Our publications

• 2023

  • Agua Salud Alphavirus Infection, Dissemination and Transmission in Aedes aegypti Mosquitoes.

    • Jagtap SV, Brink J, Frank SC, Badusche M, Leggewie M, Sreenu VB, Fuss J, Schnettler E, Altinli M
    • Viruses. 2023 May 3;15(5):1113. doi: 10.3390/v15051113.
    • 2023-05-03

  • Antiviral RNAi Response in Culex quinquefasciatus-Derived HSU Cells.

    • Altinli M, Leggewie M, Schulze J, Gyanwali R, Badusche M, Sreenu VB, Fuss J, Schnettler E.
    • Viruses. 2023 Feb 4;15(2):436. doi: 10.3390/v15020436.
    • 2023-02-04

• 2022

  • Antiviral RNAi Response against the Insect-Specific Agua Salud Alphavirus.

    • Altinli M, Leggewie M, Badusche M, Gyanwali R, Scherer C, Schulze J, Sreenu VB, Fegebank M, Zibrat B, Fuss J, Junglen S, Schnettler E.
    • mSphere. 2022 Feb 23;7(1):e0100321. doi: 10.1128/msphere.01003-21. Epub 2022 Feb 16.
    • 2022-02-23

  • Mutational analysis of Aedes aegypti Dicer 2 provides insights into the biogenesis of antiviral exogenous small interfering RNAs.

    • Gestuveo RJ, Parry R, Dickson LB, Lequime S, Sreenu VB, Arnold MJ, Khromykh AA, Schnettler E, Lambrechts L, Varjak M, Kohl A.
    • PLoS Pathog. 2022 Jan 6;18(1):e1010202. doi: 10.1371/journal.ppat.1010202. eCollection 2022 Jan.
    • 2022-01-06

• 2021

  • Symbiotic Interactions Between Mosquitoes and Mosquito Viruses.

    • Altinli M, Schnettler E, Sicard M.
    • Front Cell Infect Microbiol. 2021 Aug 30;11:694020. doi: 10.3389/fcimb.2021.694020. eCollection 2021.
    • 2021-08-30

  • An Aedes aegypti-Derived Ago2 Knockout Cell Line to Investigate Arbovirus Infections.

    • Scherer C, Knowles J, Sreenu VB, Fredericks AC, Fuss J, Maringer K, Fernandez-Sesma A, Merits A, Varjak M, Kohl A, Schnettler E
    • Viruses. 2021 Jun 3;13(6):1066. doi: 10.3390/v13061066.
    • 2021-06-03

• 2020

  • aBravo Is a Novel Aedes aegypti Antiviral Protein that Interacts with, but Acts Independently of, the Exogenous siRNA Pathway Effector Dicer 2.

    • Varjak M, Gestuveo RJ, Burchmore R, Schnettler E, Kohl A.
    • Viruses. 2020 Jul 11;12(7):748. doi: 10.3390/v12070748.
    • 2020-07-11

  • Identification and RNAi Profile of a Novel Iflavirus Infecting Senegalese Aedes vexans arabiensis Mosquitoes.

    • Parry R, Naccache F, Ndiaye EH, Fall G, Castelli I, Lühken R, Medlock J, Cull B, Hesson JC, Montarsi F, Failloux AB, Kohl A, Schnettler E, Diallo M, Asgari S, Dietrich I, Becker SC.
    • Viruses. 2020 Apr 14;12(4):440. doi: 10.3390/v12040440.
    • 2020-04-14

  • The Aedes aegypti Domino Ortholog p400 Regulates Antiviral Exogenous Small Interfering RNA Pathway Activity and ago-2 Expression.

    • McFarlane M, Almire F, Kean J, Donald CL, McDonald A, Wee B, Lauréti M, Varjak M, Terry S, Vazeille M, Gestuveo RJ, Dietrich I, Loney C, Failloux AB, Schnettler E, Pondeville E, Kohl A.
    • mSphere. 2020 Apr 8;5(2):e00081-20. doi: 10.1128/mSphere.00081-20.
    • 2020-04-08

• 2019

  • Tick-borne encephalitis virus inhibits rRNA synthesis and host protein production in human cells of neural origin.

