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As the efficiency of the malaria vaccine RTS,S (Mosquirix™) has decreased considerably over time, we have looked for a means to prolong the protective effect by manipulating the immune response in a mouse model.
We looked at animals genetically-deficient in so-called regulatory T lymphocytes, a group of cells that inhibit other immune cells. These animals showed a temporarily stronger reaction to both the first and second vaccinations but no development of so-called memory cells, which mediate long-term protection. Immunological memory therefore appears to be regulated by other, yet unknown mechanisms.
Maria del Rosario Espinoza Mora, Christiane Steeg, Susanne Tartz, Volker Heussler, Bernhard Fleischer, Thomas Jacobs and external co-operation partners (see publication)