Arbeitgruppe:

News from the group

The German Ambassador to Ghana H. E. Rüdiger John visited the Barrier nursing course at the Komfo Anokye Teaching Hospital and Ebo-Diagnostics workshop at the Kumasi Centre for Collaborative Research conducted by the Clinical Research Unit of the Bernhard Nocht Institute for Tropical Medicine

Research Projects

The impact of Helicobacter pylori infection on immune regulation and clinical course in HIV patients in Ghana (HHECO)

Recently, the interplay between Human immunodeficiency virus (HIV) and Helicobacter pylori infection has attracted attention. A number of studies reported more favorable immune and clinical parameters in HIV-infected individuals with H. pylori. The inverse relationship between H. pylori infection and immunocompetence of the host is unexpected, since most chronic infections are more common in patients with progressed HIV disease. For other co-infections, such as Tropheryma whipplei there are no published data available on prevalence or impact in PLHIV.

We aim to investigate the impact of H. pylori and other relevant co-infections on immune activation and clinical outcomes in a cohort of 1000 HIV-positive patients at the Komfo Anokye Teaching hospital.

Collaborators

Dr. Torsten Feldt, University Hospital Düsseldorf, Germany
Dr. Fred Stephen Sarfo, Komfo Anokye Teaching Hospital, Kumasi, Ghana
Prof. Dr. Gerd Dieter Burchard, Institute for Interdisciplinary Medicine, Hamburg, Germany

Funding

BMBF

ESTHER Partnership Program

The Deutsche Gesellschaft für Internationale Zusammenarbeit (GIZ) GmbH coordinates Germany’s contribution to the European ESTHER Alliance on behalf of the German Federal Ministry for Economic Cooperation and Development (BMZ) through the ESTHER Germany Secretariat. Members of the Alliance committed to develop the Initiative by implementing capacity building activities through twinnings between hospitals of the North and hospitals and health structures in the developing countries, in order to provide comprehensive and quality care for people living with HIV/AIDS and related diseases.

The partnership between the Komfo Anokye Teaching Hospital and the Bernhard Nocht Institute for Tropical Medicine started in 2009. Capacity Development is at the core of this partnership and is seen as an holistic approach through which the partner organization mobilizes, maintains, adapts and expands its ability to manage its own sustainable development. Common project ideas, joint activities and continuous communication and exchange generate the desired results. During the second project phase, routine TB screening for HIV patients could be established and the management of HIV/TB co-infected patients optimized. The aim of the ongoing third project phase is to improve the quality of antiretroviral treatment of HIV positive patients.


Collaborators 

Dr. Fred Stephen Sarfo, Komfo Anokye Teaching Hospital, Kumasi, Ghana

Funding

ESTHER/GIZ

Kumasi Cohort Study (KCS) on the efficacy of first and second line ART in HIV positive patients in Ghana

As of 2011, 56 000 adult people living with HIV (PLHIV) were treated with antiretroviral drugs in Ghana. This represents a fourth of all adult PLHIV in Ghana and a 47% coverage among people with advanced HIV infection. In a cohort of 1500 HIV-infected patients on first-line ART at the Komfo Anokye Teaching hospital, the proportion of treatment failures and its determinates should be investigated. During this study we will establish a cohort of PLHIV who will be switched to second-line ART after virological or immunological treatment failure. Here as well, we aim to investigate the efficacy of this second-line ART, which is of high interest due to the fact that there is no third-line option available in Ghana.


Collaborators

Dr. Torsten Feldt, University Hospital Düsseldorf, Germany
Dr. Fred Stephen Sarfo, Komfo Anokye Teaching Hospital, Kumasi, Ghana

Funding 

Gilead Sciences and ESTHER/GIZ

Impact of infectious diseases on physical and mental development in African children. CDS – The Child Development Study

Infectious diseases are highly prevalent in developing countries and contribute exceptionally to morbidity and mortality. Several infectious diseases have been linked to physical as well as cognitive, behavioural and emotional (summarized as "mental") child development. These diseases, e.g. intestinal parasitic diseases leading to diarrhoea, malabsorption and anaemia, strongly and negatively influence child development already during the first years of life with long-term consequences for further thriving and psychosocial functioning. Data on these interconnected determinants of health, however, are still sparse. The significance of early childhood development has not been adequately acknowledged in the majority of health care systems, and standardized outcome measures do virtually not exist in most developing countries. Consequently, impaired child development is rarely detected, and early interventions to improve healthy outcome cannot be applied.

