Our publications
Publication Highlights
2025
Entamoeba histolytica extracellular vesicles drive pro-inflammatory monocyte signaling
- Barbara Honecker, Valentin A. Bärreiter, Katharina Höhn, Balázs Horváth, Karel Harant, Nahla Galal Metwally, Claudia Marggraff, Juliett Anders, Stephanie Leyk, Maria del Pilar Martínez-Tauler, Annika Bea, Charlotte Hansen, Helena Fehling, Melanie Lütkemeyer, Stephan Lorenzen, Sören Franzenburg, Hanna Lotter, Iris Bruchhaus
- PLoS Negl Trop Dis. 2025 Apr10;19(4):e0012997. doi: 10.1371/journal.pntd.0012997.
2024
Immunological clues to sex differences in parasitic diseases
- Julie Sellau, Charlotte Sophie Hansen, Rosa Isela Gálvez, Lara Linnemann, Barbara Honecker, Hanna Lotter
- Trends in Parasitology, DOI: 10.1016/j.pt.2024.09.006
2023
Genes differentially expressed between pathogenic and non-pathogenic Entamoeba histolytica clones influence pathogenicity-associated phenotypes by multiple mechanisms
- Juliett Anders, Constantin König, Corinna Lender, Arne Hellhund, Sarah Nehls, Ibrahim Shalabi, Barbara Honecker, Stephan Lorenzen, Martin Meyer, Jenny Matthiesen, Dániel Cadar, Thomas Roeder, Nahla Galal Metwally, Hannelore Lotter, Iris Bruchhaus
- Plos Pathogens.https://doi.org/10.1371/journal.ppat.1011745
Testosterone affects type I/type II interferon response of neutrophils during hepatic amebiasis
- Marco Er-Lukowiak, Sonja Hänzelmann, Moritz Rothe, David T. Moamenpour, Fabian Hausmann, Robin Khatri, Charlotte Hansen, Jennifer Boldt, Valentin A. Bärreiter, Barbara Honecker, Annika Bea, Marie Groneberg, Helena Fehling, Claudia Marggraff, Dániel Cadar, Stefan Bonn, Julie Sellau, Hanna Lotter
- Frontiers in Immunology, Sec. Parasite Immunology, Volume 14 - 2023 | https://doi.org/10.3389/fimmu.2023.1279245
Sex and Gender Differences in Infection and Treatments for Infectious Diseases
- Marco Er-Lukowiak, Charlotte Hansen, Hanna Lotter
- Springer Link. Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY,volume 441)
2022
The Properties of Proinflammatory Ly6Chi Monocytes Are Differentially Shaped by Parasitic and Bacterial Liver Infections
- Hoenow S, Yan K, Noll J, Groneberg M, Casar C, Lory NC, Vogelsang M, Hansen C, Wolf V, Fehling H, Sellau J, Mittrücker HW, Lotter H
- Cells. 2022 Aug 16;11(16):2539. doi: 10.3390/cells11162539
HIF-1α modulates sex-specific Th17/Treg responses during hepatic amoebiasis
- Groneberg M, Hoenow S, Marggraff C, Fehling H, Metwally NG, Hansen C, Bruchhaus I, Tiegs G, Sellau J, Lotter H
- Journal of Hepatology. 2022 Jan;76(1):160-173. doi: 10.1016/j.jhep.2021.09.020
2021
CCR2 Deficiency Impairs Ly6Clo and Ly6Chi Monocyte Responses in Orientia tsutsugamushi Infection
- Petermann M, Orfanos Z, Sellau J, Gharaibeh M, Lotter H, Fleischer B, Keller C
- Frontiers in Immunology. 2021 Jul 5;12:670219. doi: 10.3389/fimmu.2021.670219
The underlying cellular immune pathology of Entamoeba histolytica-induced hepatic amoebiasis
- Sellau J, Groneberg M, Hoenow S, Lotter H
- Hepatology. 2021 Aug;75(2):481-482. doi: 10.1016/j.jhep.2021.03.018
Monocyte dysregulation: consequences for hepatic infections
- Sellau J, Puengel T, Hoenow S, Groneberg M, Tacke F, Lotter H
- Semin Immunopathol. 2021 Aug;43(4):493-506. doi: 10.1007/s00281-021-00852-1
High Content Analysis of Macrophage-Targeting Eh PIb-Compounds against Cutaneous and Visceral Leishmania Species
