Our publication highlights
T cells expressing multiple co-inhibitory molecules in acute malaria are not exhausted but exert a suppressive function in mice
- Brandi J, Lehmann C, Kaminski LC, Schulze Zur Wiesch J, Addo M, Ramharter M, Mackroth M, Jacobs T, Riehn M.
- Eur J Immunol. 2021 Nov 9. doi: 10.1002/eji.202149424
Molecular and functional heterogeneity of IL-10-producing CD4+ T cells.
- Brockmann L, Soukou S, Steglich B, Czarnewski P, Zhao L, Wende S, Bedke T, Ergen C, Manthey C, Agalioti T, Geffken M, Seiz O, Parigi SM, Sorini C, Geginat J, Fujio K, Jacobs T, Roesch T, Izbicki JR, Lohse AW, Flavell RA, Krebs C, Gustafsson JA, Antonson P, Roncarolo MG, Villablanca E, Gagliani N, Huber S
- Nat Commun. 2018; 9:5457. doi: 10.1038/s41467-018-07581-4
Differential expression pattern of co-inhibitory molecules on CD4+ T cells in uncomplicated versus complicated malaria
- Abel A, Steeg C, Aminkiah F, Addai-Mensah O, Addo M, Gagliani N, Casar C, Yar DD, Owusu-Dabo E, Jacobs T, Mackroth MS.
- Sci Rep. 2018 Mar 19;8(1):4789. doi: 10.1038/s41598-018-22659-1
Acute Malaria Induces PD1+CTLA4+ Effector T Cells with Cell-Extrinsic Suppressor Function.
- Mackroth MS, Abel A, Steeg C, Schulze Zur Wiesch J, Jacobs T.
- PLoS Pathog. 2016 Nov 1;12(11):e1005909. doi: 10.1371/journal.ppat.1005909. eCollection 2016 Nov
All publications
2022
Increased expression of multiple co-inhibitory molecules on malaria-induced CD8+ T cells are associated with increased function instead of exhaustion
- Brandi J, Riehn M, Hadjilaou A, Jacobs T
- Front Immunol. 2022; 13: 878320.
Role of the PD-1/PD-L1 Pathway in Experimental Trypanosoma cruzi Infection and Potential Therapeutic Options
- Arana Y, Gálvez RI, Jacobs T
- Front Immunol. 2022; 13: 866120
Exhausted PD-1+ TOX+ CD8+ T Cells Arise Only in Long-Term Experimental Trypanosoma cruzi Infection
- Gálvez RI and Jacobs T
- Front. Immunol., 03 June 2022 Sec. Parasite Immunology
2021
Deciphering the Plasmodium falciparum malaria-specific CD4+ T-cell response: ex vivo detection of high frequencies of PD-1+TIGIT+ EXP1-specific CD4+ T cells using a novel HLA-DR11-restricted MHC class II tetramer
- Schulte S, Heide J, Ackermann C, Peine S, Ramharter M, Mackroth MS, Woost R, Jacobs T, Schulze zur Wiesch J
- Clinical and Experimental Immunology, Volume 207, Issue 2, February 2022, Pages 227–236
The Effects of Acute Cardiovascular Exercise on Memory and Its Associations With Exercise-Induced Increases in Neurotrophic Factors
- Kuhne LA, Ksiezarczyk AM, Braumann KM, Reer R, Jacobs T, Röder B, Hötting K.
- Front Aging Neurosci. 2021 Nov 8;13:750401. doi: 10.3389/fnagi.2021.750401
Altered Cytokine Response of Human Brain Endothelial Cells after Stimulation with Malaria Patient Plasma
- Raacke M, Kerr A, Dörpinghaus M, Brehmer J, Wu Y, Lorenzen S, Fink C, Jacobs T, Roeder T, Sellau J, Bachmann A, Metwally NG, Bruchhaus I.
- Cells. 2021 Jul 1;10(7):1656. doi: 10.3390/cells10071656.
