Our publication
2023
N'-Phenylacetohydrazide Derivatives as Potent Ebola Virus Entry Inhibitors with an Improved Pharmacokinetic Profile
- Garcia-Rubia A, Lasala F, Ginex T, Morales-Tenorio M, Olal C, Heung M, Oquist P, Galindo I, Cuesta-Geijo MÁ, Casasnovas JM, Campillo NE, Canales Á, Alonso C, Martínez A, Muñoz-Fontela C, Delgado R, Gil C
- J Med Chem. 2023 Apr 27;66(8):5465-5483. doi: 10.1021/acs.jmedchem.2c01785
Use of Hu-PBL Mice to Study Pathogenesis of Human-Restricted Viruses
- Brunetti JE, Kitsera M, Muñoz-Fontela C, Rodríguez E
- Viruses. 2023 Jan 13;15(1):228. doi: 10.3390/v15010228
Animal Model Alternatives in Filovirus and Bornavirus Research
- Widerspick L, Steffen JF, Tappe D, Muñoz-Fontela C
- Viruses. 2023 Jan 4;15(1):158. doi: 10.3390/v15010158
2022
In vivo characterization of the novel ebolavirus Bombali virus suggests a low pathogenic potential for humans
- Bodmer BS, Breithaupt A, Heung M, Brunetti JE, Henkel C, Müller-Guhl J, Rodríguez E, Wendt L, Winter SL, Vallbracht M, Müller A, Römer S, Chlanda P, Muñoz-Fontela C, Hoenen T, Escudero-Pérez B
- Emerg Microbes Infect. 2023 Dec;12(1):2164216. doi: 10.1080/22221751.2022.2164216
An introduction to the Marburg virus vaccine consortium, MARVAC
- Cross RW, Longini IM, Becker S, Bok K, Boucher D, Carroll MW, Díaz JV, Dowling WE, Draghia-Akli R, Duworko JT, Dye JM, Egan MA, Fast P, Finan A, Finch C, Fleming TR, Fusco J, Geisbert TW, Griffiths A, Günther S, Hensley LE, Honko A, Hunegnaw R, Jakubik J, Ledgerwood J, Luhn K, Matassov D, Meshulam J, Nelson EV, Parks CL, Rustomjee R, Safronetz D, Schwartz LM, Smith D, Smock P, Sow Y, Spiropoulou CF, Sullivan NJ, Warfield KL, Wolfe D, Woolsey C, Zahn R, Henao-Restrepo AM, Muñoz-Fontela C, Marzi A
- PLoS Pathog. 2022 Oct 13;18(10):e1010805. doi: 10.1371/journal.ppat.1010805
Lessons from the pandemic: Responding to emerging zoonotic viral diseases-a Keystone Symposia report
- Cable J, Fauci A, Dowling WE, Günther S, Bente DA, Yadav PD, Madoff LC, Wang LF, Arora RK, Van Kerkhove M, Chu MC, Jaenisch T, Epstein JH, Frost SDW, Bausch DG, Hensley LE, Bergeron É, Sitaras I, Gunn MD, Geisbert TW, Muñoz-Fontela C, Krammer F, de Wit E, Nordenfelt P, Saphire EO, Gilbert SC, Corbett KS, Branco LM, Baize S, van Doremalen N, Krieger MA, Clemens SAC, Hesselink R, Hartman D
- Ann N Y Acad Sci. 2022 Dec;1518(1):209-225. doi: 10.1111/nyas.14898
Making more COVID-19 vaccines available to address global needs: Considerations and a framework for their evaluation
- Krause PR, Arora N, Dowling W, Muñoz-Fontela C, Funnell S, Gaspar R, Gruber MF, Hacker A, Henao-Restrepo AM, Plotkin S, Rees HV, Smith DK, Swaminathan S
- Vaccine. 2022 Sep 22;40(40):5749-5751. doi: 10.1016/j.vaccine.2022.07.028
Avatar Mice Underscore the Role of the T Cell-Dendritic Cell Crosstalk in Ebola Virus Disease and Reveal Mechanisms of Protection in Survivors
- Rottstegge M, Tipton T, Oestereich L, Ruibal P, Nelson EV, Olal C, Port JR, Seibel J, Pallasch E, Bockholt S, Koundouno FR, Boré JA, Rodríguez E, Escudero-Pérez B, Günther S, Carroll MW, Muñoz-Fontela C
- J Virol. 2022 Sep 28;96(18):e0057422. doi: 10.1128/jvi.00574-22
A platform trial design for preventive vaccines against Marburg virus and other emerging infectious disease threats