- Fehling H, Niss H, Bea A, Kottmayr N, Brinker C, Hoenow S, Sellau J, Gilberger TW, Ting F, Landschulze D, Meier C, Clos J, Lotter H
- Microorganisms. 2021 Feb 18;9(2):422. doi: 10.3390/microorganisms9020422
2020
Programmed Cell Death Ligand (PD-L)-1 Contributes to the Regulation of CD4+ T Effector and Regulatory T Cells in Cutaneous Leishmaniasis
- de Freitas E Silva R, Gálvez RI, Pereira VRA, de Brito MEF, Choy SL, Lotter H, Bosurgi L, Jacobs T
- Frontiers in Immunology. 2020 Oct 22;11:574491. doi: 10.3389/fimmu.2020.574491
An Alcohol Dehydrogenase 3 (ADH3) from Entamoeba histolytica Is Involved in the Detoxification of Toxic Aldehydes
- König C, Meyer M, Lender C, Nehls S, Wallaschkowski T, Holm T, Matthies T, Lercher D, Matthiesen J, Fehling H, Roeder T, Reindl S, Rosenthal M, Metwally NG, Lotter H, Bruchhaus I
- Microorganisms. 2020 Oct 19;8(10):1608. doi: 10.3390/microorganisms8101608
Androgens predispose males to monocyte-mediated immunopathology by inducing the expression of leukocyte recruitment factor CXCL1
- Sellau J, Groneberg M, Fehling H, Thye T, Hoenow S, Marggraff C, Weskamm M, Hansen C, Stanelle-Bertram S, Kuehl S, Noll J, Wolf V, Metwally NG, Hagen SH, Dorn C, Wernecke J, Ittrich H, Tannich E, Jacobs T, Bruchhaus I, Altfeld M, Lotter H
- Nat Commun. 2020 Jul 10;11(1):3459. doi: 10.1038/s41467-020-17260-y
Anti-leishmanial effects of synthetic EhPiB analogs derived from Entamoeba histolytica liopopeptidephosphoglycan
- Fehling H, Choy SL, Ting F, Landschulze D, Bernin H, Lender SC, Mühlenpfordt M, Bifeld E, Eick J, Marggraff C, Kottmayr N, Groneberg M, Hoenow S, Sellau J, Clos J, Meier C, Lotter H
- Antimicrobial Agents and Chemotherapy, doi: 10.1128/AAC.00161-20
Testosterone protects against severe influenza by reducing the pro-inflammatory cytokine response in the murine lung
- Tuku B, Stanelle -Bertram S, Sellau J, Beck S, Bai T, Mounogue Kouassi N, Preuß A, Hoenow S, Renné T, Lotter H, Gabriel G
- Front Immunol. 2020 Apr; 11:697. doi: 10.3389/fimmu.2020.00697
2019
Sex differences in immunity
- Lotter H, Altfeld M
- Seminars in Immunopathologyl. 2019 Mar;41(2):133-135. doi: 10.1007/s00281-018-00728-x
2018
Androgen-dependent immune modulation in parasitic infection
- Sellau J, Groneberg M, Lotter H
- Seminars in Immunopathology. 2019 Mar;41(2):213-224. doi: 10.1007/s00281-018-0722-9
Trigger-induced RNAi gene silencing to identify pathogenicity factors of Entamoeba histolytica
- Matthiesen J, Lender C, Haferkorn A, Fehling H, Meyer M, Matthies T, Tannich E, Roeder T, Lotter H, Bruchhaus I
- FASEB Journal. 2019 Feb;33(2):1658-1668. doi: 10.1096/fj.201801313R
Male offspring born to mildly ZIKV-infected mice are at risk of developing neurocognitive disorders in adulthood
- Stanelle-Bertram S, Walendy-Gnirß K, Speiseder T, Thiele S, Asante IA, Dreier C, Kouassi NM, Preuß A, Pilnitz-Stolze G, Müller U, Thanisch S, Richter M, Scharrenberg R, Kraus V, Dörk R, Schau L, Herder V, Gerhauser I, Pfankuche VM, Käufer C, Waltl I, Moraes T, Sellau J, Hoenow S, Schmidt-Chanasit J, Jansen S, Schattling B, Ittrich H, Bartsch U, Renné T, Bartenschlager R, Arck P, Cadar D, Friese MA, Vapalahti O, Lotter H, Benites S, Rolling L, Gabriel M, Baumgärtner W, Morellini F, Hölter SM, Amarie O, Fuchs H, Hrabe de Angelis M, Löscher W, Calderon de Anda F, Gabriel G
- Nat Microbiol 2018:3:1161-1174. doi: 10.1038/s41564-018-0236-1
