropenkrankheiten in Hamburg, 1900-1945
von Erich Mannweiler
245 Seiten, Reihe "Abhandlungen des Naturwissenschaftlichen Vereins in Hamburg"
ISBN 3-931374-32-7

Das Hamburger Tropeninstitut 1919-1945: Auswärtige Kulturpolitik und Kolonialrevisionismus nach Versailles
von Stefan Wulf
244 Seiten, Hamburger Beiträge zur Wissenschaftsgeschichte Bd. 9, Dietrich Reimer Verlag
ISBN 3-496-02537-9

Wissenschaftliche Publikationen

Hier finden Sie ausgewählte Publikationen der Forschungsgruppen.
Weitere Publikationen finden Sie auf der entsprechenden Webseite jeder Gruppe.

Abteilung Molekulare Parasitologie

The cytokine profile of human NKT cells and PBMCs is dependent on donor sex and glycolipid ligands used for stimulation.
Bernin H, Fehling H, Marggraff C, Tannich E, Lotter H
Med Microbiol Infect (2016), in press

Phylogeny of haemosporidian blood parasites revealed by a multi-gene approach.
Borner J, Pick C, Thiede J, Kolawole OM, Kingsley MT, Schulze J, Cottontail VM, Wellinghausen N, Schmidt-Chanasit J, Bruchhaus I, Burmester T.
Mol Microbiol. 2015 Jul;97(2):301-14. doi: 10.1111/mmi.13024. Epub 2015 May 9.

Distribution of individual members of the mosquito Anopheles maculipennis complex in Germany identified by newly developed real-time PCR assays.
Lühken R, Czajka C, Steinke S, Jöst H, Schmidt-Chanasit J, Pfitzner W, Becker N, Kiel E, Krüger A, Tannich E.
Med Vet Entomol. 2016 Jan 20. doi: 10.1111/mve.12161. [Epub ahead of print]

Rapid-antigen test negative malaria in a traveller returning from Thailand, molecularly diagnosed as Plasmodium knowlesi
Mackroth MS, Tappe D, Tannich E, Addo M, Rothe C.
Open Forum Infect Dis (2016), in press

IL-23 promotes immunopathology and prevents IL-13-dependent tissue repair associated with Ly6Clo monocytes in Entamoeba histolytica-induced liver damage.
Noll J, Helk E, Fehling H, Bernin H, Marggraff C, Jacobs T, Huber S, Pelczar P, Ernst T, Ittrich H, Otto B, Mittrücker HW, Hölscher C, Tacke F, Bruchhaus I, Tannich E, Lotter H.
J Hepatol. 2016 Jan 22. pii: S0168-8278(16)00019-2. doi: 10.1016/j.jhep.2016.01.013. [Epub ahead of print]

Tropheryma whipplei in children with diarrhoea in rural Ghana.
Vinnemeier CD, Klupp EM, Krumkamp R, Rolling T, Fischer N, Owusu-Dabo E, Addo MM, Adu-Sarkodie Y, Käsmaier J, Aepfelbacher M, Cramer JP, May J, Tannich E.
Clin Microbiol Infect. 2016 Jan;22(1):65.e1-3. doi: 10.1016/j.cmi.2015.09.022. Epub 2015 Oct 8.

Laborgruppe Bruchhaus

Overexpression of Differentially Expressed Genes Identified in Non-pathogenic and Pathogenic Entamoeba histolytica Clones Allow Identification of New Pathogenicity Factors Involved in Amoebic Liver Abscess Formation.
Meyer M, Fehling H, Matthiesen J, Lorenzen S, Schuldt K, Bernin H, Zaruba M, Lender C, Ernst T, Ittrich H, Roeder T, Tannich E, Lotter H, Bruchhaus I.
PLoS Pathog. 2016 Aug 30;12(8):e1005853. doi: 10.1371/journal.ppat.1005853.

2. Social stress increases the susceptibility to infection in the ant Harpegnathos saltator.
Schneider SA, Scharffetter C, Wagner AE, Boesch C, Bruchhaus I, Rimbach G, Roeder T.
Sci Rep. 2016 May 10;6:25800. doi: 10.1038/srep25800.

Phylogeny of haemosporidian blood parasites revealed by a multi-gene approach.
Borner J, Pick C, Thiede J, Kolawole OM, Kingsley MT, Schulze J, Cottontail VM, Wellinghausen N, Schmidt-Chanasit J, Bruchhaus I, Burmester T.
Mol Phylogenet Evol. 2016 Jan;94(Pt A):221-31. doi: 10.1016/j.ympev.2015.09.003. Epub 2015 Sep 11.

