Department of Virology

Overview

Research of the Department of Virology is focussed on molecular aspects of the life cycle, the virus-host cell interaction, and the pathogenesis of tropical viruses. Two groups of viruses with particular relevance for tropical countries are being investigated: 1. Highly pathogenic tropical viruses causing geographically restricted outbreaks with high case fatality rates (BSL4 pathogens Lassa fever virus and Ebola virus). 2. Viruses with a broader and long-term impact on public health affecting a large number of developing countries (Dengue virus and human immunodeficiency virus [HIV]). Methodology includes genetic modification of viruses, cell biology as well as animal experimentation in BSL3 and BSL4 facilities. Final aim of the work is the translation of basic research results into novel strategies for prevention, control, diagnostics, and treatment of tropical virus infections. To facilitate the translation of research results and transfer of technology to the endemic countries, the department closely cooperates with scientists in Africa and Asia.

Research Projects

Pathogenesis of viral hemorrhagic fevers

To study the pathogenesis of viral hemorrhagic fevers caused by e.g. Lassa Virus, Ebola Virus, Crimean-Congo-Hemorrhagic fever virus we analyze clinical and immunological parameters of patient samples. We also develop mouse models to study the pathogenesis in a laboratory setting and use those to test antiviral substances. Another interest is the understanding of virus immunology in the natural host Mastomys natalensis.          More.

Lassa virus research in Africa

With the establishment of a laboratory for molecular diagnostics of Lassa fever at a tertiary hospital in an endemic area in Nigeria, we have laid the foundation for studies aiming at understanding the pathophysiology of Lassa fever and improving the clinical management of this deadly disease.          More.

Structure and Biochemistry of the Replication Machinery of Arena- and Bunyaviruses

We combine structural biology with biochemistry to understand the molecular and structural mechanisms how negative strand RNA viruses use their own proteins and interact with cellular proteins in order to replicate and transcribe their RNA genome.          More.

Outbreak Response, Ebola and subsequent research activities

We are coordinating the project "Establishment of Mobile Laboratories for Pathogens up to Risk Group 4 in Combination with CBRN Capacity Building in Sub-Saharan Africa", which is funded by the European Comission. Since the beginning of the Ebola outbreak in 2014 The European Mobile Laboratory is constantly performing diagnostics in the field in West Africa.

In response to the Ebola epidemic we are coordinating the EU research initiative EVIDENT (Ebola Virus Disease: Correlates of protection, determinants of outcome, and clinical management): a multi-national team of experts from 11 partnering institutions is scientifically exploiting specimens from EVD patients collected as part of the outbreak response in Guinea, Sierra Leone and Nigeria and gathering critical knowledge on B and T cell immunology, biomarkers, virus evolution, virulence determinants, and transmission of Ebola Virus.

Rodent control to prevent Lassa fever

As part of the LAROCS (Lassa Fever in Guinea and Sierra Leone: rodent control, and seasonality of human exposure to rodents) consortium we study how the abundance of the natural host of the Lassa virus, Mastomys natalensis, influences infection rates in humans.          More.

Development of new methods of serological assays in clinical virology

Our research is dedicated to applied and basic aspects of haemorrhagic fevervirus (VHF) biology. The main focus is on bunyaviruses in human and animal sera and the isolation of known and unknown viruses.     More.

Highly variable viruses: HIV-1 and Dengue Virus

We investigate how highly variable viruses like HIV-1 and Dengue infect their target cells, how N-glycans influence the first steps of the viral entry process and how the humoral immune response against these viruses is guiding viral evolution and escape.

The European Virus Archive (EVA)

The European Virus Archive expanded from a European to a global organization and now also includes joint research activities, some of which are performed at the Bernhard Nocht Institute.

Development of Diagnostic Tests - Prof. Schmitz

We are working on the development of diagnostic assays to detect virus specific antibodies.          More.

Publication Highlights

For more publications see the respective research projects.
Department of Virology (Prof. Stephan Günther)
2017

Structural insights into reptarenavirus cap-snatching machinery
Maria Rosenthal, Nadja Gogrefe, Dominik Vogel, Juan Reguera, Bianka Rauschenberger, Stephen Cusack, Stephan Günther, Sophia Reindl
PLoS Pathog. 2017 May 15;13(5):e1006400. doi: 10.1371/journal.ppat.1006400.

Persistence and clearance of Ebola virus RNA from seminal fluid of Ebola virus disease survivors: a longitudinal analysis and modelling study.
Sissoko D, Duraffour S, Kerber R, Kolie JS, Beavogui AH, Camara AM, Colin G, Rieger T, Oestereich L, Pályi B, Wurr S, Guedj J, Nguyen TH, Eggo RM, Watson CH, Edmunds WJ, Bore JA, Koundouno FR, Cabeza-Cabrerizo M, Carter LL, Kafetzopoulou LE, Kuisma E, Michel J, Patrono LV, Rickett NY, Singethan K, Rudolf M, Lander A, Pallasch E, Bockholt S, Rodríguez E, Di Caro A, Wölfel R, Gabriel M, Gurry C, Formenty P, Keïta S, Malvy D, Carroll MW, Anglaret X, Günther S.
Lancet Glob Health. 2017 Jan;5(1):e80-e88. doi: 10.1016/S2214-109X(16)30243-1.

Transcriptomic signatures differentiate survival from fatal outcomes in humans infected with Ebola virus.
Liu X, Speranza E, Muñoz-Fontela C, Haldenby S, Rickett NY, Garcia-Dorival I, Fang Y, Hall Y, Zekeng EG, Lüdtke A, Xia D, Kerber R, Krumkamp R, Duraffour S, Sissoko D, Kenny J, Rockliffe N, Williamson ED, Laws TR, N'Faly M, Matthews DA, Günther S, Cossins AR, Sprecher A, Connor JH, Carroll MW, Hiscox JA.
Genome Biol. 2017 Jan 19;18(1):4. doi: 10.1186/s13059-016-1137-3.

Ebola virus infection kinetics in chimeric mice reveal a key role of T cells as barriers for virus dissemination.
Lüdtke A, Ruibal P, Wozniak DM, Pallasch E, Wurr S, Bockholt S, Gómez-Medina S, Qiu X, Kobinger GP, Rodríguez E, Günther S, Krasemann S, Idoyaga J, Oestereich L, Muñoz-Fontela C.
Sci Rep. 2017 Mar 3;7:43776. doi: 10.1038/srep43776

Department of Virology (Prof. Stephan Günther)
2016

Unique human immune signature of Ebola virus disease in Guinea.
Ruibal P, Oestereich L, Lüdtke A, Becker-Ziaja B, Wozniak DM, Kerber R, ..., Carroll MW, Günther S, Muñoz-Fontela C.
Nature. 2016 May 5;533(7601):100-4. doi: 10.1038/nature17949.

Real-time, portable genome sequencing for Ebola surveillance.
Quick J, Loman NJ, Duraffour S, Simpson JT, Severi E, Cowley L, ..., Formenty P, Günther S, Carroll MW.
Nature. 2016 Feb 3. doi: 10.1038/nature16996.

Department of Virology (Prof. Stephan Günther)
2015

Cytokine kinetics of Zika virus-infected patients from acute to reconvalescent phase.
Tappe D, Pérez-Girón JV, Zammarchi L, Rissland J, Ferreira DF, Jaenisch T, Gómez-Medina S, Günther S, Bartoloni A, Muñoz-Fontela C, Schmidt-Chanasit J.
Med Microbiol Immunol. 2015 Dec 24.

Efficacy of Favipiravir Alone and in Combination With Ribavirin in a Lethal, Immunocompetent Mouse Model of Lassa Fever.
Oestereich L, Rieger T, Lüdtke A, Ruibal P, Wurr S, Pallasch E, Bockholt S, Krasemann S, Muñoz-Fontela C, Günther S.
J Infect Dis. 2015 Nov 3. pii: jiv522.

Temporal and spatial analysis of the 2014-2015 Ebola virus outbreak in West Africa.
Carroll MW, Matthews DA, Hiscox JA, Elmore MJ, Pollakis G, Rambaut A, Hewson R, García-Dorival I, Bore JA, Koundouno R, ... and Günther S.
Nature. 2015 Aug 6;524(7563):97-101. doi: 10.1038/nature14594.

Ebola virus disease in mice with transplanted human hematopoietic stem cells.
Lüdtke A, Oestereich L, Ruibal P, Wurr S, Pallasch E, Bockholt S, Ip WH, Rieger T, Gómez-Medina S, Stocking C, Rodríguez E, Günther S, Muñoz-Fontela C.
J Virol. 2015 Apr;89(8):4700-4. doi: 10.1128/JVI.03546-14.

