Our publications

• 2022

  • Promastigote-to-Amastigote Conversion in Leishmania spp.-A Molecular View

    • Clos J, Grünebast J, Holm M
    • Pathogens. 2022;11(9):1052.
    • 2022-09-15

  • Design, Synthesis and Antiparasitic Evaluation of Click Phospholipids

    • George E Magoulas, Pantelis Afroudakis, Kalliopi Georgikopoulou, Marina Roussaki, Chiara Borsari, Theano Fotopoulou, Nuno Santarem, Emile Barrias, Paloma Tejera Nevado, Julia Hachenberg, Eugenia Bifeld, Bernhard Ellinger, Maria Kuzikov, Irini Fragiadaki, Effie Scoulica, Joachim Clos, Sheraz Gul, Maria Paola Costi, Wanderley de Souza, Kyriakos C Prousis, Anabela Cordeiro da Silva, Theodora Calogeropoulou
    • Molecules 2021, 26, 4204
    • 2022-07-10

• 2021

  • Repurposing Carvedilol as a Novel Inhibitor of the Trypanosoma cruzi Autophagy Flux That Affects Parasite Replication and Survival

    • Cynthia Vanesa Rivero, Santiago José Martínez, Paul Novick, Juan Agustín Cueto, Betiana Nebaí Salassa, María Cristina Vanrell, Xiaomo Li, Carlos Alberto Labriola, Luis Mariano Polo, David M Engman, Joachim Clos, Patricia Silvia Romano
    • Frontiers in Cellular and Infection Microbiology 11: 657257
    • 2021-08-21

  • Life Cycle Stage-Specific Accessibility of Leishmania donovani Chromatin at Transcription Start Regions

    • Grunebast, J.; Lorenzen, S.; Zummack, J.; Clos, J.
    • mSystems, 10.1128/mSystems.00628-21
    • 2021-07-01

  • High Content Analysis of Macrophage-Targeting EhPIb-Compounds against Cutaneous and Visceral Leishmania Species

    • Fehling, Helena; Niss, Hanno; Bea, Annika; Kottmayr, Nadine; Brinker, Christine; Hoenow, Stefan; Sellau, Julie; Gilberger, Tim-Wolf; Ting, Frederic; Landschulze, Dirk; Meier, Chris; Clos, Joachim; Lotter, Hannelore
    • Microorganisms 2, 422 ff.
    • 2021-02-18

• 2020

  • Leishmania: Responding to environmental signals and challenges without regulated transcription

    • Grünebast J, Clos J.
    • Comput Struct Biotechnol J. 2020;18:4016-4023.
    • 2020-12-07

  • Application of CRISPR/Cas9-Based Reverse Genetics in Leishmania braziliensis: Conserved Roles for HSP100 and HSP23

    • Adaui, V.; Kröber-Boncardo, C.; Brinker, C.; Zirpel, H.; Sellau, J.; Arévalo, J.; Dujardin, J.-C.; Clos, J.
    • Genes 2020, 11, 1159.
    • 2020-11-01

  • The Leishmania donovani SENP Protease Is Required for SUMO Processing but Not for Viability

    • Bea, A.; Krober-Boncardo, C.; Sandhu, M.; Brinker, C.; Clos, J.
    • Genes 11, 1198
    • 2020-10-14

  • Antileishmanial Effects of Synthetic EhPIb Analogs Derived from the Entamoeba histolytica Lipopeptidephosphoglycan

    • Fehling, H.; Choy, S. L.; Ting, F.; Landschulze, D.; Bernin, H.; Lender, S. C.; Muhlenpfordt, M.; Bifeld, E.; Eick, J.; Marggraff, C.; Kottmayr, N.; Groneberg, M.; Hoenow, S.; Sellau, J.; Clos, J.; Meier, C.; Lotter, H.
    • Antimicrob Agents Chemother 64, DOI: 10.1128/AAC.00161-20
    • 2020-06-23

  • Casein kinase 1.2 over expression restores stress resistance to Leishmania donovani HSP23 null mutants

