• Arbeitsgruppe Lotter: Marie Groneberg, Charlotte Hansen, Malte Vogelsang, Helena Fehling, Julie Sellau,

    Stefan Hoenow, Claudia Marggraff, Hanna Lotter, Nadine Kottmayr

Overview

  • Immune processes underlying amebic liver abscess (ALA) formation and regeneration
  • Background for the sex bias in invasive amebias
  • In vivo imaging of Entamoeba histolytica

Research Projects

Immune processes underlying ALA formation and regeneration

Stefan Hoenow, Marie Groneberg, Claudia Marggraff

 Human amebiasis results from intestinal infections with the protozoan parasite Entamoeba histolytica (E. histolytica). The two major clinical symptoms that derive from the infections, the amebic colitis and the amebic liver abscess (ALA), represent major health problems in subtropical and tropical areas as well as in travellers. The parasite usually asymptomatically colonizes the bowel system, but occasionally it invades the mucosa and spreads via the blood stream into other organs, mainly in the liver. To investigate immunological backgrounds for the development of ALA, we have established a mouse model that resembles the human disease in terms of a comparable pathology and a similar sex distribution. Using selective depletion strategies and various knockout mutant mice, we were able to show that innate immune cells like the inflammatory Ly6Chi monocytes, but also liver resident Kupffer cells substantially contribute to the liver destruction via production of TNFα. IL-23 further contributes to immunopathology of ALA by stabilizing IL-17 production and CCL2 expression. On the other hand, tissue repair is initiated by the presence of anti-inflammatory Ly6Clo monocytes in the liver that produce IL-13 and further develop into alternative activated M2 macrophages expressing Arginase 1.

 

Funding:

SFB841, " Leberentzündung: Infektion, Immunregulation und Konsequenzen" Project A2

Sex dimorphisms in the immune system

Julie Sellau, Marie Groneberg, Svenja Kühl

 An increasing body of evidence suggests an involvement of sex-based influences on the outcome of infectious, autoimmune and tumor diseases. This could be either attributed to X- or Y-chromosome linked-genes, environmental risk factors or sex hormones that act on immune responses involved in the outcome of a disease. Amebic liver abscess, a major severe symptom arising from human infections with the protozoan parasite Entamoeba  (E.)  histolytica, occurs independent from the infection rate with a clear sex bias towards adult men. With the aid of a mouse model that reflects the same sex dimorphism as observed in human, we found that testosterone significantly influenced the outcome of the disease. Female mice treated with testosterone lost their ability to control the abscess development and the parasite burden in the liver and Natural killer T cells, which were crucial for the control of the disease, produced less amounts of the protective cytokine IFNγ. In contrast, abscess development in male individuals was enabled by an immunopathology mediated by a C-C chemokine ligand  (CCL) 2-dependent recruitment of inflammatory monocytes and the production of TNFα and Nitric Oxide. Interestingly, we found higher CCL2 serum levels in the serum of men and male mice infected with the parasite compared to female individuals. In a larger consortium consisting of groups from the UKE, the Heinrich Pette Institute and the BNITM and funded by the BWFG we now want to identify common immune mechanisms that might underlie the sex-dependent outcome in a variety of diseases.

Funding:

Landesforschungsförderung Hamburg; "Geschlechtsdimorphismus im Immunsystem: Bedeutung für Erkrankung und Immunität" (LFF-FV45)