Emergence of Zaire Ebola virus disease in Guinea.
Baize S, Pannetier D, Oestereich L, Rieger T, Koivogui L, Magassouba N, Soropogui B, Sow MS, Keïta S, De Clerck H, Tiffany A, Dominguez G, Loua M, Traoré A, Kolié M, Malano ER, Heleze E, Bocquin A, Mély S, Raoul H, Caro V, Cadar D, Gabriel M, Pahlmann M, Tappe D, Schmidt-Chanasit J, Impouma B, Diallo AK, Formenty P, Van Herp M, Günther S.
N Engl J Med. 2014 Oct 9;371(15):1418-25. doi: 10.1056/NEJMoa1404505.

All Publications

Department of Virology (Prof. Stephan Günther)
2017

Rapid outbreak sequencing of Ebola virus in Sierra Leone identifies transmission chains linked to sporadic cases.
Arias A, Watson SJ, Asogun D, Tobin EA, ..., Gabriel M, Wölfel R, Di Caro A, Carroll MW, Günther S, Redd J, Naidoo D, Pybus OG, Rambaut A, Kellam P, Goodfellow I, Cotten M.
Virus Evol. 2016 Jun 22;2(1):vew016. doi: 10.1093/ve/vew016.

Prevalence of Lassa Virus Disease (LVD) in Nigerian children with fever or fever and convulsions in an endemic area.
Akhuemokhan OC, Ewah-Odiase RO, Akpede N, Ehimuan J, Adomeh DI, Odia I, Olomu SC, Pahlmann M, Becker-Ziaja B, Happi CT, Asogun DA, Okogbenin SA, Okokhere PO, Dawodu OS, Omoike IU, Sabeti PC, Günther S, Akpede GO.
PLoS Negl Trop Dis. 2017 Jul 3;11(7):e0005711. doi: 10.1371/journal.pntd.0005711.

Arenavirus Dynamics in Experimentally and Naturally Infected Rodents.
Mariën J, Borremans B, Gryseels S, Broecke BV, Becker-Ziaja B, Makundi R, Massawe A, Reijniers J, Leirs H.
Ecohealth. 2017 Jun 14. doi: 10.1007/s10393-017-1256-7.

Novel cross-reactive monoclonal antibodies against Ebolavirus glycoproteins show protection in a murine challenge model.
Duehr J, Wohlbold TJ, Oestereich L, Chromikova V, Amanat F, Rajendran M, Gomez-Medina S, Mena I, TenOever BR, García-Sastre A, Basler CF, Munoz-Fontela C, Krammer F.
J Virol. 2017 Jun 7. pii: JVI.00652-17. doi: 10.1128/JVI.00652-17.

Different features of Vδ2 T and NK cells in fatal and non-fatal human Ebola infections.
Cimini E, Viola D, Cabeza-Cabrerizo M, Romanelli A, Tumino N, Sacchi A, Bordoni V, Casetti R, Turchi F, Martini F, Bore JA, Koundouno FR, Duraffour S, Michel J, Holm T, Zekeng EG, Cowley L, Garcia Dorival I, Doerrbecker J, Hetzelt N, Baum JHJ, Portmann J, Wölfel R, Gabriel M, Miranda O, Díaz G, Díaz JE, Fleites YA, Piñeiro CA, Castro CM, Koivogui L, Magassouba N, Diallo B, Ruibal P, Oestereich L, Wozniak DM, Lüdtke A, Becker-Ziaja B, Capobianchi MR, Ippolito G, Carroll MW, Günther S, Di Caro A, Muñoz-Fontela C, Agrati C.
PLoS Negl Trop Dis. 2017 May 30;11(5):e0005645.

Structural insights into reptarenavirus cap-snatching machinery.
Rosenthal M, Gogrefe N, Vogel D, Reguera J, Rauschenberger B, Cusack S, Günther S, Reindl S
PLoS Pathog. 2017 May 15;13(5):e1006400. doi: 10.1371/journal.ppat.1006400.

External quality assessment study for ebolavirus PCR-diagnostic promotes international preparedness during the 2014 - 2016 Ebola outbreak in West Africa.
Ellerbrok H, Jacobsen S, Patel P, Rieger T, Eickmann M, Becker S, Günther S, Naidoo D, Schrick L, Keeren K, Targosz A, Teichmann A, Formenty P, Niedrig M.
PLoS Negl Trop Dis. 2017 May 1;11(5):e0005570. doi: 10.1371/journal.pntd.0005570.

No measurable adverse effects of Lassa, Morogoro and Gairo arenaviruses on their rodent reservoir host in natural conditions.
Mariën J, Borremans B, Gryseels S, Soropogui B, De Bruyn L, Bongo GN, Becker-Ziaja B, de Bellocq JG, Günther S, Magassouba N, Leirs H, Fichet-Calvet E
Parasit Vectors. 2017 Apr 27;10(1):210. doi: 10.1186/s13071-017-2146-0.

Virus genomes reveal factors that spread and sustained the Ebola epidemic.
Dudas G, Carvalho LM, Bedford T, Tatem AJ, Baele G, Faria NR, Park DJ, Ladner JT, Arias A, Asogun D, Bielejec F, Caddy SL, Cotten M, D'Ambrozio J, Dellicour S, Caro AD, Diclaro JW, Duraffour S, Elmore MJ, Fakoli LS, Faye O, Gilbert ML, Gevao SM, Gire S, Gladden-Young A, Gnirke A, Goba A, Grant DS, Haagmans BL, Hiscox JA, Jah U, Kugelman JR, Liu D, Lu J, Malboeuf CM, Mate S, Matthews DA, Matranga CB, Meredith LW, Qu J, Quick J, Pas SD, Phan MV, Pollakis G, Reusken CB, Sanchez-Lockhart M, Schaffner SF, Schieffelin JS, Sealfon RS, Simon-Loriere E, Smits SL, Stoecker K, Thorne L, Tobin EA, Vandi MA, Watson SJ, West K, Whitmer S, Wiley MR, Winnicki SM, Wohl S, Wölfel R, Yozwiak NL, Andersen KG, Blyden SO, Bolay F, Carroll MW, Dahn B, Diallo B, Formenty P, Fraser C, Gao GF, Garry RF, Goodfellow I, Günther S, Happi CT, Holmes EC, Kargbo B, Keïta S, Kellam P, Koopmans MP, Kuhn JH, Loman NJ, Magassouba N, Naidoo D, Nichol ST, Nyenswah T, Palacios G, Pybus OG, Sabeti PC, Sall A, Ströher U, Wurie I, Suchard MA, Lemey P, Rambaut A.
Nature. 2017 Apr 12. doi: 10.1038/nature22040.

Increased Proinflammatory Cytokine Levels in Prolonged Arthralgia in Ross River Virus Infection.
Tappe D, Pérez-Girón JV, Gómez-Medina S, Günther S, Muñoz-Fontela C, Schmidt-Chanasit J.
Emerg Infect Dis. 2017 Apr;23(4):702-704. doi: 10.3201/eid2304.160466.

Ebola virus infection kinetics in chimeric mice reveal a key role of T cells as barriers for virus dissemination.
Lüdtke A, Ruibal P, Wozniak DM, Pallasch E, Wurr S, Bockholt S, Gómez-Medina S, Qiu X, Kobinger GP, Rodríguez E, Günther S, Krasemann S, Idoyaga J, Oestereich L, Muñoz-Fontela C.
Sci Rep. 2017 Mar 3;7:43776. doi: 10.1038/srep43776.

Genetic Diversity and New Lineages of Dengue Virus Serotypes 3 and 4 in Returning Travelers, Germany, 2006-2015.
Shihada S, Emmerich P, Thomé-Bolduan C, Jansen S, Günther S, Frank C, Schmidt-Chanasit J, Cadar D.
Emerg Infect Dis. 2017 Feb;23(2):272-275. doi: 10.3201/eid2302.160751.

Transcriptomic signatures differentiate survival from fatal outcomes in humans infected with Ebola virus.
Liu X, Speranza E, Muñoz-Fontela C, Haldenby S, Rickett NY, Garcia-Dorival I, Fang Y, Hall Y, Zekeng EG, Lüdtke A, Xia D, Kerber R, Krumkamp R, Duraffour S, Sissoko D, Kenny J, Rockliffe N, Williamson ED, Laws TR, N'Faly M, Matthews DA, Günther S, Cossins AR, Sprecher A, Connor JH, Carroll MW, Hiscox JA.
Genome Biol. 2017 Jan 19;18(1):4. doi: 10.1186/s13059-016-1137-3.

