Publications Laborgruppe Bachmann
2023
A microtubule associated protein is essential for malaria parasite transmission
- Wichers-Misterek JS, Binder AM, Mesén-Ramírez P, Dorner LP, Safavi S, Fuchs G, Lenz TL, Bachmann A, Wilson D, Frischknecht F, Gilberger TW.
- mBio. 2023 Feb 28;14(1):e0331822. doi: 10.1128/mbio.03318-22. Epub 2023 Jan 10. PMID: 36625655
2022
CD36—A Host Receptor Necessary for Malaria Parasites to Establish and Maintain Infection
- Anna Bachmann, Nahla Galal Metwally, Johannes Allweier, Jakob Cronshagen, Maria del Pilar Martinez Tauler, Agnes Murk, Lisa Katharina Roth, Hanifeh Torabi, Yifan Wu, Thomas Gutsmann and Iris Bruchhaus
- Microorganisms
Functional inactivation of Plasmodium falciparum GSK3 modulates erythrocyte invasion and blocks gametocyte maturation.
- Arne Alder, Louisa Wilcke, Emma Pietsch, Heidrun von Thien, Samuel Pazicky, Christian Löw, Paolo Mesen-Ramirez, Anna Bachmann, Paul-Christian Burda, Conrad Kunick, Holger Sondermann, Danny Wilson and Tim-Wolf Gilberger
- J Biol Chem. 2022 Sep; 298(9): 102360.
Analysis of var transcript patterns by quantitative real-time PCR
- Anna Bachmann, Thomas Lavstsen
- Malaria Immunology pp 149–171
PMRT1, a Plasmodium-specific parasite plasma membrane transporter, is essential for asexual and sexual blood stage development
- Wichers JS, Mesén-Ramírez P, Fuchs G, Yu-Strzelczyk J, Stäcker J, von Thien H, Alder A, Henshall I, Liffner B, Nagel G, Löw C, Wilson D, Spielmann T, Gao S, Gilberger TW, Bachmann A, Strauss J
- mBio. 2022 Apr 26;13(2):e0062322. doi: 10.1128/mbio.00623-22. Epub 2022 Apr 11. PMID: 35404116
The putative bromodomain protein PfBDP7 of the human malaria parasite Plasmodium falciparum cooperates with PfBDP1 in the silencing of variant surface antigen expression
- Jennifer E. Quinn, Myriam D. Jeninga, Katharina Limm, Kapil Pareek, Tina Meißgeier, Anna Bachmann, Michael F. Duffy and Michaela Petter corresponding author
- Front Cell Dev Biol. 2022; 10: 816558.
2021
The parasitophorous vacuole nutrient channel is critical for drug access in malaria parasites and modulates the artemisinin resistance fitness cost
- Mesén-Ramirez P, Bergmann B, Elhabiri M, Zhu L, von Thien H, Castro-Peña C, Gilberger TW, Davioud-Charvet E, Bozdech Z, Bachmann A, Spielmann T
- Cell Host Microbe. 2021 Dec 8;29:1774-88. doi: 10.1016/j.chom.2021.11.002
Characterization of Apicomplexan Amino Acid Transporters (ApiATs) in the Malaria Parasite Plasmodium falciparum
- Wichers JS, van Gelder C, Fuchs G, Ruge JM, Pietsch E, Ferreira JL, Safavi S, von Thien H, Burda PC, Mesén-Ramirez P, Spielmann T, Strauss J, Gilberger TW, Bachmann A
- mSphere. 2021 Nov 10:e0074321. doi: 10.1128/mSphere.00743-21.
Altered Cytokine Response of Human Brain Endothelial Cells after Stimulation with Malaria Patient Plasma
- Raacke M, Kerr A, Dörpinghaus M, Brehmer J, Wu Y, Lorenzen S, Fink C, Jacobs T, Roeder T, Sellau J, Bachmann A, Metwally NG, Bruchhaus I
- Cells. 2021, July 1;10(7):1656. doi: 10.3390/cells10071656.
Common virulence gene expression in adult first-time infected malaria patients and severe cases
- Wichers JS, Tonkin-Hill G, Thye T, Krumkamp R, Kreuels B, Strauss J, von Thien H, Scholz JAMS, Smedegaard Hansson H, Weisel Jensen R, Turner L, Lorenz FR, Schöllhorn A, Bruchhaus I, Tannich E, Fendel R, Otto TD, Lavstsen T, Gilberger TW, Duffy MF, Bachmann A
- elife. 2021 Apr 28;10:e69040. doi: 10.7554/eLife.69040.
