News From the Group

Happy New Year!

The picture shows the members of the Molecular Infection Immunology working group. The group is dressed in winter clothes and is standing in front of the reception of the Bernhard Nocht Institute.
Happy New Year!   ©RG Lotter | December 2023

We congratulate Barbara Honecker on her successful dissertation entitled "Extracellular vesicles in host-parasite interaction of Entamoeba histolytica (Schaudinn, 1903) with primary monocytes"!

Barbara Honecker steht nach ihrer erfolgreichen Prüfung vor einer grauen Wand des Uni-Gebäudes der Botanik. Sie trägt einen Doktorhut, der ihr von der Arbeitsgruppe gebastelt wurde und hält einen bunten Blumenstrauß in der Hand.
October 2023 ©Barbara Honecker

Excursion to the wildlife park Schwarze Berge, Rosengarten, Lower Saxony

Auf dem Foto steht die Arbeitgruppe in einem Wald des Wildparks Schwarze Berge. Einige Mitglieder füttern vier Rehe, die im Vordergrund zu sehen sind.
AG Molecular Infection Immunology in the Wildlife Park July 2023.   ©Hanna Lotter

Members of the Molecular Infection Immunology Group participate in the Gordon Research Conference "Sex Differences in Immunity"

Ventura, CA, United States

April 2 - 7, 2023

The Sex Differences in Immunity GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field.

Biological sex, meaning the differences between males and females caused by differential sex chromosome complement, reproductive tissues, and concentrations of sex steroids, impacts the functioning of the immune system. Sex differences in immune function can occur as a result of differential expression of X-linked and autosomal genes due to epigenetic modifications as well as changes in sex steroid receptor signaling inside of immune cells over the life course.

Frau Hansen steht vor ihrem Poster und zeigt zwei interessierten Besuchern ihre Ergebnisse. Sie deutet dabei mit einem Finger auf eine Grafik und gibt den Interessierten Auskunft.
Charlotte Hansen and Marco ER-Lukowiak present their latest research results in the poster session of the Gordons Conference.   ©Hanna Lotter, Charlotte Hansen
Herr ER-Lukowiak steht neben seinem Poster und diskutiert freundlich mit einer interessierten Frau, die mit dem Rücken zur Kamera steht und sich die Ergebnisse ansieht.

Helena Fehling and Annika Bea win the research picture challenge at a symposium hosted by BNITM on World NTD Day (Neglected Tropical Diseases) on January 30th at Erika-Haus/ University Medical Center Hamburg-Eppendorf, Germany

 

The enemy within

A View through a microscope: This picture shows macrophages (blue) isolated from a healthy human infected in vitro with Leishmania parasites (red).

Leishmaniasis is an increasingly prevalent and complex group of poverty-related, neglected tropical disease that affects over 12 million people worldwide. As with many infectious diseases, it is observed that men are more susceptible to the disease and have severe disease progression. Leishmaniasis is endemic in at least 88 countries, but is becoming more prevalent in southern Europe due to climate change, tourism and migration. The devastating effects of the disease range from stigmatization to death, depending on the Leishmania species. To date, there is still no adequate treatment available for patients. Existing drugs for leishmaniasis generally have serious drawbacks. Therefor new drugs are urgently needed.

Leishmania parasites invade host immune cells such as macrophages, where they can survive and multiply. They can evade their clearance by manipulating the host´s immune responses. Our research group at the Bernhard Nocht Institute for Tropical Medicine has identified, synthesized and patented immunomodulators that specifically activate the human immune system to better eliminate intracellular Leishmania parasites. Results so far indicate that our molecules provide a promising approach that could improve the currently unsatisfactory situation of treating this neglected tropical disease.

Zwei Forscherinnen stehen vor einer Aufstellwand, auf der ein Bild mit schwarzem Hintergrund zu erkennen, auf dem unterschiedlich geformte in blau und rot gehaltene Zellen gezeigt sind.
Helena Fehling and Annika Bea win the research picture challenge at a symposium hosted by BNITM on World NTD Day (Neglected Tropical Diseases).   ©Fehling, Bea
Eine mikroskopische Aufnahme von Leishmanien infizierten Makrophagen. Auf einem schwarzen Huintergrund sind rot und blau gefärbte Zellen zu sehen.
Microscopic picture of leishmania infected macrophages.   ©BNITM | Fehling, Bea

Poster Award for Annika in Cartagena, Colombia

Annika Bea, Bernhard Nocht Institut for Tropical Medicine,

was awarded as best poster presentation award granted by Tropical Medicine

and Infectious Disease an open access journal by MDPI, in the 7th World

Congress on Leishmaniasis, WorldLeish7, with the abstract entitled:

"Influence of leishmania infection on the biology of host cells"

on August 6, 2022, Cartagena, Colombia.

 

Congratulations Annika!

Eine Forscherin hält ein Urkunde in den Händen. Sie trägt ein knielanges, beigefarbenes Sommerkleid und eine in die Haare gesteckte Sonnenbrille. Hinter ihr ist ein großer Schriftzug "WorldLeish7" zu sehen, darunter mehrere Logos von verschiedenen Kooperationspartnern.
Poster Award for Annika Bea in Cartagena, Colombia.   ©Annika Bea

Excursion to the Börnsen Strawberry Field 2022

Betriebsausflug der AG Molekulare Infektionsimmunologie: eine Gruppe steht vor einem Erdbeerfeld und halten jeweils eine Schale Erdbeeren in die Kamera.
Company excursion Aumühle/Börnsen July 2022.   ©Hanna Lotter

Dr. Marie Groneberg and Dr. Luzia Veletzky receive doctoral prizes from the BNITM Friends Association

01.07.2022

Of gender differences in the defence against infection and a truly neglected tropical disease

This year's doctoral prizes of the Association of Friends of the Tropical Institute Hamburg e.V. (VdF) go to Dr Marie Groneberg (Natural Sciences) and Dr Luzia Veletzky (Medicine). They are endowed with 1,000 euros each and honour particularly outstanding dissertations at the Bernhard Nocht Institute for Tropical Medicine.