Persistence and clearance of Ebola virus RNA from seminal fluid of Ebola virus disease survivors: a longitudinal analysis and modelling study.
Sissoko D, Duraffour S, Kerber R, Kolie JS, Beavogui AH, Camara AM, Colin G, Rieger T, Oestereich L, Pályi B, Wurr S, Guedj J, Nguyen TH, Eggo RM, Watson CH, Edmunds WJ, Bore JA, Koundouno FR, Cabeza-Cabrerizo M, Carter LL, Kafetzopoulou LE, Kuisma E, Michel J, Patrono LV, Rickett NY, Singethan K, Rudolf M, Lander A, Pallasch E, Bockholt S, Rodríguez E, Di Caro A, Wölfel R, Gabriel M, Gurry C, Formenty P, Keïta S, Malvy D, Carroll MW, Anglaret X, Günther S.
Lancet Glob Health. 2017 Jan;5(1):e80-e88. doi: 10.1016/S2214-109X(16)30243-1.

Interferon β-1a for the treatment of Ebola virus disease: A historically controlled, single-arm proof-of-concept trial.
Konde MK, Baker DP, Traore FA, Sow MS, Camara A, Barry AA, Mara D, Barry A, Cone M, Kaba I, Richard AA, Beavogui AH, Günther S; European Mobile Laboratory Consortium, Pintilie M, Fish EN.
PLoS One. 2017 Feb 22;12(2):e0169255.

Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ça Suffit!).
Henao-Restrepo AM, Camacho A, Longini IM, Watson CH, Edmunds WJ, Egger M, Carroll MW, Dean NE, Diatta I, Doumbia M, Draguez B, Duraffour S, Enwere G, Grais R, Günther S, Gsell PS, Hossmann S, Watle SV, Kondé MK, Kéïta S, Kone S, Kuisma E, Levine MM, Mandal S, Mauget T, Norheim G, Riveros X, Soumah A, Trelle S, Vicari AS, Røttingen JA, Kieny MP.
Lancet. 2017 Feb 4;389(10068):505-518.

Ebola Virus Persistence in Breast Milk After No Reported Illness: A Likely Source of Virus Transmission From Mother to Child.
Sissoko D, Keïta M, Diallo B, Aliabadi N, Fitter DL, Dahl BA, Akoi Bore J, Raymond Koundouno F, Singethan K, Meisel S, Enkirch T, Mazzarelli A, Amburgey V, Faye O, Alpha Sall A, Magassouba N, Carroll MW, Anglaret X, Malvy D, Formenty P, Bruce Aylward R, Keïta S, Harouna Djingarey M, Loman NJ, Günther S, Duraffour S.
Clin Infect Dis. 2017 Feb 15;64(4):513-516

Abteilung Virologie
2016

Resurgence of Ebola virus disease in Guinea linked to a survivor with virus persistence in seminal fluid for more than 500 days.
Diallo B, Sissoko D, Loman NJ, Bah HA, Bah H, Worrell MC, Conde LS, Sacko R, Mesfin S, Loua A, Kalonda JK, Erondu NA, Dahl BA, Handrick S, Goodfellow I, Meredith LW, Cotten M, Jah U, Guetiya Wadoum RE, Rollin P, Magassouba N, Malvy D, Anglaret X, Carroll MW, Aylward RB, Djingarey MH, Diarra A, Formenty P, Keïta S, Günther S, Rambaut A, Duraffour S.
Clin Infect Dis. 2016 Sep 1. pii: ciw601.

Evaluation of RealStar Reverse Transcription-Polymerase Chain Reaction Kits for Filovirus Detection in the Laboratory and Field.
Rieger T, Kerber R, El Halas H, Pallasch E, Duraffour S, Günther S, Ölschläger S.
J Infect Dis. 2016 Aug 21. pii: jiw246.

Ebola Virus Disease Is Characterized by Poor Activation and Reduced Levels of Circulating CD16+ Monocytes.
Lüdtke A, Ruibal P, Becker-Ziaja B, Rottstegge M, Wozniak DM, Cabeza-Cabrerizo M, Thorenz A, Weller R, Kerber R, Idoyaga J, Magassouba N, Gabriel M, Günther S, Oestereich L, Muñoz-Fontela C.
J Infect Dis. 2016 Aug 11. pii: jiw260.

Sexual transmission of Zika virus in Germany, April 2016.
Frank C, Cadar D, Schlaphof A, Neddersen N, Günther S, Schmidt-Chanasit J, Tappe D.
Euro Surveill. 2016 Jun 9;21(23).

Comparative Structural and Functional Analysis of Bunyavirus and Arenavirus Cap-Snatching Endonucleases.
Reguera J, Gerlach P, Rosenthal M, Gaudon S, Coscia F, Günther S, Cusack S.
PLoS Pathog. 2016 Jun 15;12(6):e1005636.

Atomic Structure and Biochemical Characterization of an RNA Endonuclease in the N Terminus of Andes Virus L Protein.
Fernández-García Y, Reguera J, Busch C, Witte G, Sánchez-Ramos O, Betzel C, Cusack S, Günther S, Reindl S.
PLoS Pathog. 2016 Jun 14;12(6):e1005635.

Evidence for widespread infection of African bats with Crimean-Congo hemorrhagic fever-like viruses.
Müller MA, Devignot S, Lattwein E, Corman VM, Maganga GD, Gloza-Rausch F, Binger T, Vallo P, Emmerich P, Cottontail VM, Tschapka M, Oppong S, Drexler JF, Weber F, Leroy EM, Drosten C.
Sci Rep. 2016 May 24;6:26637. doi: 10.1038/srep26637.

Chimeric Mice with Competent Hematopoietic Immunity Reproduce Key Features of Severe Lassa Fever.
Oestereich L, Lüdtke A, Ruibal P, Pallasch E, Kerber R, Rieger T, Wurr S, Bockholt S, Pérez-Girón JV, Krasemann S, Günther S, Muñoz-Fontela C.
PLoS Pathog. 2016 May 18;12(5):e1005656.

Unique human immune signature of Ebola virus disease in Guinea.
Ruibal P, Oestereich L, Lüdtke A, Becker-Ziaja B, Wozniak DM, Kerber R, ..., Magassouba N, Carroll MW, Günther S, Muñoz-Fontela C.
Nature. 2016 May 5;533(7601):100-4. doi: 10.1038/nature17949.

New Hosts of The Lassa Virus.
Olayemi A, Cadar D, Magassouba N, Obadare A, Kourouma F, Oyeyiola A, Fasogbon S, Igbokwe J, Rieger T, Bockholt S, Jérôme H, Schmidt-Chanasit J, Garigliany M, Lorenzen S, Igbahenah F, Fichet JN, Ortsega D, Omilabu S, Günther S, Fichet-Calvet E.
Sci Rep. 2016 May 3;6:25280. doi: 10.1038/srep25280.

Arenavirus Diversity and Phylogeography of Mastomys natalensis Rodents, Nigeria.
Olayemi A, Obadare A, Oyeyiola A, Igbokwe J, Fasogbon A, Igbahenah F, Ortsega D, Asogun D, Umeh P, Vakkai I, Abejegah C, Pahlman M, Becker-Ziaja B, Günther S, Fichet-Calvet E.
Emerg Infect Dis. 2016 Apr;22(4):687-690. doi: 10.3201/eid2204.150155.

Sustained Elevated Cytokine Levels during Recovery Phase of Mayaro Virus Infection.
Tappe D, Pérez-Girón JV, Just-Nübling G, Schuster G, Gómez-Medina S, Günther S, Muñoz-Fontela C, Schmidt-Chanasit J.
Emerg Infect Dis. 2016 Apr;22(4):750-2. doi: 10.3201/eid2204.151502.

Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in Guinea.
Sissoko D, Laouenan C, Folkesson E, ..., Van Herp M, Günther S, de Lamballerie X, Keïta S, Mentre F, Anglaret X, Malvy D; JIKI Study Group.
PLoS Med. 2016 Mar 1;13(3):e1001967. doi: 10.1371/journal.pmed.1001967.

Spatial and temporal evolution of Lassa virus in the natural host population in Upper Guinea.
Fichet-Calvet E, Ölschläger S, Strecker T, Koivogui L, Becker-Ziaja B, Camara AB, Soropogui B, Magassouba N, Günther S.
Sci Rep. 2016 Feb 25;6:21977. doi: 10.1038/srep21977.

