Our Publications
2022
Common virulence gene expression in adult first-time infected malaria patients and severe cases
- Wichers JS, Tonkin-Hill G, Thye T, Krumkamp R, Kreuels B, Strauss J, von Thien H, Scholz JAM, Smedegaard Hansson H, Weisel Jensen R, Turner L, Lorenz FR, Schöllhorn A, Bruchhaus I, Tannich E, Fendel R, D Otto T, Lavstsen T, Gilberger TW, Duffy M, Bachmann A
- Elife. 2021 Apr 28;10:e69040
Cell biological analysis reveals an essential role for Pfcerli2 in erythrocyte invasion by malaria parasites
- Liffner B, Balbin JM, Gerald J. Shami GJ, Siddiqui G, Strauss J, Frölich S, Heinemann GK, May E, Alder A, Wichers JW, Creek DJ, Tilley L, Dixon MW, Gilberger TW, Wilson DW
- Commun Biol 5, 121 (2022)
N-terminal phosphorylation regulates the activity of Glycogen Synthase Kinase 3 from Plasmodium falciparum
- Pazicky S, Alder A, Mertens H, Svergun DI, Gilberger T, Löw C
- Biochem J. 2022 Jan 13:BCJ20210829
2021
Characterization of Apicomplexan Amino Acid Transporters (ApiATs) in the Malaria Parasite Plasmodium falciparum
- Wichers JS, van Gelder C, Fuchs G, Ruge JM, Pietsch E, Ferreira JL, Safavi S, von Thien H, Burda PC, Mesén-Ramirez P, Spielmann T, Strauss J, Gilberger TW, Bachmann A
- mSphere. 2021 Dec 22;6(6):e0074321
The parasitophorous vacuole nutrient channel is critical for drug access in malaria parasites and modulates the artemisinin resistance fitness cost
- Mesén-Ramírez P, Bergmann B, Elhabiri M, Zhu L, von Thien H, Castro-Peña C, Gilberger TW, Davioud-Charvet E, Bozdech Z, Bachmann A, Spielmann T
- Cell Host Microbe. 2021 Dec 8;29(12):1774-1787.e9
CRISPR/Cas9-engineered inducible gametocyte producer lines as a valuable tool for Plasmodium falciparum malaria transmission research
- Boltryk SD, Passecker A, Alder A, Carrington E, van de Vegte-Bolmer M, van Gemert GJ, van der Starre A, Beck HP, Sauerwein RW, Kooij TWA, Brancucci NMB, Proellochs NI, Gilberger TW, Voss TS
- Nat Commun. 2021; 12: 4806
Synthesis and Antiplasmodial Activity of Bisindolylcyclobutenediones
- Lande D, Nasereddin A, Alder A, Gilberger T, Dzikowski R, Grünefeld J, Kunick C
- Molecules 26(16), 4739
The Ins and Outs of Plasmodium Rhoptries, Focusing on the Cytosolic Side
- Liffner B, Balbin JM, Wichers JS, Gilberger TW, Wilson DW
- Trends Parasitol. 2021 Apr 30:S1471-4922(21)00058-1
Identification of novel inner membrane complex and apical annuli proteins of the malaria parasite Plasmodium falciparum
- Wichers JS, Wunderlich J, Heincke D, Pazicky S, Strauss J, Schmitt M, Kimmel J, Wilcke L, Scharf S, von Thien H, Burda PC, Spielmann T, Löw C, Filarsky M, Bachmann A, Gilberger TW
- Cell Microbiol. 2021 Apr 8:e13341
A non-reactive natural product precursor of the duocarmycin family has potent and selective and antimalarial activity
- Alder A, Struck, NS, Xiu M, Johnson JW, Wang W, Pallant D, Cook MA, Rambow J, Lemcke S, Gilberger TW, Wright GD
- Cell Chemical Biology 29, 1–14, April 21
High Content Analysis of Macrophage-Targeting EhPIb-Compounds against Cutaneous and Visceral Leishmania Species
- Fehling H, Niss H, Bea A, Kottmayr N, Brinker C, Hoenow S, Sellau J, Gilberger TW, Ting F, Landschulze D, Meier C, Clos J, Lotter H
- Microorganisms. 2021 Feb 18;9(2):422
The Dynamic Roles of the Inner Membrane Complex in the Multiple Stages of the Malaria Parasite
- Ferreira JL, Heincke D, Wichers JS, Liffner B, Wilson DW, Gilberger TW
- Front Cell Infect Microbiol. 2021 Jan 8;10:611801
2020
The ZIP Code of Vesicle Trafficking in Apicomplexa: SEC1/Munc18 and SNARE Proteins
- Bisio H, Chaabene RB, Sabitzki R, Maco B, Marq JB, Gilberger TW, Spielmann T, Soldati-Favre D
- mBio. 2020 Oct 20;11(5):e02092-20
Structural role of essential light chains in the apicomplexan glideosome
- Pazicky S, Dhamotharan K, Kaszuba K, Mertens HDT, Gilberger T, Svergun D, Kosinski J, Weininger U, Löw C.
- Commun Biol. 2020 Oct 13;3(1):568
Structure-Based Identification and Functional Characterization of a Lipocalin in the Malaria Parasite Plasmodium falciparum
- Burda PC, Crosskey T, Lauk K, Zurborg A, Söhnchen C, Liffner B, Wilcke L, Pietsch E, Strauss J, Jeffries CM, Svergun DI, Wilson DW, Wilmanns M, Gilberger TW
- Cell Rep. 2020 Jun 23;31(12):107817
4-Arylthieno[2,3-b]pyridine-2-carboxamides Are a New Class of Antiplasmodial Agents
- Schweda SI, Alder A, Gilberger T, Kunick C
- Molecules. 2020 Jul 13;25(14):3187
PfCERLI1 is a conserved rhoptry associated protein essential for Plasmodium falciparum merozoite invasion of erythrocytes
- Liffner B, Frölich S, Heinemann GK, Liu B, Ralph SA, Dixon MWA, Gilberger TW, Wilson DW
- Nat Commun. 2020 Mar 16;11(1):1411
Adhesion between P. falciparum infected erythrocytes and human endothelial receptors follows alternative binding dynamics under flow and febrile conditions
- Lubiana P, Bouws P, Roth LK, Dörpinghaus M, Rehn T, Brehmer J, Wichers JS, Bachmann A, Höhn K, Roeder T, Thye T, Gutsmann T, Burmester T, Bruchhaus I, Metwally NG
- Sci Rep. 2020 Mar 11;10(1):4548
Structural Insights Into PfARO and Characterization of its Interaction With PfAIP
- Geiger M, Brown C, Wichers JS, Strauss J, Lill A, Thuenauer R, Liffner B, Wilcke L, Lemcke S, Heincke D, Pazicky S, Bachmann A, Löw C, Wilson DW, Filarsky M, Burda PC, Zhang K, Junop M, Gilberger TW
- J Mol Biol. 2020 Feb 14;432(4):878-896
Stringent Selection of Knobby Plasmodium falciparum-Infected Erythrocytes during Cytoadhesion at Febrile Temperature
- Dörpinghaus M, Fürstenwerth F, Roth LK, Bouws P, Rakotonirinalalao M, Jordan V, Sauer M, Rehn T, Pansegrau E, Höhn K, Mesén-Ramírez P, Bachmann A, Lorenzen S, Roeder T, Metwally NG, Bruchhaus I
- Microorganisms. 2020 Jan 25;8(2):174