Type of in vitro cultivation influences cytoadhesion, knob structure, protein localization and transcriptome profile of Plasmodium falciparum.
Tilly AK, Thiede J, Metwally N, Lubiana P, Bachmann A, Roeder T, Rockliffe N, Lorenzen S, Tannich E, Gutsmann T, Bruchhaus I.
Sci Rep. 2015 Nov 16;5:16766. doi: 10.1038/srep16766.

A comparative study of the localization and membrane topology of members of the RIFIN, STEVOR and PfMC-2TM protein families in Plasmodium falciparum-infected erythrocytes.
Bachmann A, Scholz JA, Janßen M, Klinkert MQ, Tannich E, Bruchhaus I, Petter M.
Malar J. 2015 Jul 16;14:274.

Magnetic Resonance Imaging of Pathogenic Protozoan Parasite Entamoeba histolytica Labeled With Superparamagnetic Iron Oxide Nanoparticles.
Ernst TM, Fehling H, Bernin H, Zaruba MD, Bruchhaus I, Adam G, Ittrich H, Lotter H.
Invest Radiol. 2015 Oct;50(10):709-18.

The Plasmodium falciparum exportome contains non-canonical PEXEL/HT proteins.
Schulze J, Kwiatkowski M, Borner J, Schlüter H, Bruchhaus I, Burmester T, Spielmann T, Pick C.
Mol Microbiol. 2015 Jul;97(2):301-14.

Laborgruppe Lotter

The cytokine profile of human NKT cells and PBMCs is dependent on donor sex and stimulus.
Bernin H, Fehling H, Marggraff C, Tannich E, Lotter H.
Med Microbiol Immunol. 2016 Feb 20. [Epub ahead of print]

IL-23 prevents IL-13-dependent tissue repair associated with Ly6Clo monocytes in Entamoeba histolytica-induced liver damage.
Noll J, Helk E, Fehling H, Bernin H, Marggraff C, Jacobs T, Huber S, Pelczar P, Ernst T, Ittrich H, Otto B, Mittrücker HW, Hölscher C, Tacke F, Bruchhaus I, Tannich E, Lotter H.
J Hepatol. 2016 Jan 22. pii: S0168-8278(16)00019-2. doi: 10.1016/j.jhep.2016.01.013. [Epub ahead of print]

Magnetic resonance imaging of pathogenic protozoan parasite Entamoeba histolytica labeled with superparamagnetic iron oxide nanoparticles.
Ernst TM, Fehling H, Bernin H, Zaruba MD, Bruchhaus I, Adam G, Ittrich H, Lotter H.
Invest Radiol. 2015 Oct;50(10):709-18. doi: 10.1097/RLI.0000000000000175.

The cell surface proteome of Entamoeba histolytica.
Biller L, Matthiesen J, Kühne V, Lotter H, Handal G, Nozaki T, Saito-Nakano Y, Schümann M, Roeder T, Tannich E, Krause E, Bruchhaus I.
Mol Cell Proteomics. 2014 Jan;13(1):132-44. doi: 10.1074/mcp.M113.031393. Epub 2013 Oct 17.

Assoz. Wissenschaftler Lorenzen (Bioinformatik)

New Hosts of The Lassa Virus
Olayemi A, Cadar D, Magassouba N, Obadare A, Kourouma F, Oyeyiola A, Fasogbon S, Igbokwe J, Rieger T, Bockholt S, Jérôme H, Schmidt-Chanasit J, Garigliany M, Lorenzen S, Igbahenah F, Fichet JN, Ortsega D, Omilabu S, Günther S, Fichet-Calvet E
Sci Rep. 2016 May 3;6:25280

Hypoxia-induced gene expression results from selective mRNA partitioning to the endoplasmic reticulum
J.J. Staudacher, I.S. Naarmann-de Vries, S.J. Ujvari, B. Klinger, M. Kasim, E. Benko, A. Ostareck-Lederer, D.H. Ostareck, A. Bondke Persson, S. Lorenzen, J.C. Meier, N. Blüthgen, P.B. Persson, A. Henrion-Caude, R. Mrowka, M. Fähling
Nucleic Acids Res 43(6):3219-36 (2015)

High-grade acute organ toxicity and p16INK4A expression as positive prognostic factors in primary radio(chemo)therapy for patients with head and neck squamous cell carcinoma
N. Tehrany, J. Kitz, M. Rave-Fränk, S. Lorenzen, L. Li, S. Küffer, C.F. Hess, P. Burfeind, H.M. Reichardt, M. Canis, T. Beißbarth, H.A. Wolff
Strahlenther Onkol. 191(7):566-72 (2015)

