Our publications
2023
Interaction of Mesonivirus and Negevirus with arboviruses and the RNAi response in Culex tarsalis-derived cells
- Agboli E, Schulze J, Jansen S, Cadar D, Sreenu VB, Leggewie M, Altinli M, Badusche M, Jöst H, Börstler J, Schmidt-Chanasit J, Schnettler E
- Parasit Vectors. 2023 Oct 13;16(1):361. doi: 10.1186/s13071-023-05985-w
The Aedes aegypti RNA interference response against Zika virus in the context of co-infection with dengue and chikungunya viruses
- Leggewie M, Scherer C, Altinli M, Gestuveo RJ, Sreenu VB, Fuss J, Vazeille M, Mousson L, Badusche M, Kohl A, Failloux AB, Schnettler E
- PLoS Negl Trop Dis. 2023 Jul 13;17(7):e0011456. doi: 10.1371/journal.pntd.0011456
Agua Salud Alphavirus Infection, Dissemination and Transmission in Aedes aegypti Mosquitoes
- Jagtap SV, Brink J, Frank SC, Badusche M, Leggewie M, Sreenu VB, Fuss J, Schnettler E, Altinli M
- Viruses. 2023 May 3;15(5):1113. doi: 10.3390/v15051113
Antiviral RNAi Response in Culex quinquefasciatus-Derived HSU Cells
- Altinli M, Leggewie M, Schulze J, Gyanwali R, Badusche M, Sreenu VB, Fuss J, Schnettler E
- Viruses. 2023 Feb 4;15(2):436. doi: 10.3390/v15020436
2022
Antiviral RNAi Response against the Insect-Specific Agua Salud Alphavirus
- Altinli M, Leggewie M, Badusche M, Gyanwali R, Scherer C, Schulze J, Sreenu VB, Fegebank M, Zibrat B, Fuss J, Junglen S, Schnettler E
- mSphere. 2022 Feb 23;7(1):e0100321. doi: 10.1128/msphere.01003-21
Mutational analysis of Aedes aegypti Dicer 2 provides insights into the biogenesis of antiviral exogenous small interfering RNAs
- Gestuveo RJ, Parry R, Dickson LB, Lequime S, Sreenu VB, Arnold MJ, Khromykh AA, Schnettler E, Lambrechts L, Varjak M, Kohl A
- PLoS Pathog. 2022 Jan 6;18(1):e1010202. doi: 10.1371/journal.ppat.1010202
2021
Symbiotic Interactions Between Mosquitoes and Mosquito Viruses
- Altinli M, Schnettler E, Sicard M
- Front Cell Infect Microbiol. 2021 Aug 30;11:694020. doi: 10.3389/fcimb.2021.694020
An Aedes aegypti-Derived Ago2 Knockout Cell Line to Investigate Arbovirus Infections
- Scherer C, Knowles J, Sreenu VB, Fredericks AC, Fuss J, Maringer K, Fernandez-Sesma A, Merits A, Varjak M, Kohl A, Schnettler E
- Viruses. 2021 Jun 3;13(6):1066. doi: 10.3390/v13061066
2020
aBravo Is a Novel Aedes aegypti Antiviral Protein that Interacts with, but Acts Independently of, the Exogenous siRNA Pathway Effector Dicer 2
- Varjak M, Gestuveo RJ, Burchmore R, Schnettler E, Kohl A
- Viruses. 2020 Jul 11;12(7):748. doi: 10.3390/v12070748
Identification and RNAi Profile of a Novel Iflavirus Infecting Senegalese Aedes vexans arabiensis Mosquitoes
- Parry R, Naccache F, Ndiaye EH, Fall G, Castelli I, Lühken R, Medlock J, Cull B, Hesson JC, Montarsi F, Failloux AB, Kohl A, Schnettler E, Diallo M, Asgari S, Dietrich I, Becker SC
- Viruses. 2020 Apr 14;12(4):440. doi: 10.3390/v12040440
The Aedes aegypti Domino Ortholog p400 Regulates Antiviral Exogenous Small Interfering RNA Pathway Activity and ago-2 Expression
- McFarlane M, Almire F, Kean J, Donald CL, McDonald A, Wee B, Lauréti M, Varjak M, Terry S, Vazeille M, Gestuveo RJ, Dietrich I, Loney C, Failloux AB, Schnettler E, Pondeville E, Kohl A