2020
T cells expressing multiple co-inhibitory molecules in acute malaria are not exhausted but exert a suppressive function in mice
- Brandi J, Lehmann C, Kaminski LC, Schulze Zur Wiesch J, Addo M, Ramharter M, Mackroth M, Jacobs T, Riehn M.
- Eur J Immunol. 2021 Nov 9. doi: 10.1002/eji.202149424
Classification of invasive bloodstream infections and Plasmodium falciparum malaria using autoantibodies as biomarkers
- Krumkamp R, Sunaina Struck N, Lorenz E, Zimmermann M, Gyau Boahen K, Sarpong N, Owusu-Dabo E, Pak GD, Jeon HJ, Marks F, Jacobs T, May J, Eibach D
- Sci Rep 10, 21168 (2020). https://doi.org/10.1038/s41598-020-78155-y
Programmed Cell Death Ligand (PD-L)-1 Contributes to the Regulation of CD4+ T Effector and Regulatory T Cells in Cutaneous Leishmaniasis
- de Freitas e Silva R, Gálvez RI, Alves Pereira VR, Felinto de Brito ME, Choy SL, Lotter H, Bosurgi Lidia, Jacobs T
- Front. Immunol., 22 October 2020 doi.org/10.3389/fimmu.2020.574491
Analysis of Co-Inhibitory Receptor Expression in COVID-19 Infection Compared to Acute Plasmodium Falciparum Malaria: LAG-3 and TIM-3 Correlate with T Cell Activation and Course of Disease
- Herrmann M, Schulte S, Wildner NH, Wittner M, Brehm TT, Ramharter M, Woost R, Lohse A, Jacobs T, Schulze Zur Wiesch J
- Front. Immunol., 26 August 2020 doi:10.3389/fimmu.2020.01870
Androgens predispose males to monocyte-mediated immunopathology by inducing the expression of leukocyte recruitment factor CXCL1
- Sellau J, Groneberg M, Fehling H, Thye T, Hoenow S, Marggraff C, Weskamm M, Hansen C, Stanelle-Bertram S, Kuehl S, Noll J, Wolf V, Metwally NG, Hagen SH, Dorn C, Wernecke J, Ittrich H, Tannich E, Jacobs T, Bruchhaus I, Altfeld M, Lotter H.
- Nat Commun. 2020 Jul 10;11(1):3459. doi: 10.1038/s41467-020-17260-y
Detection of EXP1-Specific CD4+ T Cell Responses Directed Against a Broad Range of Epitopes Including Two Promiscuous MHC Class II Binders During Acute Plasmodium falciparum Malaria
- Heide J, Wildner N, Ackermann C, Wittner M, Marget M, Sette A, Sidney J, Jacobs T, Schulze Zur Wiesch J
- Front. Immunol., 2020 Jan 22 doi:10.3389/fimmu.2019.03037
2019
Determinants of Post-Malarial Anemia in African Children Treated With Parenteral Artesunate
- Scheu K, Adegnika AA, Addo MM, Ansong D, Cramer JP, Fürst S, Kremsner PG, Kurth F, Jacobs T, May J, Ramharter M, Sylverken J, Vinnemeier CD, Agbenyega T, Rolling T
- Sci Rep. 2019 Dec 21; doi: 10.1038/s41598-019-54639-4
Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria
- Kaminski LC, Riehn M, Abel A, Steeg C, Dekugmen Yar D, Addai-Mensah O, Aminkiah F, Owusu-Dabo E, Jacobs T, Mackroth MS
- Front. Immunol., 2019 Dec 11 doi:10.3389/fimmu.2019.02917
Atypical Memory B-cells Are Associated With Plasmodium falciparum Anemia Through Anti-Phosphatidylserine Antibodies
- Rivera-Correa J, Mackroth MS, Jacobs T, Schulze Zur Wiesch J, Rolling T, Rodriguez A
- Elife. 2019 Nov 12; doi: 10.7554/eLife.48309
Cytokine Profile Distinguishes Children With P. Falciparum Malaria From Those With Bacterial Blood Stream Infections
- Struck NS, Zimmermann M, Krumkamp R, Lorenz E, Jacobs T, Rieger T, Wurr S, Günther S, Gyau Boahen K, Marks F, Sarpong N, Owusu-Dabo E, May J, Eibach D
- J Infect Dis. 2019 Nov 8; doi: 10.1093/infdis/jiz587
HCV-specific CD4+ T cells of patients with acute and chronic HCV infection display high expression of TIGIT and other co-inhibitory molecules.