- Longini IM, Yang Y, Fleming TR, Muñoz-Fontela C, Wang R, Ellenberg SS, Qian G, Halloran ME, Nason M, Gruttola V, Mulangu S, Huang Y, Donnelly CA, Henao Restrepo AM
- Clin Trials. 2022 Dec;19(6):647-654. doi: 10.1177/17407745221110880
Zaire ebolavirus surveillance near the Bikoro region of the Democratic Republic of the Congo during the 2018 outbreak reveals presence of seropositive bats
- Seifert SN, Fischer RJ, Kuisma E, Badzi Nkoua C, Bounga G, Akongo MJ, Schulz JE, Escudero-Pérez B, Akoundzie BJ, Ampiri VRB, Dieudonne A, Indolo GD, Kaba SD, Louzolo I, Macosso LN, Mavoungou Y, Miegakanda VB, Nina RA, Samabide KT, Ondzie AI, Ntoumi F, Muñoz-Fontela C, Mombouli JV, Olson SH, Walzer C, Niama FR, Munster VJ
- PLoS Negl Trop Dis. 2022 Jun 22;16(6):e0010504. doi: 10.1371/journal.pntd.0010504
Inactivation Methods for Experimental Nipah Virus Infection
- Widerspick L, Vázquez CA, Niemetz L, Heung M, Olal C, Bencsik A, Henkel C, Pfister A, Brunetti JE, Kucinskaite-Kodze I, Lawrence P, Muñoz Fontela C, Diederich S, Escudero-Pérez B
- Viruses. 2022 May 15;14(5):1052. doi: 10.3390/v14051052
Advances and gaps in SARS-CoV-2 infection models
- Muñoz-Fontela C, Widerspick L, Albrecht RA, Beer M, Carroll MW, de Wit E, Diamond MS, Dowling WE, Funnell SGP, García-Sastre A, Gerhards NM, de Jong R, Munster VJ, Neyts J, Perlman S, Reed DS, Richt JA, Riveros-Balta X, Roy CJ, Salguero FJ, Schotsaert M, Schwartz LM, Seder RA, Segalés J, Vasan SS, Henao-Restrepo AM, Barouch DH
- PLoS Pathog. 2022 Jan 13;18(1):e1010161. doi: 10.1371/journal.ppat.1010161
2021
Quantification of Type I Interferon Inhibition by Viral Proteins: Ebola Virus as a Case Study
- Locke M, Lythe G, López-García M, Muñoz-Fontela C, Carroll M, Molina-París C
- Viruses. 2021 Dec 4;13(12):2441. doi: 10.3390/v13122441
Potential pharmacological strategies targeting the Niemann-Pick C1 receptor and Ebola virus glycoprotein interaction
- Morales-Tenorio M, Ginex T, Cuesta-Geijo MÁ, Campillo NE, Muñoz-Fontela C, Alonso C, Delgado R, Gil C
- Eur J Med Chem. 2021 Nov 5:223:113654. doi: 10.1016/j.ejmech.2021.113654
Expression of the Ebola Virus VP24 Protein Compromises the Integrity of the Nuclear Envelope and Induces a Laminopathy-Like Cellular Phenotype
- Vidal S, Sánchez-Aparicio M, Seoane R, El Motiam A, Nelson EV, Bouzaher YH, Baz-Martínez M, García-Dorival I, Gonzalo S, Vázquez E, Vidal A, Muñoz-Fontela C, García-Sastre A, Rivas C
- mBio. 2021 Aug 31;12(4):e0097221. doi: 10.1128/mBio.00972-21
SARS-CoV-2 Variants and Vaccines
- Krause PR, Fleming TR, Longini IM, Peto R, Briand S, Heymann DL, Beral V, Snape MD, Rees H, Ropero AM, Balicer RD, Cramer JP, Muñoz-Fontela C, Gruber M, Gaspar R, Singh JA, Subbarao K, Van Kerkhove MD, Swaminathan S, Ryan MJ, Henao-Restrepo AM
- N Engl J Med. 2021 Jul 8;385(2):179-186. doi: 10.1056/NEJMsr2105280
Development and validation of portable, field-deployable Ebola virus point-of-encounter diagnostic assay for wildlife surveillance
- Figueroa DM, Kuisma E, Matson MJ, Ondzie AU, Bushmaker T, Seifert SN, Ntoumi F, Escudero-Pérez B, Muñoz-Fontela C, Walzer C, Olson SH, Goma-Nkoua C, Mombouli JV, Fischer RJ, Munster VJ