Beating parasites with their own weapons

Helena Fehling

Intracellular microorganisms that target immune cells can circumvent their clearance by manipulating the innate and the acquired immune response of the host. Two major human pathogens, parasites of the genus Leishmania and bacteria of the genus Mycobacterium, enter professional phagocytes like macrophages and dendritic cells (DC) where they survive and multiply. Through induction of immune evasion mechanisms the pathogen alter immune cell function and dampen protective immune responses. Therefore, immune ­stimulatory molecules that activate or re-activate target cells represent promising therapeutic tools for the treatment of these diseases. We recently isolated such an immunostimulatory molecule from the membrane of Entamoeba (E.) histolytica, a lipopeptidephosphoglycan (EhLPPG). The native molecule exhibited considerable immune cell stimulation leading to the reduction of the intracellular load of leishmania parasites in vitro and in a mouse model for the disease. In cooperation with Prof. Yukari Fujimoto from the Keio University in Japan and Prof. Chris Meier from the University of Hamburg we developed a series of synthetic analogs deduced from the two Phosphatidylinositol anchors of EhLPPG. So far, several analogs reproduced the anti-leishmanial activity of the parent compound in vitro and in vivo, presumably by inducing production of pro-inflammatory cytokines, and exhibited bactericidal activity against Mtb in vitro (Patent BNI002).

Funding:

DZIF  “Development of a new immunostimulatory compound for the treatment of Leishmaniasis and Tuberculosis.” (TTU02.902_00)       

DZIF-MD Stipendium (TI07.003)                                 

Publication Highlights

Laborgruppe Lotter

Androgens predispose males to monocyte-mediated immunopathology by inducing the expression of leukocyte recruitment factor CXCL1
Sellau J, Groneberg M, Fehling H, Thye T, Hoenow S, Marggraff C, Weskamm M, Hansen C, Stanelle-Bertram S, Kuehl S, Noll J, Wolf V, Metwally NG, Hagen SH, Dorn C, Wernecke J, Ittrich H, Tannich E, Jacobs T, Bruchhaus I, Altfeld M, Lotter H.
Nat Commun. 2020 Jul 10;11(1):3459. doi: 10.1038/s41467-020-17260-y.

Testosterone protects against severe influenza by reducing the pro-inflammatory cytokine response in the murine lung
Tuku B, Stanelle -Bertram S, Sellau J, Beck S, Bai T, Mounogue Kouassi N, Preuß A, Hoenow S, Renné T, Lotter H, Gabriel G.
Front Immunol. 2020 Apr; 11:697. doi: 10.3389/fimmu.2020.00697

Anti-leishmanial effects of synthetic EhPiB analogs derived from Entamoeba histolytica liopopeptidephosphoglycan
Fehling H, Choy SL, Ting F, Landschulze D, Bernin H, Lender SC, Mühlenpfordt M, Bifeld E, Eick J, Marggraff C, Kottmayr N, Groneberg M, Hoenow S, Sellau J, Clos J, Meier C, Lotter H.
Antimicrob Agents Chemother. 2020 May 11:AAC.00161-20. doi: 10.1128/AAC.00161-20

Androgen-dependent immune modulation in parasitic infections
Sellau J, Groneberg M, Lotter H.
Semin Immunopathol. 2019 Mar;41(2):213-224

Male offspring born to mildly ZIKV-infected mice are at risk of developing neurocognitive disorders in adulthood
Stanelle-Bertram S, ... Sellau J, Hoenow S,...Arck P... Friese, MA ... Lotter H ... Gabriel G.
Nat Microbiol 2018:3:1161-1174. doi: 10.1038/s41564-018-0236-1

IL-23 prevents IL-13-dependent tissue repair associated with Ly6Clo monocytes in Entamoeba histolytica-induced liver damage.
Noll J, Helk E, Fehling H, Bernin H, Marggraff C, Jacobs T, Huber S, Pelczar P, Ernst T, Ittrich H, Otto B, Mittrücker HW, Hölscher C, Tacke F, Bruchhaus I, Tannich E, Lotter H.
J Hepatol. 2016 Jan 22. pii: S0168-8278(16)00019-2. doi: 10.1016/j.jhep.2016.01.013. [Epub ahead of print]

The cytokine profile of human NKT cells and PBMCs is dependent on donor sex and stimulus.
Bernin H, Fehling H, Marggraff C, Tannich E, Lotter H.
Med Microbiol Immunol 2016;205:321-332. doi: 10.1007/s00430-016-0449-y

Immune markers characteristic for asymptomatically infected and diseased Entamoeba histolytica individuals and their relation to sex.
Bernin H, Marggraff C, Jacobs T, Brattig N, Le VA, Blessmann J, Lotter H.
BMC Infect Dis 2014;14:621. doi: 10.1186/s12879-014-0621-1.