Zika without symptoms in returning travellers: What are the implications?
Ginier M, Neumayr A, Günther S, Schmidt-Chanasit J, Blum J.
Travel Med Infect Dis. 2016 Jan-Feb;14(1):16-20. doi: 10.1016/j.tmaid.2016.01.012.

Rat-atouille: a mixed method study to characterize rodent hunting and consumption in the context of Lassa fever.
Bonwitt, J., Kelly, A., Ansumana, R., Sahr, F., Mari Saez, A., Borchert, M., Kock, R., Fichet-Calvet, E.
Ecohealth. 2016 Feb 19.

Real-time, portable genome sequencing for Ebola surveillance.
Quick J, Loman NJ, Duraffour S, Simpson JT, Severi E, Cowley L, Bore JA, Koundouno R, ..., Formenty P, Günther S, Carroll MW.
Nature. 2016 Feb 3. doi: 10.1038/nature16996.

Clinical Management of Ebola Virus Disease in the United States and Europe.
Uyeki TM, Mehta AK, Davey RT Jr, Liddell AM, Wolf T, Vetter P, ...; European Clinical Network on Clinical Management of Ebola Virus Disease Patients in the U.S. and Europe.
N Engl J Med. 2016 Feb 18;374(7):636-46.

Abteilung Virologie
2015

Cytokine kinetics of Zika virus-infected patients from acute to reconvalescent phase.
Tappe D, Pérez-Girón JV, Zammarchi L, Rissland J, Ferreira DF, Jaenisch T, Gómez-Medina S, Günther S, Bartoloni A, Muñoz-Fontela C, Schmidt-Chanasit J.
Med Microbiol Immunol. 2015 Dec 24.

Dilemmas in Managing Pregnant Women With Ebola: 2 Case Reports.
Caluwaerts S, Fautsch T, Lagrou D, Moreau M, Modet Camara A, Günther S, Di Caro A, Borremans B, Raymond Koundouno F, Akoi Bore J, Logue CH, Richter M, Wölfel R, Kuisma E, Kurth A, Thomas S, Burkhardt G, Erland E, Lionetto F, Lledo Weber P, de la Rosa O, Macpherson H, Van Herp M.
Clin Infect Dis. 2015 Dec 17. pii: civ1024.

Ebola vaccination.
Tschudin-Sutter S, Widmer AF, Emmerich P, Schmidt-Chanasit J, Battegay M.
Lancet. 2015 Dec 19;386(10012):2478-80.

Evolutionary origins of hepatitis A virus in small mammals.
Drexler JF, Corman VM, Lukashev AN, van den Brand JM, Gmyl AP, Brünink S, Rasche A, Seggewiβ N, Feng H, Leijten LM, Vallo P, Kuiken T, Dotzauer A, Ulrich RG, Lemon SM, Drosten C; Hepatovirus Ecology Consortium.
Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15190-5. doi: 10.1073/pnas.1516992112.

Mobile diagnostics in outbreak response, not only for Ebola: a blueprint for a modular and robust field laboratory.
Wölfel R, Stoecker K, Fleischmann E, Gramsamer B, Wagner M, Molkenthin P, Di Caro A, Günther S, Ibrahim S, Genzel GH, Ozin-Hofsäss AJ, Formenty P, Zöller L.
Euro Surveill. 2015 Nov 5;20(44). doi: 10.2807/1560-7917.ES.2015.20.44.30055.

Efficacy of Favipiravir Alone and in Combination With Ribavirin in a Lethal, Immunocompetent Mouse Model of Lassa Fever.
Oestereich L, Rieger T, Lüdtke A, Ruibal P, Wurr S, Pallasch E, Bockholt S, Krasemann S, Muñoz-Fontela C, Günther S.
J Infect Dis. 2015 Nov 3. pii: jiv522.

Delayed Disease Progression in Cynomolgus Macaques Infected with Ebola Virus Makona Strain.
Marzi A, Feldmann F, Hanley PW, Scott DP, Günther S, Feldmann H.
Emerg Infect Dis. 2015 Oct;21(10):1777-83. doi: 10.3201/eid2110.150259.

Ebola virus dynamics in mice treated with favipiravir.
Madelain V, Oestereich L, Graw F, Nguyen TH, de Lamballerie X, Mentré F, Günther S, Guedj J.
Antiviral Res. 2015 Nov;123:70-7. doi: 10.1016/j.antiviral.2015.08.015.

Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus.
Andersen KG, Shapiro BJ, Matranga CB, Sealfon R, Lin AE, Moses LM, ..., Günther S, ..., Happi CT, Garry RF, Sabeti PC.
Cell. 2015 Aug 13;162(4):738-50. doi: 10.1016/j.cell.2015.07.020.

Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: interim results from the Guinea ring vaccination cluster-randomised trial.
Henao-Restrepo AM, Longini IM, Egger M, Dean NE, Edmunds WJ, Camacho A, Carroll MW, Doumbia M, Draguez B, Duraffour S, Enwere G, Grais R, Günther S, Hossmann S, Kondé MK, Kone S, Kuisma E, Levine MM, Mandal S, Norheim G, Riveros X, Soumah A, Trelle S, Vicari AS, Watson CH, Kéïta S, Kieny MP, Røttingen JA.
Lancet. 2015 Aug 29;386(9996):857-66. doi: 10.1016/S0140-6736(15)61117-5.

Temporal and spatial analysis of the 2014-2015 Ebola virus outbreak in West Africa.
Carroll MW, Matthews DA, Hiscox JA, Elmore MJ, Pollakis G, Rambaut A, ..., Wölfel R, Formenty P, Günther S.
Nature. 2015 Aug 6;524(7563):97-101. doi: 10.1038/nature14594.

Risk Factors Associated with Ebola and Marburg Viruses Seroprevalence in Blood Donors in the Republic of Congo.
Moyen N, Thirion L, Emmerich P, Dzia-Lepfoundzou A, Richet H, Boehmann Y, Dimi Y, Gallian P, Gould EA, Günther S, de Lamballerie X.
PLoS Negl Trop Dis. 2015 Jun 5;9(6):e0003833. doi: 10.1371/journal.pntd.0003833.

Shedding dynamics of Morogoro virus, an African arenavirus closely related to Lassa virus, in its natural reservoir host Mastomys natalensis.
Borremans B, Vossen R, Becker-Ziaja B, Gryseels S, Hughes N, Van Gestel M, Van Houtte N, Günther S, Leirs H.
Sci Rep. 2015 May 29;5:10445. doi: 10.1038/srep10445.

International external quality assessment study for molecular detection of Lassa virus.
Nikisins S, Rieger T, Patel P, Müller R, Günther S, Niedrig M.
PLoS Negl Trop Dis. 2015 May 21;9(5):e0003793. doi: 10.1371/journal.pntd.0003793.

Acute Zika virus infection after travel to Malaysian Borneo, September 2014.
Tappe D, Nachtigall S, Kapaun A, Schnitzler P, Günther S, Schmidt-Chanasit J.
Emerg Infect Dis. 2015 May;21(5):911-3. doi: 10.3201/eid2105.141960.

Extending the "social": anthropological contributions to the study of viral haemorrhagic fevers.
Brown H, Kelly AH, Mari Saez A, Fichet-Calvet E, Ansumana R, Bonwitt J, Magassouba N, Sahr F, Borchert M.
PLoS Negl Trop Dis. 2015 Apr 16;9(4):e0003651. doi: 10.1371/journal.pntd.0003651. eCollection 2015 Apr.

International external quality control assessment for the serological diagnosis of dengue infections.
Domingo C, Alves MJ, de Ory F, Teichmann A, Schmitz H, Müller R, Niedrig M.
BMC Infect Dis. 2015 Apr 1;15:167.

Ebola virus disease in mice with transplanted human hematopoietic stem cells.
Lüdtke A, Oestereich L, Ruibal P, Wurr S, Pallasch E, Bockholt S, Ip WH, Rieger T, Gómez-Medina S, Stocking C, Rodríguez E, Günther S, Muñoz-Fontela C.
J Virol. 2015 Apr;89(8):4700-4. doi: 10.1128/JVI.03546-14.

Research efforts to control highly pathogenic arenaviruses: a summary of the progress and gaps.
Kerber R, Reindl S, Romanowski V, Gómez RM, Ogbaini-Emovon E, Günther S, ter Meulen J.
J Clin Virol. 2015 Mar;64:120-7. doi: 10.1016/j.jcv.2014.12.004. Review.

Effect of lysine to arginine mutagenesis in the V3 loop of HIV-1 gp120 on viral entry efficiency and neutralization.
Schwalbe B, Schreiber M.
PLoS One. 2015 Mar 18;10(3):e0119879. doi: 10.1371/journal.pone.0119879. eCollection 2015.