    • Selinger M, Tykalová H, Štěrba J, Věchtová P, Vavrušková Z, Lieskovská J, Kohl A, Schnettler E, Grubhoffer L.
    • PLoS Negl Trop Dis. 2019 Sep 27;13(9):e0007745. doi: 10.1371/journal.pntd.0007745. eCollection 2019 Sep.
    • 2019-09-27

  • Mosquito-Specific Viruses-Transmission and Interaction.

    • Agboli E, Leggewie M, Altinli M, Schnettler E.
    • Viruses. 2019 Sep 17;11(9):873. doi: 10.3390/v11090873.
    • 2019-09-17

  • Metaviromics Reveals Unknown Viral Diversity in the Biting Midge Culicoides impunctatus.

    • Modha S, Hughes J, Bianco G, Ferguson HM, Helm B, Tong L, Wilkie GS, Kohl A, Schnettler E.
    • Viruses. 2019 Sep 17;11(9):865. doi: 10.3390/v11090865.
    • 2019-09-17

• 2018

  • Antiviral RNA Interference Activity in Cells of the Predatory Mosquito, Toxorhynchites amboinensis.

    • Donald CL, Varjak M, Aguiar ERGR, Marques JT, Sreenu VB, Schnettler E, Kohl A
    • Viruses. 2018 Dec 6;10(12):694. doi: 10.3390/v10120694.
    • 2018-12-06

  • RNAi-mediated antiviral immunity in insects and their possible application.

    • Leggewie M, Schnettler E.
    • Curr Opin Virol. 2018 Oct;32:108-114. doi: 10.1016/j.coviro.2018.10.004. Epub 2018 Nov 12.
    • 2018-11-12

  • Detection, infection dynamics and small RNA response against Culex Y virus in mosquito-derived cells.

    • Franzke K, Leggewie M, Sreenu VB, Jansen S, Heitmann A, Welch SR, Brennan B, Elliott RM, Tannich E, Becker SC, Schnettler E.
    • J Gen Virol. 2018 Dec;99(12):1739-1745. doi: 10.1099/jgv.0.001173. Epub 2018 Nov 5.
    • 2018-11-05

  • The antiviral piRNA response in mosquitoes?

    • Varjak M, Leggewie M, Schnettler E.
    • J Gen Virol. 2018 Dec;99(12):1551-1562. doi: 10.1099/jgv.0.001157. Epub 2018 Oct 29.
    • 2018-10-29

  • Spindle-E Acts Antivirally Against Alphaviruses in Mosquito Cells.

    • Varjak M, Dietrich I, Sreenu VB, Till BE, Merits A, Kohl A, Schnettler E.
    • Viruses. 2018 Feb 18;10(2):88. doi: 10.3390/v10020088.
    • 2018-02-18

• 2017

  • Characterization of the Zika virus induced small RNA response in Aedes aegypti cells.

    • Varjak M, Donald CL, Mottram TJ, Sreenu VB, Merits A, Maringer K, Schnettler E, Kohl A.
    • PLoS Negl Trop Dis. 2017 Oct 17;11(10):e0006010. doi: 10.1371/journal.pntd.0006010. eCollection 2017 Oct.
    • 2017-10-17

  • Analysis of tick-borne encephalitis virus-induced host responses in human cells of neuronal origin and interferon-mediated protection.

    • Selinger M, Wilkie GS, Tong L, Gu Q, Schnettler E, Grubhoffer L, Kohl A.
    • J Gen Virol. 2017 Aug;98(8):2043-2060. doi: 10.1099/jgv.0.000853. Epub 2017 Aug 8.
    • 2017-08-08

  • Understanding the role of microRNAs in the interaction of Aedes aegypti mosquitoes with an insect-specific flavivirus.

