Arbeitgruppe: UKE-associated Addo lab,

(from left to right and back to front)

1. Row: Madeleine Zinser, Dai Ton Tran, Etienne Bartels, Joseph Poetsch, Reza Jan Neumann, Till Koch
2. Row: Christine Dahlke, Anahita Fathi, My Linh Ly, Marylyn Addo
UKE-associated Addo lab, (from left to right and back to front) 1. Row: Madeleine Zinser, Dai Ton Tran, Etienne Bartels, Joseph Poetsch, Reza Jan Neumann, Till Koch 2. Row: Christine Dahlke, Anahita Fathi, My Linh Ly, Marylyn Addo

Overview

The focus of our laboratory is to investigate and develop vaccine strategies for infections with emerging viruses such as Ebola virus and the Middle Eastern Respiratory Syndrome (MERS) coronavirus and other clinically relevant viruses (including HIV, HBV).

Newly emerging infections pose a serious threat to public health because they lack effective medical countermeasures when they emerge. The WHO has constructed a list of priority pathogens that are likely to cause severe outbreaks in the future (http://www.who.int/medicines/ebola-treatment/WHO-list-of-top-emerging-diseases/en) and for which substantial research efforts are therefore needed to be prepared in such a scenario – Ebola and MERS being two of them. Our multidisciplinary team consisting of researchers from both life sciences and medicine, seeks to understand mechanisms and correlates of immune control after vaccination through clinical trials and to use our insights to create future vaccines more strategically and effectively.

We are also interested in natural immunity to viral infections and hope to gain insight into basic principles of immune protection with a special focus on cellular immunology.

Publication Highlights

Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV
Rechtien A, Richert L, Lorenzo H, Martrus G, Hejblum B, Dahlke C, Kasonta R, Zinser M, Stubbe H, Matschl U, Lohse A, Krähling V, Eickmann M, Becker S; VEBCON Consortium, Thiébaut R, Altfeld M, Addo MM
Cell Reports 2017 Aug 29;20(9):2251-2261. doi: 10.1016/j.celrep.2017.08.023.

Dose-dependent T-cell Dynamics and Cytokine Cascade Following rVSV-ZEBOV Immunization
Dahlke C, Kasonta R, Lunemann S, Krähling V, Zinser ME, Biedenkopf N, Fehling SK, Ly ML, Rechtien A, Stubbe HC, Olearo F, Borregaard S, Jambrecina A, Stahl F, Strecker T, Eickmann M, Lütgehetmann M, Spohn M, Schmiedel S, Lohse AW, Becker S, Addo MM; VEBCON Consortium
EBioMedicine. 2017 May;19:107-118. doi: 10.1016/j.ebiom.2017.03.045. Epub 2017 Apr 5

Comprehensive Characterization of Cellular Immune Responses Following Ebola Virus Infection
Dahlke C, Lunemann S, Kasonta R, Kreuels B, Schmiedel S, Ly ML, Fehling SK, Strecker T, Becker S, Altfeld M, Sow A, Lohse AW, Muñoz-Fontela C, Addo MM
J Infect Dis. 2017 Jan 15;215(2):287-292. doi: 10.1093/infdis/jiw508

Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe
Agnandji ST, Huttner A, Zinser ME, Njuguna P, Dahlke C, Fernandes JF, Yerly S, Dayer JA, Kraehling V, Kasonta R, Adegnika AA, Altfeld M, Auderset F, Bache EB, Biedenkopf N, Borregaard S, Brosnahan JS, Burrow R, Combescure C, Desmeules J, Eickmann M, Fehling SK, Finckh A, Goncalves AR, Grobusch MP, Hooper J, Jambrecina A, Kabwende AL, Kaya G, Kimani D, Lell B, Lemaître B, Lohse AW, Massinga-Loembe M, Matthey A, Mordmüller B, Nolting A, Ogwang C, Ramharter M, Schmidt-Chanasit J, Schmiedel S, Silvera P, Stahl FR, Staines HM, Strecker T, Stubbe HC, Tsofa B, Zaki S, Fast P, Moorthy V, Kaiser L, Krishna S, Becker S, Kieny MP, Bejon P, Kremsner PG, Addo MM, Siegrist CA
N Engl J Med. 2016 Apr 28;374(17):1647-60. doi: 10.1056/NEJMoa1502924. Epub 2015 Apr 1

