Pressemitteilungen

Modern laboratory diagnostic rapidly detects Marburg virus in Guinea

Effective Management

Hamburg / Conakry, June 30, 2022 - For the first time, researchers have detected the highly contagious and often fatal Marburg virus disease in West Africa. Over the recent years, the Department of Virology at the Bernhard Nocht Institute for Tropical Medicine (BNITM) in Hamburg and the Laboratory for Hemorrhagic Fever Viruses of Guinea (LFHVG*) in Conakry have established modern diagnostic capacities in the Forest area of Guinea. "A key to the rapid detection and containment of the outbreak in August 2021 was the early warning system deep inside the country, in the town of Guéckédou," explains Dr. Sophie Duraffour, virologist at BNITM. Now, the journal The New England Journal of Medicine published the methodology and results: doi 10.1056/NEJMc2120183.

An electron micrograph (black and white) of Marburg virus. Rod-shaped with a curved end.
Image: BNITM

Marburg virus disease was previously known to circulate in Eastern, Central and Southern Africa. One of the reservoirs of Marburg virus is the Egyptian fruit bat (Rousettus aegyptiacus). Marburg virus causes a hemorrhagic fever in infected individuals which is fatal in 25 to 90 percent of the cases. There is no vaccine.

"Until now, Marburg virus disease was not known to occur in West Africa even if certain studies were suggesting this," says Dr. Duraffour, one of two leaders of the international study. “Our long-term collaboration with partners in Guéckédou and Conakry in Guinea has created capacities for reliable and rapid diagnosis of hemorrhagic fevers, including Marburg virus disease, also in resource-limited settings far from the capital”.

It is now possible to carry out state-of-the-art laboratory diagnostics where most needed and, in this particular case, in less than twelve hours after the first alert from health authorities.

Two LFHVG staff inactivate suspect samples in a negative pressure glovebox.
Two LFHVG staff inactivate suspect samples in a negative pressure glovebox.
©Fara Raymond Koundouno

The efficient outbreak management in Guinea

"The long-standing collaboration aiming to establish and maintain laboratory and research capacity with well-trained staff in locations where outbreaks are most likely to occur, has been key to success," explains the Guinean study leader Dr. N'Faly Magassouba of the LFHVG in Conakry.

The laboratory which diagnosed the case was set up in 2016 in Guéckédou about 14 to 16 hours drive away from the capital Conakry. The laboratory team, which is led by the first author of the letter, detected the Marburg virus disease outbreak at very early stage. This immediately prompted an efficient public health response and ultimately prevented the outbreak from spreading: no further cases were registered.

Another goal of the international collaboration is to enable sequencing work in Guinea. This allowed to determine the sequence of the virus directly in Conakry. The rapid availability of the virus sequence helped to investigate the origin of this emergence, which was likely due to a transmission event from an animal reservoir such as bats.

"The example in Guinea shows that our decentralized approach with setting up modern diagnostic facilities in remote areas with high chance of virus emergence indeed reduces the risk of larger outbreaks. The laboratories served a similar purpose in detecting and combatting the re-emergence of Ebola virus disease early 2021. Although West Africa has made great progress in outbreak preparedness after the large Ebola virus disease epidemic 2014 to 2016, the access to modern diagnostics tools in remote areas is still low!" emphasizes Duraffour.

The establishment of laboratory capacities in Guinea is supported by the German Ministry of Health through the Global Health Protection Programme (GHPP**).

Original publication: doi 10.1056/NEJMc2120183

 

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Portrait of Dr Sophie Duraffour
Dr Sophie Duraffour
Image: BNITM / ©Dino Schachten

* “Laboratoire des Fièvres Hémorragiques Virales de Guinée” or LFHVG
** About the Global Health Protection Programme
 

Press contacts / last authors

Sophie Duraffour, PhD
BNITM Virology Department
Tel.: +49 40 42818-641
duraffour[at]bnitm.de

N'Faly Magassouba, PhD
LFHVG, Guinea
cmagassouba01[at]gmail.com

 


Background information

International study partners

  1. Bernhard Nocht Institute for Tropical Medicine (BNITM), Hamburg, Germany
  2. KU Leuven, Leuven, Belgium
  3. Institut Pasteur Dakar, Dakar, Senegal
  4. Laboratoire des Fièvres Hémorragiques Virales de Guinée (LFHVG), Université Gamal Abdel Nasser, Conakry, Guinea
  5. World Health Organization (WHO) Guinea, Conakry, Guinea
  6. Médecins Sans Frontières (MSF) Belgium, Conakry, Guinea
  7. World Health Organization (WHO), Geneva, Switzerland
  8. University of Nebraska Medical Center, Omaha, NE, USA
  9. Agence Nationale de Sécurité Sanitaire, Conakry, Guinea
     

About Bernhard Nocht Institute for Tropical Medicine

The Bernhard Nocht Institute for Tropical Medicine (BNITM) is Germany’s largest institution for research, services and training in the field of tropical diseases and emerging infections. It is a member of the Leibniz-Association.

The current scientific focus is on malaria, haemorrhagic fever viruses, immunology, epidemiology, clinical research of tropical infections and mechanism of transmission of viruses by mosquitoes. To study highly pathogenic viruses and infected insects, the institute is equipped with laboratories of the highest biosafety levels (BSL4) and a BSL3 insectary.

BNITM comprises the National Reference Centre for Tropical Pathogens and the WHO Collaborating Centre for Arbovirus and Haemorrhagic Fever Reference and Research.

Together with the Ghanaian Ministry of Health and the University of Kumasi, it runs a modern research and training centre in the West African rainforest, which is also available to external research groups. In addition, the Institute maintains numerous other collaborations in other African countries such as Gabon, Nigeria, Tanzania and Madagascar.

Contact person

Prof. Dr Stephan Günther

Leiter / Head of Virology

Phone : +49 40 285380-547

Fax : +49 40 285380-931

Email : guenther@bnitm.de

Dr. Eleonora Schoenherr

Public Relations

Phone : +49 40 285380-269

Email : presse@bnitm.de