Within the framework of a prospective cohort study, a birth cohort of children in Ghana and Côte d'Ivoire will be recruited and followed up for initially 2 years. A nested case-control design will then be applied to assess risk factors for impaired child development. A panel of infectious and also non-infectious diseases of mother and child is to be assessed with respect to the influence on the main outcome variables, physical and mental development of the children. Both, the molecular diagnostics of parasitic diseases and the assessment of variables in early physical and mental development will build up local capacities that will be enhanced via the network. The project combines the domains of neglected infectious diseases and mental health which are integral parts of health in general. Some results have already been published and data are being analysed.

Collaborators

Dr. Carola Bindt, Dep. of Psychosomatics, Children´s Hospital, University Hospital Hamburg-Eppendorf

Prof. Dr. Stephan Ehrhardt, John Hopkins, Bloomberg School of Public Health, Baltimore, USA

Prof. Dr. Eliezer Kouakou N'Goran, Research Unit of Parasitology and Parasite Ecology at UFR Biosciences, Abidjan, Côte d'Ivoire

Dr. Harry Tagbor, Department Community Health, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana

Funding

German Research Foundation (DFG)

Saccharomyces boulardii for the prevention of antibiotic-associated diarrhoea - SacBo

SacBo is a multicentre, randomized clinical trial on antibiotic-associated diarrhoea (AAD), a frequent condition in hospitalised patients receiving antibiotic treatment. The same is true for Clostridium difficile-associated diarrhoea (CDAD) with even more grave consequences of increased morbidity and mortality. The development and evaluation of preventive strategies is one key public health challenge. In the absence of clinically evaluated alternatives, probiotics have been suggested to be beneficial for the prevention of AAD and CDAD. However, data have so far been inconclusive and recently published meta-analyses strongly recommended large state-of-the-art clinical trials on probiotic substances for the prevention of AAD and CDAD. Since the efficacy, side-effects and modes of action of different probiotic bacteria and yeast are strain specific, benefits and risks cannot be generalised. The non-pathogenic yeast Saccharomyces cerevisiae var. boulardii (Sac. boulardii) is considered the most promising probiotic substance for the prevention of AAD and CDAD. We designed a randomised, placebo controlled, double blind multicentre clinical trial to evaluate Sac. boulardii for the indication of prevention of AAD and CDAD in 1372 adult, hospitalised patients. Currently data are analysed and results will be published soon.

Principal Investigator

Prof. Dr. Stephan Ehrhardt, John Hopkins, Bloomberg School of Public Health, Baltimore, USA

Funding

Federal Ministry of Education and Research (BMBF)

Costs of dengue illness in international travelers: A multi-country study

Traveling to tropical areas is associated with increased health risks, particularly from infectious diseases. The proportion of dengue fever among febrile illness in international travelers has increased over the last years.

Infection with dengue virus can cause a spectrum of illness and may result in significant direct and indirect costs abroad and at home. However, there has been no attempt to estimate the costs of illness associated with dengue infection in international travelers.

As part of an international multicenter-study we address the gap of knowledge and estimate the economic burden due to dengue infections in international travelers.

Collaborators

Ass. Prof. Dr. Yesim Tozan, New York University, USA

Prof. Dr. Annelies Wilder-Smith; Umea University, Sweden

PD. Dr. Jakob Cramer, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany

All Publications

Arbeitsgruppe Klinische Studien
2016

Factors associated with performing tuberculosis screening of HIV-positive patients in Ghana: LASSO-based predictor selection in a large public health data set
Mueller-Using S, Feldt T, Sarfo FS, Eberhardt KA
BMC Public Health. 2016 Jul 13;16:563. doi: 10.1186/s12889-016-3239-y.

Travelers to the FIFA World Cup 2014 in Brazil: Health Risks related to Mass Gatherings / Sports Events and Implications for the Summer Olympic Games in Rio de Janeiro in 2016
Eberhardt KA, Vinnemeier CD, Dehnerdt J, Rolling T, Steffen R, Cramer JP
Travel Med Infect Dis. 2016 May-Jun;14(3):212-20. doi: 10.1016/j.tmaid.2016.05.014.

CD25+ FoxP3+ Memory CD4 T Cells Are Frequent Targets of HIV Infection In Vivo
Chachage M, Pollakis G, Kuffour EO, Haase K, Bauer A, Nadai Y, Podola L, Clowes P, Schiemann M, Henkel L, Hoffmann D, Joseph S, Bhuju S, Maboko L, Sarfo FS, Eberhardt K, Hoelscher M, Feldt T, Saathoff E, Geldmacher C
J Virol. 2016 Sep 29;90(20):8954-67. doi: 10.1128/JVI.00612-16.