- Ackermann C, Smits M, Woost R, Eberhard JM, Peine S, Kummer S, Marget M, Kuntzen T, Kwok WW, Lohse AW, Jacobs T, Boettler T, Schulze Zur Wiesch J
- Sci Rep. 2019 Jul 23;9(1):10624. doi: 10.1038/s41598-019-47024-8
Comprehensive Review of Human Plasmodium falciparum-Specific CD8+ T Cell Epitopes.
- Heide J, Vaughan KC, Sette A, Jacobs T, Schulze Zur Wiesch J
- Front Immunol. 2019 Mar 21;10:397. doi: 10.3389/fimmu.2019.00397
Differential expression pattern of co-inhibitory molecules on CD4+ T cells in uncomplicated versus complicated malaria
- Abel A, Steeg C, Aminkiah F, Addai-Mensah O, Addo M, Gagliani N, Casar C, Yar DD, Owusu-Dabo E, Jacobs T, Mackroth MS.
- Sci Rep. 2018 Mar 19;8(1):4789. doi: 10.1038/s41598-018-22659-1
2018
HVEM and CD160: Regulators of Immunopathology During Malaria Blood-Stage.
- Muscate F, Stetter N, Schramm C, Schulze Zur Wiesch J, Bosurgi L, Jacobs T
- Front Immunol. 2018 Nov 13;9:2611. doi: 10.3389/fimmu.2018.02611
Molecular and functional heterogeneity of IL-10-producing CD4+ T cells.
- Brockmann L, Soukou S, Steglich B, Czarnewski P, Zhao L, Wende S, Bedke T, Ergen C, Manthey C, Agalioti T, Geffken M, Seiz O, Parigi SM, Sorini C, Geginat J, Fujio K, Jacobs T, Roesch T, Izbicki JR, Lohse AW, Flavell RA, Krebs C, Gustafsson JA, Antonson P, Roncarolo MG, Villablanca E, Gagliani N, Huber S
- Nat Commun. 2018; 9:5457. doi: 10.1038/s41467-018-07581-4
Flt3 ligand expands bona fide innate lymphoid cell precursors in vivo.
- Parigi SM, Czarnewski P, Das S, Steeg C, Brockmann L, Fernandez-Gaitero S, Yman V, Forkel M, Höög C, Mjösberg J, Westerberg L, Färnert A, Huber S, Jacobs T, Villablanca EJ.
- Sci Rep. 2018 Jan 9;8(1):154. doi: 10.1038/s41598-017-18283-0
2016
Myeloperoxidase Attenuates Pathogen Clearance during Plasmodium yoelii Nonlethal Infection.
- Theeß W, Sellau J, Steeg C, Klinke A, Baldus S, Cramer JP, Jacobs T
- Infect Immun. 2016 Dec 29;85(1). pii: e00475-16. doi: 10.1128/IAI.00475-16. Print 2017 Jan
Acute Malaria Induces PD1+CTLA4+ Effector T Cells with Cell-Extrinsic Suppressor Function.
- Mackroth MS, Abel A, Steeg C, Schulze Zur Wiesch J, Jacobs T.
- PLoS Pathog. 2016 Nov 1;12(11):e1005909. doi: 10.1371/journal.ppat.1005909. eCollection 2016 Nov
IL-22 dampens the T cell response in experimental malaria
- Sellau J, Alvarado CF, Hoenow S, Mackroth MS, Kleinschmidt D, Huber S, & Jacobs T
- Sci. Rep. (2016) 6, 28058; doi: 10.1038/srep28058
IL-23 promotes immunopathology and prevents IL-13-dependent tissue repair associated with Ly6Clo monocytes in Entamoeba histolytica-induced liver damage.
