* European Molecular Biology Laboratory
** Leibniz-Institut für Experimentelle Virologie (LIV) / Universität Hamburg (UHH) mit Laboren am Centre for Structural Systems Biology (CSSB)
Williams H.M., Thorkelsson S. R., et al.; Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein. Nucleic Acids Research, 1-19, 2022: https://doi.org/10.1093/nar/gkac1249
Function of viral polymerase in virus replication
To understand the complicated mechanism of virus replication, structural biology focuses on one key component: viral polymerase. In an infected cell, this enzyme ensures that new viral building blocks are created and duplicates the genetic information of the virus. The genome copies are then packaged with the viral building blocks into new "virions" that can leave the cell and infect a new host. Determining the polymerase structure helps scientists understand how a virus replicates. And this information, in turn, gives researchers important clues for developing drugs that can stop the infection.
Partners with strong expertise in electron microscopy are Dr Emmanuelle Quemin, group leader at the Institute for Integrative Biology of the Cell (I2BC), France, and Prof Kay Grünewald from LIV / UHH with laboratories at CSSB in Hamburg. The research group led by Dr Stephen Cusack, head of EMBL Grenoble, focuses on the polymerase of various human pathogenic viruses, especially from the influenza virus group.
Funded by the Leibniz Association "Leibniz Competition". (Cooperative-Excellence)
The Leibniz Competition addresses the strategic goals of the Leibniz Association within the framework of the Joint Initiative for Research and Innovation. The measures motivate to conduct research and research infrastructures at the highest level and to make the resulting successes visible. With its time-limited funding, the Leibniz Competition provides incentives to further raise the profile of the Leibniz Association. In this way, it deliberately sets itself apart from measures taken by other funding organisations and institutional funding.