Our publications

Publication Highlights

2025
- Entamoeba histolytica extracellular vesicles drive pro-inflammatory monocyte signaling
  - Barbara Honecker, Valentin A. Bärreiter, Katharina Höhn, Balázs Horváth, Karel Harant, Nahla Galal Metwally, Claudia Marggraff, Juliett Anders, Stephanie Leyk, Maria del Pilar Martínez-Tauler, Annika Bea, Charlotte Hansen, Helena Fehling, Melanie Lütkemeyer, Stephan Lorenzen, Sören Franzenburg, Hanna Lotter, Iris Bruchhaus
  - PLoS Negl Trop Dis. 2025 Apr10;19(4):e0012997. doi: 10.1371/journal.pntd.0012997.
  - 2025-04-10
2024
- Immunological clues to sex differences in parasitic diseases
  - Julie Sellau, Charlotte Sophie Hansen, Rosa Isela Gálvez, Lara Linnemann, Barbara Honecker, Hanna Lotter
  - Trends in Parasitology, DOI: 10.1016/j.pt.2024.09.006
  - 2024-10-07
2023
- Genes differentially expressed between pathogenic and non-pathogenic Entamoeba histolytica clones influence pathogenicity-associated phenotypes by multiple mechanisms
  - Juliett Anders, Constantin König, Corinna Lender, Arne Hellhund, Sarah Nehls, Ibrahim Shalabi, Barbara Honecker, Stephan Lorenzen, Martin Meyer, Jenny Matthiesen, Dániel Cadar, Thomas Roeder, Nahla Galal Metwally, Hannelore Lotter, Iris Bruchhaus
  - Plos Pathogens.https://doi.org/10.1371/journal.ppat.1011745
  - 2023-12-22
- Testosterone affects type I/type II interferon response of neutrophils during hepatic amebiasis
  - Marco Er-Lukowiak, Sonja Hänzelmann, Moritz Rothe, David T. Moamenpour, Fabian Hausmann, Robin Khatri, Charlotte Hansen, Jennifer Boldt, Valentin A. Bärreiter, Barbara Honecker, Annika Bea, Marie Groneberg, Helena Fehling, Claudia Marggraff, Dániel Cadar, Stefan Bonn, Julie Sellau, Hanna Lotter
  - Frontiers in Immunology, Sec. Parasite Immunology, Volume 14 - 2023 | https://doi.org/10.3389/fimmu.2023.1279245
  - 2023-12-21
- Sex and Gender Differences in Infection and Treatments for Infectious Diseases
  - Marco Er-Lukowiak, Charlotte Hansen, Hanna Lotter
  - Springer Link. Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY,volume 441)
  - 2023-09-12
2022
- The Properties of Proinflammatory Ly6Chi Monocytes Are Differentially Shaped by Parasitic and Bacterial Liver Infections
  - Hoenow S, Yan K, Noll J, Groneberg M, Casar C, Lory NC, Vogelsang M, Hansen C, Wolf V, Fehling H, Sellau J, Mittrücker HW, Lotter H
  - Cells. 2022 Aug 16;11(16):2539. doi: 10.3390/cells11162539
  - 2022-08-16
- HIF-1α modulates sex-specific Th17/Treg responses during hepatic amoebiasis
  - Groneberg M, Hoenow S, Marggraff C, Fehling H, Metwally NG, Hansen C, Bruchhaus I, Tiegs G, Sellau J, Lotter H
  - Journal of Hepatology. 2022 Jan;76(1):160-173. doi: 10.1016/j.jhep.2021.09.020
  - 2022-01-03
2021
- CCR2 Deficiency Impairs Ly6Clo and Ly6Chi Monocyte Responses in Orientia tsutsugamushi Infection
  - Petermann M, Orfanos Z, Sellau J, Gharaibeh M, Lotter H, Fleischer B, Keller C
  - Frontiers in Immunology. 2021 Jul 5;12:670219. doi: 10.3389/fimmu.2021.670219
  - 2021-07-05
- The underlying cellular immune pathology of Entamoeba histolytica-induced hepatic amoebiasis
  - Sellau J, Groneberg M, Hoenow S, Lotter H
  - Hepatology. 2021 Aug;75(2):481-482. doi: 10.1016/j.jhep.2021.03.018
  - 2021-06-11
- Monocyte dysregulation: consequences for hepatic infections
  - Sellau J, Puengel T, Hoenow S, Groneberg M, Tacke F, Lotter H
  - Semin Immunopathol. 2021 Aug;43(4):493-506. doi: 10.1007/s00281-021-00852-1
  - 2021-04-07
- High Content Analysis of Macrophage-Targeting Eh PIb-Compounds against Cutaneous and Visceral Leishmania Species
  - Fehling H, Niss H, Bea A, Kottmayr N, Brinker C, Hoenow S, Sellau J, Gilberger TW, Ting F, Landschulze D, Meier C, Clos J, Lotter H