- One Health Outlook. 2021 May 24;3(1):9. doi: 10.1186/s42522-021-00041-y
Reduced Nucleoprotein Availability Impairs Negative-Sense RNA Virus Replication and Promotes Host Recognition
- Nilsson-Payant BE, Blanco-Melo D, Uhl S, Escudero-Pérez B, Olschewski S, Thibault P, Panis M, Rosenthal M, Muñoz-Fontela C, Lee B, tenOever BR
- J Virol. 2021 Apr 12;95(9):e02274-20. doi: 10.1128/JVI.02274-20
Longitudinal antibody and T cell responses in Ebola virus disease survivors and contacts: an observational cohort study
- Thom R, Tipton T, Strecker T, Hall Y, Akoi Bore J, Maes P, Raymond Koundouno F, Fehling SK, Krähling V, Steeds K, Varghese A, Bailey G, Matheson M, Kouyate S, Coné M, Moussa Keita B, Kouyate S, Richard Ablam A, Laenen L, Vergote V, Guiver M, Timothy J, Atkinson B, Ottowell L, Richards KS, Bosworth A, Longet S, Mellors J, Pannetier D, Duraffour S, Muñoz-Fontela C, Sow O, Koivogui L, Newman E, Becker S, Sprecher A, Raoul H, Hiscox J, Henao-Restrepo AM, Sakoba K, Magassouba N, Günther S, Kader Konde M, Carroll MW
- Lancet Infect Dis. 2021 Apr;21(4):507-516. doi: 10.1016/S1473-3099(20)30736-2
Metagenomic Snapshots of Viral Components in Guinean Bats
- Hermida Lorenzo RJ, Cadar D, Koundouno FR, Juste J, Bialonski A, Baum H, García-Mudarra JL, Hakamaki H, Bencsik A, Nelson EV, Carroll MW, Magassouba N, Günther S, Schmidt-Chanasit J, Muñoz Fontela C, Escudero-Pérez B
- Microorganisms. 2021 Mar 15;9(3):599. doi: 10.3390/microorganisms9030599
Factors associated with progression to death in patients with Lassa fever in Nigeria: an observational study
- Strampe J, Asogun DA, Speranza E, Pahlmann M, Soucy A, Bockholt S, Pallasch E, Becker-Ziaja B, Duraffour S, Bhadelia N, Ighodalo Y, Oyakhilome J, Omomoh EO, Olokor T, Adomeh DI, Ikponwonsa O, Aire C, Tobin E, Akpede N, Okokhere PO, Okogbenin SA, Akpede GO, Muñoz-Fontela C, Ogbaini-Emovon E, Günther S, Connor JH, Oestereich L
- Lancet Infect Dis. 2021 Jun;21(6):876-886. doi: 10.1016/S1473-3099(20)30737-4
Human Diversity of Killer Cell Immunoglobulin-Like Receptors and Human Leukocyte Antigen Class I Alleles and Ebola Virus Disease Outcomes
- Wawina-Bokalanga T, Vanmechelen B, Lhermitte V, Martí-Carreras J, Vergote V, Koundouno FR, Akoi-Boré J, Thom R, Tipton T, Steeds K, Moussa KB, Amento A, Laenen L, Duraffour S, Gabriel M, Ruibal P, Hall Y, Kader-Kondé M, Günther S, Baele G, Muñoz-Fontela C, Van Weyenbergh J, Carroll MW, Maes P
- Emerg Infect Dis. 2021 Jan;27(1):76-84. doi: 10.3201/eid2701.202177
2020
N-terminal VP1 Truncations Favor T = 1 Norovirus-Like Particles
- Pogan R, Weiss VU, Bond K, Dülfer J, Krisp C, Lyktey N, Müller-Guhl J, Zoratto S, Allmaier G, Jarrold MF, Muñoz-Fontela C, Schlüter H, Uetrecht C
- Vaccines (Basel). 2020 Dec 24;9(1):8. doi: 10.3390/vaccines9010008
Designs and Characterization of Subunit Ebola GP Vaccine Candidates: Implications for Immunogenicity
- Agnolon V, Kiseljak D, Wurm MJ, Wurm FM, Foissard C, Gallais F, Wehrle S, Muñoz-Fontela C, Bellanger L, Correia BE, Corradin G, Spertini F
- Front Immunol. 2020 Nov 4:11:586595. doi: 10.3389/fimmu.2020.586595
Severe Human Lassa Fever Is Characterized by Nonspecific T-Cell Activation and Lymphocyte Homing to Inflamed Tissues