TNFα-mediated liver destruction by Kupffer cells and Ly6Chi monocytes during Entamoeba histolytica infection.
Helk E, Bernin H, Ernst T, Ittrich H, Jacobs T, Heeren J, Tacke F, Tannich E, Lotter H.
PLoS Pathog. 2013 Jan;9(1):e1003096. doi: 10.1371/journal.ppat.1003096. Epub 2013 Jan 3.

Testosterone increases susceptibility to amebic liver abscess in mice and mediates inhibition of IFNγ secretion in natural killer T cells.
Lotter H, Helk E, Bernin H, Jacobs T, Prehn C, Adamski J, González-Roldán N, Holst O, Tannich E.
PLoS One. 2013;8(2):e55694. doi: 10.1371/journal.pone.0055694. Epub 2013 Feb 12.

All Publications

2020
2020

Androgens predispose males to monocyte-mediated immunopathology by inducing the expression of leukocyte recruitment factor CXCL1
Sellau J, Groneberg M, Fehling H, Thye T, Hoenow S, Marggraff C, Weskamm M, Hansen C, Stanelle-Bertram S, Kuehl S, Noll J, Wolf V, Metwally NG, Hagen SH, Dorn C, Wernecke J, Ittrich H, Tannich E, Jacobs T, Bruchhaus I, Altfeld M, Lotter H.
Nat Commun. 2020 Jul 10;11(1):3459. doi: 10.1038/s41467-020-17260-y.

Antileishmanial Effects of Synthetic EhPIb Analogs Derived from the Entamoeba histolytica Lipopeptidephosphoglycan.
Fehling H, Choy SL, Ting F, Landschulze D, Bernin H, Lender SC, Mühlenpfordt M, Bifeld E, Eick J, Marggraff C, Kottmayr N, Groneberg M, Hoenow S, Sellau J, Clos J, Meier C, Lotter H.
Antimicrob Agents Chemother. 2020 Jun 23;64(7):e00161-20. doi: 10.1128/AAC.00161-20

Testosterone Protects Against Severe Influenza by Reducing the Pro-Inflammatory Cytokine Response in the Murine Lung.
Tuku B, Stanelle-Bertram S, Sellau J, Beck S, Bai T, Kouassi NM, Preuß A, Hoenow S, Renné T, Lotter H, Gabriel G.
Front Immunol. 2020 Apr 22;11:697. doi: 10.3389/fimmu.2020.00697

2019
2019

Trigger-induced RNAi gene silencing to identify pathogenicity factors of Entamoeba histolytica.
Matthiesen J, Lender C, Haferkorn A, Fehling H, Meyer M, Matthies T, Tannich E, Roeder T, Lotter H, Bruchhaus I.
FASEB J. 2019 Feb;33(2):1658-1668. doi: 10.1096/fj.201801313R.

Androgen-dependent immune modulation in parasitic infection.
Sellau J, Groneberg M, Lotter H.
Semin Immunopathol. 2019 Mar;41(2):213-224. doi: 10.1007/s00281-018-0722-9.

Sex differences in immunity.
Lotter H, Altfeld M.
Semin Immunopathol. 2019 Mar;41(2):133-135. doi: 10.1007/s00281-018-00728-x.

Contribution of host immunity to the development of Entamoeba histolytica induced liver abscess. Eucaryome impact on human intestine homeostasis and mucosal immunology.
Sellau E, Lotter H.
Nancy Guillien (Editor); Springer, ISBN 978-3-030-44825-7, DOI 10.1007/978-3-030-44826-4.