A case of severe Ebola virus infection complicated by gram-negative septicemia
Kreuels B, Wichmann D, Emmerich P, Schmidt-Chanasit J, de Heer G, Kluge S, Sow A, Renné T, Günther S, Lohse AW, Addo MM, Schmiedel S
N Engl J Med. 2014 Dec 18;371(25):2394-401. doi: 10.1056/NEJMoa1411677. Epub 2014 Oct 22

Publications

2018

Induction and Maintenance of CX3CR1-Intermediate Peripheral Memory CD8 T Cells by Persistent Viruses and Vaccines
Gordon CL, Lee LN, Swadling L, Hutchings C, Zinser M, Highton AJ, Capone S, Folgori A, Barnes E, Klenerman P
Cell Rep. 2018 Apr 17;23(3):768-782. doi: 10.1016/j.celrep.2018.03.074.

Human MAIT cells show metabolic quiescence with rapid glucose-dependent upregulation of granzyme B upon stimulation
Zinser ME, Highton AJ, Kurioka A, Kronsteiner B, Hagel J, Leng T, Marchi E, Phetsouphanh C, Willberg CB, Dunachie SJ, Klenerman P
Immunol Cell Biol. 2018 Feb 9. doi: 10.1111/imcb.12020. [Epub ahead of print]

Differential expression pattern of co-inhibitory molecules on CD4+ T cells in uncomplicated versus complicated malaria
Abel A, Steeg C, Aminkiah F, Addai-Mensah O, Addo M, Gagliani N, Casar C, Yar DD, Owusu-Dabo E, Jacobs T, Mackroth MS
Sci Rep. 2018 Mar 19;8(1):4789. doi: 10.1038/s41598-018-22659-1.

HEV-positive blood donations represent a relevant infection risk for immunosuppressed recipients
Dirk Westhölter, Jens Hiller, Ulrike Denzer, Susanne Polywka, Francis Ayuk, Meike Rybczynski, Thomas Horvatits, Swantje Gundlach, Nicole Fischer, Marylyn M. Addo, Sven Peine, Burkhard Göke, Ansgar W. Lohse, Marc Lütgehetmann, Sven Pischke
Journal of Hepatology Volume 69, Issue 1, July 2018, Pages 36-42, https://doi.org/10.1016/j.jhep.2018.02.031

Ebola-Impfstoff-Entwicklung: Im Krisenfall schnell, aber mit hohem Sicherheitsanspruch
Madeleine E. Zinser, Saskia Borregaard, Christine Dahlke, Marylyn M. Addo
Dtsch Arztebl 2018; 115(27-28): [16]; DOI: 10.3238/PersInfek.2018.07.09.005

Identification of virus-encoded microRNAs in divergent Papillomaviruses
Rachel Chirayil, Rodney P. Kincaid, Christine Dahlke, Chad V. Kuny, Nicole Dälken, Michael Spohn, Becki Lawson, Adam Grundhoff, Christopher S. Sullivan
PLoS Pathog 14(7): e1007156. https://doi.org/10.1371/journal.ppat.1007156

2017

Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV
Rechtien A, Richert L, Lorenzo H, Martrus G, Hejblum B, Dahlke C, Kasonta R, Zinser M, Stubbe H, Matschl U, Lohse A, Krähling V, Eickmann M, Becker S; VEBCON Consortium, Thiébaut R, Altfeld M, Addo MM
Cell Rep. 2017 Aug 29;20(9):2251-2261. doi: 10.1016/j.celrep.2017.08.023.

Dose-dependent T-cell Dynamics and Cytokine Cascade Following rVSV-ZEBOV Immunization
Dahlke C, Kasonta R, Lunemann S, Krähling V, Zinser ME, Biedenkopf N, Fehling SK, Ly ML, Rechtien A, Stubbe HC, Olearo F, Borregaard S, Jambrecina A, Stahl F, Strecker T, Eickmann M, Lütgehetmann M, Spohn M, Schmiedel S, Lohse AW, Becker S, Addo MM; VEBCON Consortium.
EBioMedicine. 2017 May;19:107-118. doi: 10.1016/j.ebiom.2017.03.045. Epub 2017 Apr 5.

