Our research projects

Translational Research

In order to test which specific cell subpopulations the Lassa virus infects and which effect follows its presence, we are currently conducting infection experiments with human renal and CNS cell lines, including kidney and brain organoid models in addition to analysis of organs from our established mouse (IFNAR-/-) model.

 

 

Clinical Research

Current clinical research has identified renal failure and neurological complications, notably seizures as main predictors for fatal outcome in Lassa fever. However it is known how Lassa virus causes those complications and followingly, how to treat and prevent them. Whether direct virus effects, inflammation or bleeding cause pathology remains enigmatic. In our clinical research projects we are working to describe and decipher renal failure and CNS pathology in Lassa fever. For instance, we recently established electroencephalography (EEG) diagnosis for patients with seizures at the isolation ward in Irrua.

Three young researchers in protective suits in a patient room
Installation of EEG equipment in the Lassa fever isolation ward.

MIND Lassa

Infection with a highly-contagious, deadly pathogen and treatment on an isolation ward is a very stressful event for patients. Frequent psychiatric consultations are required to assist patients with confusion and anxiety. Furthermore, there are an increasing number of reports of stigmatization and post-treatment depression of Lassa fever patients. In order to bridge the important gap between clinical medicine and health psychology and public health, the MIND Lassa program employs an interdisciplinary team of clinicians, psychiatrists, psychologist and health-anthropologists to study psychiatric and psycho-social aspects of Lassa fever using quantitative and qualitative methods with the ultimate aim to improve patient care and public health intervention.

Leibniz Junior Research Group Omansen

Direktes Foto von Till Omansen, man sieht einen jungen Forscher im Hemd vor weißem Hintergrund
Research Group Leader

Till Omansen, Ph. D.

Telefon: +49 40 42818-267

Fax: +49 40 42818-281

E-Mail: till.omansen@bnitm.de

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