Arbeitgruppe: Arbeitsgruppe Breloer (Helminthen-Immunologie)
Arbeitsgruppe Breloer (Helminthen-Immunologie)

Overview

One-third of the world population is infected with parasitic worms, called helminths. To avoid being eliminated these parasites actively dampen the immune response of their hosts. This helminth-induced immune modulation also suppresses immune responses to third-party antigens. As a consequence, helminth-infected people may not mount successful immune responses to concomitant infections or to vaccinations. We employ the nematodes Strongyloides ratti and Litomosoides sigmodontis to investigate helminth-induced immune modulation in the mouse system. We are interested in (i) the mechanisms of protective anti-helminth immunity, (ii) the mechanisms of helminth-induced immunomodulation and (iii) the impact of concurrent helminth infection on the outcome of a vaccination against different pathogens.

Research Projects

(i) mechanisms of protective anti-helminth immunity

Strongyloides ratti and degranulating mast cells in vitro (Nikolas Rüdiger)
Strongyloides ratti and degranulating mast cells in vitro (Nikolas Rüdiger)

Employing novel mouse models for immune cell and receptor deficiencies we characterized the initiation and execution of anti-helminth immune responses to the parasitic helminths S. ratti and L. sigmodontis in the mouse system. We have shown that basophils were dispensable for the control of L. sigmodontis infections in the thoracic cavity (Hartmann 2018) while basophils and mast cells contributed to eradication of S. ratti from the intestine (Reitz 2018a and 2017). Especially IL-9-activated mast cells were indispensable for timely termination of S. ratti infection (Reitz 2018b and 2017). Interestingly, neither IL-9 nor mast cells or basophils were needed for establishment of adaptive immune memory. They rather represented essential effectors of the early innate immune response (Breloer and Abraham 2017).

(ii) mechanisms of helminth-induced immunomodulation

S. ratti is expulsed by immunocompetent mice within a month. Nevertheless, the parasite needs to downregulate the host´s immune response to survive even this short period. We have shown earlier that S. ratti actively delayed its IL-9- and mast cell-driven expulsion from the gut by expanding Foxp3+ regulatory T cells (Treg) and by inducing expression of the negative co-regulatory receptor BTLA on T effector cells (Blankenhaus 2014, Breloer 2015. Collaborating with the Feuerer-Group, we now report that mice lacking the transcriptional regulator Rbpj specifically in Foxp3+ Treg are unable to control type 2 immune responses. They display the same increased IL-9-driven mast cell responses and subsequently decreased intestinal parasite burden as complete Foxp3+ Treg deficient mice (Delacher 2019)

(iii) impact of concurrent helminth infections on the outcome of a vaccination against different pathogens

impaired anti-influenza vaccination efficacy and systemic expansion of Tr1 cells in helminth infected mice

Analysing the impact of helminth-induced immunomodulation on the immune response to third party antigens we observed reduced antibody responses to model antigen immunization in mice with pre-existing L. sigmodontis infection (Hartmann 2011, 2012 and 2015; Haben 2014). Now we have extended this observation to a clinically relevant system. L. sigmodontis-infected mice that were vaccinated against seasonal influenza using licensed human vaccines displayed suppressed antibody responses. Protection against subsequent challenge infections with the human pathogenic 2009 pandemic H1N1 influenza A virus (swine flu) was also impaired (Hartmann 2019). Interestingly, vaccination efficacy was impaired in mice vaccinated during acute L. sigmodontis infection but also in mice that were vaccinated after resolution of L. sigmodontis infection. The suppressed status of acutely and formerly L. sigmodontis-infected mice was correlated to sustained and systemic expansion of CD4+CD49+LAG3+IL-10+ Tr1 cells and partially abrogated by IL-10 receptor neutralization.

