Our publications
2023
Efficacy, safety, and tolerability of albendazole and ivermectin based regimens for the treatment of microfilaraemic loiasis in adult patients in Gabon: A randomized controlled assessor blinded clinical trial
- Zoleko-Manego R, Kreuzmair R, Veletzky L, Ndzebe-Ndoumba W, Ekoka Mbassi D, Okwu DG, Dimessa-Mbadinga-Weyat LB, Houtsa-Temgoua RD, Mischlinger J, McCall MBB, Kresmner PG, Agnandji ST, Lell B, Adegnika AA, Mombo-Ngoma G, Ramharter M
- PLoS Negl Trop Dis. 2023 Aug 28;17(8):e0011584. doi: 10.1371/journal.pntd.0011584
Epidemiology of co-infections in pregnant women living with human immunodeficiency virus 1 in rural Gabon: a cross-sectional study
- Davi SD, Okwu DG, Luetgehetmann M, Abba FM, Aepfelbacher M, Endamne LR, Alabi A, Zoleko-Manego R, Mombo-Ngoma G, Mahmoudou S, Addo MM, Ramharter M, Mischlinger J
- Infect Dis Poverty. 2023 Jul 6;12(1):64. doi: 10.1186/s40249-023-01114-y
Real-life effectiveness of anti-malarial treatment regimens: what are we aiming for?
- Mbassi DE, Pfaffendorf C, Mombo-Ngoma G, Kreuels B, Ramharter M
- Malar J. 2023 Jun 20;22(1):189. doi: 10.1186/s12936-023-04606-2
Ganaplacide (KAF156) plus lumefantrine solid dispersion formulation combination for uncomplicated Plasmodium falciparum malaria: an open-label, multicentre, parallel-group, randomised, controlled, phase 2 trial
- Ogutu B, Yeka A, Kusemererwa S, Thompson R, Tinto H, Toure AO, Uthaisin C, Verma A, Kibuuka A, Lingani M, Lourenço C, Mombo-Ngoma G, Nduba V, N'Guessan TL, Nassa GJW, Nyantaro M, Tina LO, Singh PK, El Gaaloul M, Marrast AC, Chikoto H, Csermak K, Demin I, Mehta D, Pathan R, Risterucci C, Su G, Winnips C, Kaguthi G, Fofana B, Grobusch MP
- Lancet Infect Dis. 2023 Sep;23(9):1051-1061. doi: 10.1016/S1473-3099(23)00209-8
Prevalence of and risk factors for microscopic and submicroscopic malaria infections in pregnancy: a systematic review and meta-analysis
- van Eijk AM, Stepniewska K, Hill J, Taylor SM, Rogerson SJ, Cottrell G, Chico RM, Gutman JR, Tinto H, Unger HW, Yanow SK, Meshnick SR, Ter Kuile FO, Mayor A
- Lancet Glob Health. 2023 Jul;11(7):e1061-e1074. doi: 10.1016/S2214-109X(23)00194-8
Prevalence and impact of SARS-CoV-2 infection on maternal and infant health in African populations: protocol of a multicentre prospective cohort study (MA-CoV project)
- Figueroa-Romero A, Mendes A, Mombo-Ngoma G, Mischlinger J, Esen M, Vogler M, Mazuze M, Mombo-Nzamba L, Mbadinga B, Sanz S, Ramharter M, Saute F, Nhampossa T, Menendez C, González R
- BMJ Open. 2023 May 22;13(5):e067083. doi: 10.1136/bmjopen-2022-067083
Randomized, open-label, phase 2a study to evaluate the contribution of artefenomel to the clinical and parasiticidal activity of artefenomel plus ferroquine in African patients with uncomplicated Plasmodium falciparum malaria
- Gansane A, Lingani M, Yeka A, Nahum A, Bouyou-Akotet M, Mombo-Ngoma G, Kaguthi G, Barceló C, Laurijssens B, Cantalloube C, Macintyre F, Djeriou E, Jessel A, Bejuit R, Demarest H, Marrast AC, Debe S, Tinto H, Kibuuka A, Nahum D, Mawili-Mboumba DP, Zoleko-Manego R, Mugenya I, Olewe F, Duparc S, Ogutu B
