• Staff

Overview

Implementation Research
Development and Implementation of Medicines for Malaria and Poverty Related Infectious Diseases
MED4PRID

We promote health for the pride and thrive of every people
Group leader: Ghyslain MOMBO-NGOMA

Epidemiology and control of poverty related infectious diseases (PRID) including malaria, HIV/AIDS, filariasis, schistosomiasis and others, are the main focus of our working group. We aim to improve prevention and treatment interventions. Our target population is made of pregnant women, infants, children and adolescents.

RESEARCH PROJECTS

1. MAMAH

Improving maternal and infant health by reducing malaria risks in African women: evaluation of the safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in HIV-infected pregnant women

Fundación Privada Instituto de Salud Global Barcelona (ISGlobal) with partners from Austria, Gabon, Germany, and Mozambique 
Project Coordinator: Prof. Clara Menéndez Santos, ISGlobal, Spain
Starting date:
 1 March 2018
Duration: 60 months
EDCTP Grant amount: EUR 2,985,000
Grant agreement: RIA2016MC-1613

Further information can be found on the MAMAH project webpage:

http://www.mamahproject.net/category/the-project/


2. ASAAP

Clinical evaluation of AntimalarialS tri-therapy with AtovAquone Proguanil for malaria treatment in African children (ASAAP)

Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana with partners from Benin, Burkina Faso, France, Gabon, Germany, and Mali
Project coordinator: Dr. Oumou Maiga-Ascofare (KNUST), Ghana
Starting date: 01 March 2019
Duration: 48 months
EDCTP grant amount: EUR 7,642,364
Grant agreement: RIA2017MC-2022

Further information can be found on the ASAAP project webpage: https://asaap-malaria.org/  


3. WANECAM2

A phase II and III clinical trial programme to assess safety, efficacy and transmission-blocking properties of the new antimalarial KAF156 combined with a new formulation of lumefantrine in children and adults with uncomplicated Plasmodium sp. malaria in West and Central Africa

Université des Sciences, des Techniques et des Technologies de Bamako (USTTB), Bamako, Mali, with partners from Burkina Faso, France, Gabon, Germany, the Netherlands, Niger, Sweden, Switzerland, and United Kingdom
Project coordinator: Prof. Abdoulaye Djimdé (USTTB, Mali)
Starting date: 1 March 2019
Duration: 60 months
EDCTP grant amount: EUR 10,000,000
Grant agreement: RIA2017T-2018

 

Further information can be found on the WANECAM2 website http://www.wanecam.org/


4. PAMAFRICA

Portfolio approach to developing the next generation of malaria treatments for Africa

Medicines for Malaria Venture (MMV) Cointrin, Switzerland, with partners in Burkina Faso, Gabon, Germany, Mozambique, Spain, Switzerland, and Uganda.
Project coordinator: Dr Tim Wells (MMV)
Starting date: 01 January 2020
Duration: 60 months
EDCTP grant amount: EUR 21,990,938
Grant agreement: RIA2018SD-2306

Further information can be found on the PAMAFRICA website https://www.pamafrica-consortium.org/ 


5. SINDOFO

Phase II multicenter clinical trial of a ferroquine + MMV253 short regimen for the treatment of malaria

Eberhard Karls Universität Tübingen, Tübingen, Germany with partners from Burkina Faso, Gabon, Kenya, Mozambique, Spain, and Switzerland
Project coordinator: Dr Jana Held (Universität Tübingen)
Starting date: 01 January 2021
Duration: 54 months
EDCTP grant amount: EUR 9,800,339
Grant agreement: RIA2017T-2015

Further information can be found on the PAMAFRICA website https://sindofo.net/   


6. MA-CoV

Prevalence and impact of SARS-CoV-2 infection on maternal and infant health in African populations — MA-CoV

Fundación Privada Instituto de Salud Global Barcelona (ISGlobal) with partners from Gabon, Germany, and Mozambique 
Project Coordinator: Dr. Raquel Gonzalez, ISGlobal, Spain
Starting date:
 1 July 2021
Duration: 21 months
EDCTP Grant amount: EUR 499,999
Grant agreement: RIA2020EF-2956


7. MIGG

COVID-19 in rural areas in Gabon: Support and protection of frontline health workers and community interventions

Bernhard Nocht Institut für Tropenmedizin (BNITM), Hamburg, Germany and Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon

Project Leader: Prof. Michael Ramharter, BNITM, Germany
Project Manager: 
Prof. Ghyslain Mombo-Ngoma, CERMEL, Gabon
Starting date:
 15 February 2021
Duration: 12 months
GIZ Grant amount: EUR 145.672,80
Grant agreement: 20Co021


8. PROTECT

Implementation and optimization of the national guidelines against COVID-19 to protect the rural community in Gabon

Bernhard Nocht Institut für Tropenmedizin (BNITM), Hamburg, Germany and Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon

Project Leader: Prof. Michael Ramharter, BNITM, Germany
Project Manager: 
Prof. Ghyslain Mombo-Ngoma, CERMEL, Gabon
Starting date:
 1 January 2021
Duration: 12 months
GIZ Grant amount: EUR 145.672,80
Grant agreement: 20Co013

PUBLICATION HIGHLIGHTS

Pyronaridine-artesunate real-world safety, tolerability, and effectiveness in malaria patients in 5 African countries: A single-arm, open-label, cohort event monitoring study.
Tona Lutete G, Mombo-Ngoma G, Assi SB, Bigoga JD, Koukouikila-Koussounda F, Ntamabyaliro NY, Ntoumi F, Agnandji ST, Groger M, Shin J, Borghini-Fuhrer I, Arbe-Barnes S, Allen SJ, Kremsner PG, Miller R, Duparc S, Ramharter M; CANTAM study group. PLoS Med. 2021 Jun 15;18(6):e1003669. doi: 10.1371/journal.pmed.1003669. eCollection 2021 Jun.

