Our latest publications

• 2023

  • Recent Developments in NSG and NRG Humanized Mouse Models for Their Use in Viral and Immune Research

    • Kitsera M, Brunetti JE, Rodríguez E
    • Viruses. 2023 Feb 9;15(2):478. doi: 10.3390/v15020478
    • 2023-02-15

  • In vivo characterization of the novel ebolavirus Bombali virus suggests a low pathogenic potential for humans

    • Bodmer BS, Breithaupt A, Heung M, Brunetti JE, Henkel C, Müller-Guhl J, Rodríguez E, Wendt L, Winter SL, Vallbracht M, Müller A, Römer S, Chlanda P, Muñoz-Fontela C, Hoenen T, Escudero-Pérez B
    • Emerg Microbes Infect. 2023 Dec;12(1):2164216. doi: 10.1080/22221751.2022.2164216
    • 2023-01-18

  • Use of Hu-PBL Mice to Study Pathogenesis of Human-Restricted Viruses

    • Brunetti JE, Kitsera M, Muñoz-Fontela C, Rodríguez E
    • Viruses. 2023 Jan 13;15(1):228. doi: 10.3390/v15010228
    • 2023-01-13

• 2022

  • Avatar Mice Underscore the Role of the T Cell-Dendritic Cell Crosstalk in Ebola Virus Disease and Reveal Mechanisms of Protection in Survivors

    • Rottstegge M, Tipton T, Oestereich L, Ruibal P, Nelson EV, Olal C, Port JR, Seibel J, Pallasch E, Bockholt S, Koundouno FR, Boré JA, Rodríguez E, Escudero-Pérez B, Günther S, Carroll MW, Muñoz-Fontela C
    • J Virol. 2022 Sep 28;96(18):e0057422. doi: 10.1128/jvi.00574-22
    • 2022-09-28

• 2021

  • Conserved E1B-55K SUMOylation in different human adenovirus species is a potent regulator of intracellular localization

    • Kolbe V, Ip WH, Kieweg-Thompson L, Lang J, Gruhne J, Meyer T, Wilkens B, Schie M, Thünauer R, Schreiner S, Bertzbach LD, Rodríguez E, Dobner T
    • J Virol. 2022 Feb 9;96(3):e0083821. doi: 10.1128/JVI.00838-21
    • 2021-11-17

  • N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease

    • Koudelka T, Boger J, Henkel A, Schönherr R, Krantz S, Fuchs S, Rodríguez E, Redecke L, Tholey A
    • Proteomics. 2021 Jan;21(2):e2000246. doi: 10.1002/pmic.202000246
    • 2021-01-01

• 2020

  • Animal models for COVID-19

    • Muñoz-Fontela C, Dowling WE, Funnell SGP, Gsell PS, Riveros-Balta AX, Albrecht RA, Andersen H, Baric RS, Carroll MW, Cavaleri M, Qin C, Crozier I, Dallmeier K, de Waal L, de Wit E, Delang L, Dohm E, Duprex WP, Falzarano D, Finch CL, Frieman MB, Graham BS, Gralinski LE, Guilfoyle K, Haagmans BL, Hamilton GA, Hartman AL, Herfst S, Kaptein SJF, Klimstra WB, Knezevic I, Krause PR, Kuhn JH, Le Grand R, Lewis MG, Liu WC, Maisonnasse P, McElroy AK, Munster V, Oreshkova N, Rasmussen AL, Rocha-Pereira J, Rockx B, Rodríguez E, Rogers TF, Salguero FJ, Schotsaert M, Stittelaar KJ, Thibaut HJ, Tseng CT, Vergara-Alert J, Beer M, Brasel T, Chan JFW, García-Sastre A, Neyts J, Perlman S, Reed DS, Richt JA, Roy CJ, Segalés J, Vasan SS, Henao-Restrepo AM, Barouch DH
    • Nature. 2020 Oct;586(7830):509-515. doi: 10.1038/s41586-020-2787-6
    • 2020-09-23

  • Innovations, challenges, and minimal information for standardization of humanized mice

    • Stripecke R, Münz C, Schuringa JJ, Bissig KD, Soper B, Meeham T, Yao LC, Di Santo JP, Brehm M, Rodriguez E, Wege AK, Bonnet D, Guionaud S, Howard KE, Kitchen S, Klein F, Saeb-Parsy K, Sam J, Sharma AD, Trumpp A, Trusolino L, Bult C, Shultz L
    • EMBO Molecular Medicine. 2020 Jul 7;12(7):e8662. doi: 10.15252/emmm.201708662
    • 2020-07-07

• 2019

  • Comparative pathogenesis of Ebola virus and Reston virus infection in humanized mice

    • Escudero-Pérez B, Ruibal P, Rottstegge M, Lüdtke A, Port JR, Hartmann K, Gómez-Medina S, Müller-Guhl J, Nelson EV, Krasemann S, Rodríguez E*, Muñoz-Fontela C*
    • JCI Insight. 2019 Nov 1;4(21):e126070. doi: 10.1172/jci.insight.126070
    • 2019-11-01

• 2017

  • Ebola virus infection kinetics in chimeric mice reveal a key role of T cells as barriers for virus dissemination

    • Lüdtke A, Ruibal P, Wozniak DM, Pallasch E, Wurr S, Bockholt S, Gómez-Medina S, Qiu X, Kobinger GP, Rodríguez E, Günther S, Krasemann S, Idoyaga J, Oestereich L, Muñoz-Fontela C
    • Scientific Reports. 2017 Mar 3;7:43776. doi: 10.1038/srep43776
    • 2017-03-03

  • Persistence and clearance of Ebola virus RNA from seminal fluid of Ebola virus disease survivors: a longitudinal analysis and modelling study

    • Sissoko D, Duraffour S, Kerber R, Kolie JS, Beavogui AH, Camara AM, Colin G, Rieger T, Oestereich L, Pályi B, Wurr S, Guedj J, Nguyen THT, Eggo RM, Watson CH, Edmunds WJ, Bore JA, Koundouno FR, Cabeza-Cabrerizo M, Carter LL, Kafetzopoulou LE, Kuisma E, Michel J, Patrono LV, Rickett NY, Singethan K, Rudolf M, Lander A, Pallasch E, Bockholt S, Rodríguez E, Di Caro A, Wölfel R, Gabriel M, Gurry C, Formenty P, Keïta S, Malvy D, Carroll MW, Anglaret X, Günther S
    • Lancet Glob Health. 2017 Jan;5(1):e80-e88. doi: 10.1016/S2214-109X(16)30243-1
    • 2017-01-05

  • Humanized Mice Reproduce Acute and Persistent Infection of Human Adenovirus

    • Rodríguez E, Ip WH, Kolbe V, Hartmann K, Pilnitz-Stolze G, Tekin N, Gómez-Medina S, Muñoz-Fontela C, Krasemann S, Dobner T
    • Journal of Infectious Diseases. 2017 Jan 1;215(1):70-79. doi: 10.1093/infdis/jiw499
    • 2017-01-01