    • Lee M, Etebari K, Hall-Mendelin S, van den Hurk AF, Hobson-Peters J, Vatipally S, Schnettler E, Hall R, Asgari S
    • J Gen Virol. 2017 Jul;98(7):1892-1903. doi: 10.1099/jgv.0.000832. Epub 2017 Jul 12
    • 2017-07-12

  • RNA Interference Restricts Rift Valley Fever Virus in Multiple Insect Systems.

    • Dietrich I, Jansen S, Fall G, Lorenzen S, Rudolf M, Huber K, Heitmann A, Schicht S, Ndiaye EH, Watson M, Castelli I, Brennan B, Elliott RM, Diallo M, Sall AA, Failloux AB, Schnettler E, Kohl A, Becker SC.
    • mSphere. 2017 May 3;2(3):e00090-17. doi: 10.1128/mSphere.00090-17. eCollection 2017 May-Jun
    • 2017-05-03

  • Aedes aegypti Piwi4 Is a Noncanonical PIWI Protein Involved in Antiviral Responses.

    • Varjak M, Maringer K, Watson M, Sreenu VB, Fredericks AC, Pondeville E, Donald CL, Sterk J, Kean J, Vazeille M, Failloux AB, Kohl A, Schnettler E.
    • mSphere. 2017 May 3;2(3):e00144-17. doi: 10.1128/mSphere.00144-17. eCollection 2017 May-Jun.
    • 2017-05-03

  • Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen.

    • Burt FJ, Chen W, Miner JJ, Lenschow DJ, Merits A, Schnettler E, Kohl A, Rudd PA, Taylor A, Herrero LJ, Zaid A, Ng LFP, Mahalingam S.
    • Lancet Infect Dis.; 17(4):e107-e117. doi: 10.1016/S1473-3099(16)30385-1. Epub 2017 Feb 1
    • 2017-04-17

  • The Antiviral RNAi Response in Vector and Non-vector Cells against Orthobunyaviruses.

    • Dietrich I, Shi X, McFarlane M, Watson M, Blomström AL, Skelton JK, Kohl A, Elliott RM, Schnettler E.
    • PLoS Negl Trop Dis. 2017 Jan 6;11(1):e0005272. doi: 10.1371/journal.pntd.0005272. eCollection 2017 Jan.
    • 2017-01-06

• 2016

  • Wolbachia restricts insect-specific flavivirus infection in Aedes aegypti cells.

    • Schnettler E, Sreenu VB, Mottram T, McFarlane M.
    • J Gen Virol.;97(11):3024-3029. doi: 10.1099/jgv.0.000617. Epub 2016 Sep 28.
    • 2016-11-01

  • Full Genome Sequence and sfRNA Interferon Antagonist Activity of Zika Virus from Recife, Brazil.

    • Donald CL, Brennan B, Cumberworth SL, Rezelj VV, Clark JJ, Cordeiro MT, Freitas de Oliveira França R, Pena LJ, Wilkie GS, Da Silva Filipe A, Davis C, Hughes J, Varjak M, Selinger M, Zuvanov L, Owsianka AM, Patel AH, McLauchlan J, Lindenbach BD, Fall G, Sall AA, Biek R, Rehwinkel J, Schnettler E, Kohl A
    • PLoS Negl Trop Dis.10(10):e0005048. doi: 10.1371/journal.pntd.0005048. eCollection 2016 Oct
    • 2016-10-05

  • The Importance of Socio-Economic Versus Environmental Risk Factors for Reported Dengue Cases in Java, Indonesia.

    • Wijayanti SP, Porphyre T, Chase-Topping M, Rainey SM, McFarlane M, Schnettler E, Biek R, Kohl A
    • PLoS Negl Trop Dis. ;10(9):e0004964. doi: 10.1371/journal.pntd.0004964. eCollection 2016 Sep.
    • 2016-09-07

  • Host inflammatory response to mosquito bites defines severity of arbovirus infection.