Type of in vitro cultivation influences cytoadhesion, knob structure, protein localization and transcriptome profile of Plasmodium falciparum
Tilly AK, Thiede J, Metwally N, Lubiana P, Bachmann A, Roeder T, Rockliffe N, Lorenzen S, Tannich E, Gutsmann T, Bruchhaus I
Sci Rep. 5, 16766 (2015)

Co-circulation of a novel phlebovirus and Massilia virus in sandflies, Portugal.
Amaro F, Zé-Zé L, Alves MJ, Börstler J, Clos J, Lorenzen S, Becker SC, Schmidt-Chanasit J, Cadar D.
Virol J 12(1):174 (2015)

Laborgruppe Witt
2016

Neprilysin inhibits coagulation through proteolytic inactivation of fibrinogen
Burrell M, Ravnefjord A, Henderson SJ, Schweikart F, Fowler SB, Witt S, Hansson KM, Webster CI.
PLoS One. 2016 Jul 20;11(7):e0158114. doi: 10.1371/journal.pone.0158114.

Abteilung Zellbiologie humanpathogener Parasiten
Arbeitsgruppe Clos

Geographical sequence variation in the Leishmania major virulence factor P46
Eugenia Bifeld, Mareike Chrobak, Dorothea Zander, Ulrike Schleicher, Gabriele Schönian, Joachim Clos
Infection, Genetics and Evolution 30 (2015) 195–205

Heat Shock Proteins of Leishmania: Parasites in the Driver's Seat
Joachim Clos and Antje Hombach
Adak, S., Datta, R. (Eds.), Leishmania – Current Biology and Control. Caister Academic Press, Norfolk, United Kingdom, pp. 17-36.

Leishmania donovani P23 protects parasites against HSP90 inhibitor-mediated growth arrest
Hombach A, Ommen G, Sattler V, Clos J
Cell Stress & Chaperones 2015 - in press

A Novel Marker, ARM58, Confers Antimony Resistance to Leishmania spp
Nühs A, Schäfer C, Zander D, Trübe L, Tejera Nevado P, Schmidt S, Arevalo J, Adaui V, Maes L, Dujardin J-C, Clos J
Int. J. Parasitol: Drugs and Drug Resistance (2014) 4:37-47

ARM58 Overexpression Reduces Intracellular Antimony Concentration in Leishmania infantum
Schäfer C, Tejera Nevado P, Zander D, Clos J
Antimicrob Agents Chemother (2014) 58:1565–1574

Arbeitsgruppe Hagedorn (Zellbiologie)

The autophagic machinery ensures nonlytic transmission of mycobacteria
Gerstenmaier L, Pilla R, Herrmann L, Herrmann H, Prado M, Villafano GJ, Kolonko M, Reimer R, Soldati T, King JS, Hagedorn M.
Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):E687-92. doi: 10.1073/pnas.1423318112. Epub 2015 Feb 2.

WASH is required for lysosomal recycling and efficient autophagic and phagocytic digestion
King JS, Gueho A, Hagedorn M, Gopaldass N, Leuba F SoldatiT, Insall RH
Mol Biol Cell. 2013 Sep;24(17):2714-26. doi: 10.1091/mbc.E13-02-0092. Epub 2013 Jul 24.

WASH-driven actin polymerization is required for efficient mycobacterial phagosome maturation arrest.
Kolonko M, Geffken AC, Blumer T, Hagens K, Schaible UE and Hagedorn M
Cell Microbiol 2013; 16(2):232-46.

Dynamin A, Myosin IB and Abp1 couple phagosome maturation to F-actin binding
Gopaldass N, Patel D, Kratzke R, Dieckmann R, Hausherr S, Hagedorn M, Monroy R, Krüger J, Neuhaus EM, Hoffmann E, Hille K, Kuznetsov SA, Soldati T
Traffic 2012, 13(1):120-30

Prison break: pathogens’ strategies to egress from host cells
Friedrich N, Hagedorn M, Soldati-Favre D, Soldati T
Mircobiol Mol Biol Rev 2012, 76(4):707-20

Arbeitsgruppe Spielmann (Malaria)

Identity of a Plasmodium lactate/H(+) symporter structurally unrelated to human transporters
Wu, B., Rambow, J., Bock, S., Holm-Bertelsen, J., Wiechert, M., Soares, A.B., Spielmann, T., Beitz, E
Nat. Commun., 2015 6:6284. doi: 10.1038/ncomms7284

The Plasmodium falciparum exportome contains non-canonical PEXEL/HT proteins
Schulze J, Kwiatkowski M, Borner J, Schlüter H, Bruchhaus I, Burmester T, Spielmann T#, Pick C# (#, equal contributors)
Mol Microbiol. 2015, 97:301-14. doi: 10.1111/mmi.13024

Critical Steps in Protein Export of Plasmodium falciparum Blood Stages
Spielmann T, Gilberger TW
Trends Parasitol. 2015, 31(10):514-25. doi: 10.1016/j.pt.2015.06.010.