Publication Highlights

Arbeitsgruppe Breloer (Helminthen-Immunologie)

Helminth infections suppress the efficacy of vaccination against seasonal influenza
Hartmann W, Brunn M-L, Stetter N, Gagliani N, Muskate F, Stanelle-Bertram S, Gabriel G, and Minka Breloer
Cell Reports 2019 29, 2243–2256

Rbpj expression in regulatory T cells is critical for restraining TH2 responses
Delacher M, Schmidl C, Herzig Y, Breloer M, Hartmann W, Brunk F, Kägebein D, Träger U, Hofer AC, Bittner S, Weichenhan D, Imbusch CD, Hotz-Wagenblatt A, Hielscher T, Breiling A, Federico G, Gröne HJ, Schmid RM, Rehli M, Abramson J, and Feuerer M.
Nature Communications 2019 DOI: https://doi.org/10.1038/s41467-019-09276-w

Mucosal mast cells are indispensable for the timely termination of Strongyloides ratti infection
Reitz M, Brunn ML, Rodewald HR, Feyerabend TB, Roers A, Dudeck A, Voehringer D, Jönsson F, Kühl AA, Breloer M
Mucosal Immunol 2017; 10(2): 481-492.

Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo
Ulges A, Klein M, Reuter S, Gerlitzki B, Hoffmann M, Grebe N, Staudt V, Stergiou N, Bohn T, Brühl TJ, Muth S, Yurugi H, Rajalingam K, Bellinghausen I, Tuettenberg A, Hahn S, Reißig S, Haben I, Zipp F, Waisman A. Probst HC, Beilhack A, Buchou T, Filhol-Cochet O, Boldyreff B, Breloer M, Jonuleit H, Schild H, Schmitt E and Bopp T
Nature Immunology 2015 16: 267-275.

Cutting Edge: The BTLA-HVEM Regulatory Pathway Interferes with Protective Immunity to Intestinal Helminth Infection
Breloer, M., W. Hartmann, B. Blankenhaus, M. L. Eschbach, K. Pfeffer, and T. Jacobs
Journal of Immunology 2015: 194: 1413-1416.

Foxp3+ regulatory T cells delay expulsion of intestinal nematodes by suppression of IL-9-driven mast cell activation in BALB/c but not in C57BL/6 mice
Blankenhaus B, Reitz M, Brenz Y, Eschbach ML, Hartmann W, Haben I, Sparwasser T, Huehn J, Kühl A, Feyerabend T, Rodewald H-R and Breloer M
Plos Pathogens 2014 DOI: 10.1371/journal.ppat.1003913

All Publications

2019

Helminth infections suppress the efficacy of vaccination against seasonal influenza
Hartmann W, Brunn M-L, Stetter N, Gagliani N, Muskate F, Stanelle-Bertram S, Gabriel G, and Breloer M
Cell Reports 29, 2243–2256 2019 https://doi.org/10.1016/j.celrep.10.051

Rbpj expression in regulatory T cells is critical for restraining TH2 responses
Delacher M, Schmidl C, Herzig Y, Breloer M, Hartman W, Brunk F, Kägebein D, Träger U, Hofer A-C, Weichenhan D, Imbusch C, Hotz-Wagenblatt A, Hielscher T, Breiling A, Federico G, Groene H-J, Schmid R, Rehli M, Abramson J, Feuerer M, and Bittner S
Nature Communications; Doi.org/10.1038/s41467-019-09276-w

2018

Interleukin-9 promotes early mast cell-mediated expulsion of Strongyloides ratti but is dispensable for generation of protective memory
Reitz M, Hartmann W, Rüdiger N, Orinska Z, Brunn ML and Minka Breloer
Scientific Reports 2018; 8(1):8636.

Basophils are dispensable for the establishment of protective adaptive immunity against primary and challenge infection with the intestinal helminth parasite Strongyloides ratti
Reitz M, Brunn M-L, Voehringer D and M Breloer
PLoS Neglected Tropical Diseases 12(11):e0006992. doi: 10.1371/journal.pntd.0006992.

Basophils are dispensable for the control of a filarial infection.
Hartmann W, Linnemann L C, Reitz M, Specht S, Voehringer D and M Breloer
ImmunoHorizons 2018; Doi.org/10.4049/ Immunohorizons.1800018

2017

Mucosal mast cells are indispensable for the timely termination of Strongyloides ratti infection
Reitz, M., Brunn, M. L., Rodewald, H. R., Feyerabend, T. B., Roers, A., Dudeck, A., Voehringer, D., Jonsson, F., Kuhl, A. A. and Breloer, M.
Mucosal Immunol 2017; 10, 481-492, doi:10.1038/mi.2016.56

Strongyloides infection in rodents: immune response and immune regulation
Breloer, M. & Abraham, D.
Parasitology 2017; 144, 295-315, doi:10.1017/S0031182016000111