- Malar J. 2023 Jan 3;22(1):2. doi: 10.1186/s12936-022-04420-2
2022
Malaria-associated adhesion molecule activation facilitates the destruction of uninfected red blood cells
- Dalimot JJ, Klei TRL, Beuger BM, Dikmen Z, Bouwman SAM, Mombo-Ngoma G, Zoleko-Manego R, Ndzebe-Ndoumba WF, Egée S, Kuijpers TW, Grobusch MP, van Bruggen R
- Blood Adv. 2022 Nov 8;6(21):5798-5810. doi: 10.1182/bloodadvances.2021006171
Erratum to 'In vitro activity of eravacycline, a novel synthetic halogenated tetracycline, against the malaria parasite Plasmodium falciparum' [Journal of Global Antimicrobial Resistance 24 (2021) 93-97]
- Koehne E, Kreidenweiss A, Adegbite BR, Manego RZ, McCall MBB, Mombo-Ngoma G, Adegnika AA, Agnandji ST, Mordmüller B, Held J
- J Glob Antimicrob Resist. 2022 Dec;31:395. doi: 10.1016/j.jgar.2022.10.012
Effectiveness of antimalarial drug combinations in treating concomitant urogenital schistosomiasis in malaria patients in Lambaréné, Gabon: A non-randomised event-monitoring study
- Zoleko-Manego R, Okwu DG, Handrich C, Dimessa-Mbadinga LB, Akinosho MA, Ndzebe-Ndoumba WF, Davi SD, Stelzl D, Veletzky L, Kreidenweiss A, Nordmann T, Adegnika AA, Lell B, Kremsner PG, Ramharter M, Mombo-Ngoma G
- PLoS Negl Trop Dis. 2022 Oct 31;16(10):e0010899. doi: 10.1371/journal.pntd.0010899
Distinct loiasis infection states and associated clinical and hematological manifestations in patients from Gabon
- Veletzky L, Eberhardt KA, Hergeth J, Stelzl DR, Zoleko Manego R, Mombo-Ngoma G, Kreuzmair R, Burger G, Adegnika AA, Agnandji ST, Matsiegui PB, Boussinesq M, Mordmüller B, Ramharter M
- PLoS Negl Trop Dis. 2022 Sep 19;16(9):e0010793. doi: 10.1371/journal.pntd.0010793
Burden of malaria in pregnancy among adolescent girls compared to adult women in 5 sub-Saharan African countries: A secondary individual participant data meta-analysis of 2 clinical trials
- Pons-Duran C, Mombo-Ngoma G, Macete E, Desai M, Kakolwa MA, Zoleko-Manego R, Ouédragou S, Briand V, Valá A, Kabanywanyi AM, Ouma P, Massougbodji A, Sevene E, Cot M, Aponte JJ, Mayor A, Slutsker L, Ramharter M, Menéndez C, González R
- PLoS Med. 2022 Sep 2;19(9):e1004084. doi: 10.1371/journal.pmed.1004084
Performance of Field's Stain Compared with Conventional Giemsa Stain for the Rapid Detection of Blood Microfilariae in Gabon
- Ekoka Mbassi FA, Mombo-Ngoma G, Ndoumba WN, Yovo EK, Eberhardt KA, Ekoka Mbassi D, Adegnika AA, Agnandji ST, Bouyou-Akotet MK, Ramharter M, Zoleko-Manego R
- Am J Trop Med Hyg. 2022 Jul 5;107(2):383-387. doi: 10.4269/ajtmh.22-0061
Correction: Evidence for in vitro and in vivo activity of the antimalarial pyronaridine against Schistosoma
- Koehne E, Zander N, Rodi M, Held J, Hoffmann W, Zoleko-Manego R, Ramharter M, Mombo-Ngoma G, Kremsner PG, Kreidenweiss A
- PLoS Negl Trop Dis. 2022 Jun 2;16(6):e0010512. doi: 10.1371/journal.pntd.0010512
Effectiveness of pyronaridine-artesunate against Plasmodium malariae, Plasmodium ovale spp, and mixed-Plasmodium infections: a post-hoc analysis of the CANTAM-Pyramax trial