A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults and children with uncomplicated Plasmodium falciparum malaria.
Adoke Y, Zoleko-Manego R, Ouoba S, Tiono AB, Kaguthi G, Bonzela JE, Duong TT, Nahum A, Bouyou-Akotet M, Ogutu B, Ouedraogo A, Macintyre F, Jessel A, Laurijssens B, Cherkaoui-Rbati MH, Cantalloube C, Marrast AC, Bejuit R, White D, Wells TNC, Wartha F, Leroy D, Kibuuka A, Mombo-Ngoma G, Ouattara D, Mugenya I, Phuc BQ, Bohissou F, Mawili-Mboumba DP, Olewe F, Soulama I, Tinto H; FALCI Study Group. Malar J. 2021 May 19;20(1):222. doi: 10.1186/s12936-021-03749-4.

Development of sustainable research excellence with a global perspective on infectious diseases: Centre de Recherches Médicales de Lambaréné (CERMEL), Gabon.
Ramharter M, Agnandji ST, Adegnika AA, Lell B, Mombo-Ngoma G, Grobusch MP, McCall M, Muranaka R, Kreidenweiss A, Velavan TP, Esen M, Schaumburg F, Alabi A, Druml C, Mordmüller B, Köhler C, Kremsner PG. Wien Klin Wochenschr. 2021 May;133(9-10):500-508. doi: 10.1007/s00508-020-01794-8. Epub 2021 Jan 4.

A randomized controlled trial comparing the effectiveness of individual versus household treatment for Scabies in Lambaréné, Gabon.
Matthewman J, Manego RZ, Dimessa Mbadinga LB, Šinkovec H, Völker K, Akinosho M, Haedrich C, Tardif d'Hamonville J, Lell B, Adegnika AA, Ramharter M, Mombo-Ngoma G. PLoS Negl Trop Dis. 2020 Jun 26;14(6):e0008423. doi: 10.1371/journal.pntd.0008423. eCollection 2020 Jun.

The early preclinical and clinical development of cipargamin (KAE609), a novel antimalarial compound.
Bouwman SA, Zoleko-Manego R, Renner KC, Schmitt EK, Mombo-Ngoma G, Grobusch MP. Travel Med Infect Dis. 2020 Jul-Aug;36:101765. doi: 10.1016/j.tmaid.2020.101765. Epub 2020 Jun 16.

The  early  preclinical and clinical development of ganaplacide (KAF156), a novel antimalarial compound.
Koller R, Mombo-Ngoma G, Grobusch MP. Expert Opin Investig Drugs. 2018 Oct;27(10):803-810. doi: 10.1080/13543784.2018.1524871. Epub 2018 Sep 25.

Efficacy and Safety of Fosmidomycin-Piperaquine as Nonartemisinin-Based Combination Therapy for Uncomplicated Falciparum Malaria: A Single-Arm, Age De-escalation Proof-of-Concept Study in Gabon.
Mombo-Ngoma G, Remppis J, Sievers M, Zoleko Manego R, Endamne L, Kabwende L, Veletzky L, Nguyen TT, Groger M, Lötsch F, Mischlinger J, Flohr L, Kim J, Cattaneo C, Hutchinson D, Duparc S, Moehrle J, Velavan TP, Lell B, Ramharter M, Adegnika AA, Mordmüller B, Kremsner PG. Clin Infect Dis. 2018 Jun 1;66(12):1823-1830. doi: 10.1093/cid/cix1122.


Intermittent preventive treatment of malaria in pregnancy with mefloquine in HIV-negative women: a multicentre randomized controlled trial.

González R, Mombo-Ngoma G, Ouédraogo S, Kakolwa MA, Abdulla S, Accrombessi M, Aponte JJ, Akerey-Diop D, Basra A, Briand V, Capan M, Cot M, Kabanywanyi AM, Kleine C, Kremsner PG, Macete E, Mackanga JR, Massougbodgi A, Mayor A, Nhacolo A, Pahlavan G, Ramharter M, Rupérez M, Sevene E, Vala A, Zoleko-Manego R, Menéndez C.PLoS Med. 2014 Sep 23;11(9):e1001733. doi: 10.1371/journal.pmed.1001733. eCollection 2014 Sep.

Efficacy of mefloquine intermittent preventive treatment in pregnancy against Schistosoma haematobium infection in Gabon: a nested randomized controlled assessor-blinded clinical trial.
Basra A, Mombo-Ngoma G, Melser MC, Diop DA, Würbel H, Mackanga JR, Fürstenau M, Zoleko RM, Adegnika AA, Gonzalez R, Menendez C, Kremsner PG, Ramharter M.Clin Infect Dis. 2013 Mar;56(6):e68-75. doi: 10.1093/cid/cis976. Epub 2012 Nov 21.

Phase I randomized dose-ascending placebo-controlled trials of ferroquine--a candidate anti-malarial drug--in adults with asymptomatic Plasmodium falciparum infection.
Mombo-Ngoma G, Supan C, Dal-Bianco MP, Missinou MA, Matsiegui PB, Ospina Salazar CL, Issifou S, Ter-Minassian D, Ramharter M, Kombila M, Kremsner PG, Lell B.Malar J. 2011 Mar 1;10:53. doi: 10.1186/1475-2875-10-53.

