Scientific publications by year

• 2023

  • Retinoic acid drives intestine-specific adaptation of effector ILC2s originating from distant sites

    • Nikhat Shaikh, Alex Waterhölter, Ann-Christin Gnirck, Martina Becker, Virginia Adamiak, Lena Henneken, Malte Wunderlich, Wiebke Hartmann, Lara Linnemann, Tobias Huber, Christian Krebs, Ulf Panzer, Richard Locksley, Christoph Wilhelm, Minka Breloer, and Jan-Eric Turner
    • Journal of Experimental Medicine 2023. DOI: 10.1084/jem.20221015 in press
    • 2023-09-12

  • IRF4 is required for migration of CD4+ T cells to the intestine but not for Th2 and Th17 cell maintenance

    • Constantin Schmidt, Aenne Harberts, Daniel Reimers, Tabea Bertram, Leonie Caroline Voß, Joanna Schmid, Niels Christian Lory, Michael Spohn, Friedrich Koch-Nolte, Samuel Huber, Friederike Raczkowski, Minka Breloer, and Hans-Willi Mittrücker
    • Front. Immunol. 14:1182502. doi: 10.3389/fimmu.2023.1182502
    • 2023-07-03

  • Strongyloides ratti infection in mice: immune response and immune modulation

    • Minka Breloer and Lara Linnemann
    • Philosophical Transactions of the Royal Society B (accepted for publication)
    • 2023-05-05

  • Filarial infections compromise influenza vaccination efficacy: lessons from the mouse

    • Minka Breloer and Wiebke Hartmann
    • Immunology Letters 255: 62–66
    • 2023-03-06

• 2022

  • Pre-existing helminth infection impairs the efficacy of adjuvanted influenza vaccination in mice

    • Wiebke Hartmann, Marie-Luise Brunn, Nadine Stetter, Gülsah Gabriel, Minka Breloer
    • PLoS One 2022 Mar 31;17(3):e0266456. doi: 10.1371/journal.pone.0266456. eCollection 2022.
    • 2022-03-31

• 2021

  • A combination of deworming and prime-boost vaccination regimen restores efficacy of vaccination against influenza in helminth-infected mice.

    • Nadine Stetter, Wiebke Hartmann, Marie-Luise Brunn, Stephanie Stanelle-Bertram, Gülsah Gabriel and Minka Breloer
    • Front. Immunol., 21 December 2021 | https://doi.org/10.3389/fimmu.2021.784141
    • 2021-12-21

  • Eosinophils and neutrophils eliminate migrating Strongyloides ratti larvae at the site of infection in the context of extracellular DNA trap formation

    • Ehrens A, Rüdiger N, Heepmann L, Linnemann L, Hartmann W, Hübner M, Breloer M
    • Front. Immunol., 12 August 2021 | https://doi.org/10.3389/fimmu.2021.715766
    • 2021-08-12

  • Elucidating different pattern of immunoregulation in BALB/c and C57BL/6 mice and their F1 progeny

    • Hartmann W, Blankenhaus B, Brunn ML, Meiners J, Breloer M.
    • Sci Rep. 2021 Jan 15;11(1):1536. doi: 10.1038/s41598-020-79477-7
    • 2021-01-15

• 2020

  • IL-33-facilitates rapid expulsion of the parasitic nematode Strongyloides ratti from the intestine via ILC2- and IL-9-driven mast cell activation

    • Meiners J, Reitz M, Rüdiger N, Turner JE, Heepmann L, Rudolf L, Hartmann W. McSorley HJ, Breloer M.
    • PLoS Pathog. 2020 Dec 22;16(12):e1009121. doi: 10.1371/journal.ppat.1009121.
    • 2020-12-22

  • Limited role of mast cells during infection with the parasitic nematode Litomosoides sigmodontis

    • Lara Christine Linnemann, Martina Reitz, Thorsten B. Feyerabend, Minka Breloer, Wiebke Hartmann
    • PLoS Neglected Tropical Diseases: July 31, 2020 https://doi.org/10.1371/journal.pntd.0008534
    • 2020-07-31