- mSphere. 2020 Apr 8;5(2):e00081-20. doi: 10.1128/mSphere.00081-20
2019
Tick-borne encephalitis virus inhibits rRNA synthesis and host protein production in human cells of neural origin
- Selinger M, Tykalová H, Štěrba J, Věchtová P, Vavrušková Z, Lieskovská J, Kohl A, Schnettler E, Grubhoffer L
- PLoS Negl Trop Dis. 2019 Sep 27;13(9):e0007745. doi: 10.1371/journal.pntd.0007745
Mosquito-Specific Viruses-Transmission and Interaction
- Agboli E, Leggewie M, Altinli M, Schnettler E
- Viruses. 2019 Sep 17;11(9):873. doi: 10.3390/v11090873
Metaviromics Reveals Unknown Viral Diversity in the Biting Midge Culicoides impunctatus
- Modha S, Hughes J, Bianco G, Ferguson HM, Helm B, Tong L, Wilkie GS, Kohl A, Schnettler E
- Viruses. 2019 Sep 17;11(9):865. doi: 10.3390/v11090865
2018
Antiviral RNA Interference Activity in Cells of the Predatory Mosquito, Toxorhynchites amboinensis
- Donald CL, Varjak M, Aguiar ERGR, Marques JT, Sreenu VB, Schnettler E, Kohl A
- Viruses. 2018 Dec 6;10(12):694. doi: 10.3390/v10120694
RNAi-mediated antiviral immunity in insects and their possible application
- Leggewie M, Schnettler E
- Curr Opin Virol. 2018 Oct;32:108-114. doi: 10.1016/j.coviro.2018.10.004
Detection, infection dynamics and small RNA response against Culex Y virus in mosquito-derived cells
- Franzke K, Leggewie M, Sreenu VB, Jansen S, Heitmann A, Welch SR, Brennan B, Elliott RM, Tannich E, Becker SC, Schnettler E
- J Gen Virol. 2018 Dec;99(12):1739-1745. doi: 10.1099/jgv.0.001173
The antiviral piRNA response in mosquitoes?
- Varjak M, Leggewie M, Schnettler E
- J Gen Virol. 2018 Dec;99(12):1551-1562. doi: 10.1099/jgv.0.001157
Spindle-E Acts Antivirally Against Alphaviruses in Mosquito Cells
- Varjak M, Dietrich I, Sreenu VB, Till BE, Merits A, Kohl A, Schnettler E
- Viruses. 2018 Feb 18;10(2):88. doi: 10.3390/v10020088
2017
Characterization of the Zika virus induced small RNA response in Aedes aegypti cells
- Varjak M, Donald CL, Mottram TJ, Sreenu VB, Merits A, Maringer K, Schnettler E, Kohl A
- PLoS Negl Trop Dis. 2017 Oct 17;11(10):e0006010. doi: 10.1371/journal.pntd.0006010
Analysis of tick-borne encephalitis virus-induced host responses in human cells of neuronal origin and interferon-mediated protection
- Selinger M, Wilkie GS, Tong L, Gu Q, Schnettler E, Grubhoffer L, Kohl A
- J Gen Virol. 2017 Aug;98(8):2043-2060. doi: 10.1099/jgv.0.000853
Understanding the role of microRNAs in the interaction of Aedes aegypti mosquitoes with an insect-specific flavivirus
- Lee M, Etebari K, Hall-Mendelin S, van den Hurk AF, Hobson-Peters J, Vatipally S, Schnettler E, Hall R, Asgari S
- J Gen Virol. 2017 Jul;98(7):1892-1903. doi: 10.1099/jgv.0.000832
RNA Interference Restricts Rift Valley Fever Virus in Multiple Insect Systems
- Dietrich I, Jansen S, Fall G, Lorenzen S, Rudolf M, Huber K, Heitmann A, Schicht S, Ndiaye EH, Watson M, Castelli I, Brennan B, Elliott RM, Diallo M, Sall AA, Failloux AB, Schnettler E, Kohl A, Becker SC
- mSphere. 2017 May 3;2(3):e00090-17. doi: 10.1128/mSphere.00090-17
Aedes aegypti Piwi4 Is a Noncanonical PIWI Protein Involved in Antiviral Responses
