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News

| 02.12.2021

Wrangling an octopus-like viral replication machine

Hamburg / Grenoble, December 2, 2021 - Research groups from the Bernhard Nocht Institute for Tropical Medicine, EMBL* Grenoble and the laboratory of Kay Grünewald from HPI / UHH at CSSB** have studied nine structures of an essential Lassa virus protein in different functional states. The protein is necessary for virus replication and thus provides excellent targets for antiviral agents. The results have now been published in the journal Nature Communications.

Read more in the article on the EMBL website:
www.embl.org/news/science/wrangling-an-octopus-like-viral-replication-machine

 

Original Publication:
Kouba T., Vogel D., Thorkelsson S.R, et al.; Conformational changes in Lassa virus L protein associated with promoted binding and RNA synthesis activity, Nature Communications, 2 December 2021;
DOI 10.1038/s41467-021-27305


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