• 2019

  • Helminth infections suppress the efficacy of vaccination against seasonal influenza

    • Hartmann W, Brunn M-L, Stetter N, Gagliani N, Muskate F, Stanelle-Bertram S, Gabriel G, and Breloer M
    • Cell Reports 29, 2243–2256 2019 https://doi.org/10.1016/j.celrep.10.051
    • 2019-11-19

  • Rbpj expression in regulatory T cells is critical for restraining TH2 responses

    • Delacher M, Schmidl C, Herzig Y, Breloer M, Hartman W, Brunk F, Kägebein D, Träger U, Hofer A-C, Weichenhan D, Imbusch C, Hotz-Wagenblatt A, Hielscher T, Breiling A, Federico G, Groene H-J, Schmid R, Rehli M, Abramson J, Feuerer M, and Bittner S
    • Nature Communications; Doi.org/10.1038/s41467-019-09276-w
    • 2019-04-08

• 2018

  • Basophils are dispensable for the establishment of protective adaptive immunity against primary and challenge infection with the intestinal helminth parasite Strongyloides ratti

    • Reitz M, Brunn M-L, Voehringer D and M Breloer
    • PLoS Neglected Tropical Diseases 12(11):e0006992. doi: 10.1371/journal.pntd.0006992.
    • 2018-11-29

  • Basophils are dispensable for the control of a filarial infection.

    • Hartmann W, Linnemann L C, Reitz M, Specht S, Voehringer D and M Breloer
    • ImmunoHorizons 2018; Doi.org/10.4049/ Immunohorizons.1800018
    • 2018-09-01

  • Interleukin-9 promotes early mast cell-mediated expulsion of Strongyloides ratti but is dispensable for generation of protective memory

    • Reitz M, Hartmann W, Rüdiger N, Orinska Z, Brunn ML and Minka Breloer
    • Scientific Reports 2018; 8(1):8636.
    • 2018-06-05

• 2017

  • Th2/1 Hybrid Cells Occurring in Murine and Human Strongyloidiasis Share Effector Functions of Th1 Cells

    • Bock CN, Babu S, Breloer M, Rajamanickam A, Boothra Y, Brunn ML et al.
    • Front Cell Infect Microbiol 2017; 7, 261, doi:10.3389/fcimb.2017.00261
    • 2017-06-20

• 2016

  • Filariae-retrovirus co-infection in mice is associated with suppressed virus-specific IgG immune response and higher viral loads

    • Dietze KK, Dittmer U, Koudaimi DK, Schimmer S, Reitz M, Breloer M* and Hartmann W*
    • PLoS Neglected Tropical Diseases 2016; 10(12): e0005170
    • 2016-12-06

  • Mucosal mast cells are indispensable for the timely termination of Strongyloides ratti infection

    • Reitz, M., Brunn, M. L., Rodewald, H. R., Feyerabend, T. B., Roers, A., Dudeck, A., Voehringer, D., Jonsson, F., Kuhl, A. A. and Breloer, M.
    • Mucosal Immunol 2017; 10, 481-492, doi:10.1038/mi.2016.56
    • 2016-05-25

  • Strongyloides infection in rodents: immune response and immune regulation

    • Breloer, M. & Abraham, D.
    • Parasitology 2017; 144, 295-315, doi:10.1017/S0031182016000111
    • 2016-01-15

• 2015

  • Anti-CD83 promotes IgG1 isotype switch in marginal zone B cells in response to TI-2 antigen

    • Kretschmer, B., Weber, J., Hutloff, A., Fleischer, B., Breloer, M. and Osterloh, A.
    • Immunobiology 2015 Aug;220(8):964-75. doi: 10.1016/j.imbio.2015.02.008.
    • 2015-08-15

  • Litomosoides sigmodontis induces TGF-beta receptor responsive, IL-10-producing T cells that suppress bystander T-cell proliferation in mice