Longitudinal course of ante- and postpartum generalized anxiety symptoms and associated factors in West-African women from Ghana and Côte d'Ivoire
Barthel D, Kriston L, Barkmann C, Appiah-Poku J, Te Bonle M, Esther Doris KY, Carine Esther BK, Jean Armel KE, Mohammed Y, Osei Y, Fordjour D, Owusu D, Eberhardt KA, Hinz R, Koffi M, N'Goran E, Nguah SB, Tagbor H, Schoppen S, Ehrhardt S, Bindt C; International CDS Study Group
J Affect Disord. 2016 Mar 9;197:125-133. doi: 10.1016/j.jad.2016.03.014. [Epub ahead of print]

Arbeitsgruppe Klinische Studien
2015

Helicobacter pylori co-infection is associated with decreased markers of immune activation in ART-naïve HIV-positive and in HIV-negative individuals in Ghana.
Eberhardt KA, Sarfo FS, Dompreh A, Kuffour EO, Geldmacher C, Soltau M, Schachscheider M, Drexler JF, Eis-Hübinger AM, Häussinger D, Bedu-Addo G, Phillips RO, Norman B, Burchard GD, Feldt T.
Clin Infect Dis. 2015 Nov 15;61(10):1615-23. doi: 10.1093/cid/civ577. Epub 2015 Jul 20. PubMed PMID: 26195015.

Helicobacter pylori Infection Is Associated with Higher CD4 T Cell Counts and Lower HIV-1 Viral Loads in ART-Naïve HIV-Positive Patients in Ghana
Sarfo FS, Eberhardt KA, Dompreh A, Kuffour EO, Soltau M, Schachscheider M, Drexler JF, Eis-Hübinger AM, Häussinger D, Oteng-Seifah EE, Bedu-Addo G, Phillips RO, Norman B, Burchard G, Feldt T
PLoS One. 2015 Nov 24;10(11):e0143388. doi: 10.1371/journal.pone.0143388. eCollection 2015

Screening for depression in pregnant women from Côte d׳Ivoire and Ghana: Psychometric properties of the Patient Health Questionnaire-9
Barthel D, Barkmann C, Ehrhardt S, Schoppen S, Bindt C; International CDS Study Group
J Affect Disord. 2015 Nov 15;187:232-40. doi: 10.1016/j.jad.2015.06.042. Epub 2015 Jul 29

Group B Streptococci serotype distribution in pregnant women in Ghana: assessment of potential coverage through future vaccines
Vinnemeier CD, Brust P, Owusu-Dabo E, Sarpong N, Sarfo EY, Bio Y, Rolling T, Dekker D, Adu-Sarkodie Y, Eberhardt KA, May J, Cramer JP
Trop Med Int Health. 2015 Nov;20(11):1516-1524. doi: 10.1111/tmi.12589.

2014

Mental health related determinants of parenting stress among urban mothers of young children - results from a birth-cohort study in Ghana and Côte d'Ivoire.
Guo N, Bindt C, Te Bonle M, Appiah-Poku J, Tomori C, Hinz R, Barthel D, Schoppen S, Feldt T, Barkmann C, Koffi M, Loag W, Nguah SB, Eberhardt KA, Tagbor H, Bass JK, N'Goran E, Ehrhardt S; International CDS Study Group.
BMC Psychiatry. 2014 May 29;14(1):156. doi: 10.1186/1471-244X-14-156.

2013

No association between antenatal common mental disorders in low-obstetric risk women and adverse birth outcomes in their offspring: results from the CDS study in Ghana and Côte D'Ivoire.
Bindt C, Guo N, Bonle MT, Appiah-Poku J, Hinz R, Barthel D, Schoppen S, Feldt T, Barkmann C, Koffi M, Loag W, Nguah SB, Eberhardt KA, Tagbor H, N'goran E, Ehrhardt S; International CDS Study Group.
PLoS One. 2013 Nov 18;8(11):e80711. doi: 10.1371/journal.pone.0080711. eCollection 2013.

Association of antepartum and postpartum depression in Ghanaian and Ivorian women with febrile illness in their offspring: a prospective birth cohort study.
Guo N, Bindt C, Te Bonle M, Appiah-Poku J, Hinz R, Barthel D, Koffi M, Posdzich S, Deymann S, Barkmann C, Schlüter L, Jaeger A, Blay Nguah S, Eberhardt KA, N'Goran E, Tagbor H, Ehrhardt S; International CDS Study Group.
Am J Epidemiol. 2013 Nov 1;178(9):1394-402. doi: 10.1093/aje/kwt142. Epub 2013 Sep 7.