- Port JR, Wozniak DM, Oestereich L, Pallasch E, Becker-Ziaja B, Müller J, Rottstegge M, Olal C, Gómez-Medina S, Oyakhliome J, Ighodalo Y, Omomoh E, Olokor T, Adomeh DI, Asogun D, Ogbani-Emovon E, Hartmann K, Krasemann S, Nelson EV, Escudero-Pérez B, McElroy AK, Günther S, Muñoz-Fontela C
- J Virol. 2020 Oct 14;94(21):e01367-20. doi: 10.1128/JVI.01367-20
Animal models for COVID-19
- Muñoz-Fontela C, Dowling WE, Funnell SGP, Gsell PS, Riveros-Balta AX, Albrecht RA, Andersen H, Baric RS, Carroll MW, Cavaleri M, Qin C, Crozier I, Dallmeier K, de Waal L, de Wit E, Delang L, Dohm E, Duprex WP, Falzarano D, Finch CL, Frieman MB, Graham BS, Gralinski LE, Guilfoyle K, Haagmans BL, Hamilton GA, Hartman AL, Herfst S, Kaptein SJF, Klimstra WB, Knezevic I, Krause PR, Kuhn JH, Le Grand R, Lewis MG, Liu WC, Maisonnasse P, McElroy AK, Munster V, Oreshkova N, Rasmussen AL, Rocha-Pereira J, Rockx B, Rodríguez E, Rogers TF, Salguero FJ, Schotsaert M, Stittelaar KJ, Thibaut HJ, Tseng CT, Vergara-Alert J, Beer M, Brasel T, Chan JFW, García-Sastre A, Neyts J, Perlman S, Reed DS, Richt JA, Roy CJ, Segalés J, Vasan SS, Henao-Restrepo AM, Barouch DH
- Nature. 2020 Oct;586(7830):509-515. doi: 10.1038/s41586-020-2787-6
Chikungunya Outbreak in the Republic of the Congo, 2019-Epidemiological, Virological and Entomological Findings of a South-North Multidisciplinary Taskforce Investigation
- Vairo F, Aimè Coussoud-Mavoungou MP, Ntoumi F, Castilletti C, Kitembo L, Haider N, Carletti F, Colavita F, Gruber CEM, Iannetta M, Messina F, Lanini S, Ulrich Judicaël B, Giombini E, Montaldo C, Portella C, Diafouka-Diatela S, Rueca M, Kock R, Bartolini B, Mboera L, Munster V, Fischer R, Seifert S, Muñoz-Fontela C, Escudero-Pérez B, Gomez-Medina S, Nelson EV, Kjia Tungu P, Nicastri E, Puro V, Di Caro A, Capobianchi MR, Mikolo JL, Zumla A, Ippolito G, On Behalf Of The Pandora-Id-Net Consortium Chikungunya Outbreak Group Taskforce
- Viruses. 2020 Sep 13;12(9):1020. doi: 10.3390/v12091020
Emerging preclinical evidence does not support broad use of hydroxychloroquine in COVID-19 patients
- Funnell SGP, Dowling WE, Muñoz-Fontela C, Gsell PS, Ingber DE, Hamilton GA, Delang L, Rocha-Pereira J, Kaptein S, Dallmeier KH, Neyts J, Rosenke K, de Wit E, Feldmann H, Maisonnasse P, Le Grand R, Frieman MB, Coleman CM
- Nat Commun. 2020 Aug 26;11(1):4253. doi: 10.1038/s41467-020-17907-w
Ebola Virus Disease Survivors Show More Efficient Antibody Immunity than Vaccinees Despite Similar Levels of Circulating Immunoglobulins
- Koch T, Rottstegge M, Ruibal P, Gomez-Medina S, Nelson EV, Escudero-Pérez B, Pillny M, Ly ML, Koundouno FR, Bore JA, Magassouba N, Dahlke C, Günther S, Carroll MW, Addo MM, Muñoz-Fontela C
- Viruses. 2020 Aug 20;12(9):915. doi: 10.3390/v12090915
2019
Regulation of the Ebola Virus VP24 Protein by SUMO
- Vidal S, El Motiam A, Seoane R, Preitakaite V, Bouzaher YH, Gómez-Medina S, San Martín C, Rodríguez D, Rejas MT, Baz-Martínez M, Barrio R, Sutherland JD, Rodríguez MS, Muñoz-Fontela C, Rivas C
- J Virol. 2019 Dec 12;94(1):e01687-19. doi: 10.1128/JVI.01687-19
Correction to 'Long-term wildlife mortality surveillance in northern Congo: a model for the detection of Ebola virus disease epizootics'