    • Pingen M, Bryden SR, Pondeville E, Schnettler E, Kohl A, Merits A, Fazakerley JK, Graham GJ, McKimmie CS.
    • Immunity. 2016 Jun 21;44(6):1455-69. doi: 10.1016/j.immuni.2016.06.002
    • 2016-06-21

  • Wolbachia blocks viral genome replication early in infection without a transcriptional response by the endosymbiont or host small RNA pathways.

    • Rainey SM, Martinez J, McFarlane M, Juneja P, Sarkies P, Lulla A, Schnettler E, Varjak M, Merits A, Miska EA, Jiggins FM, Kohl A.
    • PLoS Pathog. 2016 Apr 18;12(4):e1005536. doi: 10.1371/journal.ppat.1005536. eCollection 2016 Apr.
    • 2016-04-18

  • Dengue in Java, Indonesia: relevance of mosquito indices as risk predictors.

    • Wijayanti, APM; Sunaryo, S; Suprihatin, S; McFarlane, M; Rainey, SM; Dietrich, I; Schnettler, E; Biek, R and Kohl, A.
    • PLOS Neglected Tropical Diseases 2016 Mar 11;10(3):e0004500. doi: 10.1371/journal.pntd.0004500. eCollection 2016.
    • 2016-03-11

  • Modulation of potassium channels inhibits bunyavirus infection.

    • Hover, S.; King, B.; hall, B.; Loundras, EA; Taqi, H; Daly, J; dallas, M; Peers, C; Schnettler, E; McKimmie, C; Kohl, A; Barr, JN and Mankouri, J.
    • J Biol Chem 2016 Feb 12;291(7):3411-22.
    • 2016-02-12

  • Advancing vector biology research: a community survey for future directions, research applications and infrastructure requirements.

    • Kohl, A; Pondeville, E; Schnettler, E; Crisanti, A; Supparo, C; Christophides, GK; Kersey, PJ; Maslen, GL; Takken, W; Koensraadt, CJM; Oliva Nuria Busquets, CF; Abad, FX; Failloux, AB; Levashina, EA; Wilson, AJ; Veronesi, E; Pichard, M; Arnaud Marsh, S; Simard, F and Vernick, KD.
    • Pathogens and Global Health. 2016. Vol 0, Issue 0, 1-9.
    • 2016-01-01

• 2015

  • A novel insect-specific flavivirus replicates only in Aedes-derived cells and persists at high prevalence in wild Aedes vigilax populations in Sydney, Australia.

    • Breeanna McLean; Jody Hobson-Peters; Cameron E Webb; Daniel Watterson; Natalie A Prow; Hong Duyen Nguyen ; Sonja Hall-Mendelin; David Warrilow; Cheryl A Johansen; Cassie Jansen; Andrew van den Hurk; Nigel W Beebe; Esther Schnettler; Ross T Barnard; Roy Hall
    • Virology 2015 Dec;486:272-83. doi: 10.1016/j.virol.2015.07.021.
    • 2015-12-01

  • Newly identified RNAs of Raspberry leaf blotch virus encoding a related group of proteins.

    • Yuwen Lu, Wendy McGavin, Peter J.A. Cock, Esther Schnettler, Fei Yan, Jianping Chen and Stuart MacFarlane.
    • Journal of General Virology 2015 Nov;96(11):3432-9.
    • 2015-11-01

  • Transcriptome analysis reveals the host response to Schmallenberg virus in bovine cells and antagonistic effects of the NSs protein.

    • Blomström A.-L., Q. Gu, G. Barry, G. Wilkie, J. K. Skelton, M. Baird, M. McFarlane, E. Schnettler, R. M. Elliott, M. Palmarini, and A. Kohl.
    • BMC Genomics 2015 Apr 19;16:324. doi: 10.1186/s12864-015-1538-9.
    • 2015-04-19

  • Fighting arbovirus transmission: nutural and engineerd control of vector competence in Aedes mosquitoes.