Th2/1 Hybrid Cells Occurring in Murine and Human Strongyloidiasis Share Effector Functions of Th1 Cells
Bock CN, Babu S, Breloer M, Rajamanickam A, Boothra Y, Brunn ML et al.
Front Cell Infect Microbiol 2017; 7, 261, doi:10.3389/fcimb.2017.00261

2016

Filariae-retrovirus co-infection in mice is associated with suppressed virus-specific IgG immune response and higher viral loads
Dietze KK, Dittmer U, Koudaimi DK, Schimmer S, Reitz M, Breloer M* and Hartmann W*
PLoS Neglected Tropical Diseases 2016; 10(12): e0005170

2015

Litomosoides sigmodontis induces TGF-beta receptor responsive, IL-10-producing T cells that suppress bystander T-cell proliferation in mice
Hartmann, W., Schramm, C. and Breloer, M.
European Journal of Immunology 2015 Sep;45(9):2568-81. doi: 10.1002/eji.201545503.

Cutting Edge: The BTLA-HVEM Regulatory Pathway Interferes with Protective Immunity to Intestinal Helminth Infection
Breloer, M., W. Hartmann, B. Blankenhaus, M. L. Eschbach, K. Pfeffer, and T. Jacobs.
Journal of Immunology 2015: 194: 1413-1416

Protein kinase CK2 enables regulatory T cells to suppress excessive T2 responses in vivo
Ulges, A., M. Klein, S. Reuter, B. Gerlitzki, M. Hoffmann, N. Grebe, V. Staudt, N. Stergiou, T. Bohn, T. J. Bruhl, S. Muth, H. Yurugi, K. Rajalingam, I. Bellinghausen, A. Tuettenberg, S. Hahn, S. Reissig, I. Haben, F. Zipp, A. Waisman, H. C. Probst, A. Beilhack, T. Buchou, O. Filhol-Cochet, B. Boldyreff, M. Breloer, H. Jonuleit, H. Schild, E. Schmitt, and T. Bopp.
Nature immunology 2015: 16: 267-275

Anti-CD83 promotes IgG1 isotype switch in marginal zone B cells in response to TI-2 antigen
Kretschmer, B., Weber, J., Hutloff, A., Fleischer, B., Breloer, M. and Osterloh, A.
Immunobiology 2015 Aug;220(8):964-75. doi: 10.1016/j.imbio.2015.02.008.

Immune recognition of Onchocerca volvulus proteins in the human host and animal models of onchocerciasis
Manchang K, Ajonina-Ekoti I, Ndjonka D, Eisenbarth A, Achukwi M, Renz A, Brattig NW, Liebau E, Breloer M
J Helminthol 2015; 89(3): 375-386.

Arbeitsgruppe Breloer
2014

Nematode-Induced Interference with Vaccination Efficacy Targets Follicular T Helper Cell Induction and is Preserved after Termination of Infection
Irma Haben, Wiebke Hartmann and Minka Breloer
PLoS Negl Trop Dis. 2014 Sep 25;8(9):e3170. doi: 10.1371/journal.pntd.0003170.

Foxp3+ regulatory T cells delay expulsion of intestinal nematodes by suppression of IL-9-driven mast cell activation in BALB/c but not in C57BL/6 mice
Blankenhaus, B., M. Reitz, Y. Brenz, M. L. Eschbach, W. Hartmann, I. Haben, T. Sparwasser, J. Huehn, A. Kuhl, T. B. Feyerabend, H. R. Rodewald, and M. Breloer
PLoS pathogens 2014. 10: e1003913.

Immunization with Brugia malayi Hsp70 protects mice against Litomosoides sigmodontis challenge infection.
Hartmann W, Singh N, Rathaur S, Brenz Y, Liebau E, Fleischer B, Breloer M.
Parasite Immunol. 2014. 36: 141-149. doi: 10.1111/pim.12093

Heat shock protein 60: an endogenous inducer of dopaminergic cell death in Parkinson disease Journal of Neuroinflammation 2014, 11:86 doi:10.1186/1742-2094-11-86
Noelker C , More L, Osterloh A, Alvarez-Fischer D, Lescot T, Breloer M, Gold M, Oertel W H, Henze C, Michel P P, Dodel R C, Lu L, Hirsch E C, Hunot E and Hartmann A
Journal of Neuroinflammation 2014, 11:86 doi:10.1186/1742-2094-11-86

Arbeitsgruppe Breloer
2013

T-cell-derived, but not B-cell-derived, IL-10 suppresses antigen-specific T-cell responses in Litomosoides sigmodontis-infected mice.
Haben, I., W. Hartmann, S. Specht, A. Hoerauf, A. Roers, W. Muller
European Journal of Immunology 2013. 43: 1799-1805.