- Noll J, Helk E, Fehling H, Bernin H, Marggraff C, Jacobs T, Huber S, Pelczar P, Ernst T, Ittrich H, Otto B, Mittrücker HW, Hölscher C, Tacke F, Bruchhaus I, Tannich E, Lotter H.
- J Hepatol. 2016 Jan 22. pii: S0168-8278(16)00019-2. doi: 10.1016/j.jhep.2016.01.013. [Epub ahead of print]
Unique human immune signature of Ebola virus disease in Guinea
- Ruibal P, Oestereich L, Lüdtke A, Becker-Ziaja B, Wozniak DM, Kerber R, Korva M, Cabeza-Cabrerizo M, Bore JA, Koundouno FR, Duraffour S, Weller R, Thorenz A, Cimini E, Viola D, Agrati C, Repits J, Afrough B, Cowley LA, Ngabo D, Hinzmann J, Mertens M, Vitoriano I, Christopher H. Logue, Boettcher JP, Pallasch E, Sachse A, Bah A, Nitzsche K, Kuisma E, Michel J, Holm T, Zekeng EG, García-Dorival I, Wölfel R, Stoecker K, Fleischmann E, Strecker T, Di Caro A, Avšič-Županc T, Kurth A, Meschi S, Mély S, Newman E, Bocquin A, Kis Z, Kelterbaum A, Molkenthin P, Fabrizio Carletti F, Portmann J, Wolff S, Castilletti C, Schudt G, Fizet F, Ottowell LJ, Herker E, Jacobs T, Kretschmer B, Severi E, Ouedraogo N, Lago M, Negredo A, Franco L, Anda P, Schmiedel S, Kreuels B, Wichmann D, Addo MM, Lohse AW, De Clerck H, Nanclares C, Jonckheere S, Van Herp M, Sprecher A, Xiaojiang G, Carrington M, Miranda O, Castro CM, Gabriel M, Drury P, Formenty P, Diallo B, Koivogui L, Magassouba N, Carroll MW, Günther S & Muñoz-Fontela C
- Nature (2016) 533; 100–104
2015
EBI3 suppresses Th1, Th17 and Th2 immune responses after Trypanosoma cruzi infection and inhibits parasite replication by interfering with alternative macrophage activation
- Böhme J, Roßnagel C, Jacobs T, Behrends J, Hölscher C, Erdmann H.
- Immunology. 2015 Dec 23. doi: 10.1111/imm.12565. [Epub ahead of print]
Mycobacterium tuberculosis Coinfection Has No Impact on Plasmodium berghei ANKA-Induced Experimental Cerebral Malaria in C57BL/6 Mice.
- Blank J, Behrends J, Jacobs T, Schneider BE.
- Infect Immun. 2015 Dec 7;84(2):502-10.
The Application of Anti-Toso Antibody Enhances CD8+ T Cell Responses in Experimental Malaria Vaccination and Disease
- Lapke N., Tartz S., Lee KH. & Jacobs T.
- Vaccine 2015, accepted for publication
Involvement of sulfates from cruzipain, a major antigen of Trypanosoma cruzi, in the interaction with immunomodulatory molecule Siglec-E.
- Ferrero MR., Heins AM., Soprano LL., Acosta DM., Esteva MI., Jacobs T.*, Duschak VG.* *shared senior authors
- Med Microbiol Immunol. 2015 Jun 6. [Epub ahead of print]
Cutting Edge: The BTLA-HVEM Regulatory Pathway Interferes with Protective Immunity to Intestinal Helminth Infection
- Breloer M., Hartmann W., Blankenhaus B., Eschbach ML., Pfeffer K. & Jacobs T.
- J Immunol. 2015 Feb 15;194(4):1413-6. doi: 10.4049/jimmunol.1402510. Epub 2015 Jan 16.