    • Kean, J., Rainey, S.M., McFarlane, M., Donald, C.L., Schnettler, E., Kohl, A. And Pondeville, E. (2015)
    • Insects. 6(1): 236-278
    • 2015-01-01

• 2014

  • Induction and suppression of tick cell antiviral RNAi response by tick-borne flaviviruses.

    • Schnettler, E.#; Tykalova, H.; Watson, M.; Sharma, M.; Sterken, M.G.; Obbard, D.J.; Lewis, S.H.; McFarlane, M.; Bell-Sakyi, L.; Barry, G.; Weisheit, S.; Best, S.; Kuhn, R.; Pijlman, G.; Chase-Topping, M.E.; Gould, E.A.; Grubhoffer, L.; Fazakerley, J. and Kohl, A.# (2014)
    • Nucleic Acid Research 42(14): 9436-46
    • 2014-01-01

  • Characterization of Aedes aegypti innate-immune pathways that limit Chikungunya virus replication.

    • McFarlane, M.; Arias-Goeta, C.; Martin, E.; O`Hara, Z.; Lulla, A.; Mousson, L.; Graham, S.M.; Misbah, S.; Schnettler, E.; Donald, C.L.; Merits, A.; Kohl, A. and Failloux, A-B. (2014)
    • PLOS neglected tropical diseases 8(7): e2994. Doi: 10.1371/journal.pntd.0002994
    • 2014-01-01

  • NSs protein of Schmallenberg virus counteracts the antiviral response of the cell by inhibiting its transcriptional machinery.

    • Barry, G., M. Varela, M. Ratinier, A. L. Blomstrom, M. Caporale, F. Seehusen, K. Hahn, E. Schnettler, W. Baumgartner, A. Kohl and M. Palmarini (2014).
    • J Gen Virol. 95(8): 1640-1646
    • 2014-01-01

• 2013

  • Non-structural proteins of arthropod-borne bunyaviruses: roles and functions.

    • Eifan, S.*; Schnettler, E.*; Dietrich, I.; Kohl, A. And Blomstrom, A. (2013)
    • Viruses, 5(10): 2447-2468
    • 2013-01-01

  • viRome: an R package for the visualization and analysis of viral small RNA sequence datasets.

    • Watson, M.; Schnettler, E. and Kohl, A. (2013).
    • Bioinformatics, 29(15): 1902-1903
    • 2013-01-01

  • Knockdown of piRNA pathway proteins results in enhanced Semliki Forest virus production in mosquito cells.

    • Schnettler, E.#; Donald, C.L.; Human, S.; Watson, M.; Siu, R.W.C.; McFarlane, M.; Fazakerley, J.K.; Kohl, A. & Fragkoudis, R.# (2013)
    • J Gen Virol. 94 (7): 1680-1689
    • 2013-01-01

  • Schmallenberg virus pathogenesis, tropism and interaction with the innate immune system of the host.

    • Varela, M.; Schnettler, E.; Caporale, M.; Murgia, C.; Barry, G.; McFarlane, M.; McGregor, E.; Piras, I.M.; Shaw, A.; Lamm, C.; Beer, M.; Glass, M.; Herder, V.; Hanh, K.; Baumgärtner, W.; Kohl, A. & Palmarini, M. (2013)
    • PLoS Pathog. 9(1): e1003133
    • 2013-01-01

  • RNA interference targets arbovirus replication in Culicoides cells.

    • Schnettler, E.*; Ratinier, M.*; Watson, M.; Shaw, A.; McFarlane, M.; Varela, M.; Elliott, R.M.; Palmarini, M. & Kohl, A. (2013)
    • J Virol., 87(5): 2441-54
    • 2013-01-01

  • Gene silencing in tick cell lines using small interfering or long double-stranded RNA.

    • Barry, G.; Alberdi, P.; Schnettler, E.; Weisheit, S.; Kohl, A.; Fazakerley, J.K. and Bell-Sakyi, L. (2013).
    • Experimental and Applied Acarology, 59(3): 319-338
    • 2013-01-01

• 2012

  • Prophenol oxidase activity acts as a mosquito innate immune response against infection with Semliki Forest virus.