Nematode-derived proteins suppress proliferation and cytokine production of antigen-specific T cells via induction of cell death
Hartmann W, Brenz Y, Kingsley MT, Ajonina-Ekoti I, Brattig NW, Liebau E, Breloer M.
PLoS One. 2013 Jun 21;8(6):e68380. doi: 10.1371/journal.pone.0068380. Print 2013.

Comparative analysis of macrophage migration inhibitory factors (MIFs) from the parasitic nematode Onchocerca volvulus and the free-living nematode Caenorhabditis elegans.
Ajonina-Ekoti I, Kurosinski MA, Younis AE, Ndjonka D, Tanyi MK, Achukwi M, Eisenbarth A, Ajonina C, Lüersen K, Breloer M, Brattig NW, Liebau E.
Parasitol Res. 2013 Sep;112(9):3335-46. doi: 10.1007/s00436-013-3513-1. Epub 2013 Jul 3.

Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease
Noelker C, Morel L, Lescot T, Osterloh A, Alvarez-Fischer D, Breloer M, Henze C, Depboylu C, Skrzydelski D, Michel PP, Dodel RC, Lu L, Hirsch EC, Hunot S, Hartmann A
Sci Rep. 2013;3:1393. doi: 10.1038/srep01393.

Arbeitsgruppe Breloer
2012

Passive immunization with a monoclonal IgM antibody specific for Strongyloides ratti HSP60 protects mice against challenge infection
Ben Nouir N, Piédavent M, Osterloh A, Breloer M.
Vaccine. 2012 Jul 13;30(33):4971-6. doi: 10.1016/j.vaccine.2012.05.046.

Vaccination with Strongyloides ratti heat shock protein 60 increases susceptibility to challenge infection by induction of Th1 response.
Ben Nouir N, Eschbach ML, Piédavent M, Osterloh A, Kingsley MT, Erttmann K, Brattig N, Liebau E, Fleischer B, Breloer M.
Vaccine. 2012 Jan 20;30(5):862-71. doi: 10.1016/j.vaccine.2011.11.110. Epub 2011 Dec 13.

Efficient control of Plasmodium yoelii infection in BALB/c and C57BL/6 mice with pre-existing Strongyloides ratti infection.
Kolbaum J, Eschbach ML, Steeg C, Jacobs T, Fleischer B, Breloer M.
Parasite Immunol. 2012 Jul;34(7):388-93. doi: 10.1111/j.1365-3024.2012.01369.x.

Strongyloides ratti infection modulates B and T cell responses to third party antigens.
Hartmann W, Eschbach ML, Breloer M.
Exp Parasitol. 2012 Sep;132(1):69-75. doi: 10.1016/j.exppara.2011.06.001. Epub 2011 Jun 23.

Nematode-induced interference with the anti-Plasmodium CD8+ T-cell response can be overcome by optimizing antigen administration
Kolbaum, J., S. Tartz, W. Hartmann, S. Helm, A. Nagel, V. Heussler, P. Sebo, B. Fleischer, T. Jacobs, and M. Breloer
European Journal of Immunology. 2012. 42: 890-900.

Functional characterization and immune recognition of the extracellular superoxide dismutase from the human pathogenic parasite Onchocerca volvulus (OvEC-SOD)
Ajonina-Ekoti I, Ndjonka D, Tanyi MK, Wilbertz M, Younis AE, Boursou D, Kurosinski MA, Eberle R, Lüersen K, Perbandt M, Breloer M, Brattig NW, Liebau E.
Acta Trop. 2012 Oct;124(1):15-26. doi: 10.1016/j.actatropica.2012.05.013

Arbeitsgruppe Breloer
2011

Strongyloides ratti infection induces expansion of Foxp3+ regulatory T cells that interfere with immune response and parasite clearance in BALB/c mice.
Blankenhaus, B., U. Klemm, M. L. Eschbach, T. Sparwasser, J. Huehn, A. A. Kuhl, C. Loddenkemper, T. Jacobs, and M. Breloer
Journal of Immunology (2011) 186: 4295-4305.