- Groger M, Tona Lutete G, Mombo-Ngoma G, Ntamabyaliro NY, Kahunu Mesia G, Muena Mujobu TB, Dimessa Mbadinga LB, Zoleko Manego R, Egger-Adam D, Borghini-Fuhrer I, Shin J, Miller R, Arbe-Barnes S, Duparc S, Ramharter M
- Lancet Microbe. 2022 Aug;3(8):e598-e605. doi: 10.1016/S2666-5247(22)00092-1
Challenges in the clinical development pathway for triple and multiple drug combinations in the treatment of uncomplicated falciparum malaria
- Bassat Q, Maïga-Ascofaré O, May J, Clain J, Mombo-Ngoma G, Groger M, Adegnika AA, Agobé JD, Djimde A, Mischlinger J, Ramharter M
- Malar J. 2022 Feb 22;21(1):61. doi: 10.1186/s12936-022-04079-9
Assessing fetal growth in Africa: Application of the international WHO and INTERGROWTH-21st standards in a Beninese pregnancy cohort
- Yovo E, Accrombessi M, Agbota G, Hocquette A, Atade W, Ladikpo OT, Mehoba M, Degbe A, Mombo-Ngoma G, Massougbodji A, Jackson N, Fievet N, Heude B, Zeitlin J, Briand V
- PLoS One. 2022 Jan 21;17(1):e0262760. doi: 10.1371/journal.pone.0262760
2021
Evaluation of the safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in HIV-infected pregnant women: protocol of a multicentre, two-arm, randomised, placebo-controlled, superiority clinical trial (MAMAH project)
- González R, Nhampossa T, Mombo-Ngoma G, Mischlinger J, Esen M, Tchouatieu AM, Pons-Duran C, Dimessa LB, Lell B, Lagler H, Garcia-Otero L, Zoleko Manego R, El Gaaloul M, Sanz S, Piqueras M, Sevene E, Ramharter M, Saute F, Menendez C
- BMJ Open. 2021 Nov 23;11(11):e053197. doi: 10.1136/bmjopen-2021-053197
A comparison of different scores for diagnosis and mortality prediction of adults with sepsis in Low-and-Middle-Income Countries: a systematic review and meta-analysis
- Adegbite BR, Edoa JR, Ndzebe Ndoumba WF, Dimessa Mbadinga LB, Mombo-Ngoma G, Jacob ST, Rylance J, Hänscheid T, Adegnika AA, Grobusch MP
- EClinicalMedicine. 2021 Oct 30;42:101184. doi: 10.1016/j.eclinm.2021.101184
The Supposedly Innocuous Eye Worm: Or, What Could Make You Put Chili in Your Eye?
- Veletzky L, Mombo-Ngoma G, Ramharter M
- Am J Trop Med Hyg. 2021 Sep 13;105(6):1448-1449. doi: 10.4269/ajtmh.21-0319
Diagnostic performance of capillary and venous blood samples in the detection of Loa loa and Mansonella perstans microfilaraemia using light microscopy
- Mischlinger J, Manego RZ, Mombo-Ngoma G, Ekoka Mbassi D, Hackbarth N, Ekoka Mbassi FA, Davi SD, Kreuzmair R, Veletzky L, Hergeth J, Ndoumba WN, Pitzinger P, Groger M, Matsiegui PB, Adegnika AA, Agnandji ST, Lell B, Ramharter M
- PLoS Negl Trop Dis. 2021 Aug 16;15(8):e0009623. doi: 10.1371/journal.pntd.0009623
Evidence for in vitro and in vivo activity of the antimalarial pyronaridine against Schistosoma
- Koehne E, Zander N, Rodi M, Held J, Hoffmann W, Zoleko-Manego R, Ramharter M, Mombo-Ngoma G, Kremsner PG, Kreidenweiss A
- PLoS Negl Trop Dis. 2021 Jun 24;15(6):e0009511. doi: 10.1371/journal.pntd.0009511
Pyronaridine-artesunate real-world safety, tolerability, and effectiveness in malaria patients in 5 African countries: A single-arm, open-label, cohort event monitoring study