    • Hartmann, W., Schramm, C. and Breloer, M.
    • European Journal of Immunology 2015 Sep;45(9):2568-81. doi: 10.1002/eji.201545503.
    • 2015-07-03

  • Protein kinase CK2 enables regulatory T cells to suppress excessive T2 responses in vivo

    • Ulges, A., M. Klein, S. Reuter, B. Gerlitzki, M. Hoffmann, N. Grebe, V. Staudt, N. Stergiou, T. Bohn, T. J. Bruhl, S. Muth, H. Yurugi, K. Rajalingam, I. Bellinghausen, A. Tuettenberg, S. Hahn, S. Reissig, I. Haben, F. Zipp, A. Waisman, H. C. Probst, A. Beilhack, T. Buchou, O. Filhol-Cochet, B. Boldyreff, M. Breloer, H. Jonuleit, H. Schild, E. Schmitt, and T. Bopp.
    • Nature immunology 2015: 16: 267-275
    • 2015-01-19

  • Cutting Edge: The BTLA-HVEM Regulatory Pathway Interferes with Protective Immunity to Intestinal Helminth Infection

    • Breloer, M., W. Hartmann, B. Blankenhaus, M. L. Eschbach, K. Pfeffer, and T. Jacobs.
    • Journal of Immunology 2015: 194: 1413-1416
    • 2015-01-16

• 2014

  • Nematode-Induced Interference with Vaccination Efficacy Targets Follicular T Helper Cell Induction and is Preserved after Termination of Infection

    • Irma Haben, Wiebke Hartmann and Minka Breloer
    • PLoS Negl Trop Dis. 2014 Sep 25;8(9):e3170. doi: 10.1371/journal.pntd.0003170.
    • 2014-12-25

  • Heat shock protein 60: an endogenous inducer of dopaminergic cell death in Parkinson disease Journal of Neuroinflammation 2014, 11:86 doi:10.1186/1742-2094-11-86

    • Noelker C, More L, Osterloh A, Alvarez-Fischer D, Lescot T, Breloer M, Gold M, Oertel W H, Henze C, Michel P P, Dodel R C, Lu L, Hirsch E C, Hunot E and Hartmann A
    • Journal of Neuroinflammation 2014, 11:86 doi:10.1186/1742-2094-11-86
    • 2014-05-08

  • Immune recognition of Onchocerca volvulus proteins in the human host and animal models of onchocerciasis

    • Manchang K, Ajonina-Ekoti I, Ndjonka D, Eisenbarth A, Achukwi M, Renz A, Brattig NW, Liebau E, Breloer M
    • J Helminthol 2015; 89(3): 375-386.
    • 2014-04-10

  • Foxp3+ regulatory T cells delay expulsion of intestinal nematodes by suppression of IL-9-driven mast cell activation in BALB/c but not in C57BL/6 mice

    • Blankenhaus, B., M. Reitz, Y. Brenz, M. L. Eschbach, W. Hartmann, I. Haben, T. Sparwasser, J. Huehn, A. Kuhl, T. B. Feyerabend, H. R. Rodewald, and M. Breloer
    • PLoS pathogens 2014. 10: e1003913.
    • 2014-02-06

• 2013

  • Immunization with Brugia malayi Hsp70 protects mice against Litomosoides sigmodontis challenge infection.

    • Hartmann W, Singh N, Rathaur S, Brenz Y, Liebau E, Fleischer B, Breloer M.
    • Parasite Immunol. 2014. 36: 141-149. doi: 10.1111/pim.12093
    • 2013-12-11

  • Comparative analysis of macrophage migration inhibitory factors (MIFs) from the parasitic nematode Onchocerca volvulus and the free-living nematode Caenorhabditis elegans.

    • Ajonina-Ekoti I, Kurosinski MA, Younis AE, Ndjonka D, Tanyi MK, Achukwi M, Eisenbarth A, Ajonina C, Lüersen K, Breloer M, Brattig, NW and Liebau E.
    • Parasitology Research 2013; 112: 3335-3346.
    • 2013-07-03

  • T-cell-derived, but not B-cell-derived, IL-10 suppresses antigen-specific T-cell responses in Litomosoides sigmodontis-infected mice.