Comprehensive Characterization of Cellular Immune Responses Following Ebola Virus Infection
Dahlke C, Lunemann S, Kasonta R, Kreuels B, Schmiedel S, Ly ML, Fehling SK, Strecker T, Becker S, Altfeld M, Sow A, Lohse AW, Muñoz-Fontela C, Addo MM
J Infect Dis. 2017 Jan 15;215(2):287-292. doi: 10.1093/infdis/jiw508.

Acute HIV-1 infection is associated with increased plasma levels of heme oxygenase-1 and presence of heme oxygenase-1-specific regulatory T cells
Angin M, Fathi A, King M, Ledoux MB, Piechocka-Trocha A, Altfeld M, Addo MM.
AIDS. 2017 Mar 13;31(5):635-641. doi: 10.1097/QAD.0000000000001390.

Chronic pancreatitis in patients with liver cirrhosis negatively affects graft survival after liver transplantation.
Wehmeyer MH, Dammermann W, Seiz O, Zinser ME, Galante A, Lohse AW, Sterneck M, Nashan B, Herden U, Lüth S.
Pancreatology. 2017 Nov - Dec;17(6):898-904. doi: 10.1016/j.pan.2017.09.006. Epub 2017 Sep 14.

Response to fever and utilization of standby emergency treatment (SBET) for malaria in travellers to Southeast Asia: a questionnaire-based cohort study
Vinnemeier CD, Rothe C, Kreuels B, Addo MM, Vygen-Bonnet S, Cramer JP, Rolling T
Malar J. 2017 Jan 25;16(1):44. doi: 10.1186/s12936-017-1678-2.

Pre-travel advice at a crossroad: Medical preparedness of travellers to South and Southeast-Asia - The Hamburg Airport Survey
Rolling T, Mühlenpfordt M, Addo MM, Cramer JP, Vinnemeier CD
Travel Med Infect Dis. 2017 Jul - Aug;18:41-45. doi: 10.1016/j.tmaid.2017.07.008. Epub 2017 Jul 18.

A dose-dependent plasma signature of the safety and immunogenicity of the rVSV-Ebola vaccine in Europe and Africa
Huttner A, Combescure C, Grillet S, Haks MC, Quinten E, Modoux C, Agnandji ST, Brosnahan J, Dayer JA, Harandi AM, Kaiser L, Medaglini D, Monath T; VEBCON and VSV-EBOVAC Consortia, Roux-Lombard P, Kremsner PG, Ottenhoff TH, Siegrist CA
Sci Transl Med. 2017 Apr 12;9(385). pii: eaaj1701. doi: 10.1126/scitranslmed.aaj1701.

Helminthic infections in returning travelers and migrants with eosinophilia: Diagnostic value of medical history, eosinophil count and IgE
Salzer HJF, Rolling T, Vinnemeier CD, Tannich E, Schmiedel S, Addo MM, Cramer JP
Travel Med Infect Dis. 2017 Nov - Dec;20:49-55. doi: 10.1016/j.tmaid.2017.09.001. Epub 2017 Sep 4.

HEV-positive blood donations represent a relevant infection risk for immunosuppressed recipients
Westhölter D, Hiller J, Denzer U, Polywka S, Ayuk F, Rybczynski M, Horvatits T, Gundlach S, Blöcker J, Schulze Zur Wiesch J, Fischer N, Addo MM, Peine S, Göke B, Lohse AW, Lütgehetmann M, Pischke S
J Hepatol. 2018 Jul;69(1):36-42. doi: 10.1016/j.jhep.2018.02.031. Epub 2018 Mar 15.

2016

Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe
Agnandji ST, Huttner A, Zinser ME, Njuguna P, Dahlke C, Fernandes JF, Yerly S, Dayer JA, Kraehling V, Kasonta R, Adegnika AA, Altfeld M, Auderset F, Bache EB, Biedenkopf N, Borregaard S, Brosnahan JS, Burrow R, Combescure C, Desmeules J, Eickmann M, Fehling SK, Finckh A, Goncalves AR, Grobusch MP, Hooper J, Jambrecina A, Kabwende AL, Kaya G, Kimani D, Lell B, Lemaître B, Lohse AW, Massinga-Loembe M, Matthey A, Mordmüller B, Nolting A, Ogwang C, Ramharter M, Schmidt-Chanasit J, Schmiedel S, Silvera P, Stahl FR, Staines HM, Strecker T, Stubbe HC, Tsofa B, Zaki S, Fast P, Moorthy V, Kaiser L, Krishna S, Becker S, Kieny MP, Bejon P, Kremsner PG, Addo MM, Siegrist CA
N Engl J Med. 2016 Apr 28;374(17):1647-60. doi: 10.1056/NEJMoa1502924. Epub 2015 Apr 1.