2018
2018

Male offspring born to mildly ZIKV-infected mice are at risk of developing neurocognitive disorders in adulthood.
Stanelle-Bertram S, ..., Sellau J, Hoenow S, ..., Arck P, ..., Friese MA, ..., Lotter H, ... Gabriel G.
Nat Microbiol. 2018 Oct;3(10):1161-1174. doi: 10.1038/s41564-018-0236-1.

2017
2017

Synthetic analogs of an Entamoeba histolytica glycolipid designed to combat intracellular Leishmania infection.
Choy SL, Bernin H, Aiba T, Bifeld E, Lender SC, Mühlenpfordt M, Noll J, Eick J, Marggraff C, Niss H, Roldán NG, Tanaka S, Kitamura M, Fukase K, Clos J, Tannich E, Fujimoto Y, Lotter H.
Sci Rep. 2017 Aug 25;7(1):9472. doi: 10.1038/s41598-017-09894-8.

Employing BINOL-Phosphoroselenoyl Chloride for Selective Inositol Phosphorylation and Synthesis of Glycosyl Inositol Phospholipid from Entamoeba histolytica.
Aiba T, Suehara S, Choy SL, Maekawa Y, Lotter H, Murai T, Inuki S, Fukase K, Fujimoto Y.
Chemistry. 2017 Jun 16;23(34):8304-8308. doi: 10.1002/chem.201701298

2016
2016

Overexpression of Differentially Expressed Genes Identified in Non-pathogenic and Pathogenic Entamoeba histolytica Clones Allow Identification of New Pathogenicity Factors Involved in Amoebic Liver Abscess Formation.
Meyer M, Fehling H, Matthiesen J, Lorenzen S, Schuldt K, Bernin H, Zaruba M, Lender C, Ernst T, Ittrich H, Roeder T, Tannich E, Lotter H, Bruchhaus I.
PLoS Pathog. 2016 Aug 30;12(8):e1005853. doi: 10.1371/journal.ppat.1005853.

The cytokine profile of human NKT cells and PBMCs is dependent on donor sex and stimulus.
Bernin H, Fehling H, Marggraff C, Tannich E, Lotter H.
Med Microbiol Immunol. 2016 Aug;205(4):321-32. doi: 10.1007/s00430-016-0449-y.

IL-23 prevents IL-13-dependent tissue repair associated with Ly6Clo monocytes in Entamoeba histolytica-induced liver damage.
Noll J, Helk E, Fehling H, Bernin H, Marggraff C, Jacobs T, Huber S, Pelczar P, Ernst T, Ittrich H, Otto B, Mittrücker HW, Hölscher C, Tacke F, Bruchhaus I, Tannich E, Lotter H.
J Hepatol. 2016 May;64(5):1147-57. doi: 10.1016/j.jhep.2016.01.013.

Patent: New immunostimulatory compounds.
Lotter H, Tannich E, Bernin H, Fujimoto, Y, Fukase K, Gonzalez-Roldan N
30.03.2016. Application: 28.09.2014. EP, Patent application EP15770891.8; RU, RU2017114429; IN, IN201747014564; BR, BR112017006177-5.

2015
2015

Sex differences in H7N9 influenza A virus pathogenesis.
Hoffmann J, Otte A, Thiele S, Lotter H, Shu Y, Gabriel G.
Vaccine. 2015 Dec 8;33(49):6949-54. doi: 10.1016/j.vaccine.2015.08.044. Epub 2015 Aug 25.

Magnetic resonance imaging of pathogenic protozoan parasite Entamoeba histolytica labeled with superparamagnetic iron oxide nanoparticles.
Ernst TM, Fehling H, Bernin H, Zaruba MD, Bruchhaus I, Adam G, Ittrich H, Lotter H.
Invest Radiol. 2015 Oct;50(10):709-18. doi: 10.1097/RLI.0000000000000175.