    • Haben, I., W. Hartmann, S. Specht, A. Hoerauf, A. Roers, W. Muller
    • European Journal of Immunology 2013. 43: 1799-1805.
    • 2013-07-01

  • Nematode-derived proteins suppress proliferation and cytokine production of antigen-specific T Cells via induction of cell death.

    • Hartmann W, Brenz Y, Kingsley MT, Ajonina-Ekoti I, Brattig NW, Liebau E and Breloer M
    • PLoS One 2013 8: e68380.
    • 2013-06-21

  • Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease.

    • Noelker C, Morel L, Lescot T, Osterloh A, Alvarez-Fischer D, Breloer M, Henze C, Depboylu C, Skrzydelski D, Michel PP, Dodel RC, Lu L, Hirsch EC, Hunot S and Hartmann A
    • Scientific Reports 2013; 3: 1393.
    • 2013-03-06

• 2012

  • Functional characterization and immune recognition of the extracellular superoxide dismutase from the human pathogenic parasite Onchocerca volvulus (OvEC-SOD).

    • Ajonina-Ekoti I, Ndjonka D, Tanyi MK, Wilbertz M, Younis AE, Boursou D, Kurosinski MA, Eberle R, Lüersen K, Perbandt M, Breloer, M, Brattig NW and Liebau E.
    • Acta Tropica 2012; 124: 15-26.
    • 2012-10-01

  • Efficient control of Plasmodium yoelii infection in BALB/c and C57BL/6 mice with pre-existing Strongyloides ratti infection

    • Kolbaum J, Eschbach ML, Steeg C, Jacobs T, Fleischer B and Breloer M.
    • Parasite Immunology 2012; 34: 388-393.
    • 2012-05-03

  • Vaccination with Strongyloides ratti heat shock protein 60 increases susceptibility to challenge infection by induction of Th1 response

    • Nouir NB, Eschbach ML, Piédavent, M, Osterloh A, Kingsley MT, Erttmann K, Brattig N, Liebau E, Fleischer B and Breloer M
    • Vaccine 2012; 30: 862-871.
    • 2012-01-22

• 2011

  • Nematode-induced interference with the anti-Plasmodium CD8+ T-cell response can be overcome by optimizing antigen administration.

    • Kolbaum J, Tartz S, Hartmann W, Helm S, Nagel A, Heussler V, Sebo P, Fleischer B, Jacobs T and Breloer M.
    • European Journal of Immunology 2012; 42: 890-900.
    • 2011-12-12

  • Hartmann W, Haben I, Fleischer B and Breloer M. Pathogenic nematodes suppress humoral responses to third-party antigens in vivo by IL-10-mediated interference with Th cell function

    • Hartmann W, Haben I, Fleischer B and Breloer M
    • Journal of Immunology 2011; 187: 4088-4099.
    • 2011-10-15

  • Strongyloides ratti infection modulates B and T cell responses to third party antigens

    • Hartmann W, Eschbach ML and Breloer M
    • Experimental Parasitology 2012; 132: 69-75
    • 2011-06-23

  • Activated T cells induce rapid CD83 expression on B cells by engagement of CD40.

    • Kretschmer B, Kühl S, Fleischer B and Breloer M
    • Immunology Letters 2011; 136: 221-227.
    • 2011-05-01

  • Strongyloides ratti infection induces expansion of Foxp3+ regulatory T cells that interfere with immune response and parasite clearance in BALB/c mice

    • Blankenhaus B, Klemm U, Eschbach ML, Sparwasser T, Huehn J, Kühl AA, Loddenkemper C, Jacobs T and Breloer M.
    • Journal of Immunology 2011; 186: 4295-4305.
    • 2011-04-01

• 2010

  • Efficient control of Leishmania and Strongyloides despite partial suppression of nematode-induced Th2 response in co-infected mice.