- Kuisma E, Olson SH, Cameron KN, Reed PE, Karesh WB, Ondzie AI, Akongo MJ, Kaba SD, Fischer RJ, Seifert SN, Muñoz-Fontela C, Becker-Ziaja B, Escudero-Pérez B, Goma-Nkoua C, Munster VJ, Mombouli JV
- Philos Trans R Soc Lond B Biol Sci. 2019 Nov 25;374(1786):20190658. doi: 10.1098/rstb.2019.0658
Comparative pathogenesis of Ebola virus and Reston virus infection in humanized mice
- Escudero-Pérez B, Ruibal P, Rottstegge M, Lüdtke A, Port JR, Hartmann K, Gómez-Medina S, Müller-Guhl J, Nelson EV, Krasemann S, Rodríguez E, Muñoz-Fontela C
- JCI Insight. 2019 Nov 1;4(21):e126070. doi: 10.1172/jci.insight.126070
Long-term wildlife mortality surveillance in northern Congo: a model for the detection of Ebola virus disease epizootics
- Kuisma E, Olson SH, Cameron KN, Reed PE, Karesh WB, Ondzie AI, Akongo MJ, Kaba SD, Fischer RJ, Seifert SN, Muñoz-Fontela C, Becker-Ziaja B, Escudero-Pérez B, Goma-Nkoua C, Munster VJ, Mombouli JV
- Philos Trans R Soc Lond B Biol Sci. 2019 Sep 30;374(1782):20180339. doi: 10.1098/rstb.2018.0339
Role of Type I Interferons on Filovirus Pathogenesis
- Escudero-Pérez B, Muñoz-Fontela C
- Vaccines (Basel). 2019 Feb 20;7(1):22. doi: 10.3390/vaccines7010022
Analysis of exotic squirrel trade and detection of human infections with variegated squirrel bornavirus 1, Germany, 2005 to 2018
- Tappe D, Frank C, Homeier-Bachmann T, Wilking H, Allendorf V, Schlottau K, Muñoz-Fontela C, Rottstegge M, Port JR, Rissland J, Eisermann P, Beer M, Schmidt-Chanasit J
- Euro Surveill. 2019 Feb;24(8):1800483. doi: 10.2807/1560-7917.ES.2019.24.8.1800483
2018
T-Cell Receptor Diversity and the Control of T-Cell Homeostasis Mark Ebola Virus Disease Survival in Humans
- Speranza E, Ruibal P, Port JR, Feng F, Burkhardt L, Grundhoff A, Günther S, Oestereich L, Hiscox JA, Connor JH, Muñoz-Fontela C
- J Infect Dis. 2018 Nov 22;218(suppl_5):S508-S518. doi: 10.1093/infdis/jiy352
Kinetics of Soluble Mediators of the Host Response in Ebola Virus Disease
- Kerber R, Krumkamp R, Korva M, Rieger T, Wurr S, Duraffour S, Oestereich L, Gabriel M, Sissoko D, Anglaret X, Malvy D, May J, Županc TA, Muñoz-Fontela C, Günther S
- J Infect Dis. 2018 Nov 22;218(suppl_5):S496-S503. doi: 10.1093/infdis/jiy429
Outbreaks in a Rapidly Changing Central Africa - Lessons from Ebola
- Munster VJ, Bausch DG, de Wit E, Fischer R, Kobinger G, Muñoz-Fontela C, Olson SH, Seifert SN, Sprecher A, Ntoumi F, Massaquoi M, Mombouli JV
- N Engl J Med. 2018 Sep 27;379(13):1198-1201. doi: 10.1056/NEJMp1807691
Distinct Immunogenicity and Efficacy of Poxvirus-Based Vaccine Candidates against Ebola Virus Expressing GP and VP40 Proteins
- Lázaro-Frías A, Gómez-Medina S, Sánchez-Sampedro L, Ljungberg K, Ustav M, Liljeström P, Muñoz-Fontela C, Esteban M, García-Arriaza J
- J Virol. 2018 May 14;92(11):e00363-18. doi: 10.1128/JVI.00363-18. Print 2018 Jun 1
Immune barriers of Ebola virus infection
- McElroy AK, Mühlberger E, Muñoz-Fontela C
- Curr Opin Virol. 2018 Feb:28:152-160. doi: 10.1016/j.coviro.2018.01.010
2017
Novel Cross-Reactive Monoclonal Antibodies against Ebolavirus Glycoproteins Show Protection in a Murine Challenge Model
- Duehr J, Wohlbold TJ, Oestereich L, Chromikova V, Amanat F, Rajendran M, Gomez-Medina S, Mena I, tenOever BR, García-Sastre A, Basler CF, Munoz-Fontela C, Krammer F