2012

Antepartum depression and anxiety associated with disability in African women: cross-sectional results from the CDS study in Ghana and Côte d'Ivoire.
Bindt C, Appiah-Poku J, Te Bonle M, Schoppen S, Feldt T, Barkmann C, Koffi M, Baum J, Nguah SB, Tagbor H, Guo N, N'Goran E, Ehrhardt S; International CDS Study Group.
PLoS One. 2012;7(10):e48396. doi: 10.1371/journal.pone.0048396. Epub 2012 Oct 26.

2010

Expected effects of specific ions versus real effects of their intake from a bottled water.
Vaquero MP, Pérez-Granados AM, Schoppen S.
Med Clin (Barc). 2011 Apr 30;136(12):555-6. doi: 10.1016/j.medcli.2010.06.025. Epub 2010 Nov 11. Spanish. No abstract available.

Influence of the leptin G-2548A polymorphism on leptin levels and anthropometric measurements in healthy Spanish adolescents.
Riestra P, Garcia-Anguita A, Viturro E, Schoppen S, de Oya M, Garcés C.
Ann Hum Genet. 2010 Jul;74(4):335-9. doi: 10.1111/j.1469-1809.2010.00586.x.

Sex-specific association between leptin receptor polymorphisms and leptin levels and BMI in healthy adolescents.
Riestra P, García-Anguita A, Schoppen S, López-Simón L, De Oya M, Garcés C.
Acta Paediatr. 2010 Oct;99(10):1527-30. doi: 10.1111/j.1651-2227.2010.01877.x. Epub 2010 Jun 8.

Leptin and adiponectin levels in pubertal children: relationship with anthropometric variables and body composition.
Schoppen S, Riestra P, García-Anguita A, López-Simón L, Cano B, de Oya I, de Oya M, Garcés C.
Clin Chem Lab Med. 2010 May;48(5):707-11. doi: 10.1515/CCLM.2010.142.

Postprandial lipaemia and endothelial adhesion molecules in pre- and postmenopausal Spanish women.
Schoppen S, Pérez-Granados AM, Navas-Carretero S, Vaquero MP.
Nutr Hosp. 2010 Mar-Apr;25(2):256-61.

2009

Reduction in cardiovascular risk by sodium-bicarbonated mineral water in moderately hypercholesterolemic young adults.
Pérez-Granados AM, Navas-Carretero S, Schoppen S, Vaquero MP.
J Nutr Biochem. 2010 Oct;21(10):948-53. doi: 10.1016/j.jnutbio.2009.07.010. Epub 2009 Dec 1.

Postprandial lipaemia and adhesion molecules in pre- and postmenopausal Spanish women.
Schoppen S, Pérez-Granados AM, Navas-Carretero S, Vaquero MP.
Nutr Hosp. 2009; in press.

Sex hormone-binding globulin levels and metabolic syndrome and its features in adolescents.
de Oya I, Schoppen S, Lasunción MA, Cano B, López-Simón L, Riestra P, de Oya M, Garcés C.
Pediatr Diabetes. Epub ahead of print 2009.

Iron biomarkers in iron deficient women consuming a red meat versus an oily fish diet.
Navas-Carretero S, Pérez-Granados AM, Sarriá B, Schoppen S, Vaquero MP.
J Physiol Biochem. 2009;65:165-174

Fat intake influences the effect of the hepatic lipase C-514T polymorphism on HDL-cholesterol levels in children.
Riestra P, López-Simón L, Ortega H, Gorgojo L, Martin-Moreno JM, Schoppen S, de Oya M, Garcés C.
Exp Biol Med. 2009;234:744-9.

An oily fish diet reduces insulin resistance compared to a red meat diet in young iron deficient women.
Navas-Carretero S, Perez-Granados AM, Schoppen S, Vaquero MP.
Brit J Nutr. 2009;102:546-53.

Genetic determinants of plasma HDL-cholesterol levels in prepubertal children.
López-Simon L, de Oya M, Lasunción MA, Riestra P, Benavente M, de Oya I, Cano B, Schoppen S, Gárces C.
Clin Chim Acta. 2009;403:203-6.

2008

Hormone levels in 12- to 15-year-old boys and girls in Spain and their relationship with anthropometric variables.
Garces C, de Oya I, Lopez-Simon L, Cano B, Schoppen S, Gil A, de Oya M.
Clin Biochem. 2008;41:621-4.

Menopausia y Nutrición: La gran desconocida.
Vaquero MP, Navas-Carretero S, Pérez-Granados AM, Schoppen S.
Nutr Hosp. 2008;1:S52-54.

2007

Iron bioavailability from pate enriched with encapsulated ferric pyrophosphate or ferrous gluconate in rats.
Navas-Carretero S, Pérez-Granados AM, Sarriá B, Schoppen S, Vaquero MP.
Food Sci Tech Int. 2007;13:159-63.