Host immunity and tissue destruction during amebic liver abscess formation.
Helk E, Bernin H and Lotter H.
Nozaki, Tomoyoshi, Bhattacharya, Alok (Editors), Springer, ISBN 978-4-431-55199-7.

2014

Sex bias in the outcome of human tropical infectious diseases: influence of steroid hormones.
Bernin H, Lotter H.
J Infect Dis. 2014 Jul 15;209 Suppl 3:S107-13. doi: 10.1093/infdis/jit610.

The cell surface proteome of Entamoeba histolytica.
Biller L, Matthiesen J, Kühne V, Lotter H, Handal G, Nozaki T, Saito-Nakano Y, Schümann M, Roeder T, Tannich E, Krause E, Bruchhaus I.
Mol Cell Proteomics. 2014 Jan;13(1):132-44. doi: 10.1074/mcp.M113.031393. Epub 2013 Oct 17.

2013

Overexpression of specific cysteine peptidases confers pathogenicity to a nonpathogenic Entamoeba histolytica clone.
Matthiesen J, Bär AK, Bartels AK, Marien D, Ofori S, Biller L, Tannich E, Lotter H, Bruchhaus I.
MBio. 2013 Mar 26;4(2). pii: e00072-13. doi: 10.1128/mBio.00072-13.

Testosterone increases susceptibility to amebic liver abscess in mice and mediates inhibition of IFNγ secretion in natural killer T cells.
Helk E, Bernin H, Ernst T, Ittrich H, Jacobs T, Heeren J, Tacke F, Tannich E, Lotter H.
PLoS Pathog. 2013 Jan;9(1):e1003096. doi: 10.1371/journal.ppat.1003096. Epub 2013 Jan 3.

TNFα-mediated liver destruction by Kupffer cells and Ly6Chi monocytes during Entamoeba histolytica infection.
Helk E, Bernin H, Ernst T, Ittrich H, Jacobs T, Heeren J, Tacke F, Tannich E, Lotter H.
PLoS Pathog. 2013 Jan;9(1):e1003096. doi: 10.1371/journal.ppat.1003096. Epub 2013 Jan 3.

2010

Differences in the transcriptome signatures of two genetically related Entamoeba histolytica cell lines derived from the same isolate with different pathogenic properties.
Biller L, Davis PH, Tillack M, Matthiesen J, Lotter H, Stanley SL Jr, Tannich E, Bruchhaus I.
BMC Genomics. 2010 Jan 26;11:63. doi: 10.1186/1471-2164-11-63.

2009

Comparison of two genetically related Entamoeba histolytica cell lines derived from the same isolate with different pathogenic properties.
Biller L, Schmidt H, Krause E, Gelhaus C, Matthiesen J, Handal G, Lotter H, Janssen O, Tannich E, Bruchhaus I.
Proteomics. 2009 Sep;9(17):4107-20. doi: 10.1002/pmic.200900022.

Natural killer T cells activated by a lipopeptidophosphoglycan from Entamoeba histolytica are critically important to control amebic liver abscess.
Lotter H, González-Roldán N, Lindner B, Winau F, Isibasi A, Moreno-Lafont M, Ulmer AJ, Holst O, Tannich E, Jacobs T.
PLoS Pathog. 2009 May;5(5):e1000434. doi: 10.1371/journal.ppat.1000434. Epub 2009 May 15.

2008

Attenuated recombinant Yersinia as live oral vaccine carrier to protect against amoebiasis.
Lotter H, Rüssmann H, Heesemann J, Tannich E.
Int J Med Microbiol. 2008 Jan;298(1-2):79-86. Epub 2007 Sep 27.