- J Virol. 2017 Jul 27;91(16):e00652-17. doi: 10.1128/JVI.00652-17
Ebola Virus Disease in Humans: Pathophysiology and Immunity
- Muñoz-Fontela C, McElroy AK
- Curr Top Microbiol Immunol. 2017;411:141-169. doi: 10.1007/82_2017_11
Different features of Vδ2 T and NK cells in fatal and non-fatal human Ebola infections
- Cimini E, Viola D, Cabeza-Cabrerizo M, Romanelli A, Tumino N, Sacchi A, Bordoni V, Casetti R, Turchi F, Martini F, Bore JA, Koundouno FR, Duraffour S, Michel J, Holm T, Zekeng EG, Cowley L, Garcia Dorival I, Doerrbecker J, Hetzelt N, Baum JHJ, Portmann J, Wölfel R, Gabriel M, Miranda O, Díaz G, Díaz JE, Fleites YA, Piñeiro CA, Castro CM, Koivogui L, Magassouba N, Diallo B, Ruibal P, Oestereich L, Wozniak DM, Lüdtke A, Becker-Ziaja B, Capobianchi MR, Ippolito G, Carroll MW, Günther S, Di Caro A, Muñoz-Fontela C, Agrati C
- PLoS Negl Trop Dis. 2017 May 30;11(5):e0005645. doi: 10.1371/journal.pntd.0005645
Increased Proinflammatory Cytokine Levels in Prolonged Arthralgia in Ross River Virus Infection
- Tappe D, Pérez-Girón JV, Gómez-Medina S, Günther S, Muñoz-Fontela C, Schmidt-Chanasit J
- Emerg Infect Dis. 2017 Apr;23(4):702-704. doi: 10.3201/eid2304.160466
Ebola virus infection kinetics in chimeric mice reveal a key role of T cells as barriers for virus dissemination.
- Lüdtke A, Ruibal P, Wozniak DM, Pallasch E, Wurr S, Bockholt S, Gómez-Medina S, Qiu X, Kobinger GP, Rodríguez E, Günther S, Krasemann S, Idoyaga J, Oestereich L, Muñoz-Fontela C.
- Sci Rep. 2017 Mar 3;7:43776. doi: 10.1038/srep43776.
Ebola virus infection kinetics in chimeric mice reveal a key role of T cells as barriers for virus dissemination
- Lüdtke A, Ruibal P, Wozniak DM, Pallasch E, Wurr S, Bockholt S, Gómez-Medina S, Qiu X, Kobinger GP, Rodríguez E, Günther S, Krasemann S, Idoyaga J, Oestereich L, Muñoz-Fontela C
- Sci Rep. 2017 Mar 3:7:43776. doi: 10.1038/srep43776
Monocyte-derived dendritic cells enhance protection against secondary influenza challenge by controlling the switch in CD8+ T-cell immunodominance
- Cruz JL, Pérez-Girón JV, Lüdtke A, Gómez-Medina S, Ruibal P, Idoyaga J, Muñoz-Fontela C
- Eur J Immunol. 2017 Feb;47(2):345-352. doi: 10.1002/eji.201646523
Transcriptomic signatures differentiate survival from fatal outcomes in humans infected with Ebola virus
- Liu X, Speranza E, Muñoz-Fontela C, Haldenby S, Rickett NY, Garcia-Dorival I, Fang Y, Hall Y, Zekeng EG, Lüdtke A, Xia D, Kerber R, Krumkamp R, Duraffour S, Sissoko D, Kenny J, Rockliffe N, Williamson ED, Laws TR, N'Faly M, Matthews DA, Günther S, Cossins AR, Sprecher A, Connor JH, Carroll MW, Hiscox JA
- Genome Biol. 2017 Jan 19;18(1):4. doi: 10.1186/s13059-016-1137-3
Humanized Mice Reproduce Acute and Persistent Human Adenovirus Infection
- Rodríguez E, Ip WH, Kolbe V, Hartmann K, Pilnitz-Stolze G, Tekin N, Gómez-Medina S, Muñoz-Fontela C, Krasemann S, Dobner T
- J Infect Dis. 2017 Jan 1;215(1):70-79. doi: 10.1093/infdis/jiw499
2016
Regulation of Ebola virus VP40 matrix protein by SUMO
- Baz-Martínez M, El Motiam A, Ruibal P, Condezo GN, de la Cruz-Herrera CF, Lang V, Collado M, San Martín C, Rodríguez MS, Muñoz-Fontela C, Rivas C.