- Varjak M, Maringer K, Watson M, Sreenu VB, Fredericks AC, Pondeville E, Donald CL, Sterk J, Kean J, Vazeille M, Failloux AB, Kohl A, Schnettler E
- mSphere. 2017 May 3;2(3):e00144-17. doi: 10.1128/mSphere.00144-17
Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen
- Burt FJ, Chen W, Miner JJ, Lenschow DJ, Merits A, Schnettler E, Kohl A, Rudd PA, Taylor A, Herrero LJ, Zaid A, Ng LFP, Mahalingam S
- Lancet Infect Dis.; 17(4):e107-e117. doi: 10.1016/S1473-3099(16)30385-1
The Antiviral RNAi Response in Vector and Non-vector Cells against Orthobunyaviruses
- Dietrich I, Shi X, McFarlane M, Watson M, Blomström AL, Skelton JK, Kohl A, Elliott RM, Schnettler E
- PLoS Negl Trop Dis. 2017 Jan 6;11(1):e0005272. doi: 10.1371/journal.pntd.0005272
2016
Wolbachia restricts insect-specific flavivirus infection in Aedes aegypti cells
- Schnettler E, Sreenu VB, Mottram T, McFarlane M
- J Gen Virol.;97(11):3024-3029. doi: 10.1099/jgv.0.000617
Full Genome Sequence and sfRNA Interferon Antagonist Activity of Zika Virus from Recife, Brazil
- Donald CL, Brennan B, Cumberworth SL, Rezelj VV, Clark JJ, Cordeiro MT, Freitas de Oliveira França R, Pena LJ, Wilkie GS, Da Silva Filipe A, Davis C, Hughes J, Varjak M, Selinger M, Zuvanov L, Owsianka AM, Patel AH, McLauchlan J, Lindenbach BD, Fall G, Sall AA, Biek R, Rehwinkel J, Schnettler E, Kohl A
- PLoS Negl Trop Dis.10(10):e0005048. doi: 10.1371/journal.pntd.0005048
The Importance of Socio-Economic Versus Environmental Risk Factors for Reported Dengue Cases in Java, Indonesia
- Wijayanti SP, Porphyre T, Chase-Topping M, Rainey SM, McFarlane M, Schnettler E, Biek R, Kohl A
- PLoS Negl Trop Dis. ;10(9):e0004964. doi: 10.1371/journal.pntd.0004964
Host inflammatory response to mosquito bites defines severity of arbovirus infection
- Pingen M, Bryden SR, Pondeville E, Schnettler E, Kohl A, Merits A, Fazakerley JK, Graham GJ, McKimmie CS
- Immunity. 2016 Jun 21;44(6):1455-69. doi: 10.1016/j.immuni.2016.06.002
Wolbachia blocks viral genome replication early in infection without a transcriptional response by the endosymbiont or host small RNA pathways
- Rainey SM, Martinez J, McFarlane M, Juneja P, Sarkies P, Lulla A, Schnettler E, Varjak M, Merits A, Miska EA, Jiggins FM, Kohl A
- PLoS Pathog. 2016 Apr 18;12(4):e1005536. doi: 10.1371/journal.ppat.1005536
Dengue in Java, Indonesia: relevance of mosquito indices as risk predictors
- Wijayanti SP, Sunaryo S, Suprihatin S, McFarlane M, Rainey SM, Dietrich I, Schnettler E, Biek R, Kohl A
- PLOS Neglected Tropical Diseases 2016 Mar 11;10(3):e0004500. doi: 10.1371/journal.pntd.0004500
Modulation of potassium channels inhibits bunyavirus infection
- Hover S, King B, Hall B, Loundras EA, Taqi H, Daly J, Dallas M, Peers C, Schnettler E, McKimmie C, Kohl A, Barr JN, Mankouri J
- J Biol Chem. 2016 Feb 12;291(7):3411-22. doi: 10.1074/jbc.M115.692673
Advancing vector biology research: a community survey for future directions, research applications and infrastructure requirements
- Kohl A, Pondeville E, Schnettler E, Crisanti A, Supparo C, Christophides GK, Kersey PJ, Maslen GL, Takken W, Koenraadt CJ, Oliva CF, Busquets N, Abad FX, Failloux AB, Levashina EA, Wilson AJ, Veronesi E, Pichard M, Arnaud Marsh S, Simard F, Vernick KD