Zika virus infections imported to Italy: clinical, immunological and virological findings, and public health implications.
Zammarchi L, Stella G, Mantella A, Bartolozzi D, Tappe D, Günther S, Oestereich L, Cadar D, Muñoz-Fontela C, Bartoloni A, Schmidt-Chanasit J.
J Clin Virol. 2015 Feb;63:32-5. doi: 10.1016/j.jcv.2014.12.005.

Gairo virus, a novel arenavirus of the widespread Mastomys natalensis: Genetically divergent, but ecologically similar to Lassa and Morogoro viruses.
Gryseels S, Rieger T, Oestereich L, Cuypers B, Borremans B, Makundi R, Leirs H, Günther S, Goüy de Bellocq J.
Virology. 2015 Feb;476:249-56. doi: 10.1016/j.virol.2014.12.011.

Identification of essential outstanding questions for an adequate European laboratory response to Ebolavirus Zaire West Africa 2014.
Reusken C, Niedrig M, Pas S, Anda P, Baize S, Charrel R, Di Caro A, Drosten C, Fernandez-Garcia MD, Franco L, Gunther S, Leparc-Goffart I, Martina B, Pannetier D, Papa A, Sanchez-Seco MP, Vapalahti O, Koopmans M.
J Clin Virol. 2015 Jan;62:124-34.

Lactating mothers infected with Ebola virus: EBOV RT-PCR of blood only may be insufficient.
Moreau M, Spencer C, Gozalbes JG, Colebunders R, Lefevre A, Gryseels S, Borremans B, Gunther S, Becker D, Bore JA, Koundouno FR, Di Caro A, Wölfel R, Decroo T, Van Herp M, Peetermans L, Camara AM.
Euro Surveill. 2015 Jan 22;20(3). pii: 21017.

Health care response to CCHF in US soldier and nosocomial transmission to health care providers, Germany, 2009.
Conger NG, Paolino KM, Osborn EC, Rusnak JM, Günther S, Pool J, Rollin PE, Allan PF, Schmidt-Chanasit J, Rieger T, Kortepeter MG.
Emerg Infect Dis. 2015 Jan;21(1):23-31. doi: 10.3201/eid2101.141413.

Using modelling to disentangle the relative contributions of zoonotic and anthroponotic transmission: the case of lassa fever.
Lo Iacono G, Cunningham AA, Fichet-Calvet E, Garry RF, Grant DS, Khan SH, Leach M, Moses LM, Schieffelin JS, Shaffer JG, Webb CT, Wood JL.
PLoS Negl Trop Dis. 2015 Jan 8;9(1):e3398. doi: 10.1371/journal.pntd.0003398.

Abteilung Virologie
2014

Management of pregnant women infected with Ebola virus in a treatment centre in Guinea, June 2014.
Baggi FM, Taybi A, Kurth A, Van Herp M, Di Caro A, Wölfel R, Günther S, Decroo T, Declerck H, Jonckheere S.
Euro Surveill. 2014 Dec 11;19(49). pii: 20983.

Detection of serotype-specific antibodies to the four dengue viruses using an immune complex binding (ICB) ELISA.
Emmerich P, Mika A, Schmitz H.
PLoS Negl Trop Dis. 2013 Dec 26;7(12):e2580.

Complete genome sequences of three ebola virus isolates from the 2014 outbreak in west Africa.
Hoenen T, Groseth A, Feldmann F, Marzi A, Ebihara H, Kobinger G, Günther S, Feldmann H.
Genome Announc. 2014 Dec 18;2(6). pii: e01331-14. doi: 10.1128/genomeA.01331-14.

A case of severe Ebola virus infection complicated by gram-negative septicemia.
Kreuels B, Wichmann D, Emmerich P, Schmidt-Chanasit J, de Heer G, Kluge S, Sow A, Renné T, Günther S, Lohse AW, Addo MM, Schmiedel S.
N Engl J Med. 2014 Dec 18;371(25):2394-401. doi: 10.1056/NEJMoa1411677.

Human Dobrava-Belgrade hantavirus infection, Kosovo.
Emmerich P, Müller N, Heinemann P, Rother E, Jakupi X, Günther S, Cadar D, Schmidt-Chanasit J.
J Clin Virol. 2014 Nov;61(3):439-41. doi: 10.1016/j.jcv.2014.09.013.

Nomenclature- and database-compatible names for the two Ebola virus variants that emerged in Guinea and the Democratic Republic of the Congo in 2014.
Kuhn JH, Andersen KG, Baize S, ..., Gabriel M, ..., Günther S, ..., Formenty P.
Viruses. 2014 Nov 24;6(11):4760-99. doi: 10.3390/v6114760.

Evidence for a decrease in transmission of Ebola virus--Lofa County, Liberia, June 8-November 1, 2014.
Sharma A, Heijenberg N, Peter C, Bolongei J, Reeder B, Alpha T, Sterk E, Robert H, Kurth A, Cannas A, Bocquin A, Strecker T, Logue C, Di Caro A, Pottage T, Yue C, Stoecker K, Wölfel R, Gabriel M, Günther S, Damon I; Centers for Disease Control and Prevention (CDC).
MMWR Morb Mortal Wkly Rep. 2014 Nov 21;63(46):1067-71.

O'nyong-nyong virus infection imported to Europe from Kenya by a traveler.
Tappe D, Kapaun A, Emmerich P, Campos Rde M, Cadar D, Günther S, Schmidt-Chanasit J.
Emerg Infect Dis. 2014 Oct;20(10):1766-7. doi: 10.3201/eid2010.140823.

Emergence of Zaire Ebola virus disease in Guinea.
Baize S, Pannetier D, Oestereich L, Rieger T, Koivogui L, Magassouba N, Soropogui B, Sow MS, Keïta S, De Clerck H, Tiffany A, Dominguez G, Loua M, Traoré A, Kolié M, Malano ER, Heleze E, Bocquin A, Mély S, Raoul H, Caro V, Cadar D, Gabriel M, Pahlmann M, Tappe D, Schmidt-Chanasit J, Impouma B, Diallo AK, Formenty P, Van Herp M, Günther S.
N Engl J Med. 2014 Oct 9;371(15):1418-25. doi: 10.1056/NEJMoa1404505.

Crimean-Congo hemorrhagic fever virus clades V and VI (Europe 1 and 2) in ticks in Kosovo, 2012.
Sherifi K, Cadar D, Muji S, Robaj A, Ahmeti S, Jakupi X, Emmerich P, Krüger A.
PLoS Negl Trop Dis. 2014 Sep 25;8(9):e3168.

Lassa serology in natural populations of rodents and horizontal transmission.
Fichet-Calvet E, Becker-Ziaja B, Koivogui L, Günther S.
Vector Borne Zoonotic Dis. 2014 Sep;14(9):665-74. doi: 10.1089/vbz.2013.1484.

Dengue virus transmission by blood stem cell donor after travel to Sri Lanka; Germany, 2013.
Punzel M, Korukluoğlu G, Caglayik DY, Menemenlioglu D, Bozdag SC, Tekgündüz E, Altuntaş F, Campos Rde M, Burde B, Günther S, Tappe D, Cadar D, Schmidt-Chanasit J.
Emerg Infect Dis. 2014 Aug;20(8):1366-9. doi: 10.3201/eid2008.140508.

Role of the C terminus of Lassa virus L protein in viral mRNA synthesis.
Lehmann M, Pahlmann M, Jérôme H, Busch C, Lelke M, Günther S.
J Virol. 2014 Aug;88(15):8713-7. doi: 10.1128/JVI.00652-14.

Genome analysis of Mayaro virus imported to Germany from French Guiana.
Friedrich-Jänicke B, Emmerich P, Tappe D, Günther S, Cadar D, Schmidt-Chanasit J.
Emerg Infect Dis. 2014 Jul;20(7):1255-7. doi: 10.3201/eid2007.140043.

Persisting arthralgia due to Mayaro virus infection in a traveler from Brazil: is there a risk for attendants to the 2014 FIFA World Cup?
Slegers CA, Keuter M, Günther S, Schmidt-Chanasit J, van der Ven AJ, de Mast Q.
J Clin Virol. 2014 Jul;60(3):317-9. doi: 10.1016/j.jcv.2014.04.020.

Evaluation of antiviral efficacy of ribavirin, arbidol, and T-705 (favipiravir) in a mouse model for Crimean-Congo hemorrhagic fever.
Oestereich L, Rieger T, Neumann M, Bernreuther C, Lehmann M, Krasemann S, Wurr S, Emmerich P, de Lamballerie X, Ölschläger S, Günther S.
PLoS Negl Trop Dis. 2014 May 1;8(5):e2804. doi: 10.1371/journal.pntd.0002804.

Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model.
Oestereich L, Lüdtke A, Wurr S, Rieger T, Muñoz-Fontela C, Günther S.
Antiviral Res. 2014 May;105:17-21. doi: 10.1016/j.antiviral.2014.02.014.

A virus-envelope paired competitive assay to study entry efficiency of human immunodeficiency virus type 1 in vitro.
Schwalbe B, Hauser H, Schreiber M.
J Virol Methods. 2014 May 22;205C:91-98. doi: 10.1016/j.jviromet.2014.05.009.

First case of laboratory-confirmed Zika virus infection imported into Europe, November 2013.
Tappe D, Rissland J, Gabriel M, Emmerich P, Gunther S, Held G, Smola S, Schmidt-Chanasit J.
Euro Surveill. 2014 Jan 30;19(4). pii: 20685.

Autochthonous dengue virus infection in Japan imported into Germany, September 2013.
Schmidt-Chanasit J, Emmerich P, Tappe D, Gunther S, Schmidt S, Wolff D, Hentschel K, Sagebiel D, Schoneberg I, Stark K, Frank C.
Euro Surveill. 2014 Jan 23;19(3). pii: 20681.

Abteilung Virologie
2013

Genetic shift of env V3 loop viral sequences in patients with HIV-associated neurocognitive disorder during antiretroviral therapy.
Eggers C, Müller O, Thordsen I, Schreiber M, Methner A.
J Neurovirol. 2013 Dec;19(6):523-30.

Hospital-based surveillance for viral hemorrhagic fevers and hepatitides in Ghana.
Bonney JH, Osei-Kwasi M, Adiku TK, Barnor JS, Amesiya R, Kubio C, Ahadzie L, Olschläger S, Lelke M, Becker-Ziaja B, Pahlmann M, Günther S.
PLoS Negl Trop Dis. 2013 Sep 19;7(9):e2435. doi: 10.1371/journal.pntd.0002435.

Increase in West Nile virus infections imported to Germany in 2012.
Gabriel M, Emmerich P, Frank C, Fiedler M, Rashidi-Alavijeh J, Jochum C, Günther S, Auerhammer K, Rupprecht HJ, Blank RT, Sacher N, Pertzborn L, Stark K, Schrauzer T, Schmidt-Chanasit J.
Clin Virol. 2013 Nov;58(3):587-9. doi: 10.1016/j.jcv.2013.08.027.

Infection of type I interferon receptor-deficient mice with various old world arenaviruses: a model for studying virulence and host species barriers.
Rieger T, Merkler D, Günther S.
PLoS One. 2013 Aug 22;8(8):e72290. doi: 10.1371/journal.pone.0072290.

Containing a Lassa fever epidemic in a resource-limited setting: outbreak description and lessons learned from Abakaliki, Nigeria (January-March 2012).
Ajayi NA, Nwigwe CG, Azuogu BN, Onyire BN, Nwonwu EU, Ogbonnaya LU, Onwe FI, Ekaete T, Günther S, Ukwaja KN.
nt J Infect Dis. 2013 Nov;17(11):e1011-6. doi: 10.1016/j.ijid.2013.05.015.

The N terminus of Andes virus L protein suppresses mRNA and protein expression in mammalian cells.
Heinemann P, Schmidt-Chanasit J, Günther S.
J Virol. 2013 Jun;87(12):6975-85. doi: 10.1128/JVI.00043-13.

Biosafety Level-4 laboratories in Europe: opportunities for public health, diagnostics, and research.
Nisii C, Castilletti C, Raoul H, Hewson R, Brown D, Gopal R, Eickmann M, Gunther S, Mirazimi A, Koivula T, Feldmann H, Di Caro A, Capobianchi MR, Ippolito G.
PLoS Pathog. 2013 Jan;9(1):e1003105. doi: 10.1371/journal.ppat.1003105.

Seroepidemiological study reveals regional co-occurrence of Lassa- and Hantavirus antibodies in Upper Guinea, West Africa.
Klempa B, Koulemou K, Auste B, Emmerich P, Thomé-Bolduan C, Günther S, Koivogui L, Krüger DH, Fichet-Calvet E.
Trop Med Int Health. 2013 Mar;18(3):366-71. doi: 10.1111/tmi.12045.

14. Prolonged polyarthralgia in a German traveller with Mayaro virus infection without inflammatory correlates.
Theilacker C, Held J, Allering L, Emmerich P, Schmidt-Chanasit J, Kern WV, Panning M.
BMC Infect Dis. 2013 Aug 8;13:369.

Abteilung Virologie
2012

High diversity of RNA viruses in rodents, Ethiopia.
Meheretu Y, Cížková D, Těšíková J, Welegerima K, Tomas Z, Kidane D, Girmay K, Schmidt-Chanasit J, Bryja J, Günther S, Bryjová A, Leirs H, Goüy de Bellocq J.
Emerg Infect Dis. 2012 Dec;18(12):2047-50. doi: 10.3201/eid1812.120596.

Molecular diagnostics for lassa fever at Irrua specialist teaching hospital, Nigeria: lessons learnt from two years of laboratory operation.
Asogun DA, Adomeh DI, Ehimuan J, Odia I, Hass M, Gabriel M, Ölschläger S, Becker-Ziaja B, Folarin O, Phelan E, Ehiane PE, Ifeh VE, Uyigue EA, Oladapo YT, Muoebonam EB, Osunde O, Dongo A, Okokhere PO, Okogbenin SA, Momoh M, Alikah SO, Akhuemokhan OC, Imomeh P, Odike MA, Gire S, Andersen K, Sabeti PC, Happi CT, Akpede GO, Günther S.
PLoS Negl Trop Dis. 2012;6(9):e1839. doi: 10.1371/journal.pntd.0001839.

West Nile virus meningoencephalitis imported into Germany.
Schultze-Amberger J, Emmerich P, Günther S, Schmidt-Chanasit J.
Emerg Infect Dis. 2012 Oct;18(10):1698-700. doi: 10.3201/eid1810.120204.

Hospital-based surveillance for Lassa fever in Edo State, Nigeria, 2005-2008.
Ehichioya DU, Asogun DA, Ehimuan J, Okokhere PO, Pahlmann M, Ölschläger S, Becker-Ziaja B, Günther S, Omilabu SA.
Trop Med Int Health. 2012 Aug;17(8):1001-4. doi: 10.1111/j.1365-3156.2012.03010.x.

Acute liver failure, multiorgan failure, cerebral oedema, and activation of proangiogenic and antiangiogenic factors in a case of Marburg haemorrhagic fever.
van Paassen J, Bauer MP, Arbous MS, Visser LG, Schmidt-Chanasit J, Schilling S, Ölschläger S, Rieger T, Emmerich P, Schmetz C, van de Berkmortel F, van Hoek B, van Burgel ND, Osterhaus AD, Vossen AC, Günther S, van Dissel JT.
Lancet Infect Dis. 2012 Aug;12(8):635-42. doi: 10.1016/S1473-3099(12)70018-X.

Rapid and specific detection of Lassa virus by reverse transcription-PCR coupled with oligonucleotide array hybridization.
Ölschläger S, Günther S.
J Clin Microbiol. 2012 Jul;50(7):2496-9. doi: 10.1128/JCM.00998-12.

Two laboratory-confirmed cases of Japanese encephalitis imported to Germany by travelers returning from Southeast Asia.
Tappe D, Nemecek A, Zipp F, Emmerich P, Gabriel M, Günther S, Dobler G, Schmidt-Chanasit J, Stich A.
J Clin Virol. 2012 Jul;54(3):282-5. doi: 10.1016/j.jcv.2012.03.004.

Mayaro virus infection in traveler returning from Amazon Basin, northern Peru.
Neumayr A, Gabriel M, Fritz J, Günther S, Hatz C, Schmidt-Chanasit J, Blum J.
Emerg Infect Dis. 2012 Apr;18(4):695-6. doi: 10.3201/eid1804.111717.

Epizootic emergence of Usutu virus in wild and captive birds in Germany.
Becker N, Jöst H, Ziegler U, Eiden M, Höper D, Emmerich P, Fichet-Calvet E, Ehichioya DU, Czajka C, Gabriel M, Hoffmann B, Beer M, Tenner-Racz K, Racz P, Günther S, Wink M, Bosch S, Konrad A, Pfeffer M, Groschup MH, Schmidt-Chanasit J.
PLoS One. 2012;7(2):e32604. doi: 10.1371/journal.pone.0032604.