ALL PUBLICATIONS

2021

Koehne E, Zander N, Rodi M, Held J, Hoffmann W, Zoleko-Manego R, Ramharter M, Mombo-Ngoma G, Kremsner PG, Kreidenweiss A. Evidence for in vitro and in vivo activity of the antimalarial pyronaridine against Schistosoma. PLoS Negl Trop Dis. 2021 Jun 24;15(6):e0009511. doi: 10.1371/journal.pntd.0009511. eCollection 2021 Jun.

Tona Lutete G, Mombo-Ngoma G, Assi SB, Bigoga JD, Koukouikila-Koussounda F, Ntamabyaliro NY, Ntoumi F, Agnandji ST, Groger M, Shin J, Borghini-Fuhrer I, Arbe-Barnes S, Allen SJ, Kremsner PG, Miller R, Duparc S, Ramharter M; CANTAM study group. Pyronaridine-artesunate real-world safety, tolerability, and effectiveness in malaria patients in 5 African countries: A single-arm, open-label, cohort event monitoring study. PLoS Med. 2021 Jun 15;18(6):e1003669. doi: 10.1371/journal.pmed.1003669. eCollection 2021 Jun.

Pugliese CM, Adegbite BR, Edoa JR, Mombo-Ngoma G, Obone-Atome FA, Heuvelings CC, Bélard S, Kalkman LC, Leopold SJ, Hänscheid T, Adegnika AA, Huson MA, Grobusch MP. Point-of-care ultrasound to assess volume status and pulmonary oedema in malaria patients. Infection. 2021 Jun 10. doi: 10.1007/s15010-021-01637-2.

Nouatin O, Mengue JB, Dejon-Agobé JC, Fendel R, Ibáñez J, Ngoa UA, Edoa JR, Adégbité BR, Honkpéhédji YJ, Zinsou JF, Hounkpatin AB, Moutairou K, Homoet A, Esen M, Kreidenweiss A, Hoffman SL, Theisen M, Luty AJF, Lell B, Agnandji ST, Mombo-Ngoma G, Ramharter M, Kremsner P, Mordmüller B, Adegnika AA. Exploratory analysis of the effect of helminth infection on the immunogenicity and efficacy of the asexual blood-stage malaria vaccine candidate GMZ2. PLoS Negl Trop Dis. 2021 Jun 1;15(6):e0009361. doi: 10.1371/journal.pntd.0009361. eCollection 2021 Jun.

Adoke Y, Zoleko-Manego R, Ouoba S, Tiono AB, Kaguthi G, Bonzela JE, Duong TT, Nahum A, Bouyou-Akotet M, Ogutu B, Ouedraogo A, Macintyre F, Jessel A, Laurijssens B, Cherkaoui-Rbati MH, Cantalloube C, Marrast AC, Bejuit R, White D, Wells TNC, Wartha F, Leroy D, Kibuuka A, Mombo-Ngoma G, Ouattara D, Mugenya I, Phuc BQ, Bohissou F, Mawili-Mboumba DP, Olewe F, Soulama I, Tinto H; FALCI Study Group. A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults and children with uncomplicated Plasmodium falciparum malaria. Malar J. 2021 May 19;20(1):222. doi: 10.1186/s12936-021-03749-4.

Honkpéhèdji YJ, Adegbite BR, Zinsou JF, Dejon-Agobé JC, Edoa JR, Zoleko Manego R, McCall M, Mbong Ngwese M, Lotola Mougeni F, Mombo-Ngoma G, Ramharter M, Kremsner PG, Lell B, Yazdanbakhsh M, Esen M, Adegnika AA. Association of low birth weight and polyparasitic infection during pregnancy in Lambaréné, Gabon. Trop Med Int Health. 2021 Apr 15. doi: 10.1111/tmi.13591.

Zoleko-Manego R, Mischlinger J, Dejon-Agobé JC, Basra A, Mackanga JR, Akerey Diop D, Adegnika AA, Agnandji ST, Lell B, Kremsner PG, Matsiegui PB, González R, Menendez C, Ramharter M, Mombo-Ngoma G. Birth weight, growth, nutritional status and mortality of infants from Lambaréné and Fougamou in Gabon in their first year of life. PLoS One. 2021 Feb 9;16(2):e0246694. doi: 10.1371/journal.pone.0246694. eCollection 2021.

Ramharter M, Agnandji ST, Adegnika AA, Lell B, Mombo-Ngoma G, Grobusch MP, McCall M, Muranaka R, Kreidenweiss A, Velavan TP, Esen M, Schaumburg F, Alabi A, Druml C, Mordmüller B, Köhler C, Kremsner PG. Development of sustainable research excellence with a global perspective on infectious diseases: Centre de Recherches Médicales de Lambaréné (CERMEL), Gabon. Wien Klin Wochenschr. 2021 May;133(9-10):500-508. doi: 10.1007/s00508-020-01794-8. Epub 2021 Jan 4.

Koehne E, Kreidenweiss A, Adegbite BR, Manego RZ, McCall MBB, Mombo-Ngoma G, Adegnika AA, Agnandji ST, Mordmüller B, Held J. In vitro activity of eravacycline, a novel synthetic halogenated tetracycline, against the malaria parasite Plasmodium falciparum. J Glob Antimicrob Resist. 2021 Mar;24:93-97. doi: 10.1016/j.jgar.2020.11.024. Epub 2020 Dec 7.