  - Microorganisms. 2021 Feb 18;9(2):422. doi: 10.3390/microorganisms9020422
  - 2021-02-18
2020
- Programmed Cell Death Ligand (PD-L)-1 Contributes to the Regulation of CD4+ T Effector and Regulatory T Cells in Cutaneous Leishmaniasis
  - de Freitas E Silva R, Gálvez RI, Pereira VRA, de Brito MEF, Choy SL, Lotter H, Bosurgi L, Jacobs T
  - Frontiers in Immunology. 2020 Oct 22;11:574491. doi: 10.3389/fimmu.2020.574491
  - 2020-10-22
- An Alcohol Dehydrogenase 3 (ADH3) from Entamoeba histolytica Is Involved in the Detoxification of Toxic Aldehydes
  - König C, Meyer M, Lender C, Nehls S, Wallaschkowski T, Holm T, Matthies T, Lercher D, Matthiesen J, Fehling H, Roeder T, Reindl S, Rosenthal M, Metwally NG, Lotter H, Bruchhaus I
  - Microorganisms. 2020 Oct 19;8(10):1608. doi: 10.3390/microorganisms8101608
  - 2020-10-19
- Androgens predispose males to monocyte-mediated immunopathology by inducing the expression of leukocyte recruitment factor CXCL1
  - Sellau J, Groneberg M, Fehling H, Thye T, Hoenow S, Marggraff C, Weskamm M, Hansen C, Stanelle-Bertram S, Kuehl S, Noll J, Wolf V, Metwally NG, Hagen SH, Dorn C, Wernecke J, Ittrich H, Tannich E, Jacobs T, Bruchhaus I, Altfeld M, Lotter H
  - Nat Commun. 2020 Jul 10;11(1):3459. doi: 10.1038/s41467-020-17260-y
  - 2020-07-10
- Anti-leishmanial effects of synthetic EhPiB analogs derived from Entamoeba histolytica liopopeptidephosphoglycan
  - Fehling H, Choy SL, Ting F, Landschulze D, Bernin H, Lender SC, Mühlenpfordt M, Bifeld E, Eick J, Marggraff C, Kottmayr N, Groneberg M, Hoenow S, Sellau J, Clos J, Meier C, Lotter H
  - Antimicrobial Agents and Chemotherapy, doi: 10.1128/AAC.00161-20
  - 2020-05-11
- Testosterone protects against severe influenza by reducing the pro-inflammatory cytokine response in the murine lung
  - Tuku B, Stanelle -Bertram S, Sellau J, Beck S, Bai T, Mounogue Kouassi N, Preuß A, Hoenow S, Renné T, Lotter H, Gabriel G
  - Front Immunol. 2020 Apr; 11:697. doi: 10.3389/fimmu.2020.00697
  - 2020-04-11
2019
- Sex differences in immunity
  - Lotter H, Altfeld M
  - Seminars in Immunopathologyl. 2019 Mar;41(2):133-135. doi: 10.1007/s00281-018-00728-x
  - 2019-02-11
2018
- Androgen-dependent immune modulation in parasitic infection
  - Sellau J, Groneberg M, Lotter H
  - Seminars in Immunopathology. 2019 Mar;41(2):213-224. doi: 10.1007/s00281-018-0722-9
  - 2018-10-23
- Trigger-induced RNAi gene silencing to identify pathogenicity factors of Entamoeba histolytica
  - Matthiesen J, Lender C, Haferkorn A, Fehling H, Meyer M, Matthies T, Tannich E, Roeder T, Lotter H, Bruchhaus I
  - FASEB Journal. 2019 Feb;33(2):1658-1668. doi: 10.1096/fj.201801313R
  - 2018-08-31
- Male offspring born to mildly ZIKV-infected mice are at risk of developing neurocognitive disorders in adulthood
  - Stanelle-Bertram S, Walendy-Gnirß K, Speiseder T, Thiele S, Asante IA, Dreier C, Kouassi NM, Preuß A, Pilnitz-Stolze G, Müller U, Thanisch S, Richter M, Scharrenberg R, Kraus V, Dörk R, Schau L, Herder V, Gerhauser I, Pfankuche VM, Käufer C, Waltl I, Moraes T, Sellau J, Hoenow S, Schmidt-Chanasit J, Jansen S, Schattling B, Ittrich H, Bartsch U, Renné T, Bartenschlager R, Arck P, Cadar D, Friese MA, Vapalahti O, Lotter H, Benites S, Rolling L, Gabriel M, Baumgärtner W, Morellini F, Hölter SM, Amarie O, Fuchs H, Hrabe de Angelis M, Löscher W, Calderon de Anda F, Gabriel G
  - Nat Microbiol 2018:3:1161-1174. doi: 10.1038/s41564-018-0236-1
  - 2018-03-11
2017
- Synthetic analogs of an Entamoeba histolytica glycolipid designed to combat intracellular Leishmania infection