2014
Depletion of regulatory T cells augments a vaccine-induced T effector cell response against the liver-stage of malaria but fails to increase memory
- Espinoza Mora R, Steeg C, Tartz S, Heussler V, Sparwasser T, Link A, Fleischer B & Jacobs T
- PLoS One 2014; 12:e104627
Immune markers characteristic for asymptomatically infected and diseased Entamoeba histolytica individuals and their relation to sex
- Bernin H, Marggraff C, Jacobs T, Brattig N, An L, Blessmann J & Lotter H.
- BMC Infect Dis. 2014 Nov 25;14:621. doi: 10.1186/s12879-014-0621-1.
2013
Hepatocytes contribute to immune regulation in the liver by activation of the Notch signaling pathway in T cells.
- Burghardt S., Erhardt A., Claass B., Huber S., Jacobs T., Stevanovic M., Schmidt-Arras D., Rose-John S., Karimi K. & Tiegs G.
- J Immunol. 2013 Dec 1;191(11):5574-82. doi: 10.4049/jimmunol.1300826. Epub 2013 Oct 18.
Testosterone increases susceptibility to amebic liver abscess in mice and mediates inhibition of IFNγ secretion in natural killer T cells.
- Lotter H., Helk E., Bernin H., Jacobs T., Prehn C., Adamski J., González-Roldán N., Holst O. & Tannich E.
- PLoS One. 2013;8(2):e55694. doi: 10.1371/journal.pone.0055694. Epub 2013 Feb 12.
A new approach to generate a safe double-attenuated Plasmodium liver stage vaccine.
- Nagel A., Prado M., Heitmann A., Tartz S., Jacobs T., Deschermeier C., Helm S., Stanway R. & Heussler V.
- Int J Parasitol. 2013 May;43(6):503-14. doi: 10.1016/j.ijpara.2013.01.010. Epub 2013 Mar 13.
Plasmodium berghei sporozoite challenge of vaccinated BALB/c mice leads to the induction of humoral immunity and improved function of CD8(+) memory T cells.
- Tartz S., Deschermeier C., Retzlaff S., Heussler V., Sebo P., Fleischer B. & Jacobs T.
- Eur J Immunol. 2013 Mar;43(3):693-704. doi: 10.1002/eji.201142262. Epub 2013 Jan 18.
TNFα-mediated liver destruction by kupffer cells and Ly6Chi monocytes during Entamoeba histolytica infection.
- Helk E., Bernin H., Ernst T., Ittrich H., Jacobs T., Heeren J., Tacke F., Tannich E. & Lotter H.
- PLoS Pathog. 2013 Jan;9(1):e1003096. doi: 10.1371/journal.ppat.1003096. Epub 2013 Jan 3.
2012
Dissection of minimal sequence requirements for rhoptry membrane targeting in the malaria parasite.
- Cabrera A., Herrmann S., Warszta D., Santos JM., John Peter AT., Kono M., Debrouver S., Jacobs T., Spielmann T., Ungermann C., Soldati-Favre D. & Gilberger TW.
- Traffic. 2012 Oct;13(10):1335-50. doi: 10.1111/j.1600-0854.2012.01394.x. Epub 2012 Aug 1.
Efficient control of Plasmodium yoelii infection in BALB/c and C57BL/6 mice with pre-existing Strongyloides ratti infection
- Kolbaum J., Eschbach M.-L., Steeg C., Jacobs T., Fleischer B. & Breloer M.
- Parasite Immunol. 2012 Jul;34(7):388-93. doi: 10.1111/j.1365-3024.2012.01369.x.
Nematode-induced interference with the anti-Plasmodium CD8+ T-cell response can be overcome by optimizing antigen administration.
- Kolbaum J., Tartz S., Helm S., Nagel A., Heussler V., Sebo P., Fleischer B., Jacobs T.* & Breloer M.* *contributed equally
- Eur J Immunol. 2012 Apr;42(4):890-900. doi: 10.1002/eji.201141955. Epub 2012 Jan 19.