2020

Matthewman J, Manego RZ, Dimessa Mbadinga LB, Šinkovec H, Völker K, Akinosho M, Haedrich C, Tardif d'Hamonville J, Lell B, Adegnika AA, Ramharter M, Mombo-Ngoma G. A randomized controlled trial comparing the effectiveness of individual versus household treatment for Scabies in Lambaréné, Gabon. PLoS Negl Trop Dis. 2020 Jun 26;14(6):e0008423. doi: 10.1371/journal.pntd.0008423. eCollection 2020

Veletzky L, Hergeth J, Stelzl DR, Mischlinger J, Manego RZ, Mombo-Ngoma G, McCall MBB, Adegnika AA, Agnandji ST, Metzger WG, Matsiegui PB, Lagler H, Mordmüller B, Budke C, Ramharter M. Burden of disease in Gabon caused by loiasis: a cross-sectional survey. Lancet Infect Dis. 2020 Nov;20(11):1339-1346. doi: 10.1016/S1473-3099(20)30256-5. Epub 2020 Jun 22.

Bouwman SA, Zoleko-Manego R, Renner KC, Schmitt EK, Mombo-Ngoma G, Grobusch MP. The early preclinical and clinical development of cipargamin (KAE609), a novel antimalarial compound. Travel Med Infect Dis. 2020 Jul-Aug;36:101765. doi: 10.1016/j.tmaid.2020.101765. Epub 2020 Jun 16.

Dejon-Agobé JC, Honkpehedji YJ, Zinsou JF, Edoa JR, Adégbitè BR, Mangaboula A, Agnandji ST, Mombo-Ngoma G, Ramharter M, Kremsner PG, Lell B, Grobusch MP, Adegnika AA. Epidemiology of Schistosomiasis and Soil-Transmitted Helminth Coinfections among Schoolchildren Living in Lambaréné, Gabon. Am J Trop Med Hyg. 2020 Jul;103(1):325-333. doi: 10.4269/ajtmh.19-0835. Epub 2020 May 14.

Lalremruata A, Nguyen TT, McCall MBB, Mombo-Ngoma G, Agnandji ST, Adegnika AA, Lell B, Ramharter M, Hoffman SL, Kremsner PG, Mordmüller B. Recombinase Polymerase Amplification and Lateral Flow Assay for Ultrasensitive Detection of Low-Density Plasmodium falciparum Infection from Controlled Human Malaria Infection Studies and Naturally Acquired Infections. J Clin Microbiol. 2020 Apr 23;58(5):e01879-19. doi: 10.1128/JCM.01879-19. Print 2020 Apr 23.

Bretscher MT, Dahal P, Griffin J, Stepniewska K, Bassat Q, Baudin E, D'Alessandro U, Djimde AA, Dorsey G, Espié E, Fofana B, González R, Juma E, Karema C, Lasry E, Lell B, Lima N, Menéndez C, Mombo-Ngoma G, Moreira C, Nikiema F, Ouédraogo JB, Staedke SG, Tinto H, Valea I, Yeka A, Ghani AC, Guerin PJ, Okell LC. The duration of chemoprophylaxis against malaria after treatment with artesunate-amodiaquine and artemether-lumefantrine and the effects of pfmdr1 86Y and pfcrt 76T: a meta-analysis of individual patient data. BMC Med. 2020 Feb 25;18(1):47. doi: 10.1186/s12916-020-1494-3.

Huijben S, Macete E, Mombo-Ngoma G, Ramharter M, Kariuki S, Desai M, Shi YP, Mwangoka G, Massougbodji A, Cot M, Ndam NT, Uberegui E, Gupta H, Cisteró P, Aponte JJ, González R, Menéndez C, Mayor A. Counter-Selection of Antimalarial Resistance Polymorphisms by Intermittent Preventive Treatment in Pregnancy. J Infect Dis. 2020 Jan 2;221(2):293-303. doi: 10.1093/infdis/jiz451

2019

Adegbite BR, Edoa JR, Honkpehedji YJ, Zinsou FJ, Dejon-Agobe JC, Mbong-Ngwese M, Lotola-Mougueni F, Koehne E, Lalremruata A, Kreidenweiss A, Nguyen TT, Kun J, Agnandji ST, Lell B, Safiou AR, Obone Atome FA, Mombo-Ngoma G, Ramharter M, Velavan TP, Mordmüller B, Kremsner PG, Adegnika AA. Monitoring of efficacy, tolerability and safety of artemether-lumefantrine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Lambaréné, Gabon: an open-label clinical trial. Malar J. 2019 Dec 16;18(1):424. doi: 10.1186/s12936-019-3015-4.

Koehne E, Kreidenweiss A, Zoleko Manego R, McCall M, Mombo-Ngoma G, Mackwitz MKW, Hansen FK, Held J. Histone deacetylase inhibitors with high in vitro activities against Plasmodium falciparum isolates collected from Gabonese children and adults. Sci Rep. 2019 Nov 22;9(1):17336. doi: 10.1038/s41598-019-53912-w.

Zoleko Manego R, Koehne E, Kreidenweiss A, Nzigou Mombo B, Adegbite BR, Dimessa Mbadinga LB, Akinosho M, Matthewman J, Adegnika AA, Ramharter M, Mombo-Ngoma G. Description of Plasmodium falciparum infections in central Gabon demonstrating high parasite densities among symptomatic adolescents and adults. Malar J. 2019 Nov 21;18(1):371. doi: 10.1186/s12936-019-3002-9.

Nguyen TT, Nzigou Mombo B, Lalremruata A, Koehne E, Zoleko Manego R, Dimessa Mbadinga LB, Adegnika AA, Agnandji ST, Lell B, Kremsner PG, Velavan TP, Ramharter M, Mordmüller B, Mombo-Ngoma G. DNA recovery from archived RDTs for genetic characterization of Plasmodium falciparum in a routine setting in Lambaréné, Gabon. Malar J. 2019 Oct 2;18(1):336. doi: 10.1186/s12936-019-2972-y.