Abteilung Virologie
2011

Management of accidental exposure to Ebola virus in the biosafety level 4 laboratory, Hamburg, Germany.
Günther S, Feldmann H, Geisbert TW, Hensley LE, Rollin PE, Nichol ST, Ströher U, Artsob H, Peters CJ, Ksiazek TG, Becker S, ter Meulen J, Olschläger S, Schmidt-Chanasit J, Sudeck H, Burchard GD, Schmiedel S.
J Infect Dis. 2011 Nov;204 Suppl 3:S785-90. doi: 10.1093/infdis/jir298.

Cross-species analysis of the replication complex of Old World arenaviruses reveals two nucleoprotein sites involved in L protein function.
Kerber R, Rieger T, Busch C, Flatz L, Pinschewer DD, Kümmerer BM, Günther S.
J Virol. 2011 Dec;85(23):12518-28. doi: 10.1128/JVI.05091-11.

Structure of the Lassa virus nucleoprotein revealed by X-ray crystallography, small-angle X-ray scattering, and electron microscopy.
Brunotte L, Kerber R, Shang W, Hauer F, Hass M, Gabriel M, Lelke M, Busch C, Stark H, Svergun DI, Betzel C, Perbandt M, Günther S.
J Biol Chem. 2011 Nov 4;286(44):38748-56. doi: 10.1074/jbc.M111.278838.

Specific detection of antibodies to different flaviviruses using a new immune complex ELISA.
Schmitz H, Gabriel M, Emmerich P.
Med Microbiol Immunol. 2011 Nov;200(4):233-9.

Isolation of usutu virus in Germany.
Jöst H, Bialonski A, Maus D, Sambri V, Eiden M, Groschup MH, Günther S, Becker N, Schmidt-Chanasit J.
Am J Trop Med Hyg. 2011 Sep;85(3):551-3. doi: 10.4269/ajtmh.2011.11-0248.

Medical importance of Sindbis virus in south-west Germany.
Jöst H, Bürck-Kammerer S, Hütter G, Lattwein E, Lederer S, Litzba N, Bock-Hensley O, Emmerich P, Günther S, Becker N, Niedrig M, Schmidt-Chanasit J.
Clin Virol. 2011 Nov;52(3):278-9. doi: 10.1016/j.jcv.2011.08.002.

Phylogenetic analysis of Puumala virus subtype Bavaria, characterization and diagnostic use of its recombinant nucleocapsid protein.
Mertens M, Kindler E, Emmerich P, Esser J, Wagner-Wiening C, Wölfel R, Petraityte-Burneikiene R, Schmidt-Chanasit J, Zvirbliene A, Groschup MH, Dobler G, Pfeffer M, Heckel G, Ulrich RG, Essbauer SS.
Virus Genes. 2011 Oct;43(2):177-91.

Novel arenavirus sequences in Hylomyscus sp. and Mus (Nannomys) setulosus from Côte d'Ivoire: implications for evolution of arenaviruses in Africa.
Coulibaly-N'Golo D, Allali B, Kouassi SK, Fichet-Calvet E, Becker-Ziaja B, Rieger T, Olschläger S, Dosso H, Denys C, Ter Meulen J, Akoua-Koffi C, Günther S.
PLoS One. 2011;6(6):e20893. doi: 10.1371/journal.pone.0020893.

Depletion of GTP pool is not the predominant mechanism by which ribavirin exerts its antiviral effect on Lassa virus.
Ölschläger S, Neyts J, Günther S.
Antiviral Res. 2011 Aug;91(2):89-93. doi: 10.1016/j.antiviral.2011.05.006.

Presence of Mopeia virus, an African arenavirus, related to biotope and individual rodent host characteristics: implications for virus transmission.
Borremans B, Leirs H, Gryseels S, Günther S, Makundi R, de Bellocq JG.
Vector Borne Zoonotic Dis. 2011 Aug;11(8):1125-31. doi: 10.1089/vbz.2010.0010.

An unusual cause of elevated liver function tests in an elderly female.
Frickmann H, Gabriel M, Polywka S, Bonow I, Günther S, Schmidt-Chanasit J.
J Clin Virol. 2011 Jun;51(2):93-5. doi: 10.1016/j.jcv.2011.02.012.

Current molecular epidemiology of Lassa virus in Nigeria.
Ehichioya DU, Hass M, Becker-Ziaja B, Ehimuan J, Asogun DA, Fichet-Calvet E, Kleinsteuber K, Lelke M, ter Meulen J, Akpede GO, Omilabu SA, Günther S, Olschläger S.
J Clin Microbiol. 2011 Mar;49(3):1157-61. doi: 10.1128/JCM.01891-10.

Isolation and phylogenetic analysis of Batai virus, Germany.
Jöst H, Bialonski A, Schmetz C, Günther S, Becker N, Schmidt-Chanasit J.
Am J Trop Med Hyg. 2011 Feb;84(2):241-3. doi: 10.4269/ajtmh.2011.10-0483.

Complete sequence and phylogenetic characterisation of Crimean-Congo hemorrhagic fever virus from Afghanistan.
Olschläger S, Gabriel M, Schmidt-Chanasit J, Meyer M, Osborn E, Conger NG, Allan PF, Günther S.
J Clin Virol. 2011 Jan;50(1):90-2. doi: 10.1016/j.jcv.2010.09.018.

Domain structure of Lassa virus L protein.
Brunotte L, Lelke M, Hass M, Kleinsteuber K, Becker-Ziaja B, Günther S.
J Virol. 2011 Jan;85(1):324-33. doi: 10.1128/JVI.00721-10.

Abteilung Virologie
2010

Functional dissection of the alphavirus capsid protease: sequence requirements for activity.
Thomas S, Rai J, John L, Günther S, Drosten C, Pützer BM, Schaefer S.
Virol J. 2010 Nov 18;7:327. doi: 10.1186/1743-422X-7-327.

The N-terminal domain of the arenavirus L protein is an RNA endonuclease essential in mRNA transcription.
Morin B, Coutard B, Lelke M, Ferron F, Kerber R, Jamal S, Frangeul A, Baronti C, Charrel R, de Lamballerie X, Vonrhein C, Lescar J, Bricogne G, Günther S, Canard B.
PLoS Pathog. 2010 Sep 16;6(9):e1001038. doi: 10.1371/journal.ppat.1001038.

Establishment of fruit bat cells (Rousettus aegyptiacus) as a model system for the investigation of filoviral infection.
Krähling V, Dolnik O, Kolesnikova L, Schmidt-Chanasit J, Jordan I, Sandig V, Günther S, Becker S.
PLoS Negl Trop Dis. 2010 Aug 24;4(8):e802. doi: 10.1371/journal.pntd.0000802.

Chikungunya and dengue virus antibodies in a traveller with severe arthralgia returning from India.
Tappe D, Schmidt-Chanasit J, Günther S, Schulze MH, Stich A.
J Clin Virol. 2010 Nov;49(3):148-50. doi: 10.1016/j.jcv.2010.05.012.

Detection of all species of the genus Alphavirus by reverse transcription-PCR with diagnostic sensitivity.
Grywna K, Kupfer B, Panning M, Drexler JF, Emmerich P, Drosten C, Kümmerer BM.
J Clin Microbiol. 2010 Sep;48(9):3386-7.

Early serodiagnosis of acute human Crimean-Congo hemorrhagic fever virus infections by novel capture assays.
Emmerich P, Avsic-Zupanc T, Chinikar S, Saksida A, Thomé-Bolduan C, Parczany-Hartmann A, Langroudi AG, Moradi M, Ahmeti S, Günther S, Schmidt-Chanasit J.
J Clin Virol. 2010 Aug;48(4):294-5. doi: 10.1016/j.jcv.2010.05.002.

Long-term survival of an urban fruit bat seropositive for Ebola and Lagos bat viruses.
Hayman DT, Emmerich P, Yu M, Wang LF, Suu-Ire R, Fooks AR, Cunningham AA, Wood JL.
PLoS One. 2010 Aug 4;5(8):e11978.

A 12-year molecular survey of clinical herpes simplex virus type 2 isolates demonstrates the circulation of clade A and B strains in Germany.
Schmidt-Chanasit J, Bialonski A, Heinemann P, Ulrich RG, Günther S, Rabenau HF, Doerr HW.
J Clin Virol. 2010 Jul;48(3):208-11. doi: 10.1016/j.jcv.2010.04.009.