2011
B and T Lymphocyte Attenuator (BTLA) Restricts the Protective Immune Response Against Experimental Malaria
- Adler G., Steeg C., Pfeffer K., Murphy T.L., Murphy K.M., Langhorne J. & Jacobs T.
- J Immunol. 2011 Nov 15;187(10):5310-9. doi: 10.4049/jimmunol.1101456. Epub 2011 Oct 12.
Strongyloides ratti infection induces expansion of Foxp3+ regulatory T cells that interfere with immune response and parasite clearance in BALB/c mice.
- Blankenhaus B., Klemm U., Eschbach M.-L., Sparwasser T., Huehn J., Kühl A.A., Loddenkemper C., Jacobs T. & Breloer M.
- J Immunol. 2011 Apr 1;186(7):4295-305. doi: 10.4049/jimmunol.1001920. Epub 2011 Feb 18.
Invasion of Trypanosoma cruzi into host cells is impaired by N-propionylmannosamine and other N-acylmannosamines.
- Lieke T., Gröbe D., Blanchard V., Grunow D., Tauber R., Zimmermann-Kordmann M., Jacobs T. & Reutter W.
- Glycoconj J. 2011 Jan;28(1):31-7. doi: 10.1007/s10719-010-9321-2. Epub 2011 Jan 15.
2010
Differential effects of C3d on the immunogenicity of gene gun vaccines encoding Plasmodium falciparum and Plasmodium berghei MSP1.
- Weiss R., Gabler M., Jacobs T., Gilberger T.W., Thalhamer J. & Scheiblhofer S.
- Vaccine. 2010 Jun 17;28(28):4515-22. doi: 10.1016/j.vaccine.2010.04.054. Epub 2010 May 15.
Molecular interaction of Siglecs (sialic acid-binding Ig-like lectins) with sialylated ligands on Trypanosoma cruzi.
- Jacobs T., Erdmann H. & Fleischer B.
- Eur J Cell Biol. 2010 Jan;89(1):113-6. doi: 10.1016/j.ejcb.2009.10.006. Epub 2009 Nov 11.
2009
Limited role of CD4+Foxp3+ regulatory T cells in the control of experimental cerebral malaria.
- Steeg C., Adler A., Sparwasser T., Fleischer B. & Jacobs T.
- J Immunol. 2009 Dec 1;183(11):7014-22. doi: 10.4049/jimmunol.0901422. Epub 2009 Nov 4.
Sialylated ligands on pathogenic Trypanosoma cruzi interact with Siglec-E (sialic acid-binding Ig-like lectin-E).
- Erdmann H., Steeg C., Koch-Nolte F., Fleischer B. & Jacobs T.
- Cell Microbiol. 2009 Nov;11(11):1600-11. doi: 10.1111/j.1462-5822.2009.01350.x. Epub 2009 Jun 22.
Natural killer T cells activated by a lipopeptidophosphoglycan from Entamoeba histolytica are critically important to control amebic liver abscess.
- Lotter H., González-Roldán N., Lindner B., Winau F., Isibasi A., Moreno-Lafont M., Ulmer A. J., Holst O., Tannich E. & Jacobs T.
- PLoS Pathog. 2009 May;5(5):e1000434. doi: 10.1371/journal.ppat.1000434. Epub 2009 May 15.
2008
Complete protection against P. berghei malaria upon heterologous prime/boost immunization against circumsporozoite protein employing Salmonella type III secretion system and Bordetella adenylate cyclase toxoid.
- Tartz S., Rüssmann H., Kamanova J., Sebo P., Sturm A., Heussler V., Fleischer B. & Jacobs T.
- Vaccine. 2008 Nov 5;26(47):5935-43. doi: 10.1016/j.vaccine.2008.08.057. Epub 2008 Sep 17.
MyD88/IL-18-dependent pathways rather than TLRs control early parasitaemia in non-lethal Plasmodium yoelii infection.
- Cramer J. P., Kamena F., Lepenies B., Hölscher C., Freudenberg M. A., Burchard Gerd D., Kirschning C. J., Seeberger P. H. & Jacobs T.
