families (Flaviviridae, Bunyaviridae, Togaviridae) as well as some that are unclassified. Studies show that many mosquitoes are naturally infected with at least one MSV, but it is not known if some MSVs

ecificity, metal-dependent RNA cleavage, and stabilization of the enzymatic domain. Alongside, we show the impact of these residues mutations on the hydrolysis reaction. PLoS Pathogens. 12(6): e1005635

Komplikationen verursachen. Publikationen: Cubillán-Marín J et al., Vesicle adapters in malaria parasites show conservation and flexibility of protein sorting machinery, Journal of Cell Biology 2025, doi: 10.1083/jcb

endothelial protein C receptor (EPCR). In contrast, infections dominated by CD36-binding parasites show mild disease courses. Interestingly, between 75%-85% of Pf EMP1s in a parasite isolate possess a binding

their similarity to each other. However, more than a third of all proteins of P. falciparum parasites show no resemblance to any of these components found in other organisms, representing biology unique to

distribution. Using selective depletion strategies and various knockout mutant mice, we were able to show that innate immune cells like the inflammatory Ly6C hi monocytes, but also liver resident Kupffer