2006

Increased expression of the major cysteine proteinases by stable episomal transfection underlines the important role of EhCP5 for the pathogenicity of Entamoeba histolytica.
Tillack M, Nowak N, Lotter H, Bracha R, Mirelman D, Tannich E, Bruchhaus I.
Mol Biochem Parasitol. 2006 Sep;149(1):58-64. Epub 2006 May 19.

The current status of an amebiasis vaccine.
Lotter H, Tannich E.
Arch Med Res. 2006 Feb;37(2):292-6.

Sexual dimorphism in the control of amebic liver abscess in a mouse model of disease.
Lotter H, Jacobs T, Gaworski I, Tannich E.
Infect Immun. 2006 Jan;74(1):118-24.

2004

Oral vaccination with recombinant Yersinia enterocolitica expressing hybrid type III proteins protects gerbils from amebic liver abscess.
Lotter H, Rüssmann H, Heesemann J, Tannich E.
Infect Immun. 2004 Dec;72(12):7318-21.

Resistance of Entamoeba histolytica to the cysteine proteinase inhibitor E64 is associated with secretion of pro-enzymes and reduced pathogenicity.
Nowak N, Lotter H, Tannich E, Bruchhaus I.
J Biol Chem. 2004 Sep 10;279(37):38260-6. Epub 2004 Jun 23.

2002

Differential gene expression in Entamoeba histolytica isolated from amoebic liver abscess.
Bruchhaus I, Roeder T, Lotter H, Schwerdtfeger M, Tannich E.
Mol Microbiol. 2002 May;44(4):1063-72.

Cooperations

Laborgruppe Lotter

Graduiertenschule (LCI)

Leibniz-Zentrum für Infektionsforschung

Therapeutische Aktivität eines Entamoeba histolytica - NKT-Zellliganden gegen experimentelle kutane Leishmaniose und Tuberkulose.

gemeinsam mit Dr. C. Hölscher: Forschungszentrum Borstel - Infektionsimmunologie

Starting date: 2015
Project website: https://www.lc-infection.de/de/lci-graduate-school.html

Graduiertenschule (LCI)

Leibniz-Zentrum für Infektionsforschung

Mechanismen, die den Geschlechtsunterschieden bei der angeborenen Immunität gegen Virusinfektionen zugrunde liegen.

gemeinsam mit Prof. Dr. M. Altfeld: Heinrich-Pette-Institut - Virus Immunologie

Starting date: 2015
Project website: https://www.lc-infection.de/de/lci-graduate-school.html

Graduiertenschule (LCI)

Leibniz-Zentrum für Infektionsforschung

Einfluss von Testosteron auf die Immunreaktion und die Neuroentwicklung bei Nachkommen von ZIKV-infizierten Müttern

Starting date: 2018
Project website: https://www.lc-infection.de/de/lci-graduate-school.html

Graduiertenschule (LCI)

Leibniz-Zentrum für Infektionsforschung

Parasitäre Infektion in Leber-Organoid-Immunzell-Kokulturen

gemeinsam mit Dr. Dr. M. Bunders: Heinrich-Pette-Institut - Virus Immunologie

Starting date: 2020
Project website: https://www.lc-infection.de/de/lci-graduate-school.html

Herz Graduate School - Host-pathogen crosstalk

Herz Stiftung

Einfluss der Leishmania-Infektion auf die Biologie der Wirtszellen

gemeinsam mit PD Dr. J. Clos: Bernhard-Nocht-Institut für Tropenmedizin - Leishmaniasen

Starting date: 2020

Herz Graduate School - Host-pathogen crosstalk

Herz Stiftung

Entschlüsselung der Interaktion zwischen Entamoeba histolytica und dem

menschlichen Wirt während der Darm- und Leberinvasion

gemeinsam mit Prof. Dr. I. Bruchhaus: Bernhard-Nocht-Institut für Tropenmedizin - Protozoologie


News from the group

Wir gratulieren Frau Dr. Sarah Corinna Lender zum Erreichen des Doktorgrades!