    • Kröber-Boncardo Constanze, Lorenzen Stephan, Brinker Christine, Clos Joachim
    • Scientific Reports
    • 2020-01-01

  • Heat Shock Proteins in Leishmania Parasites

    • Kröber-Boncardo C., Grünebast J., Clos J.
    • In: . Heat Shock Proteins. Springer, Dordrecht. https://doi.org/10.1007/7515_2020_27
    • 2020-01-01

• 2019

  • Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani

    • Corpas-Lopez, V. Moniz, S. Thomas, M. Wall, R. J. Torrie, L. S. Zander-Dinse, D. Tinti, M. Brand, S. Stojanovski, L. Manthri, S. Hallyburton, I. Zuccotto, F. Wyatt, P. G. De Rycker, M. Horn, D. Ferguson, M. A. J. Clos, J. Read, K. D. Fairlamb, A. H. Gilbert, I. H. Wyllie, S.
    • ACS Infect Dis (2019) 5, 111-122
    • 2019-05-01

  • Gene Replacement by Homologous Recombination

    • Zirpel, H. Clos, J.
    • Methods Mol Biol (2019) 1971, 169-188
    • 2019-01-01

  • Cosmid Library Construction and Functional Cloning

    • Clos, J. Zander-Dinse, D.
    • Methods Mol Biol (2019) 1971, 123-140
    • 2019-01-01

  • Generation of Bone Marrow-Derived Macrophages for In Vitro Infection Experiments

    • Bifeld, E.
    • Methods Mol Biol (2019) 1971, 237-247
    • 2019-01-01

  • Quantification of Intracellular Leishmania spp. Using Real-Time Quantitative PCR (qPCR)

    • Bifeld, E.
    • Methods Mol Biol (2019) 1971, 249-263
    • 2019-01-01

  • Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform

    • Moraes, C. B. Witt, G. Kuzikov, M. Ellinger, B. Calogeropoulou, T. Prousis, K. C. Mangani, S. Di Pisa, F. Landi, G. Iacono, L. D. Pozzi, C. Freitas-Junior, L. H. Dos Santos Pascoalino, B. Bertolacini, C. P. Behrens, B. Keminer, O. Leu, J. Wolf, M. Reinshagen, J. Cordeiro-da-Silva, A. Santarem, N. Venturelli, A. Wrigley, S. Karunakaran, D. Kebede, B. Pohner, I. Muller, W. Panecka-Hofman, J. Wade, R. C. Fenske, M. Clos, J. Alunda, J. M. Corral, M. J. Uliassi, E. Bolognesi, M. L. Linciano, P. Quotadamo, A. Ferrari, S. Santucci, M. Borsari, C. Costi, M. P. Gul, S.
    • SLAS Discov 24, 346-361
    • 2019-01-01

  • Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics

    • Borsari, C. Jimenez-Anton, M. D. Eick, J. Bifeld, E. Torrado, J. J. Olias-Molero, A. I. Corral, M. J. Santarem, N. Baptista, C. Severi, L. Gul, S. Wolf, M. Kuzikov, M. Ellinger, B. Reinshagen, J. Witt, G. Linciano, P. Tait, A. Costantino, L. Luciani, R. Tejera Nevado, P. Zander-Dinse, D. Franco, C. H. Ferrari, S. Moraes, C. B. Cordeiro-da-Silva, A. Ponterini, G. Clos, J. Alunda, J. M. Costi, M. P.
    • Eur J Med Chem 183, 111676
    • 2019-01-01

  • Leishmania donovani 90 kD Heat Shock Protein - Impact of Phosphosites on Parasite Fitness, Infectivity and Casein Kinase Affinity

    • Hombach-Barrigah, A. Bartsch, K. Smirlis, D. Rosenqvist, H. MacDonald, A. Dingli, F. Loew, D. Spath, G. F. Rachidi, N. Wiese, M. Clos, J.
    • Sci Rep 9, 5074
    • 2019-01-01

  • Leishmania - Methods and Protocols

    • Clos, J. ed.
    • Methods in Molecular Biology (2019) 1971, 1-368
    • 2019-01-01