Pellicle formation in the malaria parasite
Kono M, Heincke D, Wilcke L, Wong T, Bruns C, Herrmann S, Spielmann T, Gilberger TW
J Cell Sci. 2016, 129(4):673-80. doi: 10.1242/jcs.181230.

Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding
Boddey JA, O'Neill MT, Lopaticki S, Carvalho TG, Hodder AN, Nebl T, Wawra S, van West P, Ebrahimzadeh Z, Richard D, Flemming S, Spielmann T, Przyborski J, Babon JJ, Cowman AF
Nat Commun. 2016, 7:10470. doi: 10.1038/ncomms10470

Arbeitsgruppe Schnettler (Molekulare Entomologie)

Advancing vector biology research: a community survey for future directions, research applications and infrastructure requirements.
Kohl, A; Pondeville, E; Schnettler, E; Crisanti, A; Supparo, C; Christophides, GK; Kersey, PJ; Maslen, GL; Takken, W; Koensraadt, CJM; Oliva Nuria Busquets, CF; Abad, FX; Failloux, AB; Levashina, EA; Wilson, AJ; Veronesi, E; Pichard, M; Arnaud Marsh, S; Simard, F and Vernick, KD.
Pathogens and Global Health. 2016. Vol 0, Issue 0, 1-9.

Host inflammatory response to mosquito bites defines severity of arbovirus infection.
Pingen M, Bryden SR, Pondeville E, Schnettler E, Kohl A, Merits A, Fazakerley JK, Graham GJ, McKimmie CS.
Immunity. 2016 Jun 21;44(6):1455-69. doi: 10.1016/j.immuni.2016.06.002

Wolbachia blocks viral genome replication early in infection without a transcriptional response by the endosymbiont or host small RNA pathways.
Rainey SM, Martinez J, McFarlane M, Juneja P, Sarkies P, Lulla A, Schnettler E, Varjak M, Merits A, Miska EA, Jiggins FM, Kohl A.
PLoS Pathog. 2016 Apr 18;12(4):e1005536. doi: 10.1371/journal.ppat.1005536. eCollection 2016 Apr.

Dengue in Java, Indonesia: relevance of mosquito indices as risk predictors.
Wijayanti, APM; Sunaryo, S; Suprihatin, S; McFarlane, M; Rainey, SM; Dietrich, I; Schnettler, E; Biek, R and Kohl, A.
PLOS Neglected Tropical Diseases 2016 Mar 11;10(3):e0004500. doi: 10.1371/journal.pntd.0004500. eCollection 2016.

Modulation of potassium channels inhibits bunyavirus infection.
Hover, S.; King, B.; hall, B.; Loundras, EA; Taqi, H; Daly, J; dallas, M; Peers, C; Schnettler, E; McKimmie, C; Kohl, A; Barr, JN and Mankouri, J.
J Biol Chem 2016 Feb 12;291(7):3411-22.

Arbeitsgruppe Jacobs (Protozoen Immunologie)

The Application of Anti-Toso Antibody Enhances CD8+ T Cell Responses in Experimental Malaria Vaccination and Disease
Lapke N., Tartz S., Lee KH. & Jacobs T.
Vaccine 2015, accepted for publication

Cutting Edge: The BTLA-HVEM Regulatory Pathway Interferes with Protective Immunity to Intestinal Helminth Infection
Breloer M., Hartmann W., Blankenhaus B., Eschbach ML., Pfeffer K. & Jacobs T.
J Immunol. 2015 Feb 15;194(4):1413-6. doi: 10.4049/jimmunol.1402510. Epub 2015 Jan 16.