Pathogenic nematodes suppress humoral responses to third-party antigens in vivo by IL-10-mediated interference with Th cell function
Hartmann, W., I. Haben, B. Fleischer, and M. Breloer.
Journal of Immunology (2011) 187: 4088-4099

Efficient control of Leishmania and Strongyloides despite partial suppression of nematode-induced Th2 response in co-infected mice.
Kolbaum J, Ritter U, Zimara N, Brewig N, Eschbach ML, Breloer M.
Parasite Immunol. 2011 Apr;33(4):226-35. doi: 10.1111/j.1365-3024.2010.01273.x.

Activated T cells induce rapid CD83 expression on B cells by engagement of CD40.
Kretschmer B, Kühl S, Fleischer B, Breloer M.
Immunol Lett. 2011 May;136(2):221-7. doi: 10.1016/j.imlet.2011.01.013. Epub 2011 Jan 28.

2010

Strongyloides ratti infection induces transient nematode-specific Th2 response and reciprocal suppression of IFN-gamma production in mice
Eschbach ML, Klemm U, Kolbaum J, Blankenhaus B, Brattig N, Breloer M
Parasite Immunol 2010; 32(5): 370-383

Arbeitsgruppe Breloer
2009

Engagement of CD83 on B cells modulates B cell function in vivo.
Kretschmer B, Lüthje K, Schneider S, Fleischer B, Breloer M.
J Immunol. 2009 Mar 1;182(5):2827-34. doi: 10.4049/jimmunol.0803153.

Heat shock protein 60 (HSP60) stimulates neutrophil effector functions.
Osterloh A, Geisinger F, Piédavent M, Fleischer B, Brattig N, Breloer M
J Leukoc Biol. 2009 Aug;86(2):423-34. doi: 10.1189/jlb.0109011. Epub 2009 May 15.

Arbeitsgruppe Breloer
2008

CD83 on murine APC does not function as a costimulatory receptor for T cells.
Kretschmer B, Lüthje K, Ehrlich S, Osterloh A, Piedavent M, Fleischer B, Breloer M.
Immunol Lett. 2008 Oct 30;120(1-2):87-95. doi: 10.1016/j.imlet.2008.07.004. Epub 2008 Aug 20.

CD83 regulates splenic B cell maturation and peripheral B cell homeostasis.
Lüthje K, Kretschmer B, Fleischer B, Breloer M.
Int Immunol. 2008 Aug;20(8):949-60. doi: 10.1093/intimm/dxn054. Epub 2008 Jun 10.

CD83 regulates lymphocyte maturation, activation and homeostasis
Breloer M, Fleischer B.
Trends Immunol. 2008 Apr;29(4):186-94. doi: 10.1016/j.it.2008.01.009.

CD83 expression in CD4+ T cells modulates inflammation and autoimmunity
Reinwald S, Wiethe C, Westendorf AM, Breloer M, Probst-Kepper M, Fleischer B, Steinkasserer A, Buer J, Hansen W.
J Immunol. 2008 May 1;180(9):5890-7.

Hsp60-mediated T cell stimulation is independent of TLR4 and IL-12.
Osterloh A, Veit A, Gessner A, Fleischer B, Breloer M.
Int Immunol. 2008 Mar;20(3):433-43. doi: 10.1093/intimm/dxn003

Heat shock proteins: linking danger and pathogen recognition.
Osterloh A, Breloer M.
Med Microbiol Immunol. 2008 Mar;197(1):1-8

Arbeitsgruppe Breloer
2007

CD83 modulates B cell function in vitro: increased IL-10 and reduced Ig secretion by CD83Tg B cells.
Kretschmer B, Lüthje K, Guse AH, Ehrlich S, Koch-Nolte F, Haag F, Fleischer B, Breloer M.
PLoS One. 2007 Aug 15;2(8):e755.

CD83 is a regulator of murine B cell function in vivo.
Breloer M, Kretschmer B, Lüthje K, Ehrlich S, Ritter U, Bickert T, Steeg C, Fillatreau S, Hoehlig K, Lampropoulou V, Fleischer B.
Eur J Immunol. 2007 Mar;37(3):634-48.