2017
Synthetic analogs of an Entamoeba histolytica glycolipid designed to combat intracellular Leishmania infection
- Choy SL, Bernin H, Aiba T, Bifeld E, Lender SC, Mühlenpfordt M, Noll J, Eick J, Marggraff C, Niss H, Roldán NG, Tanaka S, Kitamura M, Fukase K, Clos J, Tannich E, Fujimoto Y, Lotter H
- Scientific Reports. 2017 Aug 25;7(1):9472. doi: 10.1038/s41598-017-09894-8
Employing BINOL-Phosphoroselenoyl Chloride for Selective Inositol Phosphorylation and Synthesis of Glycosyl Inositol Phospholipid from Entamoeba histolytica
- Aiba T, Suehara S, Choy SL, Maekawa Y, Lotter H, Murai T, Inuki S, Fukase K, Fujimoto Y
- Chemistry. 2017 Jun 16;23(34):8304-8308. doi: 10.1002/chem.201701298
2016
Overexpression of Differentially Expressed Genes Identified in Non-pathogenic and Pathogenic Entamoeba histolytica Clones Allow Identification of New Pathogenicity Factors Involved in Amoebic Liver Abscess Formation
- Meyer M, Fehling H, Matthiesen J, Lorenzen S, Schuldt K, Bernin H, Zaruba M, Lender C, Ernst T, Ittrich H, Roeder T, Tannich E, Lotter H, Bruchhaus I
- PLOS Pathogens. 2016 Aug 30;12(8):e1005853. doi: 10.1371/journal.ppat.1005853
The cytokine profile of human NKT cells and PBMCs is dependent on donor sex and stimulus
- Bernin H, Fehling H, Marggraff C, Tannich E, Lotter H
- Microbiol Immunol. 2016;205:321-332. doi: 10.1007/s00430-016-0449-y
IL-23 prevents IL-13-dependent tissue repair associated with Ly6Clo monocytes in Entamoeba histolytica-induced liver damage
- Noll J, Helk E, Fehling H, Bernin H, Marggraff C, Jacobs T, Huber S, Pelczar P, Ernst T, Ittrich H, Otto B, Mittrücker HW, Hölscher C, Tacke F, Bruchhaus I, Tannich E, Lotter H
- J Hepatol. 2016 Jan 22. pii: S0168-8278(16)00019-2. doi: 10.1016/j.jhep.2016.01.013
2015
Magnetic resonance imaging of pathogenic protozoan parasite Entamoeba histolytica labeled with superparamagnetic iron oxide nanoparticles
- Ernst TM, Fehling H, Bernin H, Zaruba MD, Bruchhaus I, Adam G, Ittrich H, Lotter H
- Investigative Radiology. 2015 Oct;50(10):709-18. doi: 10.1097/RLI.0000000000000175
2014
Immune markers characteristic for asymptomatically infected and diseased Entamoeba histolytica individuals and their relation to sex
- Bernin H, Marggraff C, Jacobs T, Brattig N, Le VA, Blessmann J, Lotter H
- BMC Infect Dis 2014;14:621. doi: 10.1186/s12879-014-0621-1
Sex bias in the outcome of human tropical infectious diseases: influence of steroid hormones
- Bernin H, Lotter H
- The Journal of Infectious Diseases. 2014 Jul 15;209 Suppl 3:S107-13. doi: 10.1093/infdis/jit610
2013
Testosterone increases susceptibility to amebic liver abscess in mice and mediates inhibition of IFNγ secretion in natural killer T cells
- Lotter H, Helk E, Bernin H, Jacobs T, Prehn C, Adamski J, González-Roldán N, Holst O, Tannich E
- PLOS ONE. 2013;8(2):e55694. doi: 10.1371/journal.pone.0055694
TNFα-mediated liver destruction by Kupffer cells and Ly6Chi monocytes during Entamoeba histolytica infection
- Helk E, Bernin H, Ernst T, Ittrich H, Jacobs T, Heeren J, Tacke F, Tannich E, Lotter H
- PLoS Pathog. 2013 Jan;9(1):e1003096. doi: 10.1371/journal.ppat.1003096
2006
Sexual dimorphism in the control of amebic liver abscess in a mouse model of disease
- Hannelore Lotter, Thomas Jacobs, Iris Gaworski, Egbert Tannich
- Infection and Immunity. 2006 Jan;74(1):118-24. doi: 10.1128/IAI.74.1.118-124.2006