- Sci Rep. 2016 Nov 16:6:37258. doi: 10.1038/srep37258.
Ebola virus disease is characterized by poor activation and reduced levels of circulating CD16 (+) monocytes.
- Lüdtke A, Ruibal P, Becker-Ziaja B, Rottstegge M, Wozniak DM, Cabeza-Cabrerizo M, Thorenz A, Weller R, Kerber R, Idoyaga J, Magassouba NF, Gabriel M, Günther S, Oestereich L, Muñoz-Fontela C.
- J Infect Dis. 2016 Oct 15;214(suppl 3):S275-S280. Epub 2016 Aug 11.
Ebola Virus Disease Is Characterized by Poor Activation and Reduced Levels of Circulating CD16+ Monocytes
- Lüdtke A, Ruibal P, Becker-Ziaja B, Rottstegge M, Wozniak DM, Cabeza-Cabrerizo M, Thorenz A, Weller R, Kerber R, Idoyaga J, Magassouba N, Gabriel M, Günther S, Oestereich L, Muñoz-Fontela C
- J Infect Dis. 2016 Oct 15;214(suppl 3):S275-S280. Epub 2016 Aug 11
Chimeric mice with competent hematopoietic immunity reproduce key features of severe Lassa fever.
- Oestereich L, Lüdtke A, Ruibal P, Pallasch E, Kerber R, Rieger T, Wurr S, Bockholt S, Pérez-Girón JV, Krasemann S, Günther S, Muñoz-Fontela, C.
- PLoS Pathog. 2016 May 18;12(5):e1005656. doi: 10.1371/journal.ppat.1005656. eCollection 2016 May.
Unique human immune signature of Ebola virus disease in Guinea
- Ruibal P, Oestereich L, Lüdtke A, Becker-Ziaja B, Wozniak DM, Kerber R, Korva M, Cabeza-Cabrerizo M, Bore JA, Koundouno FR, Duraffour S, Weller R, Thorenz A, Cimini E, Viola D, Agrati C, Repits J, Afrough B, Cowley LA, Ngabo D, Hinzmann J, Mertens M, Vitoriano I, Logue CH, Boettcher JP, Pallasch E, Sachse A, Bah A, Nitzsche K, Kuisma E, Michel J, Holm T, Zekeng EG, García-Dorival I, Wölfel R, Stoecker K, Fleischmann E, Strecker T, Di Caro A, Avšič-Županc T, Kurth A, Meschi S, Mély S, Newman E, Bocquin A, Kis Z, Kelterbaum A, Molkenthin P, Carletti F, Portmann J, Wolff S, Castilletti C, Schudt G, Fizet A, Ottowell LJ, Herker E, Jacobs T, Kretschmer B, Severi E, Ouedraogo N, Lago M, Negredo A, Franco L, Anda P, Schmiedel S, Kreuels B, Wichmann D, Addo MM, Lohse AW, De Clerck H, Nanclares C, Jonckheere S, Van Herp M, Sprecher A, Xiaojiang G, Carrington M, Miranda O, Castro CM, Gabriel M, Drury P, Formenty P, Diallo B, Koivogui L, Magassouba N, Carroll MW, Günther S, Muñoz-Fontela C
- Nature. 2016 May 5;533(7601):100-4. doi: 10.1038/nature17949
Development of an antibody capture ELISA using inactivated Ebola Zaire Makona virus
- Krähling V, Becker D, Rohde C, Eickmann M, Eroğlu Y, Herwig A, Kerber R, Kowalski K, Vergara-Alert J, Becker S; European Mobile Laboratory consortium
- Med Microbiol Immunol. 2016 Apr;205(2):173-83. doi: 10.1007/s00430-015-0438-6. Epub 2015 Oct 16
Efficacy of Favipiravir Alone and in Combination With Ribavirin in a Lethal, Immunocompetent Mouse Model of Lassa Fever
- Oestereich L, Rieger T, Lüdtke A, Ruibal P, Wurr S, Pallasch E, Bockholt S, Krasemann S, Muñoz-Fontela C, Günther S
- J Infect Dis. 2016 Mar 15;213(6):934-8. doi: 10.1093/infdis/jiv522. Epub 2015 Nov 3.
