Research

Magenbakterien mildern Immunschwäche bei AIDS

Magenbakterien (Helicobacter pylori) wurden erst in den 1980er Jahren entdeckt und als eine wesentliche Ursache für Magengeschwüre und Magenkrebs erkannt.

Outpatient department in a Ghanaian hospital.
Outpatient department in a Ghanaian hospital.

When the AIDS pandemic was recognized, it was found that persons with HIV and concomitant H. pylori infection had relatively low HIV loads in the blood and relatively high numbers of helper T cells (CD4+ T lymphocytes). CD4+ T cells are the immune cells that are normally destroyed by HIV and whose loss primarily contributes to the characteristic immunodeficiencies of AIDS. Comparing HIV-positive persons with and without H. pylori infections, we now found that CD4+ T lymphocytes from persons with H. pylori are less activated and in vitro, show lower proliferation rates and fewer signs of exhaustion than CD4+ T cells from persons without H. pylori. As HIV preferentially infects activated and proliferating CD4+ T cells, these findings may help to explain why H. pylori infections may delay the progression of HIV infections towards AIDS.

 


Eberhardt K.A. et al., Clin Infect Dis. 2015, 61:1615-23.

Kirsten Eberhardt, Gerd Burchard and external co-operation partners (see publication)