Fonseca AM, González R, Bardají A, Jairoce C, Rupérez M, Jiménez A, Quintó L, Cisteró P, Vala A, Sacoor C, Gupta H, Hegewisch-Taylor J, Brew J, Ndam NT, Kariuki S, López M, Dobaño C, Chitnis CE, Ouma P, Ramharter M, Abdulla S, Aponte JJ, Massougbodji A, Briand V, Mombo-Ngoma G, Desai M, Cot M, Nhacolo A, Sevene E, Macete E, Menéndez C, Mayor A. VAR2CSA Serology to Detect Plasmodium falciparum Transmission Patterns in Pregnancy. Emerg Infect Dis. 2019 Oct;25(10):1851-1860. doi: 10.3201/eid2510.181177.

Groger M, Veletzky L, Lalremruata A, Cattaneo C, Mischlinger J, Manego Zoleko R, Kim J, Klicpera A, Meyer EL, Blessborn D, Winterberg M, Adegnika AA, Agnandji ST, Kremsner PG, Mordmüller B, Mombo-Ngoma G, Fuehrer HP, Ramharter M. Prospective Clinical and Molecular Evaluation of Potential Plasmodium ovale curtisi and wallikeri Relapses in a High-transmission Setting. Clin Infect Dis. 2019 Apr 19. pii: ciz131. doi: 10.1093/cid/ciz131.

Leroy D, Macintyre F, Adoke Y, Ouoba S, Barry A, Mombo-Ngoma G, Ndong Ngomo JM, Varo R, Dossou Y, Tshefu AK, Duong TT, Phuc BQ, Laurijssens B, Klopper R, Khim N, Legrand E, Ménard D. African isolates show a high proportion of multiple copies of the Plasmodium falciparum plasmepsin-2 gene, a piperaquine resistance marker. Malar J. 2019 Apr 10;18(1):126. doi: 10.1186/s12936-019-2756-4.

Groger M, Veletzky L, Lalremruata A, Cattaneo C, Mischlinger J, Manego Zoleko R, Kim J, Klicpera A, Meyer EL, Blessborn D, Winterberg M, Adegnika AA, Agnandji ST, Kremsner PG, Mordmüller B, Mombo-Ngoma G, Fuehrer HP, Ramharter M. Prospective Clinical and Molecular Evaluation of Potential Plasmodium ovale curtisi and wallikeri Relapses in a High-transmission Setting. Clin Infect Dis. 2019 Apr 19. pii: ciz131. doi: 10.1093/cid/ciz131.

2018

Ramharter M, Schwab M, Mombo-Ngoma G, Zoleko Manego R, Akerey-Diop D, Basra A, Mackanga JR, Würbel H, Wojtyniak JG, Gonzalez R, Hofmann U, Geditz M, Matsiegui PB, Kremsner PG, Menendez C, Kerb R, Lehr T. Population Pharmacokinetics of Mefloquine Intermittent Preventive Treatment for Malaria in Pregnancy in Gabon. Antimicrob Agents Chemother. 2018 Nov 19. pii: AAC.01113-18. doi: 10.1128/AAC.01113-18.

Koller R, Mombo-Ngoma G, Grobusch MP. The  early  preclinical and clinical development of ganaplacide (KAF156), a novel antimalarial compound. Expert Opin Investig Drugs. 2018 Oct;27(10):803-810. doi: 10.1080/13543784.2018.1524871. Epub 2018 Sep 25. Review.

Rada S, Gamper J, González R, Mombo-Ngoma G, Ouédraogo S, Kakolwa MA, Zoleko-Manego R, Sevene E, Kabanywanyi AM, Accrombessi M, Briand V, Cot M, Vala A, Kremsner PG, Abdulla S, Massougbodgi A, Nhacolo A, Aponte JJ, Macete E, Menéndez C, Ramharter M. Concordance of three alternative gestational age assessments for pregnant women from four African countries: A secondary analysis of the MIPPAD trial. PLoS One. 2018 Aug 6;13(8):e0199243. doi: 10.1371/journal.pone.0199243. eCollection 2018.

Dejon-Agobé JC, Zinsou JF, Honkpehedji YJ, Ateba-Ngoa U, Edoa JR, Adegbite BR, Mombo-NgomaG, Agnandji ST, Ramharter M, Kremsner PG, Lell B, Grobusch MP, Adegnika AA. Schistosoma haematobium effects on Plasmodium falciparum infection modified by soil-transmitted helminths in school-age children living in rural areas of Gabon. PLoS Negl Trop Dis. 2018 Aug 6;12(8):e0006663. doi: 10.1371/journal.pntd.0006663. eCollection 2018 Aug.

Mischlinger J, Pitzinger P, Veletzky L, Groger M, Zoleko-Manego R, Adegnika AA, Agnandji ST, Lell B, Kremsner PG, Mombo-Ngoma G, Mordmüller B, Ramharter M. Validity and reliability of methods to microscopically detect and quantify malaria parasitaemia. Trop Med Int Health. 2018 Sep;23(9):980-991. doi: 10.1111/tmi.13124. Epub 2018 Jul 17.

Mischlinger J, Pitzinger P, Veletzky L, Groger M, Zoleko-Manego R, Adegnika AA, et al. Use of Capillary Blood Samples Leads to Higher Parasitemia Estimates and Higher Diagnostic Sensitivity of Microscopic and Molecular Diagnostics of Malaria than Venous Blood Samples. J Infect Dis. 2018 May 25;

Lötsch F, Mombo-Ngoma G, Mischlinger J, Groger M, Veletzky L, Adegnika AA, et al. Preliminary Evidence for the Absence of Cystic Echinococcosis in Gabon: A Cross-Sectional Pilot Survey in Humans and Definitive Hosts. Am J Trop Med Hyg. 2018 May 21;

Hede MS, Fjelstrup S, Lötsch F, Zoleko RM, Klicpera A, Groger M, et al. Detection of the Malaria causing Plasmodium Parasite in Saliva from Infected Patients using Topoisomerase I Activity as a Biomarker. Sci Rep. 2018 Mar 7;8(1):4122.

