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Worm infections are among the most common tropical diseases worldwide. Parasitic worms are such successful infectious agents partly because they are able to weaken the immune response of their host. But the host also knows what to do: It reacts with a complex interplay of different messenger substances of the immune system.
BNITM-Work group Tobias Spielmann receives ERC Advanced Grant
Hamburg, Germany, April 22, 2021 – Dr. Tobias Spielmann, head of the research group "Malaria" in the section Molecular Biology and Immunology at the Bernhard Nocht Institute for Tropical Medicine (BNITM), has been awarded an ERC Advanced Grant of almost 2.4 million euros by the European Research Council (ERC). With this highly endowed funding, the research group will investigate specific forms of drug resistance in malaria parasites over the next five years.
Background and expert service
In 2000, the World Health Organization (WHO) established the World Malaria Day as an annual international day of action. Its purpose is to remind that more than three billion people in the world are at risk from malaria. The WHO and other organizations are working to roll back this infectious disease at great financial and logistical expense. This has led to a reduction in new cases in recent years. However, for the first-time last year, the WHO recorded an increase to around 230 million malaria cases worldwide, of which more than 400,000 were fatal. Children under the age of five in Africa account for more than two-thirds of the deaths. Our interview partners for journalists can be found below.
Joint major project in the fight against SARS-CoV-2
Hamburg. At the high-brilliance X-ray light source PETRA III of the German Electron Synchrotron (DESY), a research team in which the Bernhard Nocht Institute for Tropical Medicine (BNITM) is also active has identified several candidates for active agents against the coronavirus SARS-CoV-2. The promising drug candidates bind to an important protein of the virus and could thus be the basis for a drug against COVID-19.
BNITM-teams assisted in testing and sequencing patient samples
Following the request for assistance from the Ministry of Health of Guinea, the Bernhard Nocht Institute for Tropical Medicine (BNITM) sent teams to support Guinea in setting up in-country sequencing with the Oxford Nanopore MinION and to strengthen diagnostic capacity needs. The mission took place within the framework of the WHO Global outbreak alert and response network (GOARN) and the Global Health Protection Programme (GHPP) of the Federal Ministry of Health.
Which factors determine whether an infection takes a severe or mild course? This question has been occupying researchers not only since the coronavirus pandemic. In Lassa fever, the course of the disease and the chance of recovery also vary widely. A research group at the Bernhard Nocht Institute for Tropical Medicine (BNITM) found a reason in misguided immune reactions both in a mouse model of the disease as well as in Nigerian Lassa fever patients.
UKE und BNITM bekommen Forschungsförderung über 4,5 Millionen Euro
Hamburg – Dass Krankheiten bei Frauen und Männern unterschiedlich häufig auftreten und anders verlaufen, ist zunehmend belegt. Jetzt erforschen Wissenschaftlerinnen und Wissenschaftler des Universitätsklinikums Hamburg-Eppendorf (UKE) und des Bernhard-Nocht-Instituts für Tropenmedizin (BNITM) immunologische Geschlechterunterschiede, damit diese künftig schon im Vorfeld der Behandlung von Patientinnen und Patienten berücksichtigt werden können. Die Deutsche Forschungsgemeinschaft (DFG) fördert das Vorhaben der Forschungsgruppe „Geschlechtsspezifische Unterschiede in Immunantworten“ mit 4,5 Millionen Euro.
Presenter Yared Dibaba supports "World Day of Neglected Tropical Diseases" on 30 January
Hamburg. Worldwide, almost two billion people are at risk of becoming incapacitated, blind, disfigured, disabled or dying earlier due to neglected tropical diseases. The coronavirus pandemic has exacerbated this danger: many research, treatment and prevention programmes have had to be halted in countries of the global South. The Bernhard Nocht Institute for Tropical Medicine is therefore participating in an international campaign with the aim of not letting up in the fight against neglected tropical diseases - with prominent support.
Till Omansen receives coveted Leibniz funding
The Bernhard Nocht Institute for Tropical Medicine (BNITM) gets the opportunity to establish another junior research group. Dr. Till Omansen from the Department of Clinical Research has been awarded funding from the Leibniz funding programme to establish an independent Junior Research Group. The aim is to research the pathophysiology of Lassa fever. The new transnational group will be based in both the Clinical Research Department and the Virology Department of the BNITM.
Artemisinin-based combination therapy
Are child-friendly, easily soluble tablets or child syrups as effective, safe and tolerable as conventional tablets for malaria therapy? This question was investigated by the Clinical Research Department at the Bernhard Nocht Institute for Tropical Medicine (BNITM) in an elaborate, systematic analysis of available study data, which was published in the Cochrane database this month.