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Dr. Eleonora SchönherrPresse & ÖffentlichkeitsarbeitPhone: +49 40 42818-264
Mail: presse(at)bnitm.de

Dr. Jessica TiedkePresse & ÖffentlichkeitsarbeitPhone: +49 40 42818-264
Mail: presse(at)bnitm.de

Threatening Bacterial Drug Resistance in Ghana

Salmonellae are a main cause for bloodstream infections - infections with high fatality rates - in sub-Saharan Africa. Until recently, salmonellae could be treated well with antibiotics. However, like in Europe, the numbers of drug-resistant bacteria are on the rise in Africa.

Standard method for drug-resistance testing: Bacteria (a homogeneous isolate) grow to a conti-nuous layer in Petri dishes containing small discs soaked with various antibiotics. If a drug is effective, a corona free of bacteria (a so-called inhibition zone) forms around the disc. It generally applies that the larger the inhibition zone, the better the activity of the drug. If no inhibition zone is formed at all, the bacteria are fully resistant (at 4 and 7 o`clock in the figure)
Standard method for drug-resistance testing: Bacteria (a homogeneous isolate) grow to a conti-nuous layer in Petri dishes containing small discs soaked with various antibiotics. If a drug is effective, a corona free of bacteria (a so-called inhibition zone) forms around the disc. It generally applies that the larger the inhibition zone, the better the activity of the drug. If no inhibition zone is formed at all, the bacteria are fully resistant (at 4 and 7 o`clock in the figure)

Together with our cooperation partners, we have found that certain salmonellae (mainly Salmonella enterica serovar Enteritidis), which cause bloodstream infections, have developed some resistance against a widely used antibiotic in Ghana (Ciprofloxacin). Should this development continue, hardly any effective drug against these salmonellae will soon be available there.


Eibach D. et al., Clin Infect Dis 2016, 62 Suppl 1:S32-6

Daniel Eibach, Hassan Al-Emran, Denise Dekker, Ralf Krumkamp, Christa Ehmen, Anna Jaeger, Jürgen May and external cooperation partners (see publication)