Men fall ill differently, women too. Compared to women, men contract numerous viral, bacterial and parasitic infections much more frequently and severely. These include, for example, hepatitis B, covid-19, tuberculosis, Helicobacter and amoebic infections.

Prof. Hannelore Lotter's Molecular Infection Immunology group studies, among other things, gender-specific immune reactions in the formation and regeneration of amoebic liver abscesses. She had already shown that the sex hormone testosterone favours the development of liver abscesses.

Regulatory protein partly responsible for sex difference

Marie Groneberg and her colleagues followed up on these results. They analysed sex-specific differences in the acquired immune response in amoebic liver abscesses and carried out detailed molecular investigations of the immune response in the mouse model.

Among other things, they determined the occurrence and number of immune cells characterised in detail and the concentration of immunological messengers in the liver and blood of normal mice and mice with a targeted genetic defect.

They showed that in experimental amoeba infections in the liver, a specific immunoregulatory protein (HIF-1alpha) is partly responsible for the stronger immune response of the male mice. The protein is present in the liver cells of both sexes in response to amoebic infection, but influences the immune cell response of male and female animals to different degrees. Targeted knockdown of HIF-1alpha in the liver reduces the inflammation- and abscess-promoting immune response in male mice and leads to the abolition of the sex difference.


Congratulations Marie!

Ein Vorstandsmitglied der Vereinigung der Freunde des Tropeninstituts übergibt Marie Groneberg bei der feierlichen Verleihung des Preises im Hörsaal des Bernhard-Nocht-Instituts eine Urkunde. Im Hintergrund sieht man eine in dunkelbraun vertäfelte Wand.
Dr. Marie Groneberg receives doctoral award from the Association of Friends of BNITM.   ©BNITM | Presse
Die frisch gekührte Preisträgerin Marie Groneberg steht mit ihren Kolleg:innen im Institutsgarten und wird mit Luftschlangen beworfen.
Marie is celebrated by her colleagues at the subsequent summer party.   ©Claudia Marggraff

Award of the Werner Otto Prize to BNITM scientist Julie Sellau

Hamburg, 14 December 2021 - Dr Julie Sellau, scientist in the Molecular Infection Immunology group at the Bernhard Nocht Institute for Tropical Medicine, today receives the Werner Otto Award, endowed with 8000€, for her outstanding contribution to knowledge on gender-specific immunology. Her award-winning work was published in the renowned journal Nature Communications in July 2020.

Research on gender differences in infectious immunology is in its infancy. While men are more susceptible to infectious diseases, women are more prone to chronic inflammation and autoimmune diseases. In order to create better treatment options, it is important to clarify the causes.

The Lotter working group, in which Ms Sellau has been a researcher for four and a half years, is dedicated to precisely this question: Using the amoebic liver abscess, they showed that the male sex hormone testosterone causes certain immune cells, which are actually supposed to protect against invading pathogens, to increase inflammatory reactions in the liver. These immune cells thus contribute significantly to tissue damage. The findings of Dr. Sellau and her colleagues open up new approaches for more targeted personalised medicine.

 

Congratulations Julie!

Dr. Julie Sellau erhält in einem festlichen Rahmen die Urkunde überreicht. Im Hintergrund sieht man bodentiefe Fenster und  einen grauen Wintertag.
Award of the Werner Otto Prize to BNITM scientist Dr Julie Sellau.   ©BNITM | Presse

Greetings from the strawberry field!

Auf dem Bild sind gut gelaunte Mitarbeiter der AG Lotter mit Erdbeerschalen in der Hand zu sehen
Company excursion Aumühle/Börnsen July 2021.   ©Hanna Lotter

We congratulate Stefan Hoenow on his successful dissertation entitled "Charakterisierung pro-inflammatorischer Monozyten in murinen Infektionen mit Entamoeba histolytica und Listeria monocytogenes "!

Stefan Hoenow kurz nach seiner Dissertation. Er trägt einen selbstgebastelten, bunten Doktorhut auf dem Kopf, in der rechten Hand einen großen Blumenstrauß und in der linken Hand ein Sektglas.
June 2021   ©Claudia Marggraff

We congratulate Marie Groneberg on her successful dissertation entitled "Geschlechtsspezifische Immunantworten bei der hepatischen Amöbiasis"!

Marie Groneberg kurz nach der Dissertation. Sie trägt einen selbstgebastelten, bunten Doktorhut auf dem Kopf, in der rechten Hand einen großen Blumenstrauß und in der linken Hand ein Urkunde.
April 2021   ©Claudia Marggraff

Research Group Molecular Infection Immunology

Prof. Dr. Hanna Lotter: ein Portraitfoto der Arbeitsgruppenleiterin. Sie trägt braunes kinnlanges Haar und eine weiße Bluse.
Research Group Leader

Prof. Dr. Hanna Lotter

Telefon: +49 40 285380-475

E-Mail: lotter@bnitm.de

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