Synergistic and differential modulation of immune responses by Hsp60 and lipopolysaccharide.
Osterloh A, Kalinke U, Weiss S, Fleischer B, Breloer M.
J Biol Chem. 2007 Feb 16;282(7):4669-80

Arbeitsgruppe Breloer
2006

Transgenic expression of a CD83-immunoglobulin fusion protein impairs the development of immune-competent CD4-positive T cells.
Lüthje K, Cramer SO, Ehrlich S, Veit A, Steeg C, Fleischer B, Bonin Av, Breloer M.
Eur J Immunol. 2006 Aug;36(8):2035-45.

Arbeitsgruppe Breloer
2005

Heat shock protein 60 is released in immune-mediated glomerulonephritis and aggravates disease: in vivo evidence for an immunologic danger signal
Lang A, Benke D, Eitner F, Engel D, Ehrlich S, Breloer M, Hamilton-Williams E, Specht S, Hoerauf A, Floege J, von Bonin A, Kurts C.
J Am Soc Nephrol. 2005 Feb;16(2):383-91.

Arbeitsgruppe Breloer
2004

Lipopolysaccharide-free heat shock protein 60 activates T cells.
Osterloh A, Meier-Stiegen F, Veit A, Fleischer B, von Bonin A, Breloer M.
J Biol Chem. 2004 Nov 12;279(46):47906-11

2003

Purification of the eucaryotic heat-shock proteins Hsp70 and gp96.
von Bonin A, More SH, Breloer M.
Methods Mol Biol 2003; 215: 193-200

2002

'Ignorance' of antigen-specific murine CD4+ and CD8+ T cells is overruled by lipopolysaccharide and leads to specific induction of IFN-gamma.
More SH, Breloer M, Fentz AK, Fleischer B, von Bonin A.
Scand J Immunol 2002; 55(4): 329-335.

Macrophages as main inducers of IFN-gamma in T cells following administration of human and mouse heat shock protein 60.
Breloer M, More SH, Osterloh A, Stelter F, Jack RS, Bonin A
Int Immunol 2002; 14(11): 1247-1253.

Arbeitsgruppe Breloer
2001

Heat shock proteins as "danger signals": eukaryotic Hsp60 enhances and accelerates antigen-specific IFN-gamma production in T cells.
Breloer M, Dorner B, Moré SH, Roderian T, Fleischer B, von Bonin A.
Eur J Immunol. 2001 Jul;31(7):2051-9.

Eukaryotic heat shock proteins as molecular links in innate and adaptive immune responses: Hsp60-mediated activation of cytotoxic T cells
More SH, Breloer M, von Bonin A.
Int Immunol 2001; 13(9): 1121-1127.

1999

In vivo and in vitro activation of T cells after administration of Ag-negative heat shock proteins.
Breloer M, Fleischer B, von Bonin A
J Immunol 1999; 162(6): 3141-3147.

Activation of cytotoxic T cells in vitro by recombinant gp96 fusion proteins irrespective of the 'fused' antigenic peptide sequence.
More S, Breloer M, Fleischer B, von Bonin A
Immunol Lett 1999; 69(2): 275-282.

1998

Isolation of processed, H-2Kb-binding ovalbumin-derived peptides associated with the stress proteins HSP70 and gp96
Breloer M, Marti T, Fleischer B, von Bonin A
Eur J Immunol 1998; 28(3): 1016-1021.

Amino acid sequence of the D-galactose binding lectin II from the sponge Axinella polypoides (Schmidt) and identification of the carbohydrate binding site in lectin II and related lectin I.
Buck F, Schulze C, Breloer M, Strupat K, Bretting H.
Comp Biochem Physiol B Biochem Mol Biol 1998; 121(2): 153-160.

Partial agonism and independent modulation of T cell receptor and CD8 in hapten-specific cytotoxic T cells
Preckel T, Breloer M, Kohler H, von Bonin A, Weltzien HU
Eur J Immunol 1998; 28(11): 3706-3718.