Involvement of sulfates from cruzipain, a major antigen of Trypanosoma cruzi, in the interaction with immunomodulatory molecule Siglec-E.
Ferrero MR., Heins AM., Soprano LL., Acosta DM., Esteva MI., Jacobs T.*, Duschak VG.* *shared senior authors
Med Microbiol Immunol. 2015 Jun 6. [Epub ahead of print]

Depletion of regulatory T cells augments a vaccine-induced T effector cell response against the liver-stage of malaria but fails to increase memory
Espinoza Mora R, Steeg C, Tartz S, Heussler V, Sparwasser T, Link A, Fleischer B & Jacobs T
PLoS One 2014; 12:e104627

Laborgruppe Osterloh
2016

Persisting Rickettsia typhi causes fatal central nervours system inflammation
Osterloh A, Papp S, Moderzynski K, Kuehl S, Richardt U, Fleischer B
Infect Immun 2016. doi:10.1128/IAI.00034-16

CD4+ T Cells Are as Protective as CD8+ T Cells against Rickettsia typhi Infection by Activating Macrophage Bactericidal Activity
Moderzynski K, Papp S, Rauch J, Heine L, Kuehl S, Richardt U, Fleischer B, Osterloh A
PLoS Negl Trop Dis 2016 10(10): e0005089. doi:10.1371/journal.pntd.0005089

Liver Necrosis and Lethal Systemic Inflammation in a Murine Model of Rickettsia typhi Infection: Role of Neutrophils, Macrophages and NK Cells
Papp S, Moderzynski 1, Rauch J, Heine L, Kuehl S, Richardt U, Mueller H, Fleischer B, Osterloh A
PLoS Negl Trop Dis. 2016 Aug 22;10(8):e0004935. doi: 10.1371/journal.pntd.0004935.

Comparative evaluation of two Rickettsia typhi-specific quantitative real-time PCRs for research and diagnostic purposes
Papp S, Rauch J, Kuehl S, Richardt U, Keller C, Osterloh A
Med Microbiol Immunol. 2016 Oct 1

Anti-CD83 promotes IgG1 isotype switch in marginal zone B cells in response to TI-2 antigen
Kretschmer B., Weber J., Hutloff A., Fleischer B., Breloer M., Osterloh A.
Immunobiology 2015 Aug;220(8):964-75. doi: 10.1016/j.imbio.2015.02.008. Epub 2015 Feb 26.

Heat shock protein 60: an endogenous inducer of dopaminergic cell death in Parkinson disease
Noelker C, Morel L, Osterloh A, Alvarez-Fischer D, Lescot T, Breloer M, Gold M, Oertel WH, Henze C, Michel PP, Dodel RC, Lu L, Hirsch EC, Hunot S, Hartmann A
Neuroinflammation 2013; 11:86

Differential regulation of marginal zone and follicular B cell responses by CD83
Uhde M, Richardt U, Fleischer B, Osterloh A
Int Immunol 2013 Sep; 25(9):507-20

Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease
Noelker C, Morel L, Lescot T, Osterloh A, Alvarez-Fischer D, Breloer M, Henze C, Depboylu C, Skrzydelski D, Michel PP, Dodel RC, Lu L, Hirsch EC, Hunot S, Hartmann A
Sci Rep. 2013;3:1393

Arbeitsgruppe Breloer

Filariae-retrovirus co-infection in mice is associated with suppressed virus-specific IgG immune response and higher viral loads
Dietze KK, Dittmer U, Koudaimi DK, Schimmer S, Reitz M, Breloer M* and Hartmann W*
PLoS Neglected Tropical Diseases 2016; 10(12): e0005170

Mucosal mast cells are indispensable for the timely termination of Strongyloides ratti infection
Reitz M, Brunn ML, Rodewald HR, Feyerabend TB, Roers A, Dudeck A, Voehringer D, Jönsson F, Kühl AA, Breloer M
Mucosal Immunol. 2016 Jul 6. doi: 10.1038/mi.2016.56. [Epub ahead of print]

Strongyloides infection in rodents: immune response and immune regulation
Breloer M and Abraham D
Parasitology. 2016 Feb 24:1-21. [Epub ahead of print]

Functional characterization and immune recognition of the extracellular superoxide dismutase from the human pathogenic parasite Onchocerca volvulus (OvEC-SOD)
Ajonina-Ekoti I, Ndjonka D, Tanyi MK, Wilbertz M, Younis AE, Boursou D, Kurosinski MA, Eberle R, Lüersen K, Perbandt M, Breloer M, Brattig NW, Liebau E
Acta Trop. 2016 Sep;161:114. doi: 10.1016/j.actatropica.2016.05.019. Epub 2016 Jun 20

Litomosoides sigmodontis induces TGF-beta receptor responsive, IL-10-producing T cells that suppress bystander T-cell proliferation in mice
Hartmann, W., Schramm, C. and Breloer, M.
European Journal of Immunology 2015 Sep;45(9):2568-81. doi: 10.1002/eji.201545503.