• 2018

  • Molecular Preadaptation to Antimony Resistance in Leishmania donovani on the Indian Subcontinent

    • Dumetz, F. Cuypers, B. Imamura, H. Zander, D. D'Haenens, E. Maes, I. Domagalska, M. A. Clos, J. Dujardin, J. C. De Muylder, G.
    • mSphere 3, 10.1128/mSphere.00548-17
    • 2018-01-01

  • Ribosome Profiling Reveals HSP90 Inhibitor Effects on Stage-Specific Protein Synthesis in Leishmania donovani

    • Bifeld, E. Lorenzen, S. Bartsch, K. Vasquez, J. J. Siegel, T. N. Clos, J.
    • mSystems 3, 10.1128/mSystems.00214-18
    • 2018-01-01

• 2017

  • Characterization of the protein tyrosine phosphatase LmPRL-1 secreted by Leishmania major via the exosome pathway.

    • Leitherer S, Clos J, Liebler-Tenorio EM, Schleicher U, Bogdan C and Soulat D
    • Infect Immun - accepted
    • 2017-05-10

  • Hsp90 Inhibitors radicicol and geldanamycin have opposing effects onLeishmaniaAha1-dependent proliferation

    • Bartsch K, Hombach-Barrigah A and Clos J.
    • Cell Stress and Chaperones, accepted
    • 2017-01-01

  • Leishmania donovani chaperonin 10 regulates parasite internalization and intracellular survival in human macrophages

    • Colineau L, Clos J, Moon KM, Foster LJ and Reiner NE
    • Med Microbiol Immunol 206, 235-257.
    • 2017-01-01

  • Leishmania Heat Shock Proteins as Effectors of Immune Evasion and Virulence

    • Bartsch K, Eick J, Zirpel H and Clos J
    • Current Immunology Reviews, 2017, 13 - accepted
    • 2017-01-01

  • MAPK1 of Leishmania donovani interacts and phosphorylates HSP70 and HSP90 subunits of foldosome complex

    • Kaur, P., Garg, M., Hombach-Barrigah, A., Clos, J., and Goyal, N
    • Sci Rep 7, 10202
    • 2017-01-01

  • Synthetic analogs of an Entamoeba histolytica glycolipid designed to combat intracellular Leishmania infection

    • Choy, S.L., Bernin, H., Aiba, T., Bifeld, E., Lender, S.C., Muhlenpfordt, M., Noll, J., Eick, J., Marggraff, C., Niss, H., N.G. Roldan, S. Tanaka, M. Kitamura, K. Fukase, J. Clos, E. Tannich, Y. Fujimoto & H. Lotter
    • Sci Rep 7, 9472
    • 2017-01-01

• 2016

  • Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds.

    • Borsari C, Santarem N, Torrado J, Olías AI, Corral MJ, Baptista C, Gul S, Wolf M, Kuzikov M, Ellinger B, Reinshagen J, Linciano P, Tait A, Costantino L, Freitas-Junior LH, Moraes CB, Pascoalino B, Alcântara LMaria, Franco CH, Bertolacini CD, Fontana V, Tejera Nevado P, Clos J, Alunda JM, Cordeiro-da-Silva A, Ferrari S, Costi MP
    • European Journal of Medicinal Chemistry, 126, 1129-1135
    • 2016-12-17

  • A versatile qPCR assay to quantify trypanosomatidic infections of host cells and tissues.

    • Bifeld E, Tejera Nevado P, Bartsch J, Eick J, Clos J.
    • Med Microbiol Immunol. doi 10.1007/s00430-016-0460-3
    • 2016-01-01

  • Profiling of flavonol derivatives for the development of anti-trypanosomatidic drugs.