Molecular Diagnosis of Human Taenia martis Eye Infection.
Koch T, Schoen C, Muntau B, Addo M, Ostertag H, Wiechens B, Tappe D
Am J Trop Med Hyg. 2016 May 4;94(5):1055-7. doi: 10.4269/ajtmh.15-0881. Epub 2016 Feb 29.

Acute Ebola virus disease patient treatment and health-related quality of life in health care professionals: a controlled study
Lehmann M, Bruenahl CA, Addo MM, Becker S, Schmiedel S, Lohse AW, Schramm C, Loewe B
J Psychosom Res. 2016 Apr;83:69-74. doi: 10.1016/j.jpsychores.2015.09.002. Epub 2015 Sep 24. Impact Factor: 2,736

Rapid-Antigen Test Negative Malaria in a Traveler Returning From Thailand, Molecularly Diagnosed as Plasmodium knowlesi
Mackroth MS, Tappe D, Tannich E, Addo M, Rothe C
Open Forum Infect Dis. 2016 Mar 21;3(1):ofw039. doi: 10.1093/ofid/ofw039. eCollection 2016 Jan.

Clinical Management of Ebola Virus Disease in the United States and Europe
Uyeki TM, Mehta AK, Davey RT Jr, Liddell AM, Wolf T, Vetter P, Schmiedel S, Grünewald T, Jacobs M, Arribas JR, Evans L, Hewlett AL, Brantsaeter AB, Ippolito G, Rapp C, Hoepelman AI, Gutman J; Working Group of the U.S.–European Clinical Network on Clinical Management of Ebola Virus Disease Patients in the U.S. and Europe. Kallen A, Epstein L, Ströher U, Bell S, Lyon G 3rd, Kraft CS, Ribner BS, Varkey JB, Vanairsdale S, Barrett K, Lane H, Palmore T, Suffredini AF, Tseggay GK, Brown KV, Kaiser L, Schibler M, Pugin J, Addo M, Beisel C, Bornscheuer T, Cramer J, Harder F, Hildebrandt T, de Heer G, Jochum J, Kalb H, Lüth S, Mähnß B, Matthews H, Röder C, Rolling T, Rothe C, Salzer H, Schäfer G, Schmiedel S, Scholz K, Schulze zur Wiesch J, Vinnemeier C, Werner T, Frey C, Wiemer D, Emmerich P, Gabriel M, Günther S, Schmidt-Chanasit J, Kellner N, Macholz M, Neumann F, Treutler T, Wieczorek T, Bhagani S, Cropley I, Hopkins S, Mepham S, Warren S, Marshall N, Martin D, Rodger A, Arnalich F, Arsuaga M, de la Calle F, Lago M, Mora-Rillo M, Ramirez-Olivencia G, Anda P, Negredo A, Sánchez-Seco MP, Cloonan S, Horowitz H, Phillips M, Florescu D, Iwen PC, Johnson DW, Kalil AC, Koepsell S, Kratochvil CJ, Larson L, Lisco SJ, Schwedhelm MM, Smith PW, Sullivan JN, Holtan A, Kran AM, Kvale D, Ormaasen V, Rostrup M, Nicastri E, Petrosillo N, Puro V, Di Caro A, Capobianchi MR, Castilletti C, Antonini M, Taglietti F, Mérens A, Andriamanantena D, Ficko C, Flateau C, Merat S, Barth RE, Ellerbroek PE, Murk JL.
N Engl J Med. 2016 Feb 18;374(7):636-46. doi: 10.1056/NEJMoa1504874.