 

Groger M, Veletzky L, Lalremruata A, Cattaneo C, Mischlinger J, Zoleko-Manego R, et al. Prospective Clinical Trial Assessing Species-Specific Efficacy of Artemether-Lumefantrine for the Treatment of Plasmodium malariae, Plasmodium ovale, and Mixed Plasmodium Malaria in Gabon. Antimicrob Agents Chemother. 2018 Mar;62(3).

 

2017

Mombo-Ngoma G, Remppis J, Sievers M, Zoleko Manego R, Endamne L, Kabwende L, et al. Efficacy and safety of fosmidomycin-piperaquine as non-artemisinin-based combination therapy for uncomplicated falciparum malaria - A single-arm, age-de-escalation proof of concept study in Gabon. Clin Infect Dis Off Publ Infect Dis Soc Am. 2017 Dec 26;

 

Macintyre F, Adoke Y, Tiono AB, Duong TT, Mombo-Ngoma G, Bouyou-Akotet M, et al. A randomised, double-blind clinical phase II trial of the efficacy, safety, tolerability and pharmacokinetics of a single dose combination treatment with artefenomel and piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria. BMC Med. 2017 09;15(1):181.

 

Lalremruata A, Jeyaraj S, Engleitner T, Joanny F, Lang A, Bélard S, et al. Species and genotype diversity of Plasmodium in malaria patients from Gabon analysed by next generation sequencing. Malar J. 2017 Oct 3;16(1):398.

 

Supan C, Mombo-Ngoma G, Kombila M, Ospina Salazar CL, Held J, Lell B, et al. Phase 2a, Open-Label, 4-Escalating-Dose, Randomized Multicenter Study Evaluating the Safety and Activity of Ferroquine (SSR97193) Plus Artesunate, versus Amodiaquine Plus Artesunate, in African Adult Men with Uncomplicated Plasmodium falciparum Malaria. Am J Trop Med Hyg. 2017 Aug;97(2):514–25.

 

Ndam NT, Mbuba E, González R, Cisteró P, Kariuki S, Sevene E, et al. Resisting and tolerating P. falciparum in pregnancy under different malaria transmission intensities. BMC Med. 2017 17;15(1):130.

 

Manego RZ, Mombo-Ngoma G, Witte M, Held J, Gmeiner M, Gebru T, et al. Demography, maternal health and the epidemiology of malaria and other major infectious diseases in the rural department Tsamba-Magotsi, Ngounie Province, in central African Gabon. BMC Public Health. 2017 28;17(1):130.

 

Mombo-Ngoma G, Honkpehedji J, Basra A, Mackanga JR, Zoleko RM, Zinsou J, et al. Urogenital schistosomiasis during pregnancy is associated with low birth weight delivery: analysis of a prospective cohort of pregnant women and their offspring in Gabon. Int J Parasitol. 2017;47(1):69–74.

 

2016

Lötsch F, Obermüller M, Mischlinger J, Mombo-Ngoma G, Groger M, Adegnika AA, et al. Seroprevalence of Toxocara spp. in a rural population in Central African Gabon. Parasitol Int. 2016 Dec;65(6 Pt A):632–4.

 

Mombo-Ngoma G, Mackanga JR, González R, Ouedraogo S, Kakolwa MA, Manego RZ, et al. Young adolescent girls are at high risk for adverse pregnancy outcomes in sub-Saharan Africa: an observational multicountry study. BMJ Open. 2016 29;6(6):e011783.

 

Rupérez M, González R, Mombo-Ngoma G, Kabanywanyi AM, Sevene E, Ouédraogo S, et al. Mortality, Morbidity, and Developmental Outcomes in Infants Born to Women Who Received Either Mefloquine or Sulfadoxine-Pyrimethamine as Intermittent Preventive Treatment of Malaria in Pregnancy: A Cohort Study. PLoS Med. 2016 Feb;13(2):e1001964.

 

2015

Belard S, Toepfner N, Capan-Melser M, Mombo-Ngoma G, Zoleko-Manego R, Groger M, et al. Streptococcus agalactiae Serotype Distribution and Antimicrobial Susceptibility in Pregnant Women in Gabon, Central Africa. Sci Rep. 2015 Nov 25;5:17281.

 

Capan-Melser M, Mombo-Ngoma G, Akerey-Diop D, Basra A, Manego-Zoleko R, Würbel H, et al. Epidemiology of Human Herpes Virus 8 in Pregnant Women and their Newborns--A cross-sectional delivery survey in Central Gabon. Int J Infect Dis IJID Off Publ Int Soc Infect Dis. 2015 Oct;39:16–9.

 

Schmiedel Y, Mombo-Ngoma G, Labuda LA, Janse JJ, de Gier B, Adegnika AA, et al. CD4+CD25hiFOXP3+ Regulatory T Cells and Cytokine Responses in Human Schistosomiasis before and after Treatment with Praziquantel. PLoS Negl Trop Dis. 2015 Aug;9(8):e0003995.

 

 

 

Mombo-Ngoma G, Mackanga JR, Basra A, Capan M, Manego RZ, Adegnika AA, et al. Loa loa Infection in Pregnant Women, Gabon. Emerg Infect Dis. 2015 May;21(5):899a–901.