    • Borsari C, Luciani R, Pozzi C, Pohner I, Henrich S, Trande M, Cordeiro-da-Silva A, Santarem N, Baptista C, Tait A, Di Pisa F, Dello Iacono L, Landi G, Gul S, Wolf M, Kuzikov M, Ellinger B, Reinshagen J, Witt G, Gribbon P, Kohler M, Keminer O, Behrens B, Costantino L, Tejera Nevado P, Bifeld E, Eick J, Clos J, Torrado J, Jimenez-Anton MD, Corral MJ, Alunda JM, Pellati F, Wade RC, Ferrari S, Mangani S, Costi MP
    • J Med Chem. doi: 10.1021/acs.jmedchem.6b00698
    • 2016-01-01

  • Joining forces: first application of a rapamycin-induced dimerizable Cre system for conditional null mutant analysis in Leishmania.

    • Späth GF, Clos J
    • Mol Microbiol doi: 100:923-927.10.1111/mmi.13374
    • 2016-01-01

  • A Telomeric Cluster of Antimony Resistance Genes on Chromosome 34 of Leishmania infantum

    • Tejera Nevado P, Bifeld E, Höhn K, Clos J.
    • Antimicrob Agents Chemother. doi: 10.1128/AAC.00544-16
    • 2016-01-01

  • Phenotypic Characterization of a Leishmania donovani Cyclophyilin 40 Null Mutant.

    • Wai-Lok Y, Lambertz U, Colineau L, Pescher P, MacDonald A, Zander D, Retzlaff S, Eick J, Reiner NE, Clos J, Späth GF.
    • J Eukaryot Microbiol. doi: 10.1111/jeu.12329
    • 2016-01-01

• 2015

  • Leishmania donovani P23 protects parasites against HSP90 inhibitor-mediated growth arrest

    • Hombach A, Ommen G, Sattler V, Clos J
    • Cell Stress & Chaperones 2015, 20, 673-685
    • 2015-01-01

  • The genetics of Leishmania virulence

    • Bifeld, E. and Clos, J.
    • Med Microbiol Immunol, 204, 619-634
    • 2015-01-01

  • Co-circulation of a novel phlebovirus and Massilia virus in sandflies, Portugal

    • Amaro, Fatima, Ze-Ze, Libia, Alves, Maria J., Borstler, Jessica, Clos, Joachim, Lorenzen, Stephan, Becker, Stefanie Christine, Schmidt-Chanasit, Jonas, and Cadar, Daniel
    • Virology journal 12, 174
    • 2015-01-01

• 2014

  • Geographical sequence variation in the Leishmania major virulence factor P46

    • Eugenia Bifeld, Mareike Chrobak, Dorothea Zander, Ulrike Schleicher, Gabriele Schönian, Joachim Clos
    • Infection, Genetics and Evolution 30 (2015) 195–205 doi:10.1016/j.meegid.2014.12.029
    • 2014-12-01

  • Heat Shock Proteins of Leishmania: Parasites in the Driver's Seat

    • Joachim Clos and Antje Hombach
    • Adak, S., Datta, R. (Eds.), Leishmania – Current Biology and Control. Caister Academic Press, Norfolk, United Kingdom, pp. 17-36.
    • 2014-02-01

  • A Novel Marker, ARM58, Confers Antimony Resistance to Leishmania spp

    • Nühs A, Schäfer C, Zander D, Trübe L, Tejera Nevado P, Schmidt S, Arevalo J, Adaui V, Maes L, Dujardin J-C, Clos J
    • Int. J. Parasitol: Drugs and Drug Resistance (2014) 4:37-47
    • 2014-01-01

  • ARM58 Overexpression Reduces Intracellular Antimony Concentration in Leishmania infantum

    • Schäfer C, Tejera Nevado P, Zander D, Clos J
    • Antimicrob Agents Chemother (2014) 58:1565–1574
    • 2014-01-01

  • No stress - Hsp90 and the signal transduction in Leishmania

    • Hombach A, Clos J
    • Parasitology (2014) 141, 1156–1166
    • 2014-01-01

  • Cyclophilin 40-deficient Leishmania donovani fail to undergo stress-induced development of the infectious metacyclic stage

    • Yau W-L, Pescher P, Macdonald A, Zander D, Retzlaff S, Blisnick T, Rotureau B, Bastin P, Clos J, Späth G
    • Cell. Microbiol. (2014) 93:80-97
    • 2014-01-01

  • Leishmania infantum EndoG is an endo/exo-nuclease essential for parasite survival

