- Das Institut
- Reisen & Impfen
The Owusu-Dabo Group is mainly focused on Non-Communicable Diseases (NCDs) Epidemiology with emphasis on Type-2-diabetes, Hypertension and Cervical Cancers which are emerging threat to health shifting the pattern of mortality from infectious to NCDs with higher rates in low and middle income countries. Hypertension and Type-2-Diabetes studies focus on determining the levels of interaction between genetic, biochemical and environmental factors and the risk of T2DM while identifying biomarkers that predict early risk detection. Also biomarkers used to predict cardiovascular risk factors among hypertensive with diabetes mellitus are being examined to correlate clinical outcomes. Focus on cervical cancer involved genotyping high risk and low risk Human papillomavirus while novel genotypes are being studied and also other sexually transmitted infections. The group although focuses on NCDs, however, is involved in some infectious diseases including TB and is currently leading the nationwide multidrug- and extensively drug-resistant tuberculosis surveillance while investigating into biomarkers of immunity against M. tuberculosis that correlate with treatment efficacy in MDR/XDR tuberculosis.
The study aims to evaluate serum levels of inflammatory markers in relation to the risk of T2DM in rural and urban Ghana to develop a tool for early risk detection and to provide a basis for improving diagnosis and treatment.
Cervical cancer is an important public health problem in developing countries with severe annual burden. Ghana has a high incidence of cervical cancer but has no effective national screening program for HPV infection. The current methods for screening are severely challenged such as cervical cytology, which is expensive because of repeated testing and not readily available to the reach of many Ghanaian women. Pap smear is one other method for screening for cervical cancer, but has significant limitations of high false negative rates. Visual inspection with acetic acid (VIA) method is being validated in Ghana and considered as a low-technology alternative to cervical cytology. The detection of HPV infection would vary substantially depending on sampling technique and the availability of effective screening method/ technology.
Carotid to femoral pulse wave velocity (PWV) has emerged as the gold standard method of arterial stiffness for: its relative ease in determination, its perceived reliability and because of its association with incident CV disease independently of traditional risk factors. The relationships between PWV and the traditional risk factors, either addictively or independently on clinical outcomes have not been characterized in this population in Ghana.
Diagnosing TB in children presents unique challenges and the pediatric TB burden has not been adequately studied. Gaps of information exist at many levels including prevalence, incidence, geographic case distribution and current treatment in Ghana. Without accurate disease estimates for children, it is difficult to develop evidence-based policy planning and management
There is a huge gap in published literature concerning students’ health in tertiary institutions in Ghana since most students are thought to be naturally healthy. To adequately inform policy and public health responses as well as identifying the trend of medical conditions presenting at the KNUST hospital amongst new entrants to help improve managements, a clear understanding of health conditions is urgently needed.