A comparative study of iron bioavailability from cacao supplemented with ferric pyrophosphate or ferric fumarate in rats.
Navas-Carretero S, Pérez-Granados AM, Sarriá B, Schoppen S, Vaquero MP.
Ann Nutr Metab. 2007;51:204-7.

Sodium bicarbonated mineral water decreases aldosterone levels without affecting urinary excretion of bone minerals.
Schoppen S, Pérez-Granados AM, Carbajal A, Sarriá B, Navas-Carretero S, Vaquero MP.
Int J Food Sci Nutr. 2007;18:1-9.

Does Bicarbonated mineral water rich in sodium change insulin sensitivity of postmenopausal women?
Schoppen S, Sánchez-Muniz FJ, Pérez-Granados AM, , Gómez-Gerique JA, Sarriá B, Navas-Carretero S, Vaquero MP.
Nutr Hosp. 2007;22:538-44.

2006

El agua mineral natural y el riesgo cardiovascular. Endocronología y Nutrición.
Schoppen S, Pérez Granados AM, Vaquero MP.
2006;53:533-35. Review

El agua mineral natural en el contexto de una dieta osteosaludable.
Schoppen S, Pérez Granados AM, Vaquero MP.
Rev Nutr Pract. 2006; Número especial

BDNF/TrkB signaling regulates HNK-1 carbohydrate expression in regenerating motor nerves and promotes functional recovery after peripheral nerve repair.
Eberhardt KA, Irintchev A, Al-Majed AA, Simova O, Brushart TM, Gordon T, Schachner M.
Exp Neurol. 2006 Apr;198(2):500-10. Epub 2006 Feb 7. PubMed PMID: 16460731.

2005

Bone remodelling is not affected by consumption of a sodium-rich carbonated mineral water in healthy postmenopausal women.
Schoppen S, Pérez-Granados MP, Carbajal A, de la Piedra C, Vaquero MP.
Brit J Nutr. 2005;93:339-44.

Sodium bicarbonated mineral water decreases postprandial lipemia in postmenopausal women.
Schoppen S, Pérez-Granados AM, Carbajal A, Sarriá B, Sánchez-Muniz FJ, Gómez-Gerique JA, Vaquero MP.
Brit J Nutr. 2005;94:582-7.

Food, Energy and Macronutrient Intake of a Group of Postmenopausal Women who participated in a Menopause Program.
Schoppen S, Pérez-Granados AM, Carbajal A, Vivas F Vaquero MP.
Nutr Hosp. 2005;XX:101-9.

Impacts of lesion severity and tyrosine kinase receptor B deficiency on functional outcome of femoral nerve injury assessed by a novel single-frame motion analysis in mice.
Irintchev A, Simova O, Eberhardt KA, Morellini F, Schachner M.
Eur J Neurosci. 2005 Aug;22(4):802-8. Erratum in: Eur J Neurosci. 2006 Feb;23(4):1087. PubMed PMID: 16115204.

2004

A sodium-rich carbonated mineral water reduces cardiovascular risk in postmenopausal women.
Schoppen S, Pérez-Granados AM, Carbajal A, Sánchez-Muniz F, Vaquero MP.
J Nutr. 2004;134:1058-63.

2002

Modulación del metabolismo lipídico a través de los electrolitos presentes en el agua de bebida.
Pérez-Granados AM, Schoppen S, Vaquero MP.
Rev Nutr Pract. 2002:6:11-6.

Actualidad y beneficios para la salud de las aguas mineromedicinales.
Vaquero MP, Sarría B, Pérez-Granados AM, Schoppen S.
Rev Nutri Pract 2002, Número especial

2001

Propiedades fisiológicas y nutricionales de las aguas minerales naturales carbónicas.
Vaquero MP, Peréz-Granados A, Schoppen S.
Rev Nutr Prac. 2001;5:43-52

1999

Relationship between biogenic amine contents and the size of dry fermented sausages.
Bover i Cid S, Schoppen S, Izquierdo-Pulido M, Vidal-Carou MC.
Meat Science. 1999;51:305-1

Cooperations

Contact

NN (kommissarische Leitung Prof. Dr. Rolf Horstmann)

Phone: +49 40 42818-260
Fax:
E-Mail: bni@bnitm.de


Scientists

Dr. Kirsten A. Eberhardt, MD, MPS Tel: -290 Fax: -291

Dr. Stefanie Schoppen, PhD Tel: -294 Fax: -291

Doctoral/PhD Students

Johanna Dehnerdt
Marei Schachschneider

Downloads