    • Rico E, Oliva C, Gutierrez KJ, Alzate JF, Genes CM, Moreno D, Casanova E, Gigante A, Perez-Perez MJ, Camarasa MJ, Clos J, Gago F, Jimenez-Ruiz A
    • PloS one (2014) 9:e89526
    • 2014-01-01

  • A small heat shock protein is essential for thermotolerance and intracellular survival of Leishmania donovani

    • Hombach A, Ommen G, MacDonald A, Clos J
    • J. Cell Science (2014) in press doi: 10.1242/​jcs.157297
    • 2014-01-01

• 2013

  • The Hsp90-Sti1 Interaction is Critical for Leishmania donovani Proliferation in Both Life Cycle Stages

    • Hombach A, Ommen G, Chrobak M, Clos J
    • Cell Microbiol (2013) 15:585-600
    • 2013-01-01

  • The loss of virulence of histone H1 overexpressing Leishmania donovani parasites is directly associated with a reduction of HSP83 rate of translation

    • Alexandratos A, Clos J, Samiotaki M, Efstathiou A, Panayotou G, Soteriadou K, Smirlis D
    • Mol Microbiol (2013) 88:1015-1031
    • 2013-01-01

• 2012

  • Leishmania donovani HslV does not interact stably with HslU proteins

    • Chrobak M, Forster S, Meisel S, Pfefferkorn R, Forster F, Clos J
    • Int J Parasitol (2012) 42:329-339
    • 2012-01-01

  • Secreted virulence factors and immune evasion in visceral leishmaniasis

    • Lambertz U, Silverman JM, Nandan D, McMaster WR, Clos J, Foster LJ, Reiner NE
    • Journal of Leukocyte Biology (2012) 91:887-899
    • 2012-01-01

  • Rapid identification of Leishmania spp. in formalin-fixed, paraffin-embedded tissue samples by fluorescence in situ hybridization

    • Frickmann H, Alnamar Y, Essig A, Clos J, Racz P, Barth TF, Hagen RM, Fischer M, Poppert S
    • TM & IH (2012) 17:1117-1126
    • 2012-01-01

• 2010

  • Overexpression of a single Leishmania major gene is sufficient to enhance parasite infectivity in vivo and in vitro

    • Reiling L, Chrobak M, Schmetz C, Clos J
    • Mol Microbiol (2010) 76:1175-1190
    • 2010-01-01

  • Phosphoproteome dynamics reveals heat shock protein complexes specific to the Leishmania infectious stage

    • Morales M, Watanabe R, Dacher M, Chafey P, Osorio y Fortéa J, Beverley S, Ommen G, Clos J, Hem S, Lenormand P, Rousselle J-C, Namane A, Spath G
    • Proc Natl Acad Sci U S A (2010) 107:8381-8386
    • 2010-01-01

  • The co-chaperone SGT of Leishmania donovani is essential for the parasite's viability

    • Ommen G, Chrobak M, Clos J
    • Cell Stress and Chaperones (2010) 39:541-546
    • 2010-01-01

  • An exosome-based secretion pathway is responsible for protein export from Leishmania and communication with macrophages

    • Silverman JM, Clos J, de'Oliveira CC, Shirvani O, Fang Y, Wang C, Foster LJ, Reiner NE
    • J Cell Sci (2010) 123:842-852
    • 2010-01-01

  • Leishmania exosomes modulate innate and adaptive immune responses through effects on monocytes and dendritic cells

    • Silverman JM, Clos J, Horakova E, Wang AY, Wiesgigl M, Kelly I, Lynn MA, McMaster WR, Foster LJ, Levings MK, Reiner NE
    • J Immunol (2010) 185:5011-5022
    • 2010-01-01

  • LmxMPK4, an essential mitogen-activated protein kinase of Leishmania mexicana is phosphorylated and activated by the STE7-like protein kinase LmxMKK5

    • von Freyend SJ, Rosenqvist H, Fink A, Melzer IM, Clos J, Jensen ON, Wiese M
    • Int J Parasitol (2010) 40:969-978
    • 2010-01-01