Medizinische Versorgung von Flüchtlingen – Eine Fallserie des Universitätsklinikums Hamburg-Eppendorf
Peter Sothmann, Nina Schmedt auf der Günne, Marylyn Addo, Ansgar Lohse, Stefan Schmiedel
Flug und Reisemed 2016; 23 (1): 45-49, Georg Thieme Verlag, ISSN 1864-4538.

Sharp increase of imported Plasmodium vivax malaria seen in migrants from Eritrea in Hamburg, Germany
Roggelin L, Tappe D, Noack B, Addo MM, Tannich E, Rothe C
Malar J. 2016 Jun 17;15:325. doi: 10.1186/s12936-016-1366-7.

Unique human immune signature of Ebola virus disease in Guinea
Ruibal P, Oestereich L, Lüdtke A, Becker-Ziaja B, Wozniak DM, Kerber R, Korva M, Cabeza-Cabrerizo M, Bore JA, Koundouno FR, Duraffour S, Weller R, Thorenz A4,7, Cimini E, Viola D, Agrati C, Repits J, Afrough B, Cowley LA, Ngabo D, Hinzmann J, Mertens M, Vitoriano I, Logue CH, Boettcher JP, Pallasch E, Sachse A, Bah A, Nitzsche K, Kuisma E, Michel J, Holm T, Zekeng EG, García-Dorival I, Wölfel R, Stoecker K, Fleischmann E, Strecker T, Di Caro A, Avšič-Županc T, Kurth A, Meschi S, Mély S, Newman E, Bocquin A, Kis Z, Kelterbaum A, Molkenthin P, Carletti F, Portmann J, Wolff S, Castilletti C, Schudt G, Fizet A, Ottowell LJ, Herker 1, Jacobs T, Kretschmer B, Severi E, Ouedraogo N, Lago M, Negredo A, Franco L, Anda P, Schmiedel S, Kreuels B, Wichmann D, Addo MM, Lohse AW, De Clerck H, Nanclares C, Jonckheere S, Van Herp M, Sprecher A, Xiaojiang G, Carrington M, Miranda O, Castro CM, Gabriel M, Drury P, Formenty P, Diallo B, Koivogui L, Magassouba N, Carroll MW, Günther S, Muñoz-Fontela C
Nature. 2016 May 5;533(7601):100-4. doi: 10.1038/nature17949.



2015

Emerging Infections: Eine globale Herausforderung
Dahlke C., Addo M.M
Biologie in unserer Zeit, Wiley-VCH, 2015; doi:10.1002/biuz.201510578

73-jährige leber- und nierentransplantierte Patientin mit dumpfen Oberbauchschmerzen und rezidivierendem Nasenbluten
M.E. Zinser, H.J.F. Salzer, A. Stein, M. von Petersdorff, A. Koops, J. Holzhüter
INTERNIST, 56(5), 566-72. DOI: 10.1007/s00108-015-3700-5

Tim-3 blocking rescue macrophage and T cell function against Mycobacterium tuberculosis infection in HIV+ patients
Sada-Ovalle I, Ocaña-Guzman R, Pérez-Patrigeón S, Chávez-Galán L, Sierra-Madero J, Torre-Bouscoulet L, Addo MM
J Int AIDS Soc. 2015 Oct 19;18:20078. doi: 10.7448/IAS.18.1.20078

Severe Ebola virus infection complicated by gram-negative septicemia
Kreuels B, Addo MM, Schmiedel S
The New England journal of medicine. 2015; 372(14):1377. PMID: 25830439 (correspondence)

Sex differences in infectious diseases and their clinical consequences
Beisel C, van Lunzen J, Lohse AW, Addo MM, Altfeld M
Dtsch Med Wochenschr. 2015 Sep;140(18):1385-90. doi: 10.1055/s-0041-104246. Epub 2015 Sep 11. German. PMID: 26360954

Medical care vor asylum seekers and refugees at the University Medical Center Hamburg-Eppendorf – A case series
Sothmann P, Auf der Günne NS, Addo MM, Lohse A, Schmiedel S.
]. Dtsch Med Wochenschr. 2016 Jan; 141(1):34-7. doi: 10.1055/s-0041-108775. Epub 2015 Dec 28. German. PMID: 26710201