- Microbes Infect. 2008 Oct;10(12-13):1259-65. doi: 10.1016/j.micinf.2008.07.024. Epub 2008 Jul 22.
Liposome-encapsulated antigens induce a protective CTL response against Listeria monocytogenes independent of CD4+ T cell help.
- Grenningloh R., Darji A., Bauer H., zur Lage S., Chakraborty T., Jacobs T. & Weiss S.
- Scand J Immunol. 2008 Jun;67(6):594-602. doi: 10.1111/j.1365-3083.2008.02112.x. Epub 2008 Apr 21.
The antimicrobial peptide NK-2, the core region of mammalian NK-lysin, kills intraerythrocytic Plasmodium falciparum.
- Gelhaus C., Jacobs T., Andrä J. & Leippe M.
- Antimicrob Agents Chemother. 2008 May;52(5):1713-20. doi: 10.1128/AAC.01342-07. Epub 2008 Mar 10.
Simvastatin treatment shows no effect on the incidence of cerebral malaria or parasitemia during experimental malaria.
- Kobbe R., Schreiber N., May J. & Jacobs T.
- Antimicrob Agents Chemother. 2008 Apr;52(4):1583-4. doi: 10.1128/AAC.01428-07. Epub 2008 Feb 11.
Induction of experimental cerebral malaria is independent of TLR2/4/9.
- Lepenies B., Cramer J. P., Burchard G. D., Wagner H., Kirschning C. J., Fleischer B., & Jacobs T.
- Med Microbiol Immunol. 2008 Mar;197(1):39-44. Epub 2007 Aug 1.
2007
Ligation of B and T lymphocyte attenuator (BTLA) prevents the genesis of experimental cerebral malaria.
- Lepenies B., Pfeffer K., Hurchla M. A., Murphy T. L., Murphy K. M., Oetzel J., Fleischer B. & Jacobs T.
- J Immunol. 2007 Sep 15;179(6):4093-100.
The cholesterol dependent cytolysin Listeriolysin O, aggregates rafts via oligomerization
- Gekara N. O., Jacobs, T., Chakraborty, T. & Weiss, S.
- Cell Microbiol. 2005 Sep;7(9):1345-56.
CTLA-4 blockade differentially influences the outcome of non-lethal and lethal Plasmodium yoelii infections.
- Lepenies B., Gaworski I., Tartz S., Langhorne J., Fleischer B. & Jacobs T.
- Microbes Infect. 2007 May;9(6):687-94. Epub 2007 Feb 23.
2006
Spontaneous recovery of pathogenicity by Leishmania major hsp100-/- alters the immune response in mice.
- Reiling L.*, Jacobs T.*, Gaworski I., Kroemer K., Graefe G.& Clos J. *contributed equally.
- Infect Immun. 2006 Nov;74(11):6027-36.
Interaction of natural killer cells with Trypanosoma cruzi-infected fibroblasts.
- Lieke T., Graefe S. E.B., Steeg C., Fleischer B. & Jacobs T.
- Clin Exp Immunol. 2006 Aug;145(2):357-64.
Immunization with a circumsporozoite epitope fused to Bordetella adenylate cyclase in conjunction with CTLA-4 blockade confers protection against P. berghei liver stage malaria.
- Tartz S., Kamanova J., Sebo P., Bolte S., Heussler V., Fleischer B. & Jacobs T.
- Infect Immun. 2006 Apr;74(4):2277-85.
Sexual dimorphism in the control of amebic liver abscess in a mouse model of disease.
- Lotter H.*, Jacobs T.*, Gaworski I. & Tannich E. *contributed equally
- Infect Immun. 2006 Jan;74(1):118-24.
2005
Complement C3 is required for progression of cutaneous lesions and parasite dissemination in Leishmania major infection.
- Jacobs T., Andrä J., Gaworski I., Graefe S.E.B., Mellenthin K., Krömer M, Halter R., Borlak J. & Clos J.
- Med Microbiol Immunol. 2005 May;194(3):143-9. Epub 2004 Sep 17.