  • Characterization of a Subunit of the Outer Dynein Arm Docking Complex Necessary for Correct Flagellar Assembly in Leishmania donovani

    • Harder S, Thiel M, Clos J, Bruchhaus I
    • PLoS Negl Trop Dis (2010) 4:e586
    • 2010-01-01

• 2009

  • One-step generation of double-allele gene replacement mutants in Leishmania donovani

    • Ommen G, Lorenz S, Clos J
    • Int J Parasitol (2009) 39:541-546
    • 2009-01-01

  • Leishmania infantum expresses a mitochondrial nuclease homologous to EndoG that migrates to the nucleus in response to an apoptotic stimulus

    • Rico E, Alzate JF, Arias AA, Moreno D, Clos J, Gago F, Moreno I, Dominguez M, Jimenez-Ruiz A
    • Mol Biochem Parasitol (2009) 163:28-38
    • 2009-01-01

• 2008

  • Identification of a Leishmania infantum gene mediating resistance to miltefosine and SbIII

    • Choudhury K, Zander D, Kube M, Reinhardt R, Clos J
    • Int J Parasitol (2008) 38:1411-1423
    • 2008-01-01

  • Leishmania major: identification of developmentally regulated proteins in procyclic and metacyclic promastigotes

    • Mojtahedi Z, Clos J, Kamali-Sarvestani E
    • Exp Parasitol (2008) 119:422-429
    • 2008-01-01

• 2007

  • Structural characterization of beta-sheeted oligomers formed on the pathway of oxidative prion protein aggregation in vitro

    • Redecke L, von Bergen M, Clos J, Konarev PV, Svergun DI, Fittschen UE, Broekaert JA, Bruns O, Georgieva D, Mandelkow E, Genov N, Betzel C
    • J Struct Biol (2007) 157:308-320
    • 2007-01-01

• 2006

  • Spontaneous recovery of pathogenicity by Leishmania major hsp100-/- alters the immune response in mice

    • Reiling L, Jacobs T, Kroemer M, Gaworski I, Graefe S, Clos J
    • Infect Immun (2006) 74:6027-6036
    • 2006-01-01

  • Functional cloning as a means to identify Leishmania genes involved in drug resistance

    • Clos J, Choudhury K
    • Mini Rev Med Chem (2006) 6:123-129
    • 2006-01-01

• 2005

  • Complement C3 is required for the progression of cutaneous lesions and neutrophil attraction in Leishmania major infection

    • Jacobs T, Andra J, Gaworski I, Graefe S, Mellenthin K, Kromer M, Halter R, Borlak J, Clos J
    • Med Microbiol Immunol (2005) 194:143-149
    • 2005-01-01

  • Comparative analysis of the human and chicken prion protein copper binding regions at pH 6.5

    • Redecke L, Meyer-Klaucke W, Koker M, Clos J, Georgieva D, Genov N, Echner H, Kalbacher H, Perbandt M, Bredehorst R, Voelter W, Betzel C
    • J Biol Chem (2005) 280:13987-13992
    • 2005-01-01

  • Stage-specific expression of the mitochondrial co-chaperonin of Leishmania donovani, CPN10

    • Zamora-Veyl FB, Kroemer M, Zander D, Clos J
    • Kinetoplastid Biol Dis (2005) 4:3
    • 2005-01-01

• 2004

  • Oligomerization of the proteolytic products is an intrinsic property of prion proteins

    • Georgieva D, Koker M, Redecke L, Perbandt M, Clos J, Bredehorst R, Genov N, Betzel C
    • Biochem Biophys Res Commun (2004) 323:1278-1286
    • 2004-01-01

  • Synthetic human prion protein octapeptide repeat binds to the proteinase K active site

    • Georgieva D, Rypniewski W, Echner H, Perbandt M, Koker M, Clos J, Redecke L, Bredehorst R, Voelter W, Genov N, Betzel C
    • Biochem Biophys Res Commun (2004) 325:1406-1411
    • 2004-01-01

  • A Leishmania donovani gene that confers accelerated recovery from stationary phase growth arrest