1996

A biological function for the XP motif within the N terminus of major histocompatibility complex class II-associated peptides
Breloer M, Ehrlich S, Fleischer B, von Bonin A
Eur J Immunol 1996; 26(8): 1825-1829

Alumni

Doctoral Thesis

Dr. Nicolas Rüdiger (2015-2019) : Control and eradication of migrating parasitic nematode larvae by innate effector cells

Dr. Martina Reitz (2012-2018; Promotion 2016) : Funktion und Regulation von Mastzellen bei der Immunantwort der Maus (Mus musculus, Linnaeus, 1758) auf den Darmparasiten Strongyloides ratti (Sandground, 1925)

Dr. Manchang Tanyi Kingsley (2009-2012; Promotion 2015) : Onchocerca ochengi derived excretory/secretory products: immune response and immune modulation

Dr. Irma Haben (2011-2014) : Einfluss einer chronischen Wurminfektion auf die Impfantwort der Maus (Mus musculus, Linneaus, 1758) Diese Arbeit wurde prämiert mit dem Doktorandenpreis der Freunde des Tropeninstitutes und dem Promotionspreis der DGHM

Dr. Birte Blankenhaus (2008-2011) : Untersuchung der Strongyloides ratti (Sandground, 1925) Infektion in der Maus (Mus musculus, Linneaus, 1758): Der Einfluss von regulatorischen T Zellen und regulatorischen Rezeptoren

Dr. Julia Kolbaum (2008-2011) : Der Einfluss einer Nematodeninfektion auf die Immunantwort der Maus (Mus musculus, Linneaus, 1758) gegen pathogene Protozoen während Koinfektion und Vakznierungen

Dr. Birte Kretschmer (2006-2009) : Analyse des trasmembranen Glycoproteins CD83 als Regulator muriner B-Lymphozyten in vitro und in vivo (Mus musculus, Linneaus, 1758)

Dr. Katja Lüthje (2004-2007) : Einfluss von CD83 auf die Entwicklung und Aktivierung muriner B- und T-Lymphozyten (Mus musculus, Linneaus, 1758)

Dr. Anke Osterloh (2005) : Hitzeschockprotein 60 (Hsp60) als immunologischer Signalverstärker

Diploma and Master Thesis

Lennart Heepmann (2019) : Analyse der Funktion antigenpräsentierender Zellen der Maus (Mus musculus, Linnaeus 1758) während einer Infektion mit dem parasitären Fadenwurm Litomosoides sigmodontis (Chandler 1931)

Annette Beatrix Schosser (2017) : Die Rolle der C-Typ-Lektin-Rezeptoren während der Immunantwort gegen parasitäre Nematoden

Lara Linnemann (2015) : Die Rolle von Mastzellen und basophilen Granulozyten während einer Litomosoides sigmodontis (Chandler, 1931) Infektion der Maus (Mus musculus, Linnaeus, 1758)

Lisa Norkus (2014) : Untersuchung der Rolle von TGF-ß rezeptorvermittelten Signalen in T-Zellen während der protektiven Immunantwort gegen eine Strongyloides ratti (Sandground 1925) Infektion der Maus (Mus musculus, Lennaeus, 1758).

Björn Laffer (2013) : Modulation des immunologischen Status der Maus (Mus musculus, Linneaus, 1758) durch orale Therapie mit Eiern des Schweinepeitschenwurms (Trichuris suis, Schrank, 1788)

Yannick Brenz (2013) : Die Rolle von Interleukin-9 während der Strongyloides ratti Infektion in der Maus

Irma Haben (2010) : The role of T cell and B cell derived IL-10 in the immune response to Litomosoides sigmodontis

Stefanie Schneider (2007) : Charakterisierung von monoklonalen anti-Maus CD83 Antikörpern

Franziska Meyer-Stiegen (2004) : Einfluss des endogenen Gefahrensignals Hsp60 auf die T-Zell-Polarisation im Mausmodell

Postdoc

Dr. Nadia BenNouir (2009-2011) : Visiting scientis from Monastir, Tunesia. (Humboldt scholarship). Topic of research: Hsp60-based vaccination against Strongyloides ratti

Contact

Professor Minka Breloer

Phone: +49 40 42818-830
Fax: +49 40 42818-400
E-Mail: breloer@bnitm.de


Post Docs

Dr. Wiebke Hartmann (-860/-863)
Dr. Jana Meiners (-860/-863)

PhD students

Nadine Stetter -889/863
Lennart Heepmann -889/863

Downloads


Links