    • Kolbaum J, Ritter U, Zimara N, Brewig N, Eschbach ML and Breloer, M
    • Parasite Immunology 2011; 33: 226-235
    • 2010-11-09

  • Strongyloides ratti infection induces transient nematode-specific Th2 response and reciprocal suppression of IFN-gamma production in mice.

    • Eschbach ML, Klemm U, Kolbaum J, Blankenhaus B, Brattig N and Breloer M
    • Parasite Immunology 2010; 32: 370-383.
    • 2010-04-08

• 2009

  • Heat shock protein 60 (HSP60) stimulates neutrophil effector functions.

    • Osterloh A, Geisinger F, Piédavent M, Fleischer B, Brattig N and Breloer M
    • Journal of Leukocyte Biology 2009; 86: 423-434.
    • 2009-05-15

  • Engagement of CD83 on B cells modulates B cell function in vivo

    • Kretschmer B, Lüthje K, Schneider S, Fleischer B and Breloer M
    • Journal of Immunology 2009; 182: 2827-2834.
    • 2009-03-01

• 2008

  • CD83 on murine APC does not function as a costimulatory receptor for T cells

    • Kretschmer B, Lüthje K, Ehrlich S, Osterloh A, Piédavent M, Fleischer B and Breloer M
    • Immunology Letters 2008; 120: 87-95.
    • 2008-09-30

  • CD83 regulates splenic B cell maturation and peripheral B cell homeostasis.

    • Lüthje K, Kretschmer B, Fleischer B and Breloer M.
    • International Immunology 2008; 20: 949-960.
    • 2008-06-10

  • CD83 expression in CD4+ T cells modulates inflammation and autoimmunity.

    • Reinwald S, Wiethe C, Westendorf AM, Breloer M, Probst-Kepper M, Fleischer B, Steinkasserer A, Buer J and Hansen W
    • Journal of Immunology 2008; 180: 5890-5897.
    • 2008-05-01

  • CD83 regulates lymphocyte maturation, activation and homeostasis

    • Breloer M and Fleischer B
    • Trends in Immunology 2008; 29: 186-194.
    • 2008-04-01

  • Heat shock proteins: linking danger and pathogen recognition

    • Osterloh A and Breloer M
    • Medical Microbiology and Immunology 2008; 197: 1-8.
    • 2008-03-01

  • Hsp60-mediated T cell stimulation is independent of TLR4 and IL-12.

    • Osterloh A, Veit A, Gessner A, Fleischer B and Breloer M
    • International Immunology 2008; 20: 433-443.
    • 2008-02-05

  • CD83: regulator of central T cell maturation and peripheral immune response.

    • Breloer M
    • Immunology Letters 2008; 115: 16-17.
    • 2008-01-15

• 2007

  • CD83 modulates B cell function in vitro: increased IL-10 and reduced Ig secretion by CD83Tg B cells

    • Kretschmer B, Lüthje K, Guse AH, Ehrlich S, Koch-Nolte F, Haag F, Fleischer B and Breloer M
    • PLoS One 2007; 2: e755.
    • 2007-08-15

  • CD83 is a regulator of murine B cell function in vivo

    • Breloer M, Kretschmer B, Lüthje K, Ehrlich S, Ritter U, Bickert T, Steeg C, Fillatreau S, Hoehlig K, Lampropoulou V and Fleischer B.
    • European Journal of Immunology 2007; 37: 634-648.
    • 2007-02-23

  • Synergistic and differential modulation of immune responses by Hsp60 and lipopolysaccharide

    • Osterloh A, Kalinke U, Weiss S, Fleischer B and Breloer M
    • The Journal of Biological Chemistry 2007; 282: 4669-4680
    • 2007-02-16

• 2006

  • Transgenic expression of a CD83-immunoglobulin fusion protein impairs the development of immune-competent CD4-positive T cells.