Department of Virology (Prof. Stephan Günther)
2016

Ebola virus persistence in breast milk after no reported illness: a likely source of virus transmission from mother to child.
Sissoko D, Keïta M, Diallo B, Aliabadi N, Fitter DL, Dahl BA, Bore JA, Koundouno FR, Singethan K, Meisel S, Enkirch T, Mazzarelli A, Amburgey V, Faye O, Sall AA, Magassouba N, Carroll MW, Anglaret X, Malvy D, Formenty P, Aylward RB, Keïta S, Djingarey MH, Loman NJ, Günther S, Duraffour S.
Clin Infect Dis. 2016 Dec 10. pii: ciw793.

Resurgence of Ebola virus disease in Guinea linked to a survivor with virus persistence in seminal fluid for more than 500 days.
Diallo B, Sissoko D, Loman NJ, Bah HA, Bah H, Worrell MC, Conde LS, Sacko R, Mesfin S, Loua A, Kalonda JK, Erondu NA, Dahl BA, Handrick S, Goodfellow I, Meredith LW, Cotten M, Jah U, Guetiya Wadoum RE, Rollin P, Magassouba N, Malvy D, Anglaret X, Carroll MW, Aylward RB, Djingarey MH, Diarra A, Formenty P, Keïta S, Günther S, Rambaut A, Duraffour S.
Clin Infect Dis. 2016 Sep 1. pii: ciw601.

Evaluation of RealStar Reverse Transcription-Polymerase Chain Reaction Kits for Filovirus Detection in the Laboratory and Field.
Rieger T, Kerber R, El Halas H, Pallasch E, Duraffour S, Günther S, Ölschläger S.
J Infect Dis. 2016 Aug 21. pii: jiw246.

Ebola Virus Disease Is Characterized by Poor Activation and Reduced Levels of Circulating CD16+ Monocytes.
Lüdtke A, Ruibal P, Becker-Ziaja B, Rottstegge M, Wozniak DM, Cabeza-Cabrerizo M, Thorenz A, Weller R, Kerber R, Idoyaga J, Magassouba N, Gabriel M, Günther S, Oestereich L, Muñoz-Fontela C.
J Infect Dis. 2016 Aug 11. pii: jiw260.

Sexual transmission of Zika virus in Germany, April 2016.
Frank C, Cadar D, Schlaphof A, Neddersen N, Günther S, Schmidt-Chanasit J, Tappe D.
Euro Surveill. 2016 Jun 9;21(23).

Comparative Structural and Functional Analysis of Bunyavirus and Arenavirus Cap-Snatching Endonucleases.
Reguera J, Gerlach P, Rosenthal M, Gaudon S, Coscia F, Günther S, Cusack S.
PLoS Pathog. 2016 Jun 15;12(6):e1005636.

Atomic Structure and Biochemical Characterization of an RNA Endonuclease in the N Terminus of Andes Virus L Protein.
Fernández-García Y, Reguera J, Busch C, Witte G, Sánchez-Ramos O, Betzel C, Cusack S, Günther S, Reindl S.
PLoS Pathog. 2016 Jun 14;12(6):e1005635.

Laborgruppe Schmitz

Highly specific detection of antibodies to tick-borne encephalitis (TBE) virus in humans using a domain III antigen and a sensitive immune complex (IC) ELISA
Ludolfs D, Reinholz M, Schmitz H
J Clin Virol. 2009 Jun;45(2):125-8.

West Nile virus is neutralized by HOCl-modified human serum albumin that binds to domain III of the viral envelope protein E
Vossmann M, Kirst M, Ludolfs D, Schreiber M
Virology. 2008 Apr 10;373(2):322-8.

Reverse ELISA for the detection of anti West Nile virus IgG antibodies in humans
Ludolfs D, Niedrig M, Paweska JT, Schmitz H
Eur J Clin Microbiol Infect Dis. 2007 Jul;26(7):467-73.

Laboratory diagnosis of primary and secondary dengue infection
Schilling S, Ludolfs D, Van An L, Schmitz H
J Clin Virol. 2004 Nov;31(3):179-84

Arbeitsgruppe Schmidt-Chanasit (Arbovirologie)

Zika virus infection in a traveller returning to Europe from Brazil, March 2015.
Zammarchi L, Tappe D, Fortuna C, Remoli ME, Gunther S, Venturi G, Bartoloni A, Schmidt-Chanasit J.
Euro Surveill. 2015 Jun 11;20(23). pii: 21153.

