- The Institute
- Travel & Vaccines
- Alumni & Friends
That it is the aggressive properties of amoebas (Entamoeba histolytic) which cause intestinal ulcers and abscesses in organs, has always been assumed and is reflected by the name “histolytica” – histos Greek for tissue and lysis for dissolution.
It was therefore a surprise that mice in which certain immune cells (monocytes and macrophages) were knocked-down did not develop larger hepatic abscesses, but considerably smaller ones instead. Also responsible for tissue destruction in amoeba infections of mice was tumour necrosis factor (TNF), a messenger substance in the immune system that, on the other hand, appears to be very helpful in the defence against tuberculosis.
Elena Helk, Hannah Bernin, Egbert Tannich, Hanna Lotter, Thomas Jacobs, and external cooperation partners (see publication)