- Pathogens and Global Health. 2016 Jun-Jul;110(4-5):164-72. doi: 10.1080/20477724.2016.1211475
2015
A novel insect-specific flavivirus replicates only in Aedes-derived cells and persists at high prevalence in wild Aedes vigilax populations in Sydney, Australia
- McLean BJ, Hobson-Peters J, Webb CE, Watterson D, Prow NA, Nguyen HD, Hall-Mendelin S, Warrilow D, Johansen CA, Jansen CC, van den Hurk AF, Beebe NW, Schnettler E, Barnard RT, Hall RA
- Virology 2015 Dec;486:272-83. doi: 10.1016/j.virol.2015.07.021
Newly identified RNAs of Raspberry leaf blotch virus encoding a related group of proteins
- Lu Y, McGavin W, Cock PJA, Schnettler E, Yan F, Chen J, MacFarlane S
- Journal of General Virology. 2015 Nov;96(11):3432-3439. doi: 10.1099/jgv.0.000277
Transcriptome analysis reveals the host response to Schmallenberg virus in bovine cells and antagonistic effects of the NSs protein
- Blomström AL, Gu Q, Barry G, Wilkie G, Skelton JK, Baird M, McFarlane M, Schnettler E, Elliott RM, Palmarini M, Kohl A
- BMC Genomics 2015 Apr 19;16:324. doi: 10.1186/s12864-015-1538-9
Fighting arbovirus transmission: nutural and engineerd control of vector competence in Aedes mosquitoes
- Kean J, Rainey SM, McFarlane M, Donald CL, Schnettler E, Kohl A, Pondeville E
- Insects. 2015 Mar 23;6(1):236-78. doi: 10.3390/insects6010236
2014
Induction and suppression of tick cell antiviral RNAi response by tick-borne flaviviruses
- Schnettler E, Tykalová H, Watson M, Sharma M, Sterken MG, Obbard DJ, Lewis SH, McFarlane M, Bell-Sakyi L, Barry G, Weisheit S, Best SM, Kuhn RJ, Pijlman GP, Chase-Topping ME, Gould EA, Grubhoffer L, Fazakerley JK, Kohl A
- Nucleic Acid Research. 2014 Aug;42(14):9436-46. doi: 10.1093/nar/gku657
Characterization of Aedes aegypti innate-immune pathways that limit Chikungunya virus replication
- McFarlane M, Arias-Goeta C, Martin E, O'Hara Z, Lulla A, Mousson L, Rainey SM, Misbah S, Schnettler E, Donald CL, Merits A, Kohl A, Failloux AB
- PLOS neglected tropical diseases 8(7): e2994. doi: 10.1371/journal.pntd.0002994
NSs protein of Schmallenberg virus counteracts the antiviral response of the cell by inhibiting its transcriptional machinery
- Barry G, Varela M, Ratinier M, Blomström AL, Caporale M, Seehusen F, Hahn K, Schnettler E, Baumgärtner W, Kohl A, Palmarini M
- J Gen Virol. 2014 Aug;95(Pt 8):1640-1646. doi: 10.1099/vir.0.065425-0
2013
Gene silencing in tick cell lines using small interfering or long double-stranded RNA
- Barry G, Alberdi P, Schnettler E, Weisheit S, Kohl A, Fazakerley JK, Bell-Sakyi L
- Experimental and Applied Acarology. 2013 Mar;59(3):319-38. doi: 10.1007/s10493-012-9598-x
Non-structural proteins of arthropod-borne bunyaviruses: roles and functions
- Eifan S, Schnettler E, Dietrich I, Kohl A, Blomström AL
- Viruses. 2013 Oct 4;5(10):2447-68. doi: 10.3390/v5102447
viRome: an R package for the visualization and analysis of viral small RNA sequence datasets
- Watson M, Schnettler E, Kohl A
- Bioinformatics. 2013 Aug 1;29(15):1902-3. doi: 10.1093/bioinformatics/btt297
Knockdown of piRNA pathway proteins results in enhanced Semliki Forest virus production in mosquito cells.