- Tona Lutete G, Mombo-Ngoma G, Assi SB, Bigoga JD, Koukouikila-Koussounda F, Ntamabyaliro NY, Ntoumi F, Agnandji ST, Groger M, Shin J, Borghini-Fuhrer I, Arbe-Barnes S, Allen SJ, Kremsner PG, Miller R, Duparc S, Ramharter M
- PLoS Med. 2021 Jun 15;18(6):e1003669. doi: 10.1371/journal.pmed.1003669
Point-of-care ultrasound to assess volume status and pulmonary oedema in malaria patients
- Pugliese CM, Adegbite BR, Edoa JR, Mombo-Ngoma G, Obone-Atome FA, Heuvelings CC, Bélard S, Kalkman LC, Leopold SJ, Hänscheid T, Adegnika AA, Huson MA, Grobusch MP
- Infection. 2022 Feb;50(1):65-82. doi: 10.1007/s15010-021-01637-2
Exploratory analysis of the effect of helminth infection on the immunogenicity and efficacy of the asexual blood-stage malaria vaccine candidate GMZ2
- Nouatin O, Mengue JB, Dejon-Agobé JC, Fendel R, Ibáñez J, Ngoa UA, Edoa JR, Adégbité BR, Honkpéhédji YJ, Zinsou JF, Hounkpatin AB, Moutairou K, Homoet A, Esen M, Kreidenweiss A, Hoffman SL, Theisen M, Luty AJF, Lell B, Agnandji ST, Mombo-Ngoma G, Ramharter M, Kremsner P, Mordmüller B, Adegnika AA
- PLoS Negl Trop Dis. 2021 Jun 1;15(6):e0009361. doi: 10.1371/journal.pntd.0009361
A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults and children with uncomplicated Plasmodium falciparum malaria
- Adoke Y, Zoleko-Manego R, Ouoba S, Tiono AB, Kaguthi G, Bonzela JE, Duong TT, Nahum A, Bouyou-Akotet M, Ogutu B, Ouedraogo A, Macintyre F, Jessel A, Laurijssens B, Cherkaoui-Rbati MH, Cantalloube C, Marrast AC, Bejuit R, White D, Wells TNC, Wartha F, Leroy D, Kibuuka A, Mombo-Ngoma G, Ouattara D, Mugenya I, Phuc BQ, Bohissou F, Mawili-Mboumba DP, Olewe F, Soulama I, Tinto H
- Malar J. 2021 May 19;20(1):222. doi: 10.1186/s12936-021-03749-4
Association of low birth weight and polyparasitic infection during pregnancy in Lambaréné, Gabon
- Honkpéhèdji YJ, Adegbite BR, Zinsou JF, Dejon-Agobé JC, Edoa JR, Zoleko Manego R, McCall M, Mbong Ngwese M, Lotola Mougeni F, Mombo-Ngoma G, Ramharter M, Kremsner PG, Lell B, Yazdanbakhsh M, Esen M, Adegnika AA
- Trop Med Int Health. 2021 Aug;26(8):973-981. doi: 10.1111/tmi.13591
Birth weight, growth, nutritional status and mortality of infants from Lambaréné and Fougamou in Gabon in their first year of life
- Zoleko-Manego R, Mischlinger J, Dejon-Agobé JC, Basra A, Mackanga JR, Akerey Diop D, Adegnika AA, Agnandji ST, Lell B, Kremsner PG, Matsiegui PB, González R, Menendez C, Ramharter M, Mombo-Ngoma G
- PLoS One. 2021 Feb 9;16(2):e0246694. doi: 10.1371/journal.pone.0246694
Development of sustainable research excellence with a global perspective on infectious diseases: Centre de Recherches Médicales de Lambaréné (CERMEL), Gabon
- Ramharter M, Agnandji ST, Adegnika AA, Lell B, Mombo-Ngoma G, Grobusch MP, McCall M, Muranaka R, Kreidenweiss A, Velavan TP, Esen M, Schaumburg F, Alabi A, Druml C, Mordmüller B, Köhler C, Kremsner PG
- Wien Klin Wochenschr. 2021 May;133(9-10):500-508. doi: 10.1007/s00508-020-01794-8