Identification of novel inner membrane complex and apical annuli proteins of the malaria parasite Plasmodium falciparum
- Wichers JS, Wunderlich J, Heincke D, Pazicky S, Strauss J, Schmitt M, Kimmel J, Wilcke L, Scharf S, von Thien H, Burda PC, Spielmann T, Löw C, Filarsky M, Bachmann A, Gilberger TW
- Cell Microbiol. 2021 Apr 8:e13341. doi: 10.1111/cmi.13341.
2020
Adhesion between P. falciparum infected erythrocytes and human endothelial receptors follows alternative binding dynamics under flow and febrile conditions
- Lubiana P, Bouws P, Roth LK, Dörpinghaus M, Rehn T, Brehmer J, Wichers JS, Bachmann A, Höhn K, Roeder T, Thye T, Gutsmann T, Burmester T, Bruchhaus I, Metwally NG
- Sci Rep. 2020 Mar 11;10(1):4548. doi: 10.1038/s41598-020-61388-2.
Structural insights into PfARO and characterization of its interaction with PfAIP
- Geiger M, Brown C, Wichers JS, Strauss J, Lill A, Thuenauer R, Liffner B, Wilcke L, Lemcke S, Heincke D, Pazicky S, Bachmann A, Löw C, Wilson DW, Filarsky M, Burda PC, Zhang K, Junop M, Gilberger TW
- J Mol Biol. 2020 Feb 14;432(4):878-896. doi: 10.1016/j.jmb.2019.12.024.
Stringent selection of knobby Plasmodium falciparum-infected erythrocytes during cytoadhesion at febrile temperature
- Dörpinghaus M, Fürstenwerth F, Roth LK, Bouws P, Rakotonirinalalao M, Jordan V, Sauer M, Rehn T, Pansegrau E, Höhn K, Mesén-Ramírez P, Bachmann A, Lorenzen S, Roeder T, Metwally NG, Bruchhaus I
- Microorganisms. 2020 Jan 25;8(2):174. doi: 10.3390/microorganisms8020174.
2019
Dissecting the gene expression, localization, membrane topology, and function of the Plasmodium falciparum STEVOR protein family
- Wichers JS, Scholz JAM, Strauss J, Witt S, Lill A, Ehnhold LI, Neupert N, Liffner B, Lühken R, Petter M, Lorenzen S, Wilson DW, Löw C, Lavazec C, Bruchhaus I, Tannich E, Gilberger TW, Bachmann A
- mBio. 2019 Jul 30;10(4):e01500-19. doi: 10.1128/mBio.01500-19.
Controlled human malaria infection with Plasmodium falciparum demonstrates impact of naturally acquired immunity on virulence gene expression
- Bachmann A, Bruske E, Krumkamp R, Turner L, Wichers JS, Petter M, Held J, Duffy MF, Sim BKL, Hoffman SL, Kremsner PG, Lell B, Lavstsen T, Frank M, Mordmüller B, Tannich E
- PLoS Pathog. 2019 Jul 11;15(7):e1007906. doi: 10.1371/journal.ppat.1007906.
2018
Plasmodium falciparum gametocyte-infected erythrocytes do not adhere to human primary erythroblasts
- Neveu G, Dupuy F, Ladli M, Barbieri D, Naissant B, Richard C, Martins RM, Lopez-Rubio JJ, Bachmann A, Verdier F, Lavazec C
- Sci Rep. 2018 Dec 14;8(1):17886. doi: 10.1038/s41598-018-36148-y.
2017
Characterisation of Plasmodium falciparum populations selected on the human endothelial receptors P-selectin, E-selectin, CD9 and CD151
- Metwally NG, Tilly AK, Lubiana P, Roth LK, Dörpinghaus M, Lorenzen S, Schuldt K, Witt S, Bachmann A, Tidow H, Gutsmann T, Burmester T, Roeder T, Tannich E, Bruchhaus I
- Sci Rep. 2017 Jun 22;7(1):4069. doi: 10.1038/s41598-017-04241-3.
2016
Sporozoite route of infection influences in vitro var gene transcription of Plasmodium falciparum parasites from controlled human infections
- Dimonte S, Bruske E, Hass J, Supan C, Salazar CL, Held J, Tschan S, Esen M, Flötenmeyer M, Koch I, Berger J, Bachmann A, Sim BKL, Hoffman SL, Kremsner PG, Mordmüller B, Frank M
- J Infect Dis. 2016 Sep 15;214(6):884-94. doi: 10.1093/infdis/jiw225.