Tropheryma whipplei in children with diarrhea in rural Ghana
14. Vinnemeier CD, Klupp EM, Krumkamp R, Rolling T, Fischer N, Owusu-Dabo E; Addo MM, Adu-Sarkodie Y, Käsmaier J, Aepfelbacher M, Cramer JP, May J, Tannich E
Clin Microbiol Infect 2016 Jan; 22(1):65.e1-3. Doi: 10.1016/j.mi.2015.09.022 Epub 2015 Oct. 8. PMID: 26456475

Ex vivo cytosolic delivery of functional macromolecules to immune cells
Sharei A, Trifonova R, Jhunjhunwala S, Hartoularos GC, Eyerman AT, Lytton-Jean A, Angin M, Sharma S, Poceviciute R, Mao S, Heimann M, Liu S, Talkar T, Khan OF, Addo MM, von Andrian UH, Anderson DG, Langer R, Lieberman J, Jensen KF
PLoS One. 2015 Apr 13;10(4):e0118803. doi: 10.1371/journal.pone.0118803. eCollection 2015

Ebola and psychological stress of health care professionals
Lehmann M, Bruenahl CA, Löwe B, Addo MM, Schmiedel S, Lohse AW, Schramm C.
Emerging infectious diseases 21 (5), 913

Comparison of autochthonous and imported cases of hepatitis A or hepatitis E
Hartl J, Kreuels B, Polywka S, Addo M, Luethgehetmann M, Dandri M, Dammermann W, Sterneck M, Lohse AW, Pischke S
Z Gastroenterol. 2015 Jul;53(7):639-43. doi: 10.1055/s-0034-1399236. Epub 2015 Jul 13.

2014

Seltene Gerinnungsstörung oder ein Fall für den Psychiater
Zinser, M., Holstein, K., Langer, F., Voigt, P-U., Holzhüter, J.
Hamb Ärztebl, 2014(11), 30-31.

Regulatory T Cells Expanded from HIV-1-Infected Individuals Maintain Phenotype, TCR Repertoire and Suppressive Capacity
Angin M, Klarenbeek PL, King M, Sharma SM, Moodley ES, Rezai A, Piechocka-Trocha A, Toth I, Chan AT, Goulder PJ, Ndung'u T, Kwon DS, Addo MM
PLoS One. 2014 Feb 3;9(2)

. HIV-1 infection impairs regulatory T-cell suppressive capacity on a per-cell basis
Angin M, Sharma S, King M, Murooka TT, Ghebremichael M, Mempel TR, Walker BD, Bhasin MK, Addo MM
J Infect Dis. 2014 Sep 15;210(6):899-903. doi: 10.1093/infdis/jiu188. Epub 2014 Mar 23

Sex-based differences in HIV-1 pathogenesis
Addo MM, Altfeld M
J Infect Dis. 2014 Jul 15;209 Suppl 3:S86-92. doi: 10.1093/infdis/jiu175

A Case of Severe Ebola Virus Infection Complicated by Gram-Negative Septicemia
Kreuels B, Wichmann D, Emmerich P, Schmidt-Chanasit J, de Heer G, Kluge S, Sow A, Renné T, Günther S, Lohse AW, Addo MM, Schmiedel S
N Engl J Med. 2014 Oct 22. PMID: 25337633

A dead-end host: is there a way out? A position piece on the Ebola virus outbreak by the International Union of Immunology Societies
Gray CM, Addo M, Schmidt RE
Front Immunol. 2014 Oct 27;5:562. doi: 10.3389/fimmu.2014.00562

Psychosocial Stresses of Doctors and Nurses during Treatment of Patients infected with the Ebola-Virus in University Clinic Hamburg-Eppendorf in September
Lehmann H, Bruenahl CA, Loewe B, Addo MM, Schramm C, Schmiedel S
Zeitschrift für Psychosomatische Medizin und Psychotherapie 61 (1) 76-77

Contact

Prof. Dr. med. Marylyn M. Addo

Phone: +49 40 42818-420
Fax: +49 40 42818-418
E-Mail: addo@bnitm.de


Technical Staff

My Linh Ly (-420)
Reza Jan Neumann (-420)

PhD Students

Etienne Bartels (-420)

Graduate Students

Dipl. biol. Swantje Gundlach (-420)
Dai Ton Tran (-420)
Joseph Poetsch (-420)