Non-acute infections and chronic disorders are often neglected in humanitarian settings, mostly because they do not require an immediate response, and they are usually characterized by a complex management [...] s, are a clear example of complex diseases, poorly managed and lacking attention both in terms of technological and structural innovation. Prevention and the integration of health care services are crucial [...] NTDs and schistosomiasis. The majority of our studies are conducted in Madagascar, where a high burden of schistosomiasis exists. Additional studies are conducted in Sub-Saharan Africa with a major focus

(arboviruses) are of growing importance in many countries of the world. Continuing eco-climatic changes and globalization create suitable conditions for the emergence of arboviruses. Thus, we are involved in [...] virus are threats for human and animal health. In cooperation with the Nature and Biodiversity Consveration Union (NABU) we ask citizens in Germany to sent dead birds to our institute. The samples are screened [...] Downstream analysis including the detection of new viruses and phylogenetic characterization of viruses are conducted in cooperation with the Virus Discovery, Genomics and Evolution Lab (Dr. Daniel Cadar). Vector

emerging mosquito-borne diseases (NEED) [2020-2025] Mosquito-borne viruses are an emerging threat in Central Europe, which are a major challenge for researchers, stakeholders and the overall health care [...] mosquito-borne viruses, model results are updated near-real time by combining remotely available biotic and abiotic data with statistical models. The results are presented in a rapidly updated website [...] responses can be very different, e.g. surveillance strategies, vector control or vaccination, which are all associated with different costs and outcomes regarding pathogen control. Therefore, the objective

adaption to the human environment influences vector behavior and if there are consequences on virus prevalence. Ae. aegypti are trapped along a transect in Benin, West Africa, reaching from urban sites [...] vector species, including a change in the hostfeeding behavior (zoophagy to anthropophagy), humans are challenged with new pathogens. Therefore the process of vector domestication is an extremely important [...] medium anthrophogenic impact to sylvatic sites with low anthropogenic impact. All trapped Ae. aegypti are analyzed with molecular methods and metagenome analyses to determine virus prevalence. The focus should

The diseases are triggered by a wide variety of causes such as viruses, bacteria, parasites, fungi or toxins. The people most affected by NTDs are often populations and minorities who are affected by poverty [...] diseases Over one billion people worldwide are affected by Neglected tropical diseases (NTDs). Nestled within the shadows of global health priorities, NTDs are a group of 21 diseases listed by the World [...] e.g. from the BMZ, whether these funds are also provided directly to finance research or primarily for capacity and infrastructure funding, as these aspects are closely linked in NTD research in particular

the host immune system, EVs isolated from parasite cultures are used to stimulate monocytes and neutrophils in vitro . Both immune cell types are known to be involved in the immune pathology of amebiasis [...] invasive, highly pathogenic phenotype is still not well understood. In order to identify factors that are positively or negatively correlated for invasion and destruction of the liver, we used a unique tool [...] on comprehensive transcriptome studies of these clones, we identified a set of candidate genes that are potentially involved in pathogenicity. Overexpression and silencing transfectants will be used to analyse

affecting humans are of zoonotic origin. Of these, many are caused by single-strand RNA bat-borne viruses, such as Ebola virus (EBOV), Marburg virus (MARV) and Nipah virus (NiV). There are often many differences [...] levels of virus replication in the absence of disease. The mechanisms responsible for such differences are yet to be determined. Vorheriges Element Nächstes Element Team Learn more Research Projects Learn more

into the ‘Chinese’ vaccine are, however, widespread. Particularly among the Muslim population, anti-Chinese sentiments and concerns that components of the vaccine are not halal are common. In addition to concerns [...] than 40 million babies are born with a congenital birth disorder, representing 3% of all newborns. Most birth disorders occur in low- and middle-income countries. Their consequences are massive (e.g. child [...] facilitated the development of AMR. In many countries around the world the gate keepers to antibiotics are pharmacists with many people being able to purchase antibiotics without prescriptions. As part of this

these interactions affect virus evolution and transmissibility. We are studying the biotic and abiotic factors of arbovirus emergence and are involved in arbovirus outbreak response. In addition, we provide [...] provision of logistics in the form of staff and supplies. Currently, there are four study groups within the department that are performing arbovirus research worldwide. Vorheriges Element Nächstes Element

immune protection. We are using immunogenomics, flow cytometry and bioinformatics to compile multiparametric data and to identify signatures related with protection. These studies are done in collaboration [...] research projects Role of dendritic cells on filovirus immunity and dissemination Dendritic cells (DC) are at the forefront of pathogen recognition in mucosae and skin, and provide a bridge between innate an [...] DC. T cell immunity in recovery and immunopathology of Ebola virus disease and Lassa fever T cells are critical for clearance of virus-infected cells and play additional roles in adaptive immune responses