Plasmodium falciparum STEVOR phosphorylation regulates host erythrocyte deformability enabling malaria parasite transmission
- Naissant B, Dupuy F, Duffier Y, Lorthiois A, Duez J, Scholz JAM, Buffet P, Merckx A, Bachmann A, Lavazec C
- Blood. 2016 Jun 16;127(24):e42-53. doi: 10.1182/blood-2016-01-690776.
Mosquito passage dramatically changes var gene expression in controlled human Plasmodium falciparum infections
- Bachmann A, Petter M, Krumkamp R, Esen M, Held J, Scholz JAM, Li T, Sim BKL, Hoffman SL, Kremsner PG, Mordmüller B, Duffy MF, Tannich E
- PLoS Pathog. 2016 Apr 12;12(4):e1005538. doi: 10.1371/journal.ppat.1005538.
2015
Type of in vitro cultivation influences cytoadhesion, knob structure, protein localization and transcriptome profile of Plasmodium falciparum
- Tilly AK, Thiede J, Metwally NG, Lubiana P, Bachmann A, Roeder T, Rockliffe N, Lorenzen S, Tannich E, Gutsmann T, Bruchhaus I
- Sci Rep. 2015 Nov 16;5:16766. doi: 10.1038/srep16766.
A comparative study of the localization and membrane topology of members of the RIFIN, STEVOR and PfMC-2TM protein families in Plasmodium falciparum-infected erythrocytes
- Bachmann A, Scholz JAM, Janßen M, Klinkert MQ, Tannich E, Bruchhaus I, Petter M
- Malar J. 2015 Jul 16;14:274. doi: 10.1186/s12936-015-0784-2.
2014
Evidence of promiscuous endothelial binding by Plasmodium falciparum-infected erythrocytes
- Esser C, Bachmann A, Kuhn D, Schuldt K, Förster B, Thiel M, May J, Koch-Nolte F, Yáñez-Mó M, Sánchez-Madrid F, Schinkel AH, Jalkanen S, Craig AG, Bruchhaus I, Horstmann RD
- Cell Microbiol. 2014 May;16(5):701-8. doi: 10.1111/cmi.12270.
2012
Temporal expression and localization patterns of variant surface antigens in clinical Plasmodium falciparum isolates during erythrocyte schizogony
- Bachmann A, Petter M, Tilly AK, Biller L, Uliczka KA, Duffy MF, Tannich E, Bruchhaus I
- PLoS One. 2012;7(11):e49540. doi: 10.1371/journal.pone.0049540.
2011
Highly co-ordinated var gene expression and switching in clinical Plasmodium falciparum isolates from non-immune malaria patients
- Bachmann A, Predehl S, May J, Harder S, Burchard GD, Gilberger TW, Tannich E, Bruchhaus I
- Cell Microbiol. 2011 Sep;13(9):1397-409. doi: 10.1111/j.1462-5822.2011.01629.x.
2010
The essentials of protein import in the degenerate mitochondrium of Entamoeba histolytica
- Dolezal P, Dagley MJ, Kono M, Wolynec PP, Likic VA, Foo JH, Sedinova M, Tachezy J, Bachmann A, Bruchhaus I, Lithgow T
- PLoS Pathog.a 2010 Mar 19;6(3):e1000812. doi: 10.1371/journal.ppat.1000812.
2009
Absence of erythrocyte sequestration and lack of multicopy gene family expression in Plasmodium falciparum from a splenectomized malaria patient
- Bachmann A, Esser C, Petter M, Predehl S, von Kalckreuth V, Schmiedel S, Bruchhaus I, Tannich E
- https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007459
2008
An Entamoeba cysteine peptidase specifically expressed during encystations
- Ebert F, Bachmann A, Nakada-Tsukui K, Hennings I, Drescher B, Nozaki T, Tannich E, Bruchhaus I
- Parasitol Int. 2008 Dec;57(4):521-4. doi: 10.1016/j.parint.2008.07.002.
Characterization of a conserved rhoptry-associated leucine zipper-like protein in the malaria parasite Plasmodium falciparum
- Haase S, Cabrera A, Langer C, Treeck M, Struck N, Herrmann S, Jansen PW, Bruchhaus I, Bachmann A, Dias S, Cowman AF, Stunnenberg HG, Spielmann T, Gilberger TW
- Infect Immun. 2008 Mar;76(3):879-87. doi: 10.1128/IAI.00144-07.