Laboratory diagnosis of Lassa fever, liberia.
Panning M, Emmerich P, Olschläger S, Bojenko S, Koivogui L, Marx A, Lugala PC, Günther S, Bausch DG, Drosten C.
Emerg Infect Dis. 2010 Jun;16(6):1041-3. doi: 10.3201/eid1606.100040.

Lassa fever, Nigeria, 2005-2008.
Ehichioya DU, Hass M, Olschläger S, Becker-Ziaja B, Onyebuchi Chukwu CO, Coker J, Nasidi A, Ogugua OO, Günther S, Omilabu SA.
Emerg Infect Dis. 2010 Jun;16(6):1040-1. doi: 10.3201/eid1606.100080.

Neutralization of X4- and R5-tropic HIV-1 NL4-3 variants by HOCl-modified serum albumins.
Polzer S, van Yperen M, Kirst M, Schwalbe B, Schaal H, Schreiber M.
BMC Res Notes. 2010 Jun 2;3:155.

Toscana virus infection imported from Elba into Switzerland.
Gabriel M, Resch C, Günther S, Schmidt-Chanasit J.
Emerg Infect Dis. 2010 Jun;16(6):1034-6. doi: 10.3201/eid1606.091763.

T cell-dependence of Lassa fever pathogenesis.
Flatz L, Rieger T, Merkler D, Bergthaler A, Regen T, Schedensack M, Bestmann L, Verschoor A, Kreutzfeldt M, Brück W, Hanisch UK, Günther S, Pinschewer DD.
PLoS Pathog. 2010 Mar 26;6(3):e1000836. doi: 10.1371/journal.ppat.1000836.

Improved detection of Lassa virus by reverse transcription-PCR targeting the 5' region of S RNA.
Ölschläger S, Lelke M, Emmerich P, Panning M, Drosten C, Hass M, Asogun D, Ehichioya D, Omilabu S, Günther S.
J Clin Microbiol. 2010 Jun;48(6):2009-13. doi: 10.1128/JCM.02351-09.

Sympatric occurrence of 3 arenaviruses, Tanzania.
de Bellocq JG, Borremans B, Katakweba A, Makundi R, Baird SJ, Becker-Ziaja B, Günther S, Leirs H.
Emerg Infect Dis. 2010 Apr;16(4):692-5. doi: 10.3201/eid1604.091721.

Isolation and phylogenetic analysis of Sindbis viruses from mosquitoes in Germany.
Jöst H, Bialonski A, Storch V, Günther S, Becker N, Schmidt-Chanasit J.
J Clin Microbiol. 2010 May;48(5):1900-3. doi: 10.1128/JCM.00037-10.

Lambda interferon renders epithelial cells of the respiratory and gastrointestinal tracts resistant to viral infections.
Mordstein M, Neugebauer E, Ditt V, Jessen B, Rieger T, Falcone V, Sorgeloos F, Ehl S, Mayer D, Kochs G, Schwemmle M, Günther S, Drosten C, Michiels T, Staeheli P.
J Virol. 2010 Jun;84(11):5670-7. doi: 10.1128/JVI.00272-10.

Positive hepatitis E and Epstein Barr virus serology in a patient with jaundice after travel.
Tappe D, Müller A, Ziegler U, Weissbrich B, Schubert J, Günther S, Schmidt-Chanasit J, Stich A.
J Clin Virol. 2010 Jun;48(2):78-81. doi: 10.1016/j.jcv.2010.02.005.

An N-terminal region of Lassa virus L protein plays a critical role in transcription but not replication of the virus genome.
Lelke M, Brunotte L, Busch C, Günther S.
J Virol. 2010 Feb;84(4):1934-44. doi: 10.1128/JVI.01657-09.

Acute Toscana virus infection mimicked by Yersinia-induced reactive arthritis syndrome after journey to Spain.
Tappe D, Schmidt-Chanasit J, Günther S, Ries A, Ziegler U, Müller A, Stich A.
J Clin Virol. 2010 Jan;47(1):104-5. doi: 10.1016/j.jcv.2009.10.002.

Abteilung Virologie
2009

Mopeia virus-related arenavirus in natal multimammate mice, Morogoro, Tanzania.
Günther S, Hoofd G, Charrel R, Röser C, Becker-Ziaja B, Lloyd G, Sabuni C, Verhagen R, van der Groen G, Kennis J, Katakweba A, Machang'u R, Makundi R, Leirs H.
Emerg Infect Dis. 2009 Dec;15(12):2008-12. doi: 10.3201/eid1512.090864.

European perspective of 2-person rule for biosafety level 4 laboratories.
Ippolito G, Nisii C, Di Caro A, Brown D, Gopal R, Hewson R, Lloyd G, Günther S, Eickmann M, Mirazimi A, Koivula T, Georges Courbot MC, Raoul H, Capobianchi MR.
Emerg Infect Dis. 2009 Nov;15(11):1858. doi: 10.3201/eid1511.091134.

Response to imported case of Marburg hemorrhagic fever, the Netherland.
Timen A, Koopmans MP, Vossen AC, van Doornum GJ, Günther S, van den Berkmortel F, Verduin KM, Dittrich S, Emmerich P, Osterhaus AD, van Dissel JT, Coutinho RA.
Emerg Infect Dis. 2009 Aug;15(8):1171-5. doi: 10.3201/eid1508.090015.

Novel approach to differentiate subclades of varicella-zoster virus genotypes E1 and E2 in Germany.
Schmidt-Chanasit J, Olschläger S, Bialonski A, Heinemann P, Bleymehl K, Gross G, Günther S, Ulrich RG, Doerr HW.
Virus Res. 2009 Nov;145(2):347-9. doi: 10.1016/j.virusres.2009.08.003.

Highly specific detection of antibodies to tick-borne encephalitis (TBE) virus in humans using a domain III antigen and a sensitive immune complex (IC) ELISA.
Ludolfs D, Reinholz M, Schmitz H.
J Clin Virol. 2009 Jun;45(2):125-8.

Dengue and Chikungunya virus co-infection in a German traveller.
Schilling S, Emmerich P, Günther S, Schmidt-Chanasit J.
J Clin Virol. 2009 Jun;45(2):163-4. doi: 10.1016/j.jcv.2009.04.001.

Effects of mutations on HIV-1 infectivity and neutralization involving the conserved NNNT amino acid sequence in the gp120 V3 loop.
Polzer S, Müller H, Schreiber M.
FEBS Lett. 2009 Apr 2;583(7):1201-6. d

Low-density macroarray for rapid detection and identification of Crimean-Congo hemorrhagic fever virus.
Wölfel R, Paweska JT, Petersen N, Grobbelaar AA, Leman PA, Hewson R, Georges-Courbot MC, Papa A, Heiser V, Panning M, Günther S, Drosten C.
J Clin Microbiol. 2009 Apr;47(4):1025-30. doi: 10.1128/JCM.01920-08.

A 10-year molecular survey of herpes simplex virus type 1 in Germany demonstrates a stable and high prevalence of genotypes A and B.
Schmidt-Chanasit J, Bialonski A, Heinemann P, Ulrich RG, Günther S, Rabenau HF, Doerr HW.
J Clin Virol. 2009 Mar;44(3):235-7. doi: 10.1016/j.jcv.2008.12.016.

Cooperations

Dr. Cesar Muñoz-Fontela (HPI, Hamburg)

Cesar Muñoz-Fontela is head of the junior research group "Emerging Infections" at the HPI in Hamburg. We collaborate on the investigation of the immunology of viral hemorrhagic fevers (VHFs) such as Ebola virus disease and Lassa fever.

Irrua Specialist Teaching Hospital ISTH (Edo State, Nigeria)

In order to investigate the prevalence and genetic diversity of Lassa virus in Nigeria, as well as create the foundations for a study of human genetic susceptibility to Lassa Fever, we work in close collaboration with the study site at the Irrua Specialist Teaching Hospital (ISTH).

Contact

Prof. Dr. med. Stephan Günther

Phone: +49 40 42818-930
Fax: +49 40 42818-931
E-Mail: guenther@bnitm.de


PhD Students

Tobias Holm (-940)
Silke Olschewski (-935)
Anke Thielebein (-934)
Dominik Vogel (-940)
David Wozniak (-940)

Technical Staff

Michaela Bockelmann (-945)
Sabrina Bockholt (-934)
Carola Busch (-935)
Nadja Gogrefe (-935)
Sabine Kleuckling (-945)
Agnieszka Malota (-945)
Neele Neddersen (-456)
Elisa Pallasch (-934)
Kerstin Krausz (-454)
Corinna Thomé-Bolduan (-456)
Alexander Schlaphof (-456)
Stephanie Wurr (-934)