    • Lüthje K, Cramer SO, Ehrlich S, Veit A, Steeg C, Fleischer B, Bonin Av and Breloer M.
    • European Journal of Immunology 2006; 36: 2035-2045
    • 2006-07-27

• 2005

  • Heat shock protein 60 is released in immune-mediated glomerulonephritis and aggravates disease: in vivo evidence for an immunologic danger signal

    • Lang A, Benke D, Eitner F, Engel D, Ehrlich S, Breloer M, Hamilton-Williams E, Specht S, Hoerauf A, Floege J, von Bonin A and Kurts C.
    • Journal of the American Society of Nephrology 2005; 16: 383-391.
    • 2005-02-01

• 2004

  • Lipopolysaccharide-free heat shock protein 60 activates T cells

    • Osterloh A, Meier-Stiegen F, Veit A, Fleischer B, von Bonin A and Breloer M.
    • The Journal of Biological Chemistry 2004; 279: 47906-47911.
    • 2004-11-01

• 2003

  • Purification of the eucaryotic heat-shock proteins Hsp70 and gp96

    • von Bonin A, Moré SH and Breloer M.
    • Methods in Molecular Biology 2003; 215: 193-200.
    • 2003-01-01

• 2002

  • Macrophages as main inducers of IFN-gamma in T cells following administration of human and mouse heat shock protein 60.

    • Breloer M, Moré SH, Osterloh A, Stelter F, Jack RS and Bonin Av.
    • International Immunology 2002; 14: 1247-1253
    • 2002-11-01

  • 'Ignorance' of antigen-specific murine CD4+ and CD8+ T cells is overruled by lipopolysaccharide and leads to specific induction of IFN-gamma.

    • Moré SH, Breloer M, Fentz AK, Fleischer B and von Bonin A
    • Scandinavian Journal of Immunology 2002 Apr;55(4):329-35. doi: 10.1046/j.1365-3083.2002.01061.x
    • 2002-04-25

• 2001

  • Eukaryotic heat shock proteins as molecular links in innate and adaptive immune responses: Hsp60-mediated activation of cytotoxic T cells

    • Moré SH, Breloer M and von Bonin A.
    • International Immunology 2001; 13: 1121-1127.
    • 2001-09-01

  • Heat shock proteins as "danger signals": eukaryotic Hsp60 enhances and accelerates antigen-specific IFN-gamma production in T cells.

    • Breloer M, Dorner B, Moré SH, Roderian T, Fleischer B and von Bonin A.
    • European Journal of Immunology 2001; 31: 2051-2059.
    • 2001-06-27

• 1999

  • Activation of cytotoxic T cells in vitro by recombinant gp96 fusion proteins irrespective of the 'fused' antigenic peptide sequence

    • Moré S, Breloer M, Fleischer B and von Bonin A
    • Immunology Letters 1999; 69: 275-282.
    • 1999-08-03

  • In vivo and in vitro activation of T cells after administration of Ag-negative heat shock proteins.

    • Breloer M, Fleischer B and von Bonin A
    • Journal of Immunology 1999; 162: 3141-3147
    • 1999-03-15

• 1998

  • Partial agonism and independent modulation of T cell receptor and CD8 in hapten-specific cytotoxic T cells

    • Preckel T, Breloer M, Kohler H, von Bonin A and Weltzien HU
    • European Journal of Immunology 1998; 28: 3706-3718.
    • 1998-12-14

  • Amino acid sequence of the D-galactose binding lectin II from the sponge Axinella polypoides (Schmidt) and identification of the carbohydrate binding site in lectin II and related lectin I.

    • Buck F, Schulze C, Breloer M, Strupat K and Bretting H
    • Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology 1998; 121: 153-160.
    • 1998-10-01

  • Isolation of processed, H-2Kb-binding ovalbumin-derived peptides associated with the stress proteins HSP70 and gp96

    • Breloer M, Marti T, Fleischer B and von Bonin A.
    • European Journal of Immunology 1998; 28: 1016-1021.
    • 1998-01-16

• 1996

  • A biological function for the XP motif within the N terminus of major histocompatibility complex class II-associated peptides.

    • Breloer M, Ehrlich S, Fleischer B and von Bonin A
    • European Journal of Immunology 1996; 26: 1825-1829.
    • 1996-08-01