 

Sicuri E, Fernandes S, Macete E, González R, Mombo-Ngoma G, Massougbodgi A, et al. Economic evaluation of an alternative drug to sulfadoxine-pyrimethamine as intermittent preventive treatment of malaria in pregnancy. PloS One. 2015;10(4):e0125072.

 

Capan-Melser M, Mombo Ngoma G, Akerey-Diop D, Basra A, Würbel H, Groger M, et al. Evaluation of intermittent preventive treatment of malaria against group B Streptococcus colonization in pregnant women: a nested analysis of a randomized controlled clinical trial of sulfadoxine/pyrimethamine versus mefloquine. J Antimicrob Chemother. 2015;70(6):1898–902.

 

2014

Ateba-Ngoa U, Mombo-Ngoma G, Zettlmeissl E, van der Vlugt LEPM, de Jong SE, de Jong S, et al. CD4+CD25hiFOXP3+ cells in cord blood of neonates born from filaria infected mother are negatively associated with CD4+Tbet+ and CD4+RORγt+ T cells. PloS One. 2014;9(12):e114630.

 

González R, Mombo-Ngoma G, Ouédraogo S, Kakolwa MA, Abdulla S, Accrombessi M, et al. Intermittent preventive treatment of malaria in pregnancy with mefloquine in HIV-negative women: a multicentre randomized controlled trial. PLoS Med. 2014 Sep;11(9):e1001733.

 

Ateba Ngoa U, Zinsou JF, Kassa RFK, Ngoune Feugap E, Honkpehedji YJ, Massinga-Loembe M, et al. Assessment of the effect of Schistosoma haematobium co infection on malaria parasites and immune responses in rural populations in Gabon: study protocol. SpringerPlus. 2014;3:388.

 

Ramharter M, Harrison N, Bühler T, Herold B, Lagler H, Lötsch F, et al. Prevalence and risk factor assessment of Tropheryma whipplei in a rural community in Gabon: a community-based cross-sectional study. Clin Microbiol Infect Off Publ Eur Soc Clin Microbiol Infect Dis. 2014 Nov;20(11):1189–94.

 

Taylor SM, Mayor A, Mombo-Ngoma G, Kenguele HM, Ouédraogo S, Ndam NT, et al. A quality control program within a clinical trial Consortium for PCR protocols to detect Plasmodium species. J Clin Microbiol. 2014 Jun;52(6):2144–9.

 

Ulrich Sauerzopf, Yabo J Honkpehedji, Ayôla A Adgenika, Elianne N Feugap, Ghyslain Mombo Ngoma, Jean-Rodolphe Mackanga, Felix Lötsch, Marguerite M Loembe, Peter G Kremsner, Benjamin Mordmüller, Michael Ramharter: In vitro growth of Plasmodium falciparum in neonatal blood. Malaria Journal 11/2014; 13(1):436., DOI:10.1186/1475-2875-13-436

 

 

Auer-Hackenberg L, Thol F, Akerey-Diop D, Zoleko RM, Rodolphe Mackanga J, Adegnika AA, et al. Short report: premastication in rural Gabon--a cross-sectional survey. J Trop Pediatr. 2014 Apr;60(2):154–6.

 

2013

Jäckle MJ, Blumentrath CG, Zoleko RM, Akerey-Diop D, Mackanga J-R, Adegnika AA, et al. Malaria in pregnancy in rural Gabon: a cross-sectional survey on the impact of seasonality in high-risk groups. Malar J. 2013 Nov 13;12:412.

 

Schaumburg F, Alabi AS, Mombo-Ngoma G, Kaba H, Zoleko RM, Diop DA, et al. Transmission of Staphylococcus aureus between mothers and infants in an African setting. Clin Microbiol Infect Off Publ Eur Soc Clin Microbiol Infect Dis. 2014 Jun;20(6):O390-396.

 

 

Basra A, Mombo-Ngoma G, Melser MC, Diop DA, Würbel H, Mackanga J-R, et al. Efficacy of mefloquine intermittent preventive treatment in pregnancy against Schistosoma haematobium infection in Gabon: a nested randomized controlled assessor-blinded clinical trial. Clin Infect Dis Off Publ Infect Dis Soc Am. 2013 Mar;56(6):e68-75.

 

2012

Capan M, Mombo-Ngoma G, Akerey-Diop D, Basra A, Würbel H, Lendamba W, et al. Epidemiology and management of group B streptococcal colonization during pregnancy in Africa. Wien Klin Wochenschr. 2012 Nov;124 Suppl 3:14–6.

 

Mombo-Ngoma G, Kleine C, Basra A, Würbel H, Diop DA, Capan M, et al. Prospective evaluation of artemether-lumefantrine for the treatment of non-falciparum and mixed-species malaria in Gabon. Malar J. 2012 Jul 10;11:120.

 

Supan C, Mombo-Ngoma G, Dal-Bianco MP, Ospina Salazar CL, Issifou S, Mazuir F, et al. Pharmacokinetics of ferroquine, a novel 4-aminoquinoline, in asymptomatic carriers of Plasmodium falciparum infections. Antimicrob Agents Chemother. 2012 Jun;56(6):3165–73.

 

2011

Agnandji ST, Kurth F, Bélard S, Mombo-Ngoma G, Basra A, Fernandes JF, et al. Current status of the clinical development and implementation of paediatric artemisinin combination therapies in Sub-Saharan Africa. Wien Klin Wochenschr. 2011 Oct;123 Suppl 1:7–9.

 

Four Artemisinin-Based Combinations (4ABC) Study Group. A head-to-head comparison of four artemisinin-based combinations for treating uncomplicated malaria in African children: a randomized trial. PLoS Med. 2011 Nov;8(11):e1001119.