2015
Temporal and spatial analysis of the 2014-2015 Ebola virus outbreak in West Africa
- Carroll MW, Matthews DA, Hiscox JA, Elmore MJ, Pollakis G, Rambaut A, Hewson R, García-Dorival I, Bore JA, Koundouno R, Abdellati S, Afrough B, Aiyepada J, Akhilomen P, Asogun D, Atkinson B, Badusche M, Bah A, Bate S, Baumann J, Becker D, Becker-Ziaja B, Bocquin A, Borremans B, Bosworth A, Boettcher JP, Cannas A, Carletti F, Castilletti C, Clark S, Colavita F, Diederich S, Donatus A, Duraffour S, Ehichioya D, Ellerbrok H, Fernandez-Garcia MD, Fizet A, Fleischmann E, Gryseels S, Hermelink A, Hinzmann J, Hopf-Guevara U, Ighodalo Y, Jameson L, Kelterbaum A, Kis Z, Kloth S, Kohl C, Korva M, Kraus A, Kuisma E, Kurth A, Liedigk B, Logue CH, Lüdtke A, Maes P, McCowen J, Mély S, Mertens M, Meschi S, Meyer B, Michel J, Molkenthin P, Muñoz-Fontela C, Muth D, Newman EN, Ngabo D, Oestereich L, Okosun J, Olokor T, Omiunu R, Omomoh E, Pallasch E, Pályi B, Portmann J, Pottage T, Pratt C, Priesnitz S, Quartu S, Rappe J, Repits J, Richter M, Rudolf M, Sachse A, Schmidt KM, Schudt G, Strecker T, Thom R, Thomas S, Tobin E, Tolley H, Trautner J, Vermoesen T, Vitoriano I, Wagner M, Wolff S, Yue C, Capobianchi MR, Kretschmer B, Hall Y, Kenny JG, Rickett NY, Dudas G, Coltart CE, Kerber R, Steer D, Wright C, Senyah F, Keita S, Drury P, Diallo B, de Clerck H, Van Herp M, Sprecher A, Traore A, Diakite M, Konde MK, Koivogui L, Magassouba N, Avšič-Županc T, Nitsche A, Strasser M, Ippolito G, Becker S, Stoecker K, Gabriel M, Raoul H, Di Caro A, Wölfel R, Formenty P, Günther S
- Nature. 2015 Aug 6;524(7563):97-101. doi: 10.1038/nature14594. Epub 2015 Jun 17.
Human Invasive Muscular Sarcocystosis Induces Th2 Cytokine Polarization and Biphasic Cytokine Changes, Based on an Investigation among Travelers Returning from Tioman Island, Malaysia
- Tappe D, Slesak G, Pérez-Girón JV, Schäfer J, Langeheinecke A, Just-Nübling G, Muñoz-Fontela C, Püllmann K.
- Clin Vaccine Immunol. 2015 Jun;22(6):674-7. doi: 10.1128/CVI.00042-15. Epub 2015 Apr 22.
Ebola virus disease in mice with transplanted human hematopoietic stem cells
- Lüdtke, A., Oestereich, L., Ruibal, P., Wurr, S., Pallasch, E., Bockholt, S., Ip, W.H., Rieger, T., Gomez-Medina, S., Stocking, C., Rodriguez, E., Günther, S., Muñoz-Fontela, C.
- J Virol. 2015 Apr;89(8):4700-4. doi: 10.1128/JVI.03546-14. Epub 2015 Feb 11.
Zika virus infections imported to Italy: clinical, immunological and virological findings, and public health implications
- Zammarchi L, Stella G, Mantella A, Bartolozzi D, Tappe D, Günther S, Oestereich L, Cadar D, Muñoz-Fontela C, Bartoloni A, Schmidt-Chanasit J
- J Clin Virol. 2015 Feb;63:32-5. doi: 10.1016/j.jcv.2014.12.005. Epub 2014 Dec 12