Zika virus infections imported to Italy: clinical, immunological and virological findings, and public health implications.
Zammarchi L, Stella G, Mantella A, Bartolozzi D, Tappe D, Günther S, Oestereich L, Cadar D, Muñoz-Fontela C, Bartoloni A, Schmidt-Chanasit J.
J Clin Virol. 2015 Feb;63:32-5. doi: 10.1016/j.jcv.2014.12.005.

Co-circulation of a novel phlebovirus and Massilia virus in sandflies, Portugal.
Amaro F, Zé-Zé L, Alves MJ, Börstler J, Clos J, Lorenzen S, Becker SC, Schmidt-Chanasit J, Cadar D.
Virol J. 2015 Oct 24;12:174. doi: 10.1186/s12985-015-0407-0.

Putative Lineage of Novel African Usutu Virus, Central Europe.
Cadar D, Bosch S, Jöst H, Börstler J, Garigliany MM, Becker N, Schmidt-Chanasit J.
Emerg Infect Dis. 2015 Sep [date cited]. http://dx.doi.org/10.3201/eid2109.142026

A Variegated Squirrel Bornavirus Associated with Fatal Human Encephalitis.
Hoffmann B, Tappe D, Höper D, Herden C, Boldt A, Mawrin C, Niederstraßer O, Müller T, Jenckel M, van der Grinten E, Lutter C, Abendroth B, Teifke JP, Cadar D, Schmidt-Chanasit J, Ulrich RG, Beer M.
N Engl J Med. 2015 Jul 9;373(2):154-62. doi: 10.1056/NEJMoa1415627.

Acute Zika virus infection after travel to Malaysian Borneo, September 2014.
Tappe D, Nachtigall S, Kapaun A, Schnitzler P, Günther S, Schmidt-Chanasit J.
Emerg Infect Dis. 2015 May;21(5):911-3. doi: 10.3201/eid2105.141960.

Abteilung Molekulare Medizin

Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration.
Curtis J, Luo Y, Zenner HL, Cuchet-Lourenço D, Wu C, Lo K, Maes M, Alisaac A, Stebbings E, Liu JZ, Kopanitsa L, Ignatyeva O, Balabanova Y, Nikolayevskyy V, Baessmann I, Thye T, Meyer CG, Nürnberg P, Horstmann RD, Drobniewski F, Plagnol V, Barrett JC, Nejentsev S.
Nat Genet. 2015 May;47(5):523-7. doi: 10.1038/ng.3248.

Evidence of promiscuous endothelial binding by Plasmodium falciparum-infected erythrocytes.
Esser C, Bachmann A, Kuhn D, Schuldt K, Förster B, Thiel M, May J, Koch-Nolte F, Yáñez-Mó M, Sánchez-Madrid F, Schinkel AH, Jalkanen S, Craig AG, Bruchhaus I, Horstmann RD.
Cell Microbiol. 2014 May;16(5):701-8. doi: 10.1111/cmi.12270. Epub 2014 Feb 24.

Genome-wide association study indicates two novel resistance loci for severe malaria.
Timmann C, Thye T, Vens M, Evans J, May J, Ehmen C, Sievertsen J, Muntau B, Ruge G, Loag W, Ansong D, Antwi S, Asafo-Adjei E, Nguah SB, Kwakye KO, Akoto AO, Sylverken J, Brendel M, Schuldt K, Loley C, Franke A, Meyer CG, Agbenyega T, Ziegler A, Horstmann RD.
Nature. 2012 Sep 20;489(7416):443-6. doi: 10.1038/nature11334. Epub 2012 Aug 15.

Common variants at 11p13 are associated with susceptibility to tuberculosis.
Thye T, Owusu-Dabo E, Vannberg FO, van Crevel R, Curtis J, Sahiratmadja E, Balabanova Y, Ehmen C, Muntau B, Ruge G, Sievertsen J, Gyapong J, Nikolayevskyy V, Hill PC, Sirugo G, Drobniewski F, van de Vosse E, Newport M, Alisjahbana B, Nejentsev S, Ottenhoff TH, Hill AV, Horstmann RD, Meyer CG.
Nat Genet. 2012 Feb 5;44(3):257-9. doi: 10.1038/ng.1080.

A -436C>A polymorphism in the human FAS gene promoter associated with severe childhood malaria.
Schuldt K, Kretz CC, Timmann C, Sievertsen J, Ehmen C, Esser C, Loag W, Ansong D, Dering C, Evans J, Ziegler A, May J, Krammer PH, Agbenyega T, Horstmann RD.
PLoS Genet. 2011 May;7(5):e1002066. doi: 10.1371/journal.pgen.1002066. Epub 2011 May 19.

Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.
Thye T, Vannberg FO, Wong SH, Owusu-Dabo E, Osei I, Gyapong J, Sirugo G, Sisay-Joof F, Enimil A, Chinbuah MA, Floyd S, Warndorff DK, Sichali L, Malema S, Crampin AC, Ngwira B, Teo YY, Small K, Rockett K, Kwiatkowski D, Fine PE, Hill PC, Newport M, Lienhardt C, Adegbola RA, Corrah T, Ziegler A; African TB Genetics Consortium; Wellcome Trust Case Control Consortium, Morris AP, Meyer CG, Horstmann RD, Hill AV.
Nat Genet. 2010 Sep;42(9):739-41. doi: 10.1038/ng.639. Epub 2010 Aug 8.

Laborgruppe Erttmann

Multifunctional thioredoxin-like protein from the gastrointestinal parasitic nematodes Strongyloides ratti and Trichuris suis affects mucosal homeostasis
Ditgen D, Anandarajah E, Hansmann J, Winter D, Schramm G, Erttmann KD, Liebau E, Brattig NW
J Parasitol Res. 2016 Sep 26; vol. 2016, Article ID 8421597, 17 pages. doi:10.1155/2016/8421597

The genomic basis of parasitism in the Strongyloides clade of nematodes
Hunt VL, Tsai IJ, Coghlan A, Reid AJ, Holroyd N, Foth BJ, Tracey A, Cotton JA, Stanley EJ, Beasley H, Bennett HM, Brooks K, Harsha B, Kajitani R, Kulkarni A, Harbecke D, Nagayasu E, Nichol S, Ogura Y, Quail MA, Randle N, Xia D, Brattig NW, Soblik H, Ribeiro DM, Sanchez-Flores A, Hayashi T, Itoh T, Denver DR, Grant W, Stoltzfus JD, Lok JB, Murayama H, Wastling J, Streit A, Kikuchi T, Viney M, Berriman M
Nat Genet. 2016 Mar;48(3):299-307. doi: 10.1038/ng.3495. Epub 2016 Feb 1.

SPARC (secreted protein acidic and rich in cysteine) of the intestinal nematode Strongyloides ratti is involved in mucosa-associated parasite-host interaction
Anandarajah EM, Ditgen D, Hansmann J, Erttmann KD, Liebau E, Brattig NW
Mol Biochem Parasitol. 2016 Jun;207(2):75-83. doi: 10.1016/j.molbiopara.2016.06.001. Epub 2016 Jun 3.

N. N.
Arbeitsgruppe May (Infektionsepidemiologie)

Group B Streptococci Serotype Distribution in Pregnant Women in Ghana: Assessment of Potential Coverage Through Future Vaccines
Vinnemeier CD, Brust P, Owusu-Dabo E, Sarpong N, Sarfo EY, Bio Y, Rolling T, Dekker D, Adu-Sarkodie Y, Eberhardt KA, May J, Cramer JP.
Trop Med Int Health. 2015 Aug 18. [Epub ahead of print] PubMed PMID: 26285044

High detection rate of Rickettsia africae in Amblyomma variegatum but low prevalence of anti-rickettsial antibodies in healthy pregnant women in Madagascar
Keller C, Krüger A, Schwarz NG, Rakotozandrindrainy R, Rakotondrainiarivelo JP, Razafindrabe T, Derschum H, Silaghi C, Pothmann D, Veit A, Hogan B, May J, Girmann M, Kramme S, Fleischer B, Poppert S.
Ticks Tick Borne Dis. 2015 Aug 18. pii: S1877-959X(15)30003-0. [Epub ahead of print] PubMed PMID: 26318262

Is A578S SNP in K13-propeller a marker of emerging Plasmodium falciparum artemisinin-resistance in Africa?
Maiga-Ascofaré OM, May J.
J Infect Dis. 2015 Aug 12. [Epub ahead of print] PubMed PMID: 26268852

Molecular characterization of Cryptosporidium spp. Among children in rural Ghana.
Eibach D, Krumkamp R, Al-Emran HM, Sarpong N, Hagen RM, Adu-Sarkodie Y, Tannich E, May J.
PLoS Negl Trop Dis. 2015 Mar 6;9(3):e0003551. PubMed PMID: 25749411

Gastrointestinal infections and diarrheal disease in Ghanaian infants and children: an outpatient case-control study
Krumkamp R, Sarpong N, Schwarz NG, Adlkofer J, Loag W, Eibach D, Hagen RM, Adu-Sarkodie Y, Tannich E, May J.
PLoS Negl Trop Dis. 2015 Mar 4;9(3):e0003568

Arbeitsgruppe Owusu-Dabo

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