Alumni

Doctoral Thesis

Dr. Corinna Lender (2017-2019) : Genetische Manipulation des protozoischen Parasiten Entamoeba histolytica (SCHAUDINN, 1903) zur Charakterisierung putativer Pathogenitätsfaktoren

Dr. Siew Ling Choy (2015-2018) : Therapeutische Aktivität eines Entamoeba histolytica - NKT Zellliganden gegen experimentelle kutane Leishmaniose und Tuberkulose

Dr. Jill Noll (2014-2017) : Immunregulatorische Mechanismen bei der hepatischen Amöbiasis

Dr. Helena Fehling (2012-2015) : Analyse der Unterschiede pathogener und apathogener Entmoeba histolytica (SCHAUDINN, 1903) Klone in der Parasit-Wirt Interaktion

Dr. Hannah Bernin (2011-2014) : Evaluierung des immuntherapeutischen Potentials eines Lipopeptidphosphoglykans aus Entamoeba histolytica

Dr. Elena Helk (2010-2013) : Charakterisierung der Immunantwort im Mausmodell für den Amöbenleberabszess

Diploma and Master Thesis

Leonie Marie Weskamm (2019) : Geschlechtsspezifische Charakterisierung phänotypischer und funktioneller Eigenschaften von CD64+ humanen Monozyten

Farah Zoe Misterek (2018) : Master regulators of liver regeneration

Bettina Krause (2018) : Geschlechtsabhängige Expression von CXCL1 in Monozyten

Anne Haferkorn (2018) : Charakterisierung des hypothetischen Proteins (127670) mittels Überexpression bzw. Silencing in pathogenen und apathogenen Entamoeba histolytica Trophozoiten

Madeleine Glück (2018) : Untersuchung molekularer Kontrollmechanismen bei einer intrazellulären Infektion von monozytären Zelllinien mit Leishmanien spp

Marie Groneberg (2017) : E. histolytica-abhängige Immunmodulation in Monozyten und Makrophagen

Melina Mühlenpfordt (2016) : Evaluation of protective, immunological and cytotoxicv properties of synthetic immune-stimulatory molecules for the treatment of intreacellular Leishmania major infection

Sarah Corinna Lender (2015) : Immunstimulatorische Eigenschaften des Entamoeba histolytica Lipopeptidpshosphoglykans und davon abgeleiteten synthetischen Analoga

Karolin Hildebrandt (2014) : Die Rolle des Lipidstoffwechsels bei der Immunaktivierung und der Regeneration des Amöbenleberabszesses

Jill Kracht (2013) : Die Rolle der Zytokine IL-22 und IL-23 bei der Entstehung und Regeneration des Amöbenleberabszesses

Mareen Zaruba (2012) : Charakterisierung verschieden pathogener Entamoeba histolytica (Schaudinn, 1903) Klone im immunkomtetenten Tiermodell Mus musculus

Hannah Bernin (2011) : Die Rolle von neutrophilen Granulozyten und Makrophagen während der Amöbenleberabszessentstehung ausgelöst durch Entamoeba histolytica (Schaudinn, 1903)

Helena Dobbeck (2011) : Untersuchung der geschlechtsspezifischen Zytokinsekretion humaner iNKT-Zellen in Bezug auf die Amöbiasis des Menschen

Contact

Prof. Dr. med. vet. Hanna Lotter - Head of Animal Facility / Animal Welfare Officer

Phone: +49 40 42818-475
Fax: +49 40 42818-512
E-Mail: lotter@bnitm.de


Graduate Students

Charlotte Hansen (-476)
Nadine Kottmayr (-476)
Malte Vogelsang (-476)

PhD/MD Students

Annika Bea (-485)
Marie Groneberg (-483)
Stefan Hoenow (-483)
Barbara Honecker (-474)

Technical Staff

Claudia Marggraff (-476)
Svenja Kühl (-476)

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