  - Choy SL, Bernin H, Aiba T, Bifeld E, Lender SC, Mühlenpfordt M, Noll J, Eick J, Marggraff C, Niss H, Roldán NG, Tanaka S, Kitamura M, Fukase K, Clos J, Tannich E, Fujimoto Y, Lotter H
  - Scientific Reports. 2017 Aug 25;7(1):9472. doi: 10.1038/s41598-017-09894-8
  - 2017-08-25
- Employing BINOL-Phosphoroselenoyl Chloride for Selective Inositol Phosphorylation and Synthesis of Glycosyl Inositol Phospholipid from Entamoeba histolytica
  - Aiba T, Suehara S, Choy SL, Maekawa Y, Lotter H, Murai T, Inuki S, Fukase K, Fujimoto Y
  - Chemistry. 2017 Jun 16;23(34):8304-8308. doi: 10.1002/chem.201701298
  - 2017-04-08
2016
- Overexpression of Differentially Expressed Genes Identified in Non-pathogenic and Pathogenic Entamoeba histolytica Clones Allow Identification of New Pathogenicity Factors Involved in Amoebic Liver Abscess Formation
  - Meyer M, Fehling H, Matthiesen J, Lorenzen S, Schuldt K, Bernin H, Zaruba M, Lender C, Ernst T, Ittrich H, Roeder T, Tannich E, Lotter H, Bruchhaus I
  - PLOS Pathogens. 2016 Aug 30;12(8):e1005853. doi: 10.1371/journal.ppat.1005853
  - 2016-08-30
- The cytokine profile of human NKT cells and PBMCs is dependent on donor sex and stimulus
  - Bernin H, Fehling H, Marggraff C, Tannich E, Lotter H
  - Microbiol Immunol. 2016;205:321-332. doi: 10.1007/s00430-016-0449-y
  - 2016-05-20
- IL-23 prevents IL-13-dependent tissue repair associated with Ly6Clo monocytes in Entamoeba histolytica-induced liver damage
  - Noll J, Helk E, Fehling H, Bernin H, Marggraff C, Jacobs T, Huber S, Pelczar P, Ernst T, Ittrich H, Otto B, Mittrücker HW, Hölscher C, Tacke F, Bruchhaus I, Tannich E, Lotter H
  - J Hepatol. 2016 Jan 22. pii: S0168-8278(16)00019-2. doi: 10.1016/j.jhep.2016.01.013
  - 2016-01-22
2015
- Magnetic resonance imaging of pathogenic protozoan parasite Entamoeba histolytica labeled with superparamagnetic iron oxide nanoparticles
  - Ernst TM, Fehling H, Bernin H, Zaruba MD, Bruchhaus I, Adam G, Ittrich H, Lotter H
  - Investigative Radiology. 2015 Oct;50(10):709-18. doi: 10.1097/RLI.0000000000000175
  - 2015-10-05
2014
- Immune markers characteristic for asymptomatically infected and diseased Entamoeba histolytica individuals and their relation to sex
  - Bernin H, Marggraff C, Jacobs T, Brattig N, Le VA, Blessmann J, Lotter H
  - BMC Infect Dis 2014;14:621. doi: 10.1186/s12879-014-0621-1
  - 2014-11-25
- Sex bias in the outcome of human tropical infectious diseases: influence of steroid hormones
  - Bernin H, Lotter H
  - The Journal of Infectious Diseases. 2014 Jul 15;209 Suppl 3:S107-13. doi: 10.1093/infdis/jit610
  - 2014-07-15
2013
- Testosterone increases susceptibility to amebic liver abscess in mice and mediates inhibition of IFNγ secretion in natural killer T cells
  - Lotter H, Helk E, Bernin H, Jacobs T, Prehn C, Adamski J, González-Roldán N, Holst O, Tannich E
  - PLOS ONE. 2013;8(2):e55694. doi: 10.1371/journal.pone.0055694
  - 2013-02-12
- TNFα-mediated liver destruction by Kupffer cells and Ly6Chi monocytes during Entamoeba histolytica infection
  - Helk E, Bernin H, Ernst T, Ittrich H, Jacobs T, Heeren J, Tacke F, Tannich E, Lotter H
  - PLoS Pathog. 2013 Jan;9(1):e1003096. doi: 10.1371/journal.ppat.1003096
  - 2013-01-09
2006
- Sexual dimorphism in the control of amebic liver abscess in a mouse model of disease
  - Hannelore Lotter, Thomas Jacobs, Iris Gaworski, Egbert Tannich
  - Infection and Immunity. 2006 Jan;74(1):118-24. doi: 10.1128/IAI.74.1.118-124.2006
  - 2006-01-01

Contact

Prof. Dr Hanna Lotter

Our publications

Publication Highlights

2025

2024

2023

2022

2021

2020

2019

2018

2017

2016

2015

2014

2013

2006

Research Group Molecular Infection Immunology