 

Agnandji ST, Kurth F, Fernandes JF, Soulanoudjingar SS, Abossolo BP, Mombo-Ngoma G, et al. The use of paediatric artemisinin combinations in sub-Saharan Africa: a snapshot questionnaire survey of health care personnel. Malar J. 2011 Dec 14;10:365.

 

Pongratz P, Kurth F, Ngoma GM, Basra A, Ramharter M. In vitro activity of antifungal drugs against Plasmodium falciparum field isolates. Wien Klin Wochenschr. 2011 Oct;123 Suppl 1:26–30.

 

Frank M, Lehners N, Mayengue PI, Gabor J, Dal-Bianco M, Kombila DU, et al. A thirteen-year analysis of Plasmodium falciparum populations reveals high conservation of the mutant pfcrt haplotype despite the withdrawal of chloroquine from national treatment guidelines in Gabon. Malar J. 2011 Oct 17;10:304.

 

Mombo-Ngoma G, Oyakhirome S, Ord R, Gabor JJ, Greutélaers KC, Profanter K, et al. High prevalence of dhfr triple mutant and correlation with high rates of sulphadoxine-pyrimethamine treatment failures in vivo in Gabonese children. Malar J. 2011 May 14;10:123.

 

Mombo-Ngoma G, Supan C, Dal-Bianco MP, Missinou MA, Matsiegui P-B, Ospina Salazar CL, et al. Phase I randomized dose-ascending placebo-controlled trials of ferroquine--a candidate anti-malarial drug--in adults with asymptomatic Plasmodium falciparum infection. Malar J. 2011 Mar 1;10:53.

 

2010

Kurth F, Bélard S, Mombo-Ngoma G, Schuster K, Adegnika AA, Bouyou-Akotet MK, et al. Adolescence as risk factor for adverse pregnancy outcome in Central Africa--a cross-sectional study. PloS One. 2010 Dec 20;5(12):e14367.

 

Capan M, Mombo-Ngoma G, Makristathis A, Ramharter M. Anti-bacterial activity of intermittent preventive treatment of malaria in pregnancy: comparative in vitro study of sulphadoxine-pyrimethamine, mefloquine, and azithromycin. Malar J. 2010 Oct 29;9:303.

 

2009

Pearce RJ, Pota H, Evehe M-SB, Bâ E-H, Mombo-Ngoma G, Malisa AL, et al. Multiple origins and regional dispersal of resistant dhps in African Plasmodium falciparum malaria. PLoS Med. 2009 Apr 14;6(4):e1000055.

 

2007

Ramharter M, Schuster K, Bouyou-Akotet MK, Adegnika AA, Schmits K, Mombo-Ngoma G, et al. Malaria in pregnancy before and after the implementation of a national IPTp program in Gabon. Am J Trop Med Hyg. 2007 Sep;77(3):418–22.

 

Dal-Bianco MP, Köster KB, Kombila UD, Kun JFJ, Grobusch MP, Ngoma GM, et al. High prevalence of asymptomatic Plasmodium falciparum infection in Gabonese adults. Am J Trop Med Hyg. 2007 Nov;77(5):939–42.

CERMEL-GABON SITE

Medical research in sub-Saharan Africa is of high priority for societies to respond adequately to local health needs. Often enough it remains a challenge to build up capacity in infrastructure and human resources to highest international standards and to sustain this over mid-term to long-term periods due to difficulties in obtaining long-term institutional core funding, attracting highly qualified scientists for medical research and coping with ever changing structural and political environments. The Centre de Recherches Médicales de Lambaréné (CERMEL) serves as model for how to overcome such challenges and to continuously increase its impact on medical care in Central Africa and beyond. Starting off as a research annex to the Albert Schweitzer Hospital in Lambaréné, Gabon, it has since then expanded its activities to academic and regulatory clinical trials for drugs, vaccines and diagnostics in the field of malaria, tuberculosis, and a wide range of poverty related and neglected tropical infectious diseases. Advancing bioethics in medical research in Africa and steadily improving its global networks and infrastructures, CERMEL serves as a reference centre for several international consortia. In close collaboration with national authorities, CERMEL has become one of the main training hubs for medical research in Central Africa. It is hoped that CERMEL and its leitmotiv "to improve medical care for local populations" will serve as an inspiration to other institutions in sub-Saharan Africa to further increase African capacity to advance medicine.

Ramharter M. et al. Development of sustainable research excellence with a global perspective on infectious diseases: Centre de Recherches Médicales de Lambaréné (CERMEL), Gabon. Wien Klin Wochenschr. 2021 May;133(9-10):500-508. doi: 10.1007/s00508-020-01794-8. Epub 2021 Jan 4. PMID: 33398458; PMCID: PMC7781170.



Contact

Image: Ghyslain Mombo-Ngoma

Contact

Prof. Dr. med. Ghyslain MOMBO-NGOMA, MD, PhD

Phone: +24166072578 / +49 176 89217075
Fax:
E-Mail: ghyslain.mombo-ngoma@bnitm.de / ghyslain.mombongoma@cermel.org


Medical Scientific staff

Ghyslain Mombo-Ngoma
Rella Zoleko Manego
Lia Betty Dimessa Mbadinga
Fran Wilfrid Nzebe Ndoumba
Dearie Glory Okwu
Maria Schütte
Frédérique Mbang Abba

Project managers / Site coordinators / Data Management

Ms. Lidwine Badjina
Ms. Francoise Assengone
Mr. Lionel Erwan Mombo Nzamba
Mrs. Leatitia Otchague
Mr. Benjamin Mbadinga Ngoma

Medical/Graduate students

Dorothea Straessner (University of Hamburg, Germany)
Saskia Dede Davi (university of Berlin, Germany)
Emma Malinga (University of Tübingen)