    • Julio Rodriguez-Andres, J.; Rani, S.; Varjak, M.; Chase-Topping, M. E.; Ferguson, M. C.; Schnettler, E.; Fragkoudis, R.; Beck, M. H.; Barry, G.; Nash, A. A.; Merits, A.; Fazakerley, J. K.; Strand M. R. and Kohl, A.
    • PLoS Pathog. 8(11): e1002977
    • 2012-01-01

  • Non-coding flavivirus RNA displays RNAi suppressor activity in insect and mammalian cells.

    • Schnettler, E.; Sterken, M.G.; Leung, J.Y.; Metz, S.W.; Geertsema, C.; Goldbach, R.W.; Vlak, J.M.; Kohl, A.; Khromykh, A.A.; Pijlman, G.P. (2012)
    • J Virol. 86(24): 13486-13500
    • 2012-01-01

  • New insights into control of arbovirus replication and spread by insect RNA interference pathways.

    • Donald, C.; Kohl, A. and Schnettler, E. (2012)
    • Insects. 3(2): 511-531
    • 2012-01-01

  • West Nile virus encodes a microRNA-like small RNA in the 3’ untranslated region which upregulates GATA4 mRNA and facilitates virus replication in mosquito cells.

    • Hussain, M.; Torres, S.; Schnettler, E.; Funk, A.; Grundhoff, A.; Pijlman, G.; Khromykh, A.; Asgari, S. (2012)
    • Nucleic Acids Res. 40(5): 2210-2223
    • 2012-01-01

• 2011

  • Diverging affinity of tospovirus RNA silencing suppressor proteins, NSs, for various RNA duplex molecules.

    • Schnettler, E.*, Hemmes, H.*, Huismann, R., Goldbach, R.; Prins, M & Kormelink, R. (2010).
    • J Virol. Nov;84(21):11542-54
    • 2011-01-01

• 2010

  • Chikungunya virus nonstructural protein 2 inhibits type I/II interferon2 stimulated JAK-STAT signaling.

    • Fros, J., Liu, W. J., Prow, N. A., Geertsema, C., Ligtenberg, M., Vanlandingham, D. L., Schnettler, E., Vlak, J. M., Khromykh, A. A., Pijlman, G. P. (2010)
    • J Virol. Oct;84(20):10877-87
    • 2010-01-01

• 2009

  • Binding of siRNA molecules is crucial for RNAi suppressor activity of Rice hoja blanca virus NS3 in plants.

    • Hemmes, H., Kaaij, L., Lohuis, D., Prins, M., Goldbach, R. & Schnettler, E. (2009)
    • J Gen Virol. 90: 1762-1766.
    • 2009-01-01

  • The NS3 protein of rice hoja blanca virus complements the RNAi suppressor function of HIV-1 Tat.

    • Schnettler, E.*, de Vries, W.*, Hemmes, H., Haasnoot, J., Kormelink, R., Goldbach, R. & Berkhout, B. (2009)
    • EMBO Rep 10: 258-63).
    • 2009-01-01

  • Binding of siRNA molecules is crucial for RNAi suppressor activity of Rice hoja blanca virus NS3 in plants.

    • Hemmes, H., Kaaij, L., Lohuis, D., Prins, M., Goldbach, R. & Schnettler, E. (2009)
    • J Gen Virol. 90: 1762-1766.
    • 2009-01-01

  • The NS3 protein of rice hoja blanca virus complements the RNAi suppressor function of HIV-1 Tat.

    • Schnettler, E.*, de Vries, W.*, Hemmes, H., Haasnoot, J., Kormelink, R., Goldbach, R. & Berkhout, B. (2009)
    • EMBO Rep 10: 258-63).
    • 2009-01-01

• 2008

  • The NS3 protein of rice hoja blanca virus suppresses RNA silencing in mammalian cells.

    • Schnettler, E., Hemmes, H., Goldbach, R. and Prins, M. (2008)
    • J Gen Virol, 89, 336-340
    • 2008-01-01