    • Hoyer C, Zander D, Fleischer S, Schilhabel M, Kroener M, Platzer M, Clos J
    • Int J Parasitol (2004) 34:803-811
    • 2004-01-01

• 2003

  • Developmentally induced changes of the proteome in the protozoan parasite Leishmania donovani

    • Bente M, Harder S, Wiesgigl M, Heukeshoven J, Gelhaus C, Krause E, Clos J, Bruchhaus I
    • Proteomics (2003) 3:1811-1829
    • 2003-03-01

  • Comparison of the A2 gene locus in Leishmania donovani and Leishmania major and its control over cutaneous infection

    • Zhang WW, Mendez S, Ghosh A, Myler P, Ivens A, Clos J, Sacks DL, Matlashewski G
    • J Biol Chem (2003) 278:35508-35515
    • 2003-01-01

• 2002

  • Inhibition of HSP90 in Trypanosoma cruzi Induces a Stress Response but No Stage Differentiation

    • Graefe SE, Wiesgigl M, Gaworski I, Macdonald A, Clos J
    • Eukaryot Cell (2002) 1:936-943
    • 2002-01-01

• 2001

  • Heat Shock Protein 90 Homeostasis Controls Stage Differentiation in Leishmania donovani.

    • Wiesgigl M, Clos J
    • Mol Biol Cell (2001) 12:3307-3316.
    • 2001-12-01

  • Leishmania and the Leishmaniases: Use of genetic complementation to identify gene(s) which specify species-specific organ tropism of Leishmania.

    • Hoyer C, Mellenthin K, Schilhabel M, Platzer M, Clos J
    • Med. Microbiol. Immunol. (2001) 190:53-56
    • 2001-01-03

  • Leishmania and the Leishmaniases: the heat shock protein 90 of Leishmania donovani.

    • Wiesgigl M, Clos J
    • Med. Microbiol. Immunol. (2001) 190:27-31
    • 2001-01-01

• 2000

  • Cross-species Homologous Recombination in Leishmania donovani Reveals the Sites of Integration

    • Krobitsch, S. and J. Clos
    • Mol. Biochem. Parasitol. 2000 107: 123-128
    • 2000-01-02

  • Expression and Subcellular Localization of Cpn60 Protein Family Members in Leishmania donovani

    • Schlueter, A., M. Wiesgigl, C. Hoyer, S. Fleischer, L. Klaholz, C. Schmetz & J. Clos
    • Biochim. Biophys. Acta 2000 1491: 65-74
    • 2000-01-01

• 1999

  • Uniform distribution of transcription complexes on the clpB gene locus of Leishmania donovani

    • Wiesgigl, M. & J. Clos
    • Protist 1999 150: 369-373
    • 1999-01-01

• 1998

  • Leishmania donovani heat shock protein 100: characterization and function in amastigote stage differentiation

    • Krobitsch, S., Brandau, S., Hoyer, C., Schmetz, C., Hübel, A., and Clos, J.
    • J Biol Chem 1998 273, 6488-6494
    • 1998-01-01

• 1997

  • Leishmania major Hsp100 is required chiefly in the mammalian stage of the parasite

    • Hubel, A., Krobitsch, S., Horauf, A., and Clos, J.
    • Mol Cell Biol 1997 17, 5987-5995
    • 1997-01-01

• 1996

  • The genomic organization of the HSP83 gene locus is conserved in three Leishmania species

    • Hubel, A. & J. Clos
    • Exp Parasitol 1996 82: 225-228
    • 1996-01-01

• 1995

  • A member of the ClpB family of stress proteins is expressed during heat shock in Leishmania spp

    • Hubel, A., Brandau, S., Dresel, A., and Clos, J.
    • Mol Biochem Parasitol 1995 70, 107-118
    • 1995-01-01

• 1994

  • pJC20 and pJC40- two high-copy-number vectors for T7 RNA polymerase-dependent expression of recombinant genes in Escherichia coli

    • Clos, J. & S. Brandau
    • Prot. Expression Purif. 1994 5: 133-137
    • 1994-01-01