[Translate to english:] [alle Inhalte aus dem Jahresbericht BNI 2010/2011]

As increasing drug resistance makes tuberculosis (TB) ever more threatening, the need for an efficient vaccine is urgent. Most humans naturally possess powerful defence reactions against TB bacteria, which protects them against the disease. Numerous findings have indicated that a certain type of immune cells, CD4+ T lymphocytes, play an essential role, which mostly is the basis for vaccine development. These immune cells learn to react to certain structural motives of the bacteria. Surprisingly it was now found that these structural motives are strikingly similar in TB bacteria from all over the world. Thus, the recognition by CD4+ T lymphocytes appears not to be dangerous for TB bacteria since, obviously, no selective pressure is exerted on the bacteria to change the essential structural motives. Therefore it becomes even more urgent to solve the question of how to design a vaccine that instructs the immune system to kill TB bacteria in all humans – an apt example for the need of disease-oriented basic research.

Defective serum protein protects against African Tuberculosis

Mannose-binding protein (MBP) belongs to a group of serum proteins that help immune cells to recognize pathogens.


Lymphocytes weakened in Tuberculosis

It is still unclear why only one out of ten infected persons develop tuberculosis whereas the others prevent or control the infection.



Dr. Jessica Tiedke

Dr. Eleonora Schönherr

Public Relations

Tel.: +49 40 42818-264

Fax: +49 40 42818-265