- Schnettler, E.#; Donald, C.L.; Human, S.; Watson, M.; Siu, R.W.C.; McFarlane, M.; Fazakerley, J.K.; Kohl, A. & Fragkoudis, R.# (2013)
- J Gen Virol. 94 (7): 1680-1689
Schmallenberg virus pathogenesis, tropism and interaction with the innate immune system of the host
- Varela M, Schnettler E, Caporale M, Murgia C, Barry G, McFarlane M, McGregor E, Piras IM, Shaw A, Lamm C, Janowicz A, Beer M, Glass M, Herder V, Hahn K, Baumgärtner W, Kohl A, Palmarini M
- PLoS Pathog. 2013 Jan;9(1):e1003133. doi: 10.1371/journal.ppat.1003133
RNA interference targets arbovirus replication in Culicoides cells
- Schnettler E, Ratinier M, Watson M, Shaw AE, McFarlane M, Varela M, Elliott RM, Palmarini M, Kohl A
- J Virol. 2013 Mar;87(5):2441-54. doi: 10.1128/JVI.02848-12
2012
Prophenol oxidase activity acts as a mosquito innate immune response against infection with Semliki Forest virus
- Rodriguez-Andres J, Rani S, Varjak M, Chase-Topping ME, Beck MH, Ferguson MC, Schnettler E, Fragkoudis R, Barry G, Merits A, Fazakerley JK, Strand MR, Kohl A
- PLoS Pathog. 2012;8(11):e1002977. doi: 10.1371/journal.ppat.1002977
Non-coding flavivirus RNA displays RNAi suppressor activity in insect and mammalian cells
- Schnettler E, Sterken MG, Leung JY, Metz SW, Geertsema C, Goldbach RW, Vlak JM, Kohl A, Khromykh AA, Pijlman GP
- J Virol. 2012 Dec;86(24):13486-500. doi: 10.1128/JVI.01104-12
New insights into control of arbovirus replication and spread by insect RNA interference pathways
- Donald CL, Kohl A, Schnettler E
- Insects. 2012 May 29;3(2):511-31. doi: 10.3390/insects3020511
West Nile virus encodes a microRNA-like small RNA in the 3’ untranslated region which upregulates GATA4 mRNA and facilitates virus replication in mosquito cells
- Hussain M, Torres S, Schnettler E, Funk A, Grundhoff A, Pijlman GP, Khromykh AA, Asgari S
- Nucleic Acids Res. 2012 Mar;40(5):2210-23. doi: 10.1093/nar/gkr848
2011
Diverging affinity of tospovirus RNA silencing suppressor proteins, NSs, for various RNA duplex molecules
- Schnettler E, Hemmes H, Huismann R, Goldbach R, Prins M, Kormelink R
- J Virol. 2010 Nov;84(21):11542-54. doi: 10.1128/JVI.00595-10
2010
Chikungunya virus nonstructural protein 2 inhibits type I/II interferon2 stimulated JAK-STAT signaling
- Fros JJ, Liu WJ, Prow NA, Geertsema C, Ligtenberg M, Vanlandingham DL, Schnettler E, Vlak JM, Suhrbier A, Khromykh AA, Pijlman GP
- J Virol. 2010 Oct;84(20):10877-87. doi: 10.1128/JVI.00949-10
2009
Binding of siRNA molecules is crucial for RNAi suppressor activity of Rice hoja blanca virus NS3 in plants
- Hemmes H, Kaaij L, Lohuis D, Prins M, Goldbach R, Schnettler E
- J Gen Virol. 2009 Jul;90(Pt 7):1762-1766. doi: 10.1099/vir.0.010488-0
The NS3 protein of rice hoja blanca virus complements the RNAi suppressor function of HIV-1 Tat
- Schnettler E, de Vries W, Hemmes H, Haasnoot J, Kormelink R, Goldbach R, Berkhout B
- EMBO Rep. 2009 Mar;10(3):258-63. doi: 10.1038/embor.2009.6
2008
The NS3 protein of rice hoja blanca virus suppresses RNA silencing in mammalian cells
- Schnettler E, Hemmes H, Goldbach R, Prins M
- J Gen Virol. 2008 Jan;89(Pt 1):336-340. doi: 10.1099/vir.0.83293-0
