How do pathogens work?
Systems, cell and structural biology with state-of-the-art technology
In basic research on tropical pathogens, the BNITM pursues a holistic research approach. The focus is on both the pathogens themselves and their interactions with the host organism at the atomic, molecular, cellular and systemic level. The rapidly developing biochemical and bioinformatic methods open up new and promising avenues. Simultaneous investigations of a multitude of individual elements are now possible (genome, transcriptome, proteome, metabolome analyses), including their computational merging and modulation (systems biology), as well as experimental testing (e.g. by altering the pathogen genome). The infection process can be elucidated in its entirety, thus covering the entire spectrum from the